YK-4-279

Catalog No.S7679

YK-4-279 Chemical Structure

Molecular Weight(MW): 366.20

YK-4-279 is a potent inhibitor of EWS-FLI1 binding to RNA helicase A (RHA).

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Biological Activity

Description YK-4-279 is a potent inhibitor of EWS-FLI1 binding to RNA helicase A (RHA).
Targets
RNA helicase A [1]
In vitro

YK-4-279 eliminates cyclin D levels by blocking the interaction of EWS-FLI1 with RHA in EWS-FLI1-containing TC32 cells. YK-4-279 also specifically inhibits ESFT cell growth and induces apoptosis. [1] YK-4-279 also inhibits ERG and ETV1 biological activity in fusion-positive prostate cancer cells, and further decreases cell motility and invasion. [2]

In vivo In vivo, YK-4-279 (1.5 mg/dose i.p.) inhibits the growth of ESFT xenograft tumors. [1] In mouse model, YK-4-279 selectively prevents prostate cancer growth and metastasis in fusion-positive LNCaP-luc-M6 tumors. [3]

Protocol

Animal Research:[1]
+ Expand
  • Animal Models: Nude mice bearing prostate cancer PC3, TC71 or CHP-100 xenografts
  • Formulation: DMSO
  • Dosages: 1.5 mg/dose
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 73 mg/mL (199.34 mM)
Ethanol 51 mg/mL warmed (139.26 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 366.20
Formula

C17H13Cl2NO4

CAS No. 1037184-44-3
Storage powder
Synonyms N/A

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    I would like to know whether YK-4-279 is the racemate version, or whether it is the + R-enantiomer or the – S-enantiomer of the compound?

  • Answer:

    For our S7679 YK-4-279, it is a recemate.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID