Catalog No.S1764 Synonyms: Rimactane
Molecular Weight(MW): 822.94
Rifampin is a DNA-dependent RNA polymerase inhibitor, used to treat a number of bacterial infections.
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|Description||Rifampin is a DNA-dependent RNA polymerase inhibitor, used to treat a number of bacterial infections.|
Rifampin inhibits IκBα degradation and mitogen-activated protein kinase (MAPK) phosphorylation. Rifampin is found to bind to human MD-2 in a Rifampin and MD-2 concentration-dependent manner. Rifampin inhibits NF-κB activation induced by LPS (20 ng/ml) in a dose-dependent manner, with an IC50 of 44.1 μM in Blue hTLR4 293 cells (A) and immunocompetent microgial BV-2 cell. Rifampin (50 μM) suppresses NF-κB activation at varying LPS doses, and the maximum NF-κB level induced by LPS in the presence of Rifampin (50 μM) is much lower than that in the absence of Rifampin. Rifampin inhibits NO production induced by LPS (200 ng/ml) in a dose-dependent manner in BV-2 cells, with an IC50 of 21.2 μM. Rifampin suppresses LPS induced TNF-α and IL-1β production in both microglia BV-2 and RAW 264.7 macrophage cells. Rifampin-inhibiting innate immune signaling is independent of the pregnane X receptor NR1I2.  Rifampin combined with polyester vascular prostheses (PVP) functionalised with cyclodextrin (PVP-CD) results in significant bacterial adhesion reduction and growth inhibition against Gram-positive bacteria.  Rifampin (50 μg/mL) significantly reduces the CFU counts of stationary-phase cultures and reduces the CFU counts of the log-phase culture to zero. Rifampin is particularly suitable since it is bactericidal and starts killing M. tuberculosis within an hour of exposure. 
|In vitro||DMSO||100 mg/mL (121.51 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03012529||Not yet recruiting||Osteomyelitis|Diabetes|Amputation||VA Office of Research and Development||September 2017||Phase 4|
|NCT02959060||Completed||Thrombosis||Bristol-Myers Squibb||November 2016||Phase 1|
|NCT02957448||Active, not recruiting||Atherothrombotic Diseases||Bristol-Myers Squibb||November 2016||Phase 1|
|NCT02953847||Recruiting||Tuberculosis||University of Cape Town||August 2016||Phase 1|
|NCT02820935||Completed||Pharmacokinetics||Celgene Corporation||July 2016||Phase 1|
|NCT02804399||Completed||Healthy||Pfizer||July 2016||Phase 1|
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