Product Categories

DNA/RNA Synthesis Inhibitors

DNA/RNA Synthesis Inhibitors (35)
water-soluble

Cat.No.	Product Name	Information	Product Citations
S1166	Cisplatin	Cisplatin is an inorganic and water-soluble platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts.	PLoS One, 2013, 8(1), e54595
S1215	Carboplatin	Carboplatin is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism.
S1149	Gemcitabine HCl (Gemzar)	Gemcitabine Hydrochloride (Gemzar) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.	Cancer Immunol Immunother, 2013, 62(2):383-91 Pancreas, 2011, 40(5):730-9
S1224	Oxaliplatin (Eloxatin)	Oxaliplatin inhibits DNA synthesis by conforming DNA adducts.
S1229	Fludarabine Phosphate (Fludara)	Fludarabine Phosphate is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.
S1491	Fludarabine (Fludara)	Fludarabine (Fludara, F-ara-A, NSC 118218) is a STAT1 activation inhibitor and a DNA synthesis inhibitor.
S1135	Pemetrexed (Alimta)	Pemetrexed disodium (Alimta) is a novel antifolate and antimetabolite for TS, DHFR and GARFT with K_i of 1.3 nM, 7.2 nM and 65 nM, respectively.
S1270	CCT239065	CCT239065 is a novel and selective BRAF^V600E and LCK inhibitor with IC50 of 13 nM and 6 nM, respectively.
S2029	Uridine	Uridine is a nucleoside, contains a uracil attached to a ribose ring via a β-N1-glycosidic bond.
S1981	Adenine	Adenine is a purine derivative and a nucleobase with a variety of roles in biochemistry.
S1983	Adenine HCl	Adenine hydrochloride is a hydrochloride salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry.
S1982	Adenine sulfate	Adenine sulfate is a sulfate salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry.
S1995	Procarbazine HCl (Matulane)	Procarbazine hydrochloride (Matulane) is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound used as an antineoplastic agent.
S2678	NSC-207895 (XI-006)	NSC-207895 suppresses MDMX with IC50 of 2.5 µM, leading to enhanced p53 stabilization/activation and DNA damage.
S2684	CX-5461	CX-5461 selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM in HCT-116 cells.
S2554	Daphnetin	Daphnetin is an inhibitor of EGFR, PKA and PKC with IC50 of 7.67 μM, 9.33 μM and 25.01 μM, respectively.
S1648	Cytarabine	Cytarabine (Cytosine arabinoside, AraC) is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells.
S1782	Azacitidine(Vidaza)	Azacitidine is a nucleoside analogue of cytidine that specifically inhibits DNA methylation by trapping DNA methyltransferases.
S1221	Dacarbazine (DTIC-Dome)	Dacarbazine(DTIC-Dome) is an antineoplastic chemotherapy drug used in the treatment of various cancers.
S1714	Gemcitabine(Gemzar)	Gemcitabine(Gemzar) belongs to the group of medicines called antimetabolites.
S1384	Mizoribine (Bredinin)	Mizoribine (Bredinin) is an imidazole nucleoside and an immunosuppressive agent with an IC50 of approximately 100 μM.
S1334	Flupirtine maleate	Flupirtine maleate is the salt form of Flupirtine, which is a non-opioid, centrally acting analgesia, muscle relaxation and neuroprotection.
S1299	Floxuridine (Fludara)	Floxuridine (Fludara) is a prodrugs of floxuridine and an oncology agent with an GI50 of 5.1 μM for the inhibition of MDCK/PEPT1.
S1300	Ftorafur	Ftorafur is a substance being used in the treatment of some types of cancer.
S1302	Ifosfamide	Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer.
S1305	Mercaptopurine	Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.
S1289	Carmofur	Carmofur (INN) is a pyrimidine analogue used as an antineoplastic agent.
S1213	Nelarabine (Arranon)	Nelarabine (Arranon, 506U78) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells.
S1214	Bleomycin sulfate	Bleomycin sulfate (Blenoxane) is a glycopeptide antibiotic and an anticancer agent for squamous cell carcinomas (SCC) with IC50 of 4 nM in UT-SCC-19A cells.	Mol Cell Biol, 2013, ahead of print
S1217	Clafen (Cyclophosphamide)	This agent inhibited cell proliferation of NCI-H727 with IC50 at 9.3 nM.
S1218	Clofarabine	Clofarabine inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase
S1209	Adrucil(Fluorouracil)	Adrucil (Fluorouracil) is an DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS).	PLoS One, 2013, 8(1), e54595
S1199	Cladribine	Cladribine (Leustatin, Litak, 2CDA) is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50 of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively.
S1192	Raltitrexed (Tomudex)	Raltitrexed (Tomudex) is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth.
S1156	Capecitabine (Xeloda)	Capecitabine is a tumor-selective fluoropyrimidine carbamate which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU.

