Product Categories

Bendamustine HCL

Bendamustine HCL (Ribomustin, Treanda, SDX-105) is a DNA-damaging agent with IC50 of 50 μM.

Catalog No.S1212

: Tel: +1-832-582-8158[email protected]

Bendamustine HCL Chemical Structure
Molecular Weight: 394.72

Validation & Quality Control

Quality Control & MSDS

Related Compound Libraries

Bendamustine HCL is available in the following compound libraries:

Chemical Library (96-well) FDA Approved Drug Library (96-well)

Product Information

Combination Therapy

Compare Others Inhibitors

Dr. Antonino Maria Sparta demonstrates a breakthrough in leukemia research by utilizing two inhibitors produced by Selleck Chemicals.

Cat.No.	Product Name	Solubility (25°C)
S1950	Metformin HCl(Glucophage)	33 mg/mL	<1 mg/mL	<1 mg/mL
S5003	FK-506 (Tacrolimus)	<1 mg/mL	161 mg/mL	161 mg/mL
S1237	Temozolomide	5 mg/mL	39 mg/mL	<1 mg/mL
S1212	Bendamustine HCL	15 mg/mL	79 mg/mL	17 mg/mL
S2286	Cyclosporin A (Cyclosporine A)	<1 mg/mL	241 mg/mL	241 mg/mL
S2841	R428	<1 mg/mL	60 mg/mL	<1 mg/mL
S1792	Simvastatin (Zocor)	<1 mg/mL	84 mg/mL	84 mg/mL
S1622	Prednisone(Adasone)	<1 mg/mL	72 mg/mL	14 mg/mL
S1655	Ezetimibe (Zetia)	<1 mg/mL	82 mg/mL	82 mg/mL
S2487	Mycophenolic (Mycophenolate)	<1 mg/mL	64 mg/mL	18 mg/mL
S2229	Eltrombopag (SB-497115-GR)	<1 mg/mL	89 mg/mL	<1 mg/mL
S3022	Cabazitaxel (Jevtana)	<1 mg/mL	100 mg/mL	<1 mg/mL
S6002	NXY-059 (Cerovive)	76 mg/mL	76 mg/mL	1 mg/mL
S1236	Leucovorin Calcium	120 mg/mL	<1 mg/mL	<1 mg/mL
S1517	Natamycin(Pimaricin)	<1 mg/mL	7 mg/mL	<1 mg/mL
S1712	Deferasirox (Exjade)	<1 mg/mL	75 mg/mL	2 mg/mL
S1162	PA-824	<1 mg/mL	72 mg/mL	16 mg/mL
S3032	Bindarit	<1 mg/mL	65 mg/mL	65 mg/mL
S1247	Leflunomide	<1 mg/mL	54 mg/mL	54 mg/mL
S1312	Streptozotocin (Zanosar)	53 mg/mL	53 mg/mL	<1 mg/mL
S1373	Daptomycin	100 mg/mL	<1 mg/mL	<1 mg/mL
S1516	Cidofovir(Vistide)	<1 mg/mL	<1 mg/mL	<1 mg/mL
S1811	Amiloride HCl (Midamor)	6 mg/mL	53 mg/mL	5 mg/mL
S1759	Pitavastatin calcium(Livalo)	<1 mg/mL	51 mg/mL	<1 mg/mL
S1999	Sodium butyrate	22 mg/mL	<1 mg/mL	8 mg/mL
S2476	Itraconazole (Sporanox)	<1 mg/mL	4 mg/mL	<1 mg/mL
S2923	Salubrinal	<1 mg/mL	96 mg/mL	2 mg/mL
S1097	BTZ043 racemate	<1 mg/mL	22 mg/mL	<1 mg/mL
S1257	Posaconazole	<1 mg/mL	140 mg/mL	<1 mg/mL
S1276	Adapalene	<1 mg/mL	8 mg/mL	<1 mg/mL
S1356	Levetiracetam	34 mg/mL	34 mg/mL	34 mg/mL
S1408	Linezolid (Zyvox)	<1 mg/mL	68 mg/mL	8 mg/mL
S1439	Tranilast (SB 252218)	<1 mg/mL	66 mg/mL	<1 mg/mL
S2485	Mitoxantrone HCl	89 mg/mL	89 mg/mL	<1 mg/mL
S1709	Estradiol	<1 mg/mL	54 mg/mL	23 mg/mL
S2159	Tebipenem pivoxil(L-084)	<1 mg/mL	99 mg/mL	99 mg/mL
S2154	BIBR-1048 (Dabigatran)	<1 mg/mL	126 mg/mL	12 mg/mL
S1790	Rifaximin (Xifaxan)	<1 mg/mL	47 mg/mL	3 mg/mL
S1734	Meloxicam (Mobic)	<1 mg/mL	30 mg/mL	<1 mg/mL
S2597	Oseltamivir phosphate (Tamiflu)	<1 mg/mL	2 mg/mL	<1 mg/mL
S2057	Cyclophosphamide monohydrate	7 mg/mL	56 mg/mL	<1 mg/mL
S2098	Bexarotene	<1 mg/mL	8 mg/mL	<1 mg/mL
S2790	Istradefylline (KW-6002)	<1 mg/mL	6 mg/mL	<1 mg/mL
S5004	Pimecrolimus	<1 mg/mL	162 mg/mL	162 mg/mL
S1201	Dimesna	65 mg/mL	65 mg/mL	<1 mg/mL
S1331	Fluconazole	<1 mg/mL	61 mg/mL	61 mg/mL
S1340	Gatifloxacin	<1 mg/mL	7 mg/mL	<1 mg/mL
S1381	Meropenem	8 mg/mL	77 mg/mL	<1 mg/mL
S1403	Tigecycline	117 mg/mL	117 mg/mL	<1 mg/mL
S1428	Risedronate sodium	2 mg/mL	<1 mg/mL	<1 mg/mL
S1443	Zileuton	<1 mg/mL	47 mg/mL	47 mg/mL
S1466	Calcitriol (Rocaltrol)	<1 mg/mL	83 mg/mL	83 mg/mL
S1468	Alfacalcidol	<1 mg/mL	80 mg/mL	80 mg/mL
S1547	Febuxostat (Uloric)	<1 mg/mL	63 mg/mL	<1 mg/mL
S1624	Alendronate (Fosamax)	<1 mg/mL	<1 mg/mL	<1 mg/mL
S1629	Orlistat (Alli, Xenical)	<1 mg/mL	99 mg/mL	99 mg/mL
S1680	Disulfiram (Antabuse)	<1 mg/mL	59 mg/mL	59 mg/mL
S1591	Ubenimex (Bestatin)	<1 mg/mL	0.4 mg/mL	<1 mg/mL
S1653	Tretinoin	<1 mg/mL	60 mg/mL	6 mg/mL
S1896	Hydroxyurea (Cytodrox)	15 mg/mL	15 mg/mL	15 mg/mL
S1768	Cefditoren pivoxil	<1 mg/mL	124 mg/mL	<1 mg/mL
S2007	Sulindac (Clinoril)	<1 mg/mL	71 mg/mL	9 mg/mL
S1761	Suprofen (Profenal)	<1 mg/mL	52 mg/mL	52 mg/mL
S1658	Dofetilide (Tikosyn)	<1 mg/mL	88 mg/mL	<1 mg/mL
S1949	Menadione	<1 mg/mL	34 mg/mL	34 mg/mL
S2457	Clindamycin HCl (Dalacin)	92 mg/mL	92 mg/mL	<1 mg/mL
S2492	Novobiocin sodium (Albamycin)	127 mg/mL	127 mg/mL	127 mg/mL
S2504	Ribavirin (Copegus)	49 mg/mL	49 mg/mL	<1 mg/mL
S1696	Hydrocortisone (Cortisol)	<1 mg/mL	73 mg/mL	23 mg/mL
S2528	Ciclopirox (Penlac)	<1 mg/mL	42 mg/mL	42 mg/mL
S2027	Ciprofloxacin (Cipro)	<1 mg/mL	<1 mg/mL	<1 mg/mL
S1878	Ganciclovir	<1 mg/mL	50 mg/mL	<1 mg/mL
S2787	Laquinimod (ABR-215062)	<1 mg/mL	61 mg/mL	1 mg/mL
S2417	20-Hydroxyecdysone	<1 mg/mL	96 mg/mL	96 mg/mL
S1041	STF-62247	<1 mg/mL	53 mg/mL	3 mg/mL
S1211	Imiquimod	<1 mg/mL	3 mg/mL	<1 mg/mL
S1252	Entecavir hydrate	<1 mg/mL	59 mg/mL	<1 mg/mL
S1255	Nepafenac	<1 mg/mL	51 mg/mL	4 mg/mL
S1282	Artemisinin	<1 mg/mL	57 mg/mL	24 mg/mL
S1326	Edaravone (MCI-186)	<1 mg/mL	35 mg/mL	35 mg/mL
S1368	Acitretin	<1 mg/mL	20 mg/mL	<1 mg/mL
S1374	Doripenem Hydrate	26 mg/mL	36 mg/mL	<1 mg/mL
S1394	Pizotifen malate	<1 mg/mL	21 mg/mL	<1 mg/mL
S1399	Teicoplanin	342 mg/mL	<1 mg/mL	<1 mg/mL
S1407	Bimatoprost	<1 mg/mL	36 mg/mL	83 mg/mL
S1424	Prazosin HCl	<1 mg/mL	1 mg/mL	<1 mg/mL
S1444	Ziprasidone HCl	<1 mg/mL	90 mg/mL	<1 mg/mL
S1500	Betamethasone (Celestone)	<1 mg/mL	79 mg/mL	10 mg/mL
S1509	Norfloxacin (Norxacin)	<1 mg/mL	<1 mg/mL	<1 mg/mL
S1508	Alprostadil(Caverject)	<1 mg/mL	71 mg/mL	71 mg/mL
S1606	Clotrimazole (Canesten)	<1 mg/mL	11 mg/mL	69 mg/mL
S1625	Ethinyl Estradiol	<1 mg/mL	59 mg/mL	59 mg/mL
S1627	Nitazoxanide (Alinia, Annita)	<1 mg/mL	62 mg/mL	<1 mg/mL
S1628	Triamcinolone Acetonide	<1 mg/mL	87 mg/mL	13 mg/mL
S1633	Zafirlukast(Accolate)	<1 mg/mL	115 mg/mL	<1 mg/mL
S1635	Erythromycin (E-Mycin)	3 mg/mL	147 mg/mL	147 mg/mL
S1799	Ranolazine (Ranexa)	<1 mg/mL	86 mg/mL	20 mg/mL
S1716	Glyburide (Diabeta)	<1 mg/mL	99 mg/mL	<1 mg/mL
S1839	Chloroxine	<1 mg/mL	43 mg/mL	<1 mg/mL
S1666	Flucytosine (Ancobon)	5 mg/mL	8 mg/mL	<1 mg/mL
S1784	Vidarabine (Vira-A)	3 mg/mL	53 mg/mL	<1 mg/mL
S1920	Haloperidol (Haldol)	<1 mg/mL	75 mg/mL	8 mg/mL
S1751	Gadodiamide (Omniscan)	118 mg/mL	118 mg/mL	118 mg/mL
S1677	Chloramphenicol (Chloromycetin)	<1 mg/mL	65 mg/mL	65 mg/mL
S1891	Carbidopa	<1 mg/mL	4 mg/mL	<1 mg/mL
S1840	Lomustine (CeeNU)	<1 mg/mL	47 mg/mL	47 mg/mL
S1917	Crystal violet	14 mg/mL	82 mg/mL	8 mg/mL
S1729	Gemfibrozil (Lopid)	<1 mg/mL	50 mg/mL	50 mg/mL
S1774	Thioguanine	<1 mg/mL	<1 mg/mL	<1 mg/mL
S1760	Rifapentine (Priftin)	<1 mg/mL	100 mg/mL	17 mg/mL
S1988	Propylthiouracil	<1 mg/mL	34 mg/mL	19 mg/mL
S1866	Diphenhydramine HCl (Benadryl)	58 mg/mL	58 mg/mL	58 mg/mL
S1723	Indomethacin (Indocid, Indocin)	<1 mg/mL	72 mg/mL	24 mg/mL
S1725	Terbinafine (Lamisil, Terbinex)	<1 mg/mL	58 mg/mL	58 mg/mL
S1937	Isoniazid(Tubizid)	27 mg/mL	27 mg/mL	27 mg/mL
S1727	Levonorgestrel(Levonelle)	<1 mg/mL	45 mg/mL	2 mg/mL
S1737	Prednisolone(Hydroretrocortine)	<1 mg/mL	72 mg/mL	10 mg/mL
S1956	Miconazole nitrate	<1 mg/mL	96 mg/mL	1 mg/mL
S1748	Nisoldipine (Sular)	<1 mg/mL	78 mg/mL	78 mg/mL
S1773	Oxytetracycline (Terramycin)	<1 mg/mL	92 mg/mL	10 mg/mL
S2264	Artemether (SM-224)	<1 mg/mL	60 mg/mL	60 mg/mL
S1808	Nifedipine (Adalat)	<1 mg/mL	69 mg/mL	15 mg/mL
S1721	Azathioprine (Azasan, Imuran)	<1 mg/mL	54 mg/mL	<1 mg/mL
S1807	Acyclovir (Aciclovir)	<1 mg/mL	45 mg/mL	<1 mg/mL
S1679	Flurbiprofen (Ansaid)	<1 mg/mL	49 mg/mL	49 mg/mL
S2469	Fleroxacin (Quinodis)	<1 mg/mL	<1 mg/mL	<1 mg/mL
S2472	Gentamycin sulfate (Gentacycol)	115 mg/mL	<1 mg/mL	<1 mg/mL
S2479	Lincomycin HCl (Lincocin)	89 mg/mL	89 mg/mL	1 mg/mL
S2502	Quinine HCl dihydrate	43 mg/mL	79 mg/mL	79 mg/mL
S2378	Butylscopolamine bromide (Scopolamine butylbromide)	88 mg/mL	88 mg/mL	23 mg/mL
S2381	D-Mannitol (Osmitrol)	36 mg/mL	36 mg/mL	<1 mg/mL
S2388	L-carnitine(Levocarnitine)	32 mg/mL	12 mg/mL	32 mg/mL
S2544	Cefprozil hydrate (Cefzil)	<1 mg/mL	<1 mg/mL	<1 mg/mL
S2563	Oxacillin sodium monohydrate	88 mg/mL	<1 mg/mL	<1 mg/mL
S2156	LY2886721	<1 mg/mL	9 mg/mL	<1 mg/mL
S2570	Prednisolone acetate (Omnipred)	<1 mg/mL	81 mg/mL	<1 mg/mL
S2724	Heparin sodium 180 U/mg	100 mg/mL	<1 mg/mL	<1 mg/mL
S1986	Meclizine 2HCl	<1 mg/mL	1 mg/mL	<1 mg/mL
S1874	Risedronic acid (Actonel)	<1 mg/mL	<1 mg/mL	<1 mg/mL
S1854	Bifonazole	<1 mg/mL	62 mg/mL	20 mg/mL
S1835	Azithromycin (Zithromax)	<1 mg/mL	150 mg/mL	150 mg/mL
S1829	Pranlukast	<1 mg/mL	11 mg/mL	<1 mg/mL
S2413	Geniposidic acid	<1 mg/mL	16 mg/mL	2 mg/mL
S2586	Dimethyl Fumarate	<1 mg/mL	29 mg/mL	10 mg/mL
S2067	Ozagrel HCl	53 mg/mL	53 mg/mL	6 mg/mL
S2799	APO866 (FK866)	<1 mg/mL	<1 mg/mL	78 mg/mL
S3129	Trimethoprim	<1 mg/mL	58 mg/mL	<1 mg/mL
S3179	Carbenicillin disodium	84 mg/mL	5 mg/mL	<1 mg/mL
S3076	Foscarnet Sodium	3 mg/mL	7 mg/mL	<1 mg/mL
S2908	Hygromycin B	106 mg/mL	<1 mg/mL	2 mg/mL
S2910	Tempol (4-Hydroxy-TEMPO)	34 mg/mL	34 mg/mL	34 mg/mL
S4003	Lithocholic acid	<1 mg/mL	75 mg/mL	47 mg/mL
S1137	Malotilate	<1 mg/mL	58 mg/mL	58 mg/mL
S1204	Melatonin	<1 mg/mL	47 mg/mL	47 mg/mL
S1222	Dexrazoxane HCl	61 mg/mL	61 mg/mL	<1 mg/mL
S1271	Acarbose	129 mg/mL	129 mg/mL	8 mg/mL
S1278	Altretamine (Hexalen)	<1 mg/mL	15 mg/mL	33 mg/mL
S1286	Budesonide	<1 mg/mL	86 mg/mL	19 mg/mL
S1287	Bumetanide	<1 mg/mL	73 mg/mL	36 mg/mL
S1311	Pamidronate Disodium	56 mg/mL	<1 mg/mL	<1 mg/mL
S1330	Felbamate	<1 mg/mL	48 mg/mL	3 mg/mL
S1346	Heparin sodium 150 U/mg	162 mg/mL	<1 mg/mL	<1 mg/mL
S1351	Ivermectin	<1 mg/mL	175 mg/mL	28 mg/mL
S1370	Biapenem	16 mg/mL	<1 mg/mL	<1 mg/mL
S1371	Cefoselis sulfate	5 mg/mL	3 mg/mL	<1 mg/mL
S1405	Vecuronium Bromide	4 mg/mL	128 mg/mL	128 mg/mL
S1445	Zonisamide	<1 mg/mL	42 mg/mL	5 mg/mL
S1448	Azalomycin-B	<1 mg/mL	49 mg/mL	5 mg/mL
S1450	Nanchangmycin	<1 mg/mL	173 mg/mL	173 mg/mL
S1464	Marbofloxacin	<1 mg/mL	2 mg/mL	<1 mg/mL
S1469	Calcifediol	<1 mg/mL	80 mg/mL	20 mg/mL
S1467	Doxercalciferol (Hectorol)	<1 mg/mL	83 mg/mL	70 mg/mL
S1483	Iloperidone (Fanapt)	<1 mg/mL	27 mg/mL	4 mg/mL
S1499	Cefaclor (Ceclor)	<1 mg/mL	<1 mg/mL	<1 mg/mL
S1502	Cephalexin (Cefalexin)	10 mg/mL	2 mg/mL	<1 mg/mL
S1505	Aztreonam (Azactam, Cayston)	11 mg/mL	87 mg/mL	<1 mg/mL
S1601	Reserpine	<1 mg/mL	13 mg/mL	<1 mg/mL
S1603	Furosemide (Lasix)	<1 mg/mL	66 mg/mL	<1 mg/mL
S1605	Cefdinir (Omnicef)	<1 mg/mL	79 mg/mL	<1 mg/mL
S1609	Methimazole(Tapazole, Northyx)	23 mg/mL	23 mg/mL	23 mg/mL
S1610	Metolazone (Zaroxolyn)	<1 mg/mL	73 mg/mL	8 mg/mL
S1617	Sulfapyridine (Dagenan)	<1 mg/mL	1 mg/mL	<1 mg/mL
S1618	Sulfameter (Bayrena)	<1 mg/mL	56 mg/mL	<1 mg/mL
S1619	Prilocaine	<1 mg/mL	44 mg/mL	44 mg/mL
S1888	Deflazacort (Calcort)	<1 mg/mL	88 mg/mL	12 mg/mL
S1676	Amorolfine HCl	9 mg/mL	28 mg/mL	71 mg/mL
S1643	Ursodiol (Actigal Urso)	<1 mg/mL	79 mg/mL	79 mg/mL
S1644	Nitrofurazone (Nitrofural)	<1 mg/mL	40 mg/mL	<1 mg/mL
S1647	Adenosine (Adenocard)	<1 mg/mL	12 mg/mL	<1 mg/mL
S1640	Albendazole(Albenza)	<1 mg/mL	17 mg/mL	<1 mg/mL
S1641	Chlorothiazide	<1 mg/mL	59 mg/mL	<1 mg/mL
S1642	Methyldopa (Aldomet)	<1 mg/mL	<1 mg/mL	<1 mg/mL
S1636	Amphotericin B (Abelcet)	<1 mg/mL	22 mg/mL	<1 mg/mL
S1637	Docosanol (Abreva)	<1 mg/mL	<1 mg/mL	4 mg/mL
S1631	Allopurinol Sodium (Aloprim)	32 mg/mL	32 mg/mL	2 mg/mL
S1652	Monobenzone (Benoquin)	<1 mg/mL	40 mg/mL	40 mg/mL
S1671	Aminocaproic acid (Amicar)	26 mg/mL	6 mg/mL	1 mg/mL
S1715	Glipizide (Glucotrol)	<1 mg/mL	89 mg/mL	<1 mg/mL
S1667	Trichlormethiazide (Achletin)	<1 mg/mL	54 mg/mL	<1 mg/mL
S1569	Tazarotene (Avage)	<1 mg/mL	10 mg/mL	10 mg/mL
S1681	Mesalamine (Lialda)	<1 mg/mL	31 mg/mL	31 mg/mL
S1651	Telbivudine (Sebivo, Tyzeka)	48 mg/mL	48 mg/mL	2 mg/mL
S1749	L-Glutamine	29 mg/mL	<1 mg/mL	<1 mg/mL
S2124	Xylose	30 mg/mL	30 mg/mL	<1 mg/mL
S1904	Avobenzone(Parsol 1789)	<1 mg/mL	62 mg/mL	9 mg/mL
S1576	Sulfasalazine (Azulfidine)	<1 mg/mL	80 mg/mL	<1 mg/mL
S1806	Acipimox	<1 mg/mL	31 mg/mL	<1 mg/mL
S1692	Busulfan(Myleran, Busulfex)	<1 mg/mL	49 mg/mL	<1 mg/mL
S1654	Phenylbutazone (Butazolidin, Butatron)	<1 mg/mL	62 mg/mL	62 mg/mL
S1688	Betamethasone Dipropionate (Diprolene)	<1 mg/mL	101 mg/mL	66 mg/mL
S1690	Betamethasone valerate (Betnovate)	<1 mg/mL	95 mg/mL	58 mg/mL
S1691	Praziquantel (Biltricide)	<1 mg/mL	63 mg/mL	63 mg/mL
S2152	Sitafloxacin hydrate	<1 mg/mL	3 mg/mL	<1 mg/mL
S1849	Daidzein	<1 mg/mL	51 mg/mL	<1 mg/mL
S1701	Desonide	<1 mg/mL	83 mg/mL	41 mg/mL
S1794	Fenofibrate (Tricor, Trilipix)	<1 mg/mL	72 mg/mL	46 mg/mL
S1514	Cyclosporine (Neoral)	<1 mg/mL	148 mg/mL	241 mg/mL
S1685	Sulfanilamide	<1 mg/mL	34 mg/mL	17 mg/mL
S1843	Chenodeoxycholic acid	<1 mg/mL	79 mg/mL	79 mg/mL
S1669	Loteprednol etabonate	<1 mg/mL	93 mg/mL	4 mg/mL
S1848	Curcumin	<1 mg/mL	74 mg/mL	10 mg/mL
S1915	Sulfamethoxazole	<1 mg/mL	51 mg/mL	23 mg/mL
S1916	Sulfisoxazole	<1 mg/mL	53 mg/mL	2 mg/mL
S1733	Methylprednisolone	<1 mg/mL	75 mg/mL	2 mg/mL
S1952	Methoxsalen (Oxsoralen)	<1 mg/mL	43 mg/mL	5 mg/mL
S1741	Rifabutin (Mycobutin)	<1 mg/mL	60 mg/mL	40 mg/mL
S1764	Rifampin (Rifadin, Rimactane)	<1 mg/mL	165 mg/mL	30 mg/mL
S1770	Sulfadiazine	<1 mg/mL	50 mg/mL	<1 mg/mL
S1735	Mesna (Uromitexan, Mesnex)	7 mg/mL	33 mg/mL	<1 mg/mL
S1736	Methocarbamol (Robaxin)	2 mg/mL	48 mg/mL	48 mg/mL
S1683	Ipratropium bromide	83 mg/mL	83 mg/mL	83 mg/mL
S1689	Betapar(Meprednisone)	<1 mg/mL	75 mg/mL	4 mg/mL
S1698	Torsemide (Demadex)	<1 mg/mL	1 mg/mL	<1 mg/mL
S1859	Diethylstilbestrol(Stilbestrol)	<1 mg/mL	54 mg/mL	54 mg/mL
S1865	Diltiazem HCl (Tiazac)	90 mg/mL	90 mg/mL	4 mg/mL
S1703	Divalproex sodium	62 mg/mL	62 mg/mL	62 mg/mL
S1705	Progesterone (Prometrium)	<1 mg/mL	22 mg/mL	63 mg/mL
S1707	Eplerenone	<1 mg/mL	<1 mg/mL	<1 mg/mL
S1708	Hydrochlorothiazide	<1 mg/mL	60 mg/mL	13 mg/mL
S1921	Phenindione(Rectadione)	<1 mg/mL	44 mg/mL	15 mg/mL
S1895	Dipyridamole (Persantine)	<1 mg/mL	101 mg/mL	50 mg/mL
S1933	Triamcinolone(Aristocort)	<1 mg/mL	79 mg/mL	1 mg/mL
S1934	Nystatin (Mycostatin)	<1 mg/mL	19 mg/mL	<1 mg/mL
S1939	Levamisole HCl(Ergamisol)	48 mg/mL	<1 mg/mL	<1 mg/mL
S1726	Levodopa (Sinemet)	<1 mg/mL	<1 mg/mL	<1 mg/mL
S1730	Indapamide (Lozol)	<1 mg/mL	73 mg/mL	73 mg/mL
S1732	Mitotane (Lysodren)	<1 mg/mL	64 mg/mL	64 mg/mL
S1739	Thiabendazole	<1 mg/mL	40 mg/mL	1 mg/mL
S1740	Guaifenesin(Guaiphenesin)	25 mg/mL	40 mg/mL	40 mg/mL
S1965	Primidone(Mysoline)	<1 mg/mL	44 mg/mL	3 mg/mL
S1744	Niacin(Nicotinic acid)	2 mg/mL	25 mg/mL	<1 mg/mL
S1899	Nicotinamide (Niacinamide)	24 mg/mL	24 mg/mL	24 mg/mL
S1762	Pyrazinamide (Pyrazinoic acid amide)	12 mg/mL	25 mg/mL	2 mg/mL
S2008	Taurine	20 mg/mL	<1 mg/mL	<1 mg/mL
S1777	Ethionamide	<1 mg/mL	33 mg/mL	17 mg/mL
S1778	Trifluridine (Viroptic)	59 mg/mL	59 mg/mL	59 mg/mL
S1787	Teniposide (Vumon)	<1 mg/mL	40 mg/mL	<1 mg/mL
S2293	DL-Carnitine HCl	40 mg/mL	40 mg/mL	<1 mg/mL
S1675	Lubiprostone (Amitiza)	<1 mg/mL	79 mg/mL	79 mg/mL
S1820	Clofibrate (Atromid-S)	<1 mg/mL	7 mg/mL	5 mg/mL
S1853	Penicillamine (Cuprimine)	30 mg/mL	<1 mg/mL	<1 mg/mL
S1907	Metronidazole (Flagyl)	<1 mg/mL	34 mg/mL	<1 mg/mL
S1940	Levofloxacin (Levaquin)	11 mg/mL	24 mg/mL	21 mg/mL
S1957	Sulfamethizole (Proklar)	<1 mg/mL	54 mg/mL	10 mg/mL
S2021	Chlormezanone (Trancopal)	<1 mg/mL	55 mg/mL	26 mg/mL
S2609	Inulin	104 mg/mL	10 mg/mL	<1 mg/mL
S2328	Nalidixic acid (NegGram)	<1 mg/mL	6 mg/mL	<1 mg/mL
S2177	Dichlorphenamide (Diclofenamide)	<1 mg/mL	61 mg/mL	33 mg/mL
S2123	Dextrose (D-glucose)	36 mg/mL	36 mg/mL	<1 mg/mL
S1893	D-glutamine	9 mg/mL	<1 mg/mL	<1 mg/mL
S2129	Fudosteine	36 mg/mL	<1 mg/mL	<1 mg/mL
S1998	D-Cycloserine	20 mg/mL	<1 mg/mL	<1 mg/mL
S2015	Suplatast tosylate	100 mg/mL	100 mg/mL	100 mg/mL
S2125	Mestranol	<1 mg/mL	15 mg/mL	25 mg/mL
S1902	Vitamin B12	6 mg/mL	75 mg/mL	10 mg/mL
S1897	Potassium iodide	33 mg/mL	33 mg/mL	<1 mg/mL
S1900	Talc	<1 mg/mL	0.1 mg/mL	<1 mg/mL
S2467	Famciclovir (Famvir)	64 mg/mL	64 mg/mL	48 mg/mL
S2468	Fenbendazole (Panacur)	<1 mg/mL	4 mg/mL	<1 mg/mL
S2470	Fluocinolone acetonide (Flucort-N)	<1 mg/mL	90 mg/mL	12 mg/mL
S2486	Moroxydine	42 mg/mL	42 mg/mL	<1 mg/mL
S2498	Pantothenic acid (pantothenate)	44 mg/mL	44 mg/mL	<1 mg/mL
S2506	Roxithromycin (Roxl-150)	<1 mg/mL	167 mg/mL	167 mg/mL
S2510	Spectinomycin HCl	99 mg/mL	99 mg/mL	<1 mg/mL
S2511	Sulfadoxine (Sulphadoxine)	62 mg/mL	<1 mg/mL	<1 mg/mL
S2514	Tobramycin	94 mg/mL	<1 mg/mL	<1 mg/mL
S2376	Ammonium Glycyrrhizinate (AMGZ)	5 mg/mL	168 mg/mL	<1 mg/mL
S2393	Sorbitol (Glucitol)	36 mg/mL	36 mg/mL	<1 mg/mL
S2305	Grape Seed Extract	<1 mg/mL	94 mg/mL	<1 mg/mL
S2527	Methacycline HCl (Physiomycine)	5 mg/mL	3 mg/mL	<1 mg/mL
S2530	7-Aminocephalosporanic acid	<1 mg/mL	1 mg/mL	<1 mg/mL
S2532	L-Ascorbyl 6-palmitate	<1 mg/mL	83 mg/mL	83 mg/mL
S2534	Isoconazole nitrate (Travogen)	<1 mg/mL	41 mg/mL	4 mg/mL
S2535	Econazole nitrate (Spectazole)	<1 mg/mL	89 mg/mL	5 mg/mL
S2536	Miconazole (Monistat)	<1 mg/mL	83 mg/mL	83 mg/mL
S2537	Secnidazole (Flagentyl)	37 mg/mL	37 mg/mL	37 mg/mL
S2538	Acetanilide (Antifebrin)	<1 mg/mL	27 mg/mL	27 mg/mL
S2539	Lomefloxacin HCl (Maxaquin)	6 mg/mL	1 mg/mL	<1 mg/mL
S2540	Riboflavin (Vitamin B2)	<1 mg/mL	0.1 mg/mL	<1 mg/mL
S2543	Ceftiofur HCl	<1 mg/mL	112 mg/mL	40 mg/mL
S2553	5-Aminolevulinic acid HCl	34 mg/mL	34 mg/mL	6 mg/mL
S2557	Terbinafine HCl (Lamisil)	<1 mg/mL	66 mg/mL	66 mg/mL
S2559	Cortisone acetate (Cortone)	<1 mg/mL	7 mg/mL	<1 mg/mL
S2562	Hydralazine HCl	1 mg/mL	<1 mg/mL	<1 mg/mL
S2564	Cloxacillin sodium (Cloxacap)	55 mg/mL	55 mg/mL	25 mg/mL
S2568	Neomycin sulfate	143 mg/mL	<1 mg/mL	<1 mg/mL
S2155	LY2608204	<1 mg/mL	112 mg/mL	35 mg/mL
S2612	Ribitol (Adonitol)	31 mg/mL	31 mg/mL	<1 mg/mL
S2565	Amoxicillin sodium (Amox)	78 mg/mL	78 mg/mL	<1 mg/mL
S2588	Calcium levofolinate (Calcium Folinate)	9 mg/mL	<1 mg/mL	<1 mg/mL
S2716	Peramivir Trihydrate	<1 mg/mL	0.2 mg/mL	<1 mg/mL
S2608	Fluocinonide(Vanos)	<1 mg/mL	99 mg/mL	<1 mg/mL
S1823	Fenoprofen calcium	<1 mg/mL	105 mg/mL	10 mg/mL
S1825	Erdosteine	<1 mg/mL	50 mg/mL	10 mg/mL
S1985	ATP (Adenosine-Triphosphate)	110 mg/mL	<1 mg/mL	<1 mg/mL
S1987	Mometasone furoate	<1 mg/mL	6 mg/mL	<1 mg/mL
S1992	Fluticasone propionate (Flonase, Veramyst)	<1 mg/mL	100 mg/mL	5 mg/mL
S2613	Clorsulon	<1 mg/mL	76 mg/mL	7 mg/mL
S2016	Mirtazapine (Remeron, Avanza)	<1 mg/mL	53 mg/mL	53 mg/mL
S1960	Pranoprofen	<1 mg/mL	51 mg/mL	6 mg/mL
S2028	Diclazuril	<1 mg/mL	16 mg/mL	<1 mg/mL
S2032	Rebamipide	<1 mg/mL	74 mg/mL	<1 mg/mL
S2035	Epalrestat	<1 mg/mL	2 mg/mL	<1 mg/mL
S1997	Liranaftate	<1 mg/mL	<1 mg/mL	<1 mg/mL
S1875	Tranexamic acid (Transamin)	31 mg/mL	<1 mg/mL	<1 mg/mL
S1836	Albendazole Oxide (Ricobendazole)	<1 mg/mL	11 mg/mL	<1 mg/mL
S1962	Sulphadimethoxine	<1 mg/mL	62 mg/mL	<1 mg/mL
S1833	Butoconazole nitrate	<1 mg/mL	95 mg/mL	<1 mg/mL
S1911	Disodium Cromoglycate	2 mg/mL	<1 mg/mL	<1 mg/mL
S2036	Aspartame	4 mg/mL	33 mg/mL	<1 mg/mL
S1928	Alibendol	<1 mg/mL	50 mg/mL	50 mg/mL
S1611	Cefoperazone (Cefobid)	<1 mg/mL	129 mg/mL	<1 mg/mL
S1958	Sulbactam	47 mg/mL	47 mg/mL	47 mg/mL
S1881	Protionamide (Prothionamide)	<1 mg/mL	36 mg/mL	7 mg/mL
S1830	Oxfendazole	<1 mg/mL	10 mg/mL	<1 mg/mL
S2412	Genipin	78 mg/mL	78 mg/mL	<1 mg/mL
S2410	Paeoniflorin	96 mg/mL	96 mg/mL	96 mg/mL
S2409	10-DAB (10-Deacetylbaccatin)	<1 mg/mL	109 mg/mL	<1 mg/mL
S2408	Cephalomannine	<1 mg/mL	110 mg/mL	166 mg/mL
S2605	Idebenone	<1 mg/mL	68 mg/mL	68 mg/mL
S2548	Scopine HCl	38 mg/mL	38 mg/mL	38 mg/mL
S2572	Streptomycin sulfate	<1 mg/mL	292 mg/mL	<1 mg/mL
S2551	Sulbactam sodium (Unasyn)	51 mg/mL	3 mg/mL	<1 mg/mL
S2607	Buflomedil HCl	69 mg/mL	31 mg/mL	7 mg/mL
S2596	Clindamycin palmitate HCl	140 mg/mL	140 mg/mL	140 mg/mL
S2584	Clobetasol propionate	<1 mg/mL	93 mg/mL	20 mg/mL
S2610	Lonidamine	<1 mg/mL	64 mg/mL	<1 mg/mL
S2599	L-Thyroxine	<1 mg/mL	155 mg/mL	<1 mg/mL
S2589	Miglitol (Glyset)	<1 mg/mL	3 mg/mL	<1 mg/mL
S2518	NAD+	133 mg/mL	<1 mg/mL	<1 mg/mL
S2590	Pioglitazone (Actos)	<1 mg/mL	15 mg/mL	<1 mg/mL
S2615	Noradrenaline bitartrate monohydrate (Levophed)	64 mg/mL	64 mg/mL	<1 mg/mL
S1851	Oxibendazole	<1 mg/mL	1 mg/mL	<1 mg/mL
S1910	Tioconazole	<1 mg/mL	78 mg/mL	78 mg/mL
S1876	Valaciclovir HCl	72 mg/mL	14 mg/mL	<1 mg/mL
S1837	Flubendazole (Flutelmium)	<1 mg/mL	1 mg/mL	<1 mg/mL
S2041	Dyclonine HCl	6 mg/mL	15 mg/mL	36 mg/mL
S2594	Pramiracetam	<1 mg/mL	54 mg/mL	<1 mg/mL
S2048	Clindamycin phosphate	101 mg/mL	<1 mg/mL	<1 mg/mL
S2052	Oxytetracycline dihydrate	<1 mg/mL	5 mg/mL	<1 mg/mL
S2053	Cytidine	49 mg/mL	49 mg/mL	<1 mg/mL
S2045	Doxifluridine	49 mg/mL	49 mg/mL	<1 mg/mL
S1857	Etidronate (Didronel)	41 mg/mL	<1 mg/mL	<1 mg/mL
S2058	Tolnaftate	<1 mg/mL	62 mg/mL	<1 mg/mL
S2060	Bromhexine HCl	<1 mg/mL	6 mg/mL	5 mg/mL
S2062	Tiopronin (Thiola)	32 mg/mL	32 mg/mL	32 mg/mL
S2064	Balofloxacin	<1 mg/mL	5 mg/mL	<1 mg/mL
S1977	Sarafloxacin HCl	<1 mg/mL	1 mg/mL	<1 mg/mL
S2066	Moxonidine	<1 mg/mL	24 mg/mL	2 mg/mL
S2069	Argatroban	<1 mg/mL	9 mg/mL	9 mg/mL
S2074	Mecarbinate	<1 mg/mL	47 mg/mL	<1 mg/mL
S1964	Rimantadine (Flumadine)	33 mg/mL	33 mg/mL	33 mg/mL
S2082	Adiphenine HCl	70 mg/mL	30 mg/mL	18 mg/mL
S2097	Ambrisentan	<1 mg/mL	76 mg/mL	22 mg/mL
S2114	Dronedarone HCl (Multaq)	<1 mg/mL	80 mg/mL	40 mg/mL
S2116	Conivaptan HCl (Vaprisol)	<1 mg/mL	107 mg/mL	7 mg/mL
S2119	Probucol	<1 mg/mL	103 mg/mL	103 mg/mL
S2120	Arbidol HCl	<1 mg/mL	103 mg/mL	22 mg/mL
S3007	Zanamivir (Relenza)	25 mg/mL	2 mg/mL	<1 mg/mL
S3000	Carbazochrome sodium sulfonate	3 mg/mL	64 mg/mL	<1 mg/mL
S2031	Fenticonazole nitrate	<1 mg/mL	104 mg/mL	2 mg/mL
S3078	Beclomethasone dipropionate (Beclometasone dipropionate)	<1 mg/mL	104 mg/mL	18 mg/mL
S1855	Pefloxacin mesylate	67 mg/mL	14 mg/mL	<1 mg/mL
S1884	Sparfloxacin	<1 mg/mL	9 mg/mL	<1 mg/mL
S2576	Xylometazoline HCl	56 mg/mL	27 mg/mL	56 mg/mL
S1791	Bacitracin zinc	<1 mg/mL	0.15 mg/mL	<1 mg/mL
S1974	Meglumine	39 mg/mL	39 mg/mL	<1 mg/mL
S2446	Levosimendan	<1 mg/mL	56 mg/mL	<1 mg/mL
S3025	PMSF (Phenylmethylsulfonyl Fluoride)	<1 mg/mL	35 mg/mL	15 mg/mL
S3027	Fenoprofen calcium hydrate	<1 mg/mL	48 mg/mL	18 mg/mL
S2420	Aloperine	<1 mg/mL	2 mg/mL	46 mg/mL
S3121	Ornidazole	2 mg/mL	44 mg/mL	44 mg/mL
S3100	2-Thiouracil	<1 mg/mL	26 mg/mL	<1 mg/mL
S3102	Creatinine	23 mg/mL	<1 mg/mL	<1 mg/mL
S3122	Amikacin hydrate	100 mg/mL	<1 mg/mL	<1 mg/mL
S3105	Nadifloxacin	<1 mg/mL	20 mg/mL	<1 mg/mL
S3106	Pidotimod	10 mg/mL	49 mg/mL	<1 mg/mL
S3104	Moguisteine	<1 mg/mL	68 mg/mL	68 mg/mL
S3124	Dexamethasone acetate	<1 mg/mL	87 mg/mL	20 mg/mL
S3130	Biotin (Vitamin B7)	<1 mg/mL	49 mg/mL	<1 mg/mL
S3132	Sulfamerazine	<1 mg/mL	53 mg/mL	<1 mg/mL
S3133	Sulfamethazine	<1 mg/mL	56 mg/mL	<1 mg/mL
S3137	Sodium salicylate	32 mg/mL	32 mg/mL	<1 mg/mL
S3113	Pyridoxine HCl	41 mg/mL	41 mg/mL	<1 mg/mL
S3138	Methylthiouracil	<1 mg/mL	28 mg/mL	<1 mg/mL
S3139	Methenamine (Mandelamine)	<1 mg/mL	28 mg/mL	9 mg/mL
S3170	Ampicillin sodium	74 mg/mL	37 mg/mL	74 mg/mL
S3173	Antipyrine	38 mg/mL	38 mg/mL	38 mg/mL
S3140	Milnacipran HCl	57 mg/mL	57 mg/mL	57 mg/mL
S3148	Ibandronate sodium	72 mg/mL	<1 mg/mL	<1 mg/mL
S3150	Articaine HCl	64 mg/mL	64 mg/mL	64 mg/mL
S3154	Butenafine HCl	<1 mg/mL	70 mg/mL	70 mg/mL
S3155	Mepivacaine HCl	57 mg/mL	3 mg/mL	8 mg/mL
S3156	Naftifine HCl	<1 mg/mL	<1 mg/mL	8 mg/mL
S3162	Tylosin tartrate	200 mg/mL	300 mg/mL	300 mg/mL
S3174	L-Arginine HCl	42 mg/mL	<1 mg/mL	<1 mg/mL
S3189	Ropinirole HCl	60 mg/mL	10 mg/mL	<1 mg/mL
S3193	Ticarcillin sodium	<1 mg/mL	1 mg/mL	<1 mg/mL
S3195	Azlocillin sodium salt	97 mg/mL	97 mg/mL	3 mg/mL
S3201	Trifluoperazine 2HCl	96 mg/mL	88 mg/mL	96 mg/mL
S3204	Meptazinol HCl	54 mg/mL	54 mg/mL	54 mg/mL
S3188	(+,-)-Octopamine HCl	38 mg/mL	38 mg/mL	11 mg/mL
S3196	Azacyclonol	2 mg/mL	53 mg/mL	53 mg/mL
S3199	Reboxetine mesylate	82 mg/mL	82 mg/mL	<1 mg/mL
S3202	Catharanthine	<1 mg/mL	67 mg/mL	3 mg/mL
S3209	Amidopyrine	10 mg/mL	46 mg/mL	46 mg/mL
S3211	Thiamine HCl (Vitamin B1)	68 mg/mL	<1 mg/mL	<1 mg/mL
S3114	Vitamin C (Ascorbic acid)	35 mg/mL	35 mg/mL	<1 mg/mL
S3116	Sulfathiazole	<1 mg/mL	51 mg/mL	<1 mg/mL
S3045	Cinepazide maleate	107 mg/mL	107 mg/mL	<1 mg/mL
S3041	Droxidopa (L-DOPS)	<1 mg/mL	<1 mg/mL	<1 mg/mL
S2858	StemRegenin 1	<1 mg/mL	86 mg/mL	2 mg/mL
S2847	Cathepsin Inhibitor 1	<1 mg/mL	80 mg/mL	50 mg/mL
S3055	Besifloxacin HCl(Besivance)	1 mg/mL	<1 mg/mL	<1 mg/mL
S3063	Diclofenac Diethylamine	<1 mg/mL	74 mg/mL	74 mg/mL
S3062	Diclofenac Potassium	10 mg/mL	69 mg/mL	<1 mg/mL
S3059	Enrofloxacin	<1 mg/mL	1 mg/mL	<1 mg/mL
S3070	Piracetam	72 mg/mL	72 mg/mL	<1 mg/mL
S3073	Caspofungin Acetate	243 mg/mL	243 mg/mL	<1 mg/mL
S2883	4-Aminohippuric Acid	3 mg/mL	39 mg/mL	2 mg/mL
S2884	Acesulfame Potassium	40 mg/mL	40 mg/mL	<1 mg/mL
S3079	Atovaquone (Atavaquone)	<1 mg/mL	5 mg/mL	<1 mg/mL
S2877	L-NAME HCl	54 mg/mL	<1 mg/mL	<1 mg/mL
S3058	Danofloxacin Mesylate	91 mg/mL	<1 mg/mL	<1 mg/mL
S2885	A 205804	<1 mg/mL	60 mg/mL	<1 mg/mL
S2901	CCG 50014	<1 mg/mL	63 mg/mL	<1 mg/mL
S3065	Amikacin sulfate	10 mg/mL	<1 mg/mL	<1 mg/mL
S3038	Fosaprepitant dimeglumine	135 mg/mL	201 mg/mL	<1 mg/mL
S2916	ML-161	<1 mg/mL	72 mg/mL	<1 mg/mL
S2918	HC-030031	<1 mg/mL	32 mg/mL	<1 mg/mL
S4004	Ethambutol HCl	56 mg/mL	56 mg/mL	<1 mg/mL
S4005	Doxycycline HCl	<1 mg/mL	3 mg/mL	<1 mg/mL
S4006	Clinafloxacin (PD127391)	<1 mg/mL	0.03 mg/mL	<1 mg/mL
S4007	Pentamidine HCl	119 mg/mL	119 mg/mL	<1 mg/mL
S4017	Allylthiourea	<1 mg/mL	23 mg/mL	23 mg/mL
S4015	Cyclamic acid	36 mg/mL	36 mg/mL	36 mg/mL
S4020	Sodium Picosulfate	96 mg/mL	96 mg/mL	3 mg/mL
S4022	Probenecid (Benemid)	<1 mg/mL	57 mg/mL	22 mg/mL
S4032	Bismuth Subsalicylate	<1 mg/mL	0.04 mg/mL	<1 mg/mL
S4035	Vitamin D2 (Ergocalciferol)	<1 mg/mL	20 mg/mL	80 mg/mL
S4037	Doxapram HCl	25 mg/mL	87 mg/mL	2 mg/mL
S4040	Norethindrone (Norethisterone)	<1 mg/mL	60 mg/mL	5 mg/mL
S4041	Olsalazine Sodium	41 mg/mL	4 mg/mL	<1 mg/mL
S4042	Nafcillin Sodium	91 mg/mL	91 mg/mL	20 mg/mL
S4044	Toltrazuril	<1 mg/mL	85 mg/mL	<1 mg/mL
S4052	Netilmicin Sulfate	288 mg/mL	<1 mg/mL	<1 mg/mL
S4057	Methyclothiazide	<1 mg/mL	72 mg/mL	4 mg/mL
S4058	Ropivacaine HCl	46 mg/mL	62 mg/mL	<1 mg/mL
S4059	Sodium Nitroprusside	60 mg/mL	60 mg/mL	<1 mg/mL
S4060	Erythromycin Ethylsuccinate	<1 mg/mL	172 mg/mL	172 mg/mL
S4062	Ronidazole	<1 mg/mL	40 mg/mL	<1 mg/mL
S4063	Vitamin D3 (Cholecalciferol)	<1 mg/mL	77 mg/mL	77 mg/mL

