Catalog No.S1896 Synonyms: nci-c04831, nsc32065
Molecular Weight(MW): 76.05
Hydroxyurea is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
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|Description||Hydroxyurea is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.|
hydroxyurea can inhibit HIV-1 replication. In vitro experiments have shown that the 90% inhibitory concentration (IC90) of hydroxyurea for laboratory strains of HIV-1 in activated PBMC is 0.4 mM. Hydroxyurea was also found to be synergistic with the nucleoside reverse transcriptase inhibitor didanosine and to inhibit HIV-1 replication in activated PBMC; this inhibition may be due to a reduction in deoxynucleoside triphosphate pool sizes. Hydroxyurea has been shown to sensitize didanosine-resistant mutants.hydroxyurea has demonstrated activity in the treatment of sickle cell anemia by increasing the production of fetal hemoglobin, which reduces hemolysis in patients with this disease. Hydroxyurea exerts its cytostatic effect through inhibition of ribonucleotide reductase—the rate-limiting enzyme responsible for the conversion of ribonucleotides to deoxyribonucleotides, which are essential for DNA synthesis. As a result, cellular division is arrested in the S phase.
|In vitro||DMSO||15 mg/mL (197.23 mM)|
|Water||15 mg/mL (197.23 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT00001197||Completed||Sickle Cell Anemia||National Heart, Lung, and Blood Institute (NHLBI)|National Institutes of Health Clinical Center (CC)||February 7, 1984||Phase 2|
|NCT01950585||Withdrawn||Pulmonary Hypertension||National Heart, Lung, and Blood Institute (NHLBI)|The Cleveland Clinic|National Institutes of Health Clinical Center (CC)||September 6, 2013||Early Phase 1|
|NCT03020615||Not yet recruiting||Sickle Cell Anemia||St. Jude Childrens Research Hospital|National Heart, Lung, and Blood Institute (NHLBI)||February 28, 2017||Phase 2|
|NCT00270478||Completed||Sickle Cell Disease|Chronic Kidney Disease|Pulmonary Hypertension||National Heart, Lung, and Blood Institute (NHLBI)|National Institutes of Health Clinical Center (CC)||December 21, 2005||Phase 1|
|NCT02675790||Not yet recruiting||Sickle Cell Disease|Sickle Cell Anemia|Stroke||Vanderbilt University|Aminu Kano Teaching Hospital|Murtala Muhammed Specialist Hospital||December 2016||Phase 3|
|NCT02844673||Enrolling by invitation||Sickle Cell Anaemia||Muhimbili University of Health and Allied Sciences|University of Pittsburgh|Muhimbili National Hospital||October 2016||Phase 4|
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