Inhibitory Selectivity
Solubility

Cat.No.	Product Name	Solubility (25°C)
Cat.No.	Product Name	Water	DMSO	Ethanol
S1166	Cisplatin	<1 mg/mL	60 mg/mL	<1 mg/mL
S1215	Carboplatin	<1 mg/mL	<1 mg/mL	<1 mg/mL
S1149	Gemcitabine HCl (Gemzar)	23 mg/mL	<1 mg/mL	<1 mg/mL
S1224	Oxaliplatin (Eloxatin)	<1 mg/mL	14 mg/mL	<1 mg/mL
S1229	Fludarabine Phosphate (Fludara)	6 mg/mL	73 mg/mL	<1 mg/mL
S1491	Fludarabine (Fludara)	<1 mg/mL	57 mg/mL	<1 mg/mL
S1135	Pemetrexed (Alimta)	94 mg/mL	1 mg/mL	<1 mg/mL
S2029	Uridine	49 mg/mL	49 mg/mL	<1 mg/mL
S1981	Adenine	<1 mg/mL	<1 mg/mL	<1 mg/mL
S1983	Adenine HCl	4 mg/mL	8 mg/mL	<1 mg/mL
S1982	Adenine sulfate	2 mg/mL	<1 mg/mL	<1 mg/mL
S1995	Procarbazine HCl (Matulane)	52 mg/mL	<1 mg/mL	52 mg/mL
S2678	NSC-207895 (XI-006)	<1 mg/mL	0.4 mg/mL	<1 mg/mL
S2684	CX-5461	<1 mg/mL	<1 mg/mL	<1 mg/mL
S2554	Daphnetin	<1 mg/mL	36 mg/mL	<1 mg/mL
S1648	Cytarabine	48 mg/mL	1 mg/mL	<1 mg/mL
S1782	Azacitidine(Vidaza)	<1 mg/mL	49 mg/mL	<1 mg/mL
S1221	Dacarbazine (DTIC-Dome)	<1 mg/mL	3 mg/mL	<1 mg/mL
S1714	Gemcitabine(Gemzar)	<1 mg/mL	15 mg/mL	<1 mg/mL
S1384	Mizoribine (Bredinin)	52 mg/mL	1 mg/mL	<1 mg/mL
S1334	Flupirtine maleate	<1 mg/mL	84 mg/mL	3 mg/mL
S1299	Floxuridine (Fludara)	49 mg/mL	49 mg/mL	10 mg/mL
S1300	Ftorafur	8 mg/mL	40 mg/mL	7 mg/mL
S1302	Ifosfamide	52 mg/mL	52 mg/mL	52 mg/mL
S1305	Mercaptopurine	<1 mg/mL	30 mg/mL	<1 mg/mL
S1289	Carmofur	<1 mg/mL	52 mg/mL	10 mg/mL
S1213	Nelarabine (Arranon)	3 mg/mL	60 mg/mL	<1 mg/mL
S1214	Bleomycin sulfate	154 mg/mL	153 mg/mL	<1 mg/mL
S1217	Clafen (Cyclophosphamide)	43 mg/mL	52 mg/mL	52 mg/mL
S1218	Clofarabine	<1 mg/mL	61 mg/mL	<1 mg/mL
S1209	Adrucil(Fluorouracil)	<1 mg/mL	26 mg/mL	<1 mg/mL
S1199	Cladribine	<1 mg/mL	57 mg/mL	<1 mg/mL
S1192	Raltitrexed (Tomudex)	<1 mg/mL	92 mg/mL	<1 mg/mL
S1156	Capecitabine (Xeloda)	6 mg/mL	72 mg/mL	72 mg/mL

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DNA/RNA Synthesis Inhibitors

DNA/RNA Synthesis Inhibitors (35)water-soluble

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DNA/RNA Synthesis Inhibitors (35)
water-soluble