Product Description

Biological Activity Protocol Chemical Information Tech Support & FAQs

Biological Activity

Description	Bendamustine HCL (Ribomustin, Treanda, SDX-105) is a DNA-damaging agent with IC50 of 50 μM.
Targets	DNA
IC50	50 μM ^[1]
In vitro	DNA single- and double-strand breaks caused by Bendamustine are more extensive and significantly more durable than those caused by cyclophosphamide, cisplatinum, or carmustine. Bendamustine specifically regulates, transcriptionally and posttranslationally, genes involved in apoptosis, DNA repair, and mitotic checkpoints. Bendamustine uniquely regulates DNA repair pathways in non–Hodgkin's lymphoma cells compared with other alkylators. Bendamustine inhibits mitotic checkpoints and induces mitotic catastrophe. Treatment with Bendamustine results in a 60% to 80% down-regulation of the mRNA expression of all three of these genes [polo-like kinase 1 (PLK-1), Aurora Kinase A, and cyclin B1] in SU-DHL-9 cells. Twenty-six percent of the Bendamustine-treated MCF-7/ADR cells showed micronucleation compared with only 6% in DMSO control cells. ^[1] Using Bendamustine alone in concentrations from 1 μg/mL to 50 μg/mL, a dose- and time-dependent manner of cytotoxicity from 30.4% to 94.8% after 48 hours could be observed. The LD50 for untreated and pretreated CLL cells is 7.3 or 4.4 μg /mL, respectively. ^[2] Myeloid and breast carcinoma cell lines are resistant towards Bendamustine with the exception of HL-60 cells which exhibit an intermediate sensitivity. Bendamustine is found to have a very low clastogenic effect as compared with equimolar doses of lomustine. ^[3]
In vivo	A single dose of Bendamustine at 25 mg/kg demonstrates significant activity in all three tumor lines (DoHH-2, Granta 519 and RAMOS). DoHH-2 is the most sensitive, with 30% ORR and a 69% inhibition in tumor growth. Growth of Granta 519 and RAMOS is also inhibited by Bendamustine (%TGI of 74% and 81%, respectively), and the effect is more durable in Granta 519 (%TGD of 124%) than for DoHH-2 or RAMOS (69% and 43%, respectively). ^[4]
Clinical Trials	Bendamustine HCl has entered in a phase II clinical trial in the treatment of ovarian cancer.
Features

Protocol(Only for Reference)

Cell Assay: ^[1]

Cell lines	SU-DHL-1 and SU-DHL-9 cells
Concentrations	0-100 μM
Incubation Time	72 hours
Method	SU-DHL-1 and SU-DHL-9 cells are preincubated for 30 minutes with either 6 mM methoxyamine or 50 μM O6-benzylguanine, inhibitors of Ape-1 base excision repair enzyme, or alkylguanyl transferase enzyme, respectively. The cells are then exposed to various concentrations of Bendamustine for 72 hours. Cytotoxicity is evaluated by the MTT viability assay and an IC50 is determined as the drug concentration that inhibited by 50% the viability value of the untreated control. Analyses are done.

Animal Study: ^[5]

Animal Models	C.B.-17 scid mice bearing DoHH-2, Granta 519 or C.B.-17 scid-bg mice bearing SuDHL-4, RAMOS
Formulation	Control
Dosages	25 mg/kg
Administration	Administered via i.v.

References

Chemical Information

Download Bendamustine HCL SDF

Molecular Weight (MW)	394.72
Formula	C₁₆H₂₁Cl₂N₃O₂.HCl
CAS No.	3543-75-7
Synonyms	Ribomustin, Treanda, SDX-105

Solubility (25°C) DMSO 79 mg/mL Water 15 mg/mL Ethanol 17 mg/mL
Storage	2 years -20°CPowder
	2 weeks4°Cin DMSO
	6 months-80°Cin DMSO

Chemical Name

Molarity Calculator Dilution Calculator Molecular Weight Calculator

Research Area

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3Monday–Friday 9:00 AM–5:00 PM (Central Time)

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