Aciclovir

Catalog No.S1807 Synonyms: Acyclovir

Aciclovir Chemical Structure

Molecular Weight(MW): 225.2

Aciclovir is a synthetic nucleoside analogue active against herpesviruses.

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In DMSO USD 130 In stock
USD 97 In stock
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1 Customer Review

  • (A) HONE1 and (B) HK1-EBV cells were treated with TPA (40 ng/ml) and SB (3 mM) for EBV induction. After 3 h, uninduced and induced HONE1 and HK1-EBV cells were treated with the vehicle control (0.006% DMSO) or indicated concentrations of berberine for 48 h. Subsequently, the culture medium was harvested for quantitative-PCR analysis with EBNA1 primers. Each sample was normalized to the amount of the GAPDH gene; *p<0.05, compared with the control group.

    Oncol Rep, 2017, 37(4):2109-2120. Aciclovir purchased from Selleck.

Purity & Quality Control

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Biological Activity

Description Aciclovir is a synthetic nucleoside analogue active against herpesviruses.
Targets
HSV [1]
In vitro

Acyclovir sensitivity of herpes simplex virus isolates is determined in a plaque-reduction assay in Vero cells. IC50 Values are consistently 2-3 fold lower in B2 compared with the H strain of Vero cells. HSV Type 2 strains are 2-10-fold less sensitive than Type 1 strains[2].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
BSC-1 cells NHjUdJVHfW6ldHnvckBie3OjeR?= M{TFW2FvfGm4aYLhcEBi[3Srdnn0fUBw\iC2aHWgZ49ueG:3bnSge4F{KGW4YXz1ZZRm\CCjZ3HpcpN1KHSqZTDI[ZJx\XNic3ntdIxmgCC4aYL1d{B1gXCnLUGgbY4hSlOFLUGgZ4VtdHNuIFnDOVA:Oi54IN88US=> M33HfFI6OTN|MEC=
P3HR-1 cells M1zOUWZ2dmO2aX;uJIF{e2G7 MUDF[oZm[3SrdnWgZ49v[2WwdILheIlwdiCob4KgeIhmKGmwaHnibZRqd25ib3[gSZB{fGWrbj3CZZJzKH[rcoXzJGVDXi2GTlGgd5lvfGinc3nzJIlvKGi3bXHuJIx6dXCqb3LsZZN1d2mmIGCzTHIuOSClZXzsd{whTUN3ME22Mlc2KM7:TR?= NFjHe|EyOjRyOEeyOi=>
HFF cells NXO3b3Q2TnWwY4Tpc44h[XO|YYm= M3;sS2NwdmOnboTyZZRqd25iZn;yJGhUXi1zIIDsZZF2\SC{ZXT1Z5Rqd25iKG\QVkkh[nliNUClJIlvKEiIRjDj[YxteyxiRVO1NF0yNjFizszN NVLCdVNoOTR3OES5OVQ>
