Rifampin

Catalog No.S1764 Synonyms: Rimactane

Rifampin Chemical Structure

Molecular Weight(MW): 822.94

Rifampin is a DNA-dependent RNA polymerase inhibitor, used to treat a number of bacterial infections.

Size Price Stock Quantity  
In DMSO USD 90 In stock
USD 97 In stock
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Biological Activity

Description Rifampin is a DNA-dependent RNA polymerase inhibitor, used to treat a number of bacterial infections.
Targets
RNA polymerase [1]
In vitro

Rifampin inhibits IκBα degradation and mitogen-activated protein kinase (MAPK) phosphorylation. Rifampin is found to bind to human MD-2 in a Rifampin and MD-2 concentration-dependent manner. Rifampin inhibits NF-κB activation induced by LPS (20 ng/ml) in a dose-dependent manner, with an IC50 of 44.1 μM in Blue hTLR4 293 cells (A) and immunocompetent microgial BV-2 cell. Rifampin (50 μM) suppresses NF-κB activation at varying LPS doses, and the maximum NF-κB level induced by LPS in the presence of Rifampin (50 μM) is much lower than that in the absence of Rifampin. Rifampin inhibits NO production induced by LPS (200 ng/ml) in a dose-dependent manner in BV-2 cells, with an IC50 of 21.2 μM. Rifampin suppresses LPS induced TNF-α and IL-1β production in both microglia BV-2 and RAW 264.7 macrophage cells. Rifampin-inhibiting innate immune signaling is independent of the pregnane X receptor NR1I2. [1] Rifampin combined with polyester vascular prostheses (PVP) functionalised with cyclodextrin (PVP-CD) results in significant bacterial adhesion reduction and growth inhibition against Gram-positive bacteria. [2] Rifampin (50 μg/mL) significantly reduces the CFU counts of stationary-phase cultures and reduces the CFU counts of the log-phase culture to zero. Rifampin is particularly suitable since it is bactericidal and starts killing M. tuberculosis within an hour of exposure. [3]

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (121.51 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 822.94
Formula

C43H58N4O12

CAS No. 13292-46-1
Storage powder
Synonyms Rimactane

Bio Calculators

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03012529 Not yet recruiting Osteomyelitis|Diabetes|Amputation VA Office of Research and Development September 2017 Phase 4
NCT02959060 Completed Thrombosis Bristol-Myers Squibb November 2016 Phase 1
NCT02957448 Active, not recruiting Atherothrombotic Diseases Bristol-Myers Squibb November 2016 Phase 1
NCT02953847 Recruiting Tuberculosis University of Cape Town August 2016 Phase 1
NCT02820935 Completed Pharmacokinetics Celgene Corporation July 2016 Phase 1
NCT02804399 Completed Healthy Pfizer July 2016 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Related Antibodies

DNA/RNA Synthesis Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID