Research Area
Product Type
United States ( Change Country )
Clafen (Cyclophosphamide) Chemical Structure
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Bleomycin sulfate
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Carboplatin
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Clofarabine
Clofarabine inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase
Oxaliplatin (Eloxatin)
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NSC-207895 (XI-006)
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CX-5461
CX-5461 is a potent small-molecule rRNA synthesis inhibitor with an IC50 of 0.11 μM.
ABT-888 (Veliparib)
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Biological Activity
Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. In the liver, cyclophosphamide is converted to the active metabolites aldophosphamide and phosphoramide mustard, which bind to DNA, thereby inhibiting DNA replication and initiating cell death. [1]
Cyclophosphamide is given as a treatment for many types of cancer, among them lymphomas, ovary, breast, and bladder; and chronic lymphocytic leukaemia. [2]
This agent inhibited cell proliferation of NCI-H727 with IC50 at 9.3 nM. [3]
Product Information
| Molecular Weight (WM): | 261.09 |
|---|---|
| Formula: | C7H15Cl2N2O2P |
| CAS No.: | 50-18-0 |
| Synonyms: |
Endoxan, Cytoxan, Neosar, Procytox, Revimmune, Cytophosphane
|
| Dissolve in (25°C): | DMSO ≥52mg/mL |
| Water ≥43mg/mL | |
| Ethanol ≥52mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
Research Area
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