HFF cells MlHVSpVv[3Srb36gZZN{[Xl? MmrWTY5pcWKrdH;yfUBkd26lZX70doF1cW:wIILldZVqemWmIITvJJJm\HWlZTDIV3YuOSCrbnT1Z4VlKGO7dH;wZZRpd2enbnnjJIVn\mWldDCoR3BGMSCkeTC1NEAmKGmwIFjGSkBk\WyuczygSWM2OD1{LkKyJO69VQ>? NXT0cIpiOTR3OES5OVQ>
human embryonic lung cells MYjGeY5kfGmxbjDhd5NigQ>? NIjHUm9CdnSrdnnyZYwh[WO2aY\peJkhf2G|IH3lZZN2emWmIHHzJIVn\mWldHn2[UBkd26lZX70doF1cW:wIILldZVqemWmIITvJJJm\HWlZTDWZZJq[2WubHGgXo9{fGW{II\pdpV{KCiRS1GpMYlv\HWlZXSgdIxieXWnIH\vdo1ifGmxbjDpckBpfW2jbjDlcYJzgW:waXOgcJVv\yClZXzsd{whTUN3ME2xMlEh|ryP NHXCRZgyOTV2OUS1Oy=>
HEL cells MUDGeY5kfGmxbjDhd5NigQ>? Mn7DR49ueG:3bnSge4F{KHSnc4Tl[EBnd3JiYX70bU13cXKjbDDhZ5Rqfmm2eTDh[4FqdnO2IFjTWk0yMEdrIHnuJGhGVCClZXzsd{whTUN3ME2xMlMh|ryP MX:xOFY1OzN{OB?=
HEL cell NXv3NYV7TnWwY4Tpc44h[XO|YYm= M1PxPWVn\mWldHn2[UBkd26lZX70doF1cW:wIILldZVqemWmIITvJIlvcGmkaYSgWJlzd3OrbnWgb4lv[XOnIDjUT{sqKF[jcnnj[Yxt[S2cb4P0[ZIhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjbZR6KGK7IEWwKUBqdiCRS1Ggd5Rz[WmwIFjFUEBk\WyuIHzpcoV{NCCHQ{WwQVQvPTNizszN MkTLNVE1QTV3OE[=
HSV-2 MS Vero cells M2nUZ2Z2dmO2aX;uJIF{e2G7 NVjCeIhIUW6qaXLpeIlwdiCxZjD2bZJidCCleYTvdIF1cGmlIHXm[oVkfCCrbjDpcoZm[3SnZDDoeY1idiCob4Lld4tqdiCoaXLyc4Jt[XO2IHPlcIwhdW:wb3zhfYVzeyCxZjDIV3YuOiCPUzDW[ZJwKGOnbHzzJIJ6KDVyJTygSWM2OD14LkKg{txO M1jxTVEyPTh3NEW3
HSV-1 E-377 Vero cells NEfV[VhHfW6ldHnvckBie3OjeR?= MmS3TY5pcWKrdHnvckBw\iCybHHxeYUh\m:{bXH0bY9vKGmwIH3vco9t[XmncoOgc4YhUFOYLUGgSU0{PzdiVnXyc{Bk\WyuczDifUA2OCVuIFXDOVA:PC52IN88US=> NH;qW5EyOTV6NUS1Oy=>
HSV-1 KOS Vero cells NX3kbHZTTnWwY4Tpc44h[XO|YYm= NIfhXVlKdmirYnn0bY9vKG:oIIDsZZF2\SCob4LtZZRqd25iaX6gcY9vd2yjeXXyd{Bw\iCKU2[tNUBMV1NiVnXyc{Bk\WyuczDifUA2OCVuIFXDOVA:Oi5{IN88US=> NHTOXFQyOTV6NUS1Oy=>
HeLa cell MYnGeY5kfGmxbjDhd5NigQ>? M3TGZmFjcWyrdImgeI8hcW6qaXLpeEBkgXSxcHH0bI9o\W6rY3n0fUBw\iCqZYLw[ZMhe2mvcHzlfEB1gXCnIEGgeolzfXNiKFepJIlvKEinTHGgZ4VtdCCldXz0eZJmNCCLQ{WwQVAvOTlizszN MlvUNVE{PTZzMUC=
HEp-2 cells Mm\FSpVv[3Srb36gZZN{[Xl? M3SwTm1qdmmvdX2gbY5pcWKrdH;yfUBkd26lZX70doF1cW:wIHPheZNqdmdiMkWlJIlvcGmkaYTpc44hd2ZiY4n0c5BifGirYzDl[oZm[3RiaX7keYNm\CCkeTDI[ZJx\XNic3ntdIxmgCC4aYL1d{0yKCiNOUe5LUBqdiCKRYCtNkBk\Wyucx?= MUKyPFQzPTB4
