Research Area
Product Type
United States ( Change Country )
NSC-207895 (XI-006) Chemical Structure
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Biological Activity
NSC-207895 (XI-006) is a derivative of nitrobenzofuroxan and an anticancer agent with an EC50 of 1 μM. NSC-207895 (XI-006) is a highly electrophilic compound known to have both antitumor and mutagenic activities. NSC-207895 (XI-006) may lead to the damage of DNA that inhibits the growth of tumors.[1] NSC-207895 (XI-006) strikingly prevented the expression of MDMX which is a p53-binding protein and modulate the activities and stabilities of p53. NSC-207895 (XI-006) is less toxic and reduced the activities of MDMX promoter in a dose-dependent manner. Moreover,NSC-207895 (XI-006) possibly decreased the expression of MDMX via suppressing MDMX transcription. However, NSC-207895 (XI-006) induced the expression of MDM2 which is also a p53 downstream gene, despite to a less extent. In addition, NSC-207895 (XI-006) also upregulated the expression of p53 in MCF-7 cells that led to increased expression of proapoptotic genes including PUMA, BAX, as well as PIG3. Notably, NSC-207895 (XI-006), also called a small-molecule p53 activator, gives rise to MCF-7 cells to experience apoptosis and decrease the viability of cancer cells along with nutlin-3a, which dissociated the MDM2-p53 complex.
References on NSC-207895 (XI-006)
- [1] Mol Biosyst 2011 Jun;2019-30
Chemical Information
| Molecular Weight (WM): | 279.25 |
|---|---|
| Formula: | C11H13N5O4 |
| CAS No.: | 58131-57-0 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥56mg/mL |
| Water <1mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
Research Area
DNA Damage >> DNA / RNA Synthesis >> DNA / RNA Synthesis Inhibitors
Apoptosis >> p53 >> p53 Inhibitors
DNA Damage >> p53 >> p53 Inhibitors
Apoptosis >> MDM2 >> MDM2 Inhibitors
DNA Damage >> MDM2 >> MDM2 Inhibitors
Apoptosis >> p53 >> p53 Inhibitors
DNA Damage >> p53 >> p53 Inhibitors
Apoptosis >> MDM2 >> MDM2 Inhibitors
DNA Damage >> MDM2 >> MDM2 Inhibitors
Notes:
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