Aciclovir

Catalog No.S1807 Synonyms: Acyclovir

Aciclovir Chemical Structure

Molecular Weight(MW): 225.2

Aciclovir is a synthetic nucleoside analogue active against herpesviruses.

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In DMSO USD 130 In stock
USD 97 In stock
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Biological Activity

Description Aciclovir is a synthetic nucleoside analogue active against herpesviruses.
Targets
HSV [1]
In vitro

Acyclovir sensitivity of herpes simplex virus isolates is determined in a plaque-reduction assay in Vero cells. IC50 Values are consistently 2-3 fold lower in B2 compared with the H strain of Vero cells. HSV Type 2 strains are 2-10-fold less sensitive than Type 1 strains[2].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
BSC-1 cells NVTFPGVITnWwY4Tpc44h[XO|YYm= NYD5TYVoSW62aY\pdoFtKGGldHn2bZR6KG:oIITo[UBkd22yb4Xu[EB4[XNiZY\hcJVifGWmIHHnZYlve3RidHjlJGhmenCnczDzbY1xdGW6II\pdpV{KHS7cHWtNUBqdiCEU1OtNUBk\WyuczygTWM2OD1{Lk[g{txO M1G4[lI6OTN|MEC=
P3HR-1 cells NUKzTGJyTnWwY4Tpc44h[XO|YYm= NGH0TXJG\m[nY4TpeoUh[2:wY3XueJJifGmxbjDmc5IhfGinIHnubIljcXSrb36gc4YhTXC|dHXpck1D[XK{II\pdpV{KEWEVj3EUmEhe3mwdHjld4l{KGmwIHj1cYFvKGy7bYDoc4Jt[XO2b3nkJHA{UFJvMTDj[YxteyxiRVO1NF03Njd3IN88US=> NEfETlkyOjRyOEeyOi=>
HFF cells MXfGeY5kfGmxbjDhd5NigQ>? MVjDc45k\W62cnH0bY9vKG[xcjDIV3YuOSCybHHxeYUhemWmdXP0bY9vKCiYUGKpJIJ6KDVyJTDpckBJTkZiY3XscJMtKEWFNUC9NU4yKM7:TR?= NV\ONmhIOTR3OES5OVQ>
HFF cells MYTGeY5kfGmxbjDhd5NigQ>? M4XxW2lvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDy[ZF2cXKnZDD0c{Bz\WS3Y3WgTHNXNTFiaX7keYNm\CCleYTvdIF1cG:pZX7pZ{Bm\m[nY4SgLGNRTSliYomgOVAhLSCrbjDISmYh[2WubIOsJGVEPTB;Mj6yNkDPxE1? NWr2bXhYOTR3OES5OVQ>
human embryonic lung cells MUnGeY5kfGmxbjDhd5NigQ>? NIDJ[|lCdnSrdnnyZYwh[WO2aY\peJkhf2G|IH3lZZN2emWmIHHzJIVn\mWldHn2[UBkd26lZX70doF1cW:wIILldZVqemWmIITvJJJm\HWlZTDWZZJq[2WubHGgXo9{fGW{II\pdpV{KCiRS1GpMYlv\HWlZXSgdIxieXWnIH\vdo1ifGmxbjDpckBpfW2jbjDlcYJzgW:waXOgcJVv\yClZXzsd{whTUN3ME2xMlEh|ryP M2nMb|EyPTR7NEW3
HEL cells MYXGeY5kfGmxbjDhd5NigQ>? M{K1R2NwdXCxdX7kJJdieyC2ZYP0[YQh\m:{IHHueIkufmm{YXygZYN1cX[rdImgZYdicW6|dDDIV3YuOSiJKTDpckBJTUxiY3XscJMtKEWFNUC9NU4{KM7:TR?= MXmxOFY1OzN{OB?=
HEL cell NXSyc4ZFTnWwY4Tpc44h[XO|YYm= NFrnXIpG\m[nY4TpeoUh[2:wY3XueJJifGmxbjDy[ZF2cXKnZDD0c{BqdmirYnn0JHR6em:|aX7lJItqdmG|ZTCoWGssMSCYYYLpZ4VtdGFvWn;zeIVzKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ4l1gSCkeTC1NEUhcW5iT1vBJJN1emGrbjDISWwh[2WubDDsbY5meyxiRVO1NF01NjV|IN88US=> MmHzNVE1QTV3OE[=
HSV-2 MS Vero cells M3juPGZ2dmO2aX;uJIF{e2G7 M1W2SmlvcGmkaYTpc44hd2ZidnnyZYwh[3m2b4DheIhq[yCnZn\lZ5QhcW5iaX7m[YN1\WRiaIXtZY4h\m:{ZYPrbY4h\mmkcn;icIF{fCClZXzsJI1wdm:uYYnldpMhd2ZiSGPWMVIhVVNiVnXyc{Bk\WyuczDifUA2OCVuIFXDOVA:Pi5{IN88US=> NX;J[ZVHOTF3OEW0OVc>
HSV-1 E-377 Vero cells MVfGeY5kfGmxbjDhd5NigQ>? MYDJcohq[mm2aX;uJI9nKHCuYYH1[UBnd3KvYYTpc44hcW5ibX;uc4xigWW{czDv[kBJW1ZvMTDFMVM4PyCYZYLvJINmdGy|IHL5JFUxLSxiRVO1NF01NjRizszN NGTYemQyOTV6NUS1Oy=>
HSV-1 KOS Vero cells NXvzWnhRTnWwY4Tpc44h[XO|YYm= M3XEWWlvcGmkaYTpc44hd2ZicHzhdZVmKG[xcn3heIlwdiCrbjDtc45wdGG7ZYLzJI9nKEiVVj2xJGtQWyCYZYLvJINmdGy|IHL5JFUxLSxiRVO1NF0zNjJizszN Mm\UNVE2QDV2NUe=
HeLa cell NVzCRZpuTnWwY4Tpc44h[XO|YYm= MV\BZoltcXS7IITvJIlvcGmkaYSgZ5l1d3CjdHjv[4VvcWOrdImgc4YhcGW{cHXzJJNqdXCuZYigeJlx\SBzII\pdpV{KCiJKTDpckBJ\UyjIHPlcIwh[3WudIXy[UwhUUN3ME2wMlE6KM7:TR?= MWmxNVM2PjFzMB?=
HEp-2 cells NVzkRXF2TnWwY4Tpc44h[XO|YYm= MXvNbY5qdXWvIHnubIljcXSxcomgZ49v[2WwdILheIlwdiClYYXzbY5oKDJ3JTDpcohq[mm2aX;uJI9nKGO7dH;wZZRpcWNiZX\m[YN1KGmwZIXj[YQh[nliSHXydIV{KHOrbYDs[Zghfmm{dYOtNUApUzl5OTmgbY4hUEWyLUKgZ4VtdHN? NUTNSGZLOjh2MkWwOi=>
HeLa cells NV73XGdLTnWwY4Tpc44h[XO|YYm= Mm\5TY5pcWKrdHnvckBw\iCKU2[tNUBFVkFic4nueIhme2m|IHnuJJZqenW|LXnu[oVkfGWmIFjlUIEh[2WubIOsJGlEPTB;MT65JO69VQ>? MXq3O|UzOjB4
human HFF cells M4jTc2Z2dmO2aX;uJIF{e2G7 MWrJcohq[mm2b4L5JINwdmOnboTyZZRqd25ib3[geIhmKGS{dXegZYdicW6|dDD0bIUh[3m2b4DheIhq[yCnZn\lZ5Qh\m:{IFWtN|c4KHO2cnHpckBw\iCqZYLw[ZMhe2mvcHzlfEB3cXK3cz2xJEhJW1ZvMTmgbY4hcHWvYX6gTGZHKGOnbHzzMEBGSzVyPUCuNFQh|ryP NFv0[oU5Ozl2OUOz
human HFF cells NULJbG9MTnWwY4Tpc44h[XO|YYm= M2q5PWlvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDv[kB1cGViZIL1[{Bi\2GrboP0JJRp\SCleYTvdIF1cGmlIHXm[oVkfCCob4KgUXMhe3S{YXnuJI9nKGincoDld{B{cW2ybHX4JJZqenW|LUKgLGhUXi1{KTDpckBpfW2jbjDISmYh[2WubIOsJGVEPTB;MD6wPUDPxE1? NFLOZnE5Ozl2OUOz
MRC-5 cells MmWwSpVv[3Srb36gZZN{[Xl? NWr1XlF[SW62aY\pdoFtKGGldHn2bZR6KGmwIIDsZZF2\SC{ZXT1Z5Rqd25iYYPzZZkhf2G|IHTleIVzdWmwZXSgZYdicW6|dDDo[ZJx\XNic3ntdIxmgCC4aYL1d{B1gXCnIEKgLGhUXi1{KTDpckBOWkNvNTDj[YxteyxiSVO1NF0zNjVizszN Mo\ONlE2OzJyMh?=
human lung fibroblasts (MRC-5) MmH2SpVv[3Srb36gZZN{[Xl? MWjDc41xd3WwZDD3ZZMhfGW|dHXkJIZweiCjboTpeolz[WxiYXP0bZZqfHliYXfhbY5{fCCKZYLw[ZMhW2mvcHzlfEB3cXK3czDUfZBmNTFqMUixPFkqKGmwIHj1cYFvKGy3bneg[oljem:kbHHzeJMhME2UQz21LS=> NF6yb5A{ODRyOUm4
Raji cells MV7GeY5kfGmxbjDhd5NigQ>? NIf3b|BKdmirYnn0c5J6KGOxbnPlcpRz[XSrb36gc4YhfGinIHTyeYch[WejaX7zeEB1cGViYX70bYdmdiCycn;keYN1cW:wIHHnZYlve3RiUEPIVk0yKHO2cnHpckBw\iCncIP0[YlvKGKjcoKgeolzfXNvMjCoSWJXMSCrbjDSZYpqKGOnbHzzMEBGSzVyPUKuPUDPxE1? M{LvcVg{QTR7M{O=
Vero cells MlH6SpVv[3Srb36gZZN{[Xl? M4m1O2lvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBp\XKyZYOgd4lueGyneDD2bZJ2eyC2eYDlJFIhMEiVVjCyLUB{fHKjaX6gNVg3KGmwIG\ldo8h[2WubIOsJGlEPTB;MT63JO69VQ>? MVS4OVc3QTJ{
BSC-1 cells M3f6TmZ2dmO2aX;uJIF{e2G7 M3TWO2Vn\mWldHn2[UBkd26lZX70doF1cW:wIILldZVqemWmIITvJIlvcGmkaYSgbIVzeGW|IIPpcZBt\XhidnnyeZMhOSCrbjDCV2MuOSClZXzsd{BqdiCHTFnTRUwhTUN3ME2xMlUh|ryP MUGxOVY{PDByMx?=
HFF cells MlPzSpVv[3Srb36gZZN{[Xl? NYPC[Wl{TW[oZXP0bZZmKGOxbnPlcpRz[XSrb36gdoVyfWm{ZXSgeI8hcW6qaXLpeEB3[XKrY3XscIEhgm:|dHXyJJZqenW|IILldIxq[2G2aX;uJIlvKEiIRjDj[YxteyxiRVO1NF0yNjZizszN NEjS[mYyPTZ|NECwNy=>
HFF cells NIXH[YZHfW6ldHnvckBie3OjeR?= NYLSbodSTW[oZXP0bZZmKGOxbnPlcpRz[XSrb36gdoVyfWm{ZXSgeI8hcW6qaXLpeEBp\XKyZYOgd4lueGyneDD2bZJ2eyBzIHnuJGhHTiClZXzsd{BqdiCleYTvdIF1cGmlIHXm[oVkfCBqQ2DFLUBie3OjeTygSWM2OD1yLkmg{txO NUHzTGZmOTV4M{SwNFM>
Daudi cells NWj0e2FTTnWwY4Tpc44h[XO|YYm= NGHIXWFKdmirYnn0bY9vKG:oIFXCWkBz\XCuaXPheIlwdiCrbjDEZZVlcSClZXzsd{BjgSC4aYLhcEBk[XC|aXSgZY51cWenbj3FUGlUSSxiRVO1NF0xNjN|IN88US=> MlX3NVcxODR5Mk[=
african green monkey Vero cells MYHGeY5kfGmxbjDhd5NigQ>? NXHPXI9MPDhiaB?= NV\GRY5ISW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYMjDzeJJicW5iM{OzJIlv\mWldHXkJIlvKGGocnnjZY4h\3KnZX6gcY9vc2W7IG\ldo8h[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDjfZRweGG2aHnjJIVn\mWldDDh[pRmeiB2ODDodpMh[nlicHzhdZVmKHKnZIXjeIlwdiCjc4PhfUwhTUN3ME2xMlg4KM7:TR?= NWLEUHlIOjJ5MES4PVA>
WI-38 cell NUGxVnI{TnWwY4Tpc44h[XO|YYm= M4TzTGFvfGlidnnyZYwh[WO2aY\peJkh[WejaX7zeEBXYlZqcIDscIEhe3S{YXnuLUBqdiCZST2zPEBk\WyuIH3vco9t[XmncoOsJGlFPTB;NDFOwG0> M3zrRlE{OTZ7Nk[=
HEL cells MkHySpVv[3Srb36gZZN{[Xl? MnPYOEBl[Xm| M3[0VGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXjFiS1;TJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImgZYZ1\XJiNDDkZZl{NCCHQ{WwQVAvOiEQvF2= MYmyNlQ2QTh5Nh?=
HEL cells MnyxSpVv[3Srb36gZZN{[Xl? NHvKbpdCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZzIFvPV{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0MEBGSzVyPUCuNVQh|ryP NFG1OFUzOzB7OUC5Oy=>
African green monkey Vero 76 cells MXjDfZRwfG:6aXPpeJkh[XO|YYm= MWm0PE06PiCq MoP1R5l1d3SxeHnjbZR6KGGpYXnud5QhSW[{aXPhckBoemWnbjDtc45s\XliVnXyc{A4PiClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEB1dyB7NjDodpMh[nliY4L5d5RidCC4aX;s[ZQhe3SjaX7pcoctKEOFNUC9NVMh|ryP MnOyNlYyOTl7OUK=

... Click to View More Cell Line Experimental Data

In vivo low-dose oral acyclovir may be effective in the prevention of HSV infection during OKT3 treatment of seropositive patients. Continuation of acyclovir prophylaxis for two to four weeks following the conclusion of OKT3 therapy may prevent occurrence of delayed infections[3].

Protocol

Solubility (25°C)

In vitro DMSO 45 mg/mL (199.82 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 225.2
Formula

C8H11N5O3

CAS No. 59277-89-3
Storage powder
Synonyms Acyclovir

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
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Molecular Weight Calculator

Molecular Weight Calculator

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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03004183 Not yet recruiting Metastatic Non-small Cell Lung Cancer|Metastatic Triple-negative Breast Cancer Jenny C. Chang, MD|Merck Sharp & Dohme Corp.|The Methodist Hospital System January 2017 Phase 2
NCT02977533 Recruiting Progressive Multiple Sclerosis Sanofi December 2016 Phase 1
NCT02997982 Recruiting Alzheimer Disease|Mild Cognitive Impairment|Herpes Simplex Hugo Lovheim|Umeå University December 2016 Phase 2
NCT02738229 Recruiting Herpetic Gingivostomatitis St. Justines Hospital|Canadian Association of Emergency Physicians July 2016 Phase 2
NCT02768363 Recruiting Prostate Cancer Advantagene, Inc. May 2016 Phase 2|Phase 3
NCT02629809 Recruiting Leukemia|Chronic Lymphocytic Leukemia M.D. Anderson Cancer Center|Genentech, Inc.|Pharmacyclics LLC. March 2016 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID