Aciclovir

Catalog No.S1807 Synonyms: Acyclovir

Aciclovir Chemical Structure

Molecular Weight(MW): 225.2

Aciclovir is a synthetic nucleoside analogue active against herpesviruses.

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In DMSO USD 130 In stock
USD 97 In stock
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1 Customer Review

  • (A) HONE1 and (B) HK1-EBV cells were treated with TPA (40 ng/ml) and SB (3 mM) for EBV induction. After 3 h, uninduced and induced HONE1 and HK1-EBV cells were treated with the vehicle control (0.006% DMSO) or indicated concentrations of berberine for 48 h. Subsequently, the culture medium was harvested for quantitative-PCR analysis with EBNA1 primers. Each sample was normalized to the amount of the GAPDH gene; *p<0.05, compared with the control group.

    Oncol Rep, 2017, 37(4):2109-2120. Aciclovir purchased from Selleck.

Purity & Quality Control

Choose Selective Anti-infection Inhibitors

Biological Activity

Description Aciclovir is a synthetic nucleoside analogue active against herpesviruses.
Targets
HSV [1]
In vitro

Acyclovir sensitivity of herpes simplex virus isolates is determined in a plaque-reduction assay in Vero cells. IC50 Values are consistently 2-3 fold lower in B2 compared with the H strain of Vero cells. HSV Type 2 strains are 2-10-fold less sensitive than Type 1 strains[2].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
BSC-1 cells NU\4OoNoTnWwY4Tpc44h[XO|YYm= NF:5bHpCdnSrdnnyZYwh[WO2aY\peJkhd2ZidHjlJINwdXCxdX7kJJdieyCndnHseYF1\WRiYXfhbY5{fCC2aHWgTIVzeGW|IIPpcZBt\XhidnnyeZMhfHmyZT2xJIlvKEKVQz2xJINmdGy|LDDJR|UxRTJwNjFOwG0> MnvONlkyOzNyMB?=
P3HR-1 cells M3m0cmZ2dmO2aX;uJIF{e2G7 M{fqNGVn\mWldHn2[UBkd26lZX70doF1cW:wIH\vdkB1cGViaX7obYJqfGmxbjDv[kBGeHO2ZXnuMWJienJidnnyeZMhTUKYLVTORUB{gW62aHXzbZMhcW5iaIXtZY4hdHmvcHjvZoxie3SxaXSgVFNJWi1zIHPlcIx{NCCHQ{WwQVYvPzVizszN Ml7MNVI1ODh5Mk[=
HFF cells M4j6ZmZ2dmO2aX;uJIF{e2G7 M4jHUmNwdmOnboTyZZRqd25iZn;yJGhUXi1zIIDsZZF2\SC{ZXT1Z5Rqd25iKG\QVkkh[nliNUClJIlvKEiIRjDj[YxteyxiRVO1NF0yNjFizszN NUPi[3ZbOTR3OES5OVQ>
HFF cells NYXHbop3TnWwY4Tpc44h[XO|YYm= MYjJcohq[mm2b4L5JINwdmOnboTyZZRqd25icnXxeYlz\WRidH:gdoVlfWOnIFjTWk0yKGmwZIXj[YQh[3m2b4DheIhw\2WwaXOg[YZn\WO2IDjDVGUqKGK7IEWwJEUhcW5iSF\GJINmdGy|LDDFR|UxRTJwMkKg{txO M3LEXlE1PTh2OUW0
human embryonic lung cells MUjGeY5kfGmxbjDhd5NigQ>? NFjGTZpCdnSrdnnyZYwh[WO2aY\peJkhf2G|IH3lZZN2emWmIHHzJIVn\mWldHn2[UBkd26lZX70doF1cW:wIILldZVqemWmIITvJJJm\HWlZTDWZZJq[2WubHGgXo9{fGW{II\pdpV{KCiRS1GpMYlv\HWlZXSgdIxieXWnIH\vdo1ifGmxbjDpckBpfW2jbjDlcYJzgW:waXOgcJVv\yClZXzsd{whTUN3ME2xMlEh|ryP NVf5TlF7OTF3NEm0OVc>
HEL cells NIfwVFhHfW6ldHnvckBie3OjeR?= MYfDc41xd3WwZDD3ZZMhfGW|dHXkJIZweiCjboTpMZZqemGuIHHjeIl3cXS7IHHnZYlve3RiSGPWMVEpTyliaX6gTGVNKGOnbHzzMEBGSzVyPUGuN{DPxE1? MkHpNVQ3PDN|Mki=
HEL cell MoTSSpVv[3Srb36gZZN{[Xl? Mn7ISYZn\WO2aY\lJINwdmOnboTyZZRqd25icnXxeYlz\WRidH:gbY5pcWKrdDDUfZJwe2mwZTDrbY5ie2ViKGTLL{khXmG{aXPlcIxiNVqxc4TldkB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXPpeJkh[nliNUClJIlvKE:NQTDzeJJicW5iSFXMJINmdGxibHnu[ZMtKEWFNUC9OE42OyEQvF2= M4W3VlEyPDl3NUi2
HSV-2 MS Vero cells MYXGeY5kfGmxbjDhd5NigQ>? NXXKW3JpUW6qaXLpeIlwdiCxZjD2bZJidCCleYTvdIF1cGmlIHXm[oVkfCCrbjDpcoZm[3SnZDDoeY1idiCob4Lld4tqdiCoaXLyc4Jt[XO2IHPlcIwhdW:wb3zhfYVzeyCxZjDIV3YuOiCPUzDW[ZJwKGOnbHzzJIJ6KDVyJTygSWM2OD14LkKg{txO MVWxNVU5PTR3Nx?=
HSV-1 E-377 Vero cells M2HsPGZ2dmO2aX;uJIF{e2G7 MorwTY5pcWKrdHnvckBw\iCybHHxeYUh\m:{bXH0bY9vKGmwIH3vco9t[XmncoOgc4YhUFOYLUGgSU0{PzdiVnXyc{Bk\WyuczDifUA2OCVuIFXDOVA:PC52IN88US=> Mn\ONVE2QDV2NUe=
HSV-1 KOS Vero cells M{G1T2Z2dmO2aX;uJIF{e2G7 MlewTY5pcWKrdHnvckBw\iCybHHxeYUh\m:{bXH0bY9vKGmwIH3vco9t[XmncoOgc4YhUFOYLUGgT29UKF[ncn:gZ4VtdHNiYomgOVAmNCCHQ{WwQVIvOiEQvF2= NWfmdm01OTF3OEW0OVc>
HeLa cell MYLGeY5kfGmxbjDhd5NigQ>? M1HlNmFjcWyrdImgeI8hcW6qaXLpeEBkgXSxcHH0bI9o\W6rY3n0fUBw\iCqZYLw[ZMhe2mvcHzlfEB1gXCnIEGgeolzfXNiKFepJIlvKEinTHGgZ4VtdCCldXz0eZJmNCCLQ{WwQVAvOTlizszN NXfJ[25uOTF|NU[xNVA>
HEp-2 cells MmLOSpVv[3Srb36gZZN{[Xl? MXnNbY5qdXWvIHnubIljcXSxcomgZ49v[2WwdILheIlwdiClYYXzbY5oKDJ3JTDpcohq[mm2aX;uJI9nKGO7dH;wZZRpcWNiZX\m[YN1KGmwZIXj[YQh[nliSHXydIV{KHOrbYDs[Zghfmm{dYOtNUApUzl5OTmgbY4hUEWyLUKgZ4VtdHN? NYP6WY85Ojh2MkWwOi=>
HeLa cells NYHEeVc4TnWwY4Tpc44h[XO|YYm= MXLJcohq[mm2aX;uJI9nKEiVVj2xJGRPSSC|eX70bIV{cXNiaX6geolzfXNvaX7m[YN1\WRiSHXMZUBk\WyuczygTWM2OD1zLkmg{txO MmjrO|c2OjJyNh?=
human HFF cells M2TTfWZ2dmO2aX;uJIF{e2G7 M3fSS2lvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDv[kB1cGViZIL1[{Bi\2GrboP0JJRp\SCleYTvdIF1cGmlIHXm[oVkfCCob4KgSU0{Pzdic4TyZYlvKG:oIHjldpBmeyC|aX3wcIV5KH[rcoXzMVEhMEiVVj2xLUBqdiCqdX3hckBJTkZiY3XscJMtKEWFNUC9NE4xPCEQvF2= M132dFg{QTR7M{O=
human HFF cells M1mzVGZ2dmO2aX;uJIF{e2G7 NWPCVYJoUW6qaXLpeI9zgSClb37j[Y51emG2aX;uJI9nKHSqZTDkdpVoKGGpYXnud5QhfGinIHP5eI9x[XSqaXOg[YZn\WO2IH\vdkBOWyC|dILhbY4hd2ZiaHXydIV{KHOrbYDs[Zghfmm{dYOtNkApUFOYLUKpJIlvKGi3bXHuJGhHTiClZXzsd{whTUN3ME2wMlA6KM7:TR?= MXO4N|k1QTN|
MRC-5 cells MXjGeY5kfGmxbjDhd5NigQ>? NGnFcFhCdnSrdnnyZYwh[WO2aY\peJkhcW5icHzhdZVmKHKnZIXjeIlwdiCjc4PhfUB4[XNiZHX0[ZJucW6nZDDh[4FqdnO2IHjldpBmeyC|aX3wcIV5KH[rcoXzJJR6eGViMjCoTHNXNTJrIHnuJG1TSy13IHPlcIx{NCCLQ{WwQVIvPSEQvF2= M4rafFIyPTN{MEK=
human lung fibroblasts (MRC-5) NH;ne2tHfW6ldHnvckBie3OjeR?= NHj4V4JEd22yb4Xu[EB4[XNidHXzeIVlKG[xcjDhcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNiU3ntdIxmgCC4aYL1d{BVgXCnLUGoNVgyQDlrIHnuJIh2dWGwIHz1coch\mmkcn;icIF{fHNiKF3SR{02MQ>? MnO5N|A1ODl7OB?=
Raji cells MYDGeY5kfGmxbjDhd5NigQ>? M32xUGlvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDv[kB1cGViZIL1[{Bi\2GrboP0JJRp\SCjboTp[4VvKHC{b3T1Z5Rqd25iYXfhbY5{fCCSM1jSMVEhe3S{YXnuJI9nKGWyc4TlbY4h[mG{cjD2bZJ2ey1{IDjFRnYqKGmwIGLhbokh[2WubIOsJGVEPTB;Mj65JO69VQ>? MX[4N|k1QTN|
Vero cells MkPOSpVv[3Srb36gZZN{[Xl? MYfJcohq[mm2b4L5JIFkfGm4aYT5JIFo[Wmwc4SgbIVzeGW|IIPpcZBt\XhidnnyeZMhfHmyZTCyJEhJW1ZiMjmgd5Rz[WmwIEG4OkBqdiCYZYLvJINmdGy|LDDJR|UxRTFwNzFOwG0> NXzTV454QDV5NkmyNi=>
BSC-1 cells NWHUS5dWTnWwY4Tpc44h[XO|YYm= M1:4ZWVn\mWldHn2[UBkd26lZX70doF1cW:wIILldZVqemWmIITvJIlvcGmkaYSgbIVzeGW|IIPpcZBt\XhidnnyeZMhOSCrbjDCV2MuOSClZXzsd{BqdiCHTFnTRUwhTUN3ME2xMlUh|ryP MnO1NVU3OzRyMEO=
HFF cells MlvISpVv[3Srb36gZZN{[Xl? Mo\rSYZn\WO2aY\lJINwdmOnboTyZZRqd25icnXxeYlz\WRidH:gbY5pcWKrdDD2ZZJq[2WubHGgfo9{fGW{II\pdpV{KHKncHzpZ4F1cW:wIHnuJGhHTiClZXzsd{whTUN3ME2xMlYh|ryP MXqxOVY{PDByMx?=
HFF cells NHnCT4tHfW6ldHnvckBie3OjeR?= NInWOoRG\m[nY4TpeoUh[2:wY3XueJJifGmxbjDy[ZF2cXKnZDD0c{BqdmirYnn0JIhmenCnczDzbY1xdGW6II\pdpV{KDFiaX6gTGZHKGOnbHzzJIlvKGO7dH;wZZRpcWNiZX\m[YN1KCiFUFWpJIF{e2G7LDDFR|UxRTBwOTFOwG0> M3W4e|E2PjN2MECz
Daudi cells NF7pUIxHfW6ldHnvckBie3OjeR?= NX\oN4VPUW6qaXLpeIlwdiCxZjDFRnYhemWybHnjZZRqd25iaX6gSIF2\GliY3XscJMh[nlidnnyZYwh[2Gyc3nkJIFvfGmpZX6tSWxKW0FuIFXDOVA:OC5|MzFOwG0> MonyNVcxODR5Mk[=
african green monkey Vero cells MVfGeY5kfGmxbjDhd5NigQ>? MlrxOFghcA>? MkXYRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXOiC|dILhbY4hOzN|IHnu[oVkfGWmIHnuJIFnemmlYX6g[5Jm\W5ibX;ub4V6KF[ncn:gZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCleYTvdIF1cGmlIHXm[oVkfCCjZoTldkA1QCCqcoOgZpkheGyjcYXlJJJm\HWldHnvckBie3OjeTygSWM2OD1zLki3JO69VQ>? MU[yNlcxPDh7MB?=
WI-38 cell NIS3WYdHfW6ldHnvckBie3OjeR?= M4LWZmFvfGlidnnyZYwh[WO2aY\peJkh[WejaX7zeEBXYlZqcIDscIEhe3S{YXnuLUBqdiCZST2zPEBk\WyuIH3vco9t[XmncoOsJGlFPTB;NDFOwG0> MmfUNVMyPjl4Nh?=
HEL cells M4HnfmZ2dmO2aX;uJIF{e2G7 M3TodVQh\GG7cx?= NGnJdnFCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZzIFvPV{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5JIFnfGW{IESg[IF6eyxiRVO1NF0xNjJizszN NUPKcY55OjJ2NUm4O|Y>
HEL cells NFPqXHRHfW6ldHnvckBie3OjeR?= NYHFWpVkSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYMTDLU3MhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEwhTUN3ME2wMlE1KM7:TR?= M3u2OVI{ODl7MEm3
African green monkey Vero 76 cells NGPNb4xEgXSxdH;4bYNqfHliYYPzZZk> MkPnOFguQTZiaB?= M13LW2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KEGocnnjZY4h\3KnZX6gcY9vc2W7IG\ldo8hPzZiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgOFghfG9iOU[gbJJ{KGK7IHPyfZN1[WxidnnvcIV1KHO2YXnubY5oNCCFQ{WwQVE{KM7:TR?= NYTn[IpDOjZzMUm5PVI>

... Click to View More Cell Line Experimental Data

In vivo low-dose oral acyclovir may be effective in the prevention of HSV infection during OKT3 treatment of seropositive patients. Continuation of acyclovir prophylaxis for two to four weeks following the conclusion of OKT3 therapy may prevent occurrence of delayed infections[3].

Protocol

Solubility (25°C)

In vitro DMSO 45 mg/mL (199.82 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 225.2
Formula

C8H11N5O3

CAS No. 59277-89-3
Storage powder
in solvent
Synonyms Acyclovir

Bio Calculators

Molarity Calculator

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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The Serial Dilution Calculator Equation

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03004183 Not yet recruiting Metastatic Non-small Cell Lung Cancer|Metastatic Triple-negative Breast Cancer Jenny C. Chang, MD|Merck Sharp & Dohme Corp.|The Methodist Hospital System January 2017 Phase 2
NCT02977533 Recruiting Progressive Multiple Sclerosis Sanofi December 2016 Phase 1
NCT02997982 Recruiting Alzheimer Disease|Mild Cognitive Impairment|Herpes Simplex Hugo Lovheim|Umeå University December 2016 Phase 2
NCT02738229 Recruiting Herpetic Gingivostomatitis St. Justines Hospital|Canadian Association of Emergency Physicians July 2016 Phase 2
NCT02768363 Recruiting Prostate Cancer Advantagene, Inc. May 2016 Phase 2|Phase 3
NCT02629809 Recruiting Leukemia|Chronic Lymphocytic Leukemia M.D. Anderson Cancer Center|Genentech, Inc.|Pharmacyclics LLC. March 2016 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID