Research Area
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Cladribine Chemical Structure
Pemetrexed (Alimta)
Pemetrexed (Alimta) is a thymidylate synthase, DHFR and glycinamide ribonucleotide formyltransferase inhibitor with an IC50 of 25, 34, 220 nM.
Gemcitabine HCl (Gemzar)
Gemcitabine HCl (Gemzar) is an antimetabolites inhibiting DNA synthesis(cell IC50 of 0.06 μM).
Capecitabine (Xeloda)
Capecitabine (Xeloda) is an orally-administered chemotherapeutic agent (IC50 = 0.7~5 mM) and prodrug of 5-fluorouracil which is a DNA synthesis inhibitor with an IC50 for 5.0 ± 1.8 μM.
Raltitrexed (Tomudex)
Raltitrexed (Tomudex) is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth.
Decitabine
Decitabine is an available nucleoside-based DNA methyltransferase (DNMT) inhibitor with IC50 of 490, 400 and 100 nM for A549, LoVo and LoVo-DX cell lines.
Adrucil(Fluorouracil)
Adrucil(Fluorouracil) belongs to the family of drugs called antimetabolites.
Fludarabine Phosphate (Fludara)
Fludarabine Phosphate (Fludara) is a nucleoside analogue and formulated as the monophosphate form of F-ara-AMP(fludarabine, IC50 < 3 μM).
Flupirtine maleate
Flupirtine is an aminopyridine is a centrally acting nonopioid analgesic.
Fludarabine (Fludara)
Fludarabine (Fludara) is a purine analog and a chemotherapy compound with IC50 < 3 μM.
Daphnetin
Daphnetin is a dihydroxycoumarin and a novel antimalarial agent.
Biological Activity
Cladribine is an adenosine deaminase inhibitor with an IC50 of about 0.2 μM. Cladribine is a drug used to treat hairy cell leukemia (leukemic reticuloendotheliosis) and multiple sclerosis. As a purine analog, it is a synthetic anti-cancer agent that also suppresses the immune system. Chemically, cladribine mimics the nucleoside adenosine and thus inhibits the enzyme adenosine deaminase, which interferes with the cell’s ability to process DNA. Cladribine is easily destroyed by normal cells except for blood cells, with the result that it produces relatively few side effects and results in very little non-target cell loss. [1][2][3]
Product Information
| Molecular Weight (WM): | 285.69 |
|---|---|
| Formula: | C10H12ClN5O3 |
| CAS No.: | 4291-63-8 |
| Synonyms: |
Leustatin
|
| Dissolve in (25°C): | DMSO ≥57mg/mL |
| Water <1mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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