Research Area
Product Type
United States ( Change Country )
Clofarabine Chemical Structure
Cisplatin
Potent anticancer agent that blocks DNA synthesis.
Nelarabine (Arranon)
Nelarabine(Arranon) performes growth inhibitory activity (IC50= 1.61 μM) against MOLT-4 cells
Bleomycin sulfate
A glycopeptide antibiotic produced by the bacterium Streptomyces verticillus.
Carboplatin
This drug performed growth inhibitory activity in IGROV1 and OAW42 cells(IC50 of 25 and 30 mg/l,respectively).
Clafen (Cyclophosphamide)
This agent inhibited cell proliferation of NCI-H727 with IC50 at 9.3 nM.
Oxaliplatin (Eloxatin)
Oxaliplatin (Eloxatin) is a 1,2-diaminocyclohexane (DACH) carrier ligand-based groups of platinum antitumor agent with IC50 of median 1.3, 6.2 and 1.5 mM for SW480 DLD1, HT29, respectively.
CCT239065
CCT239065 is a novel, selective, and efficacious nanomolar pyridopyrazinone V600E BRAF and LCK inhibitor with IC50 of 13 nM and 6 nM, respectively.
NSC-207895 (XI-006)
NSC-207895 (XI-006) is a derivative of nitrobenzofuroxan and an anticancer agent with an EC50 of 1 μM.
CX-5461
CX-5461 is a potent small-molecule rRNA synthesis inhibitor with an IC50 of 0.11 μM.
BSI-201
BSI-201 is a potent PARP1 inhibitor with strong anti-neoplastic effect.
Biological Activity
Clofarabine is a second generation purine nucleoside analog with antineoplastic activity. It is phosphorylated intracellularly, which inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase, resulting in inhibition of DNA repair and synthesis of DNA and RNA. This nucleoside analog also disrupts mitochondrial function and membrane integrity, resulting in the release of pre-apoptotic factors, including cytochrome C and apoptotic-inducing factor, which activate apoptosis. [1]
It is used for treating relapsed or refractory acute lymphoblastic leukaemia (ALL) in children, after at least two other types of treatment have failed. [2]
Product Information
| Molecular Weight (WM): | 303.68 |
|---|---|
| Formula: | C10H11ClFN5O3 |
| CAS No.: | 123318-82-1 |
| Synonyms: |
Clolar, Evoltra
|
| Dissolve in (25°C): | DMSO ≥61mg/mL |
| Water <1mg/mL | |
| Ethanol ≥4mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
Research Area
Notes:
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