HeLa cells MWHGeY5kfGmxbjDhd5NigQ>? MlzyTY5pcWKrdHnvckBw\iCKU2[tNUBFVkFic4nueIhme2m|IHnuJJZqenW|LXnu[oVkfGWmIFjlUIEh[2WubIOsJGlEPTB;MT65JO69VQ>? NELCZ2o4PzV{MkC2
human HFF cells M3;TdmZ2dmO2aX;uJIF{e2G7 NEjPbodKdmirYnn0c5J6KGOxbnPlcpRz[XSrb36gc4YhfGinIHTyeYch[WejaX7zeEB1cGViY4n0c5BifGirYzDl[oZm[3RiZn;yJGUuOzd5IIP0doFqdiCxZjDo[ZJx\XNic3ntdIxmgCC4aYL1d{0yKCiKU2[tNUkhcW5iaIXtZY4hUE[IIHPlcIx{NCCHQ{WwQVAvODRizszN M{Hy[Vg{QTR7M{O=
human HFF cells MXLGeY5kfGmxbjDhd5NigQ>? M{DzR2lvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDv[kB1cGViZIL1[{Bi\2GrboP0JJRp\SCleYTvdIF1cGmlIHXm[oVkfCCob4KgUXMhe3S{YXnuJI9nKGincoDld{B{cW2ybHX4JJZqenW|LUKgLGhUXi1{KTDpckBpfW2jbjDISmYh[2WubIOsJGVEPTB;MD6wPUDPxE1? NEP0NXY5Ozl2OUOz
MRC-5 cells M3:3eWZ2dmO2aX;uJIF{e2G7 MVPBcpRqfmm{YXygZYN1cX[rdImgbY4heGyjcYXlJJJm\HWldHnvckBie3OjeTD3ZZMh\GW2ZYLtbY5m\CCjZ3HpcpN1KGincoDld{B{cW2ybHX4JJZqenW|IIT5dIUhOiBqSGPWMVIqKGmwIF3SR{02KGOnbHzzMEBKSzVyPUKuOUDPxE1? NIH5WoozOTV|MkCy
human lung fibroblasts (MRC-5) M33UWWZ2dmO2aX;uJIF{e2G7 Mn7PR49ueG:3bnSge4F{KHSnc4Tl[EBnd3JiYX70bZZqemGuIHHjeIl3cXS7IHHnZYlve3RiSHXydIV{KFOrbYDs[Zghfmm{dYOgWJlx\S1zKEG4NVg6MSCrbjDoeY1idiCudX7nJIZq[nKxYnzhd5R{KCiPUlOtOUk> NVLyZYR{OzB2MEm5PC=>
Raji cells MXHGeY5kfGmxbjDhd5NigQ>? NIqxZmxKdmirYnn0c5J6KGOxbnPlcpRz[XSrb36gc4YhfGinIHTyeYch[WejaX7zeEB1cGViYX70bYdmdiCycn;keYN1cW:wIHHnZYlve3RiUEPIVk0yKHO2cnHpckBw\iCncIP0[YlvKGKjcoKgeolzfXNvMjCoSWJXMSCrbjDSZYpqKGOnbHzzMEBGSzVyPUKuPUDPxE1? NHfpOWY5Ozl2OUOz
Vero cells MVzGeY5kfGmxbjDhd5NigQ>? M{jIOGlvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBp\XKyZYOgd4lueGyneDD2bZJ2eyC2eYDlJFIhMEiVVjCyLUB{fHKjaX6gNVg3KGmwIG\ldo8h[2WubIOsJGlEPTB;MT63JO69VQ>? MonrPFU4Pjl{Mh?=
BSC-1 cells M1LO[WZ2dmO2aX;uJIF{e2G7 MUfF[oZm[3SrdnWgZ49v[2WwdILheIlwdiC{ZYH1bZJm\CC2bzDpcohq[mm2IHjldpBmeyC|aX3wcIV5KH[rcoXzJFEhcW5iQmPDMVEh[2WubIOgbY4hTUyLU1GsJGVEPTB;MT61JO69VQ>? MkLZNVU3OzRyMEO=
HFF cells NYXXZ2w6TnWwY4Tpc44h[XO|YYm= NEnVclNG\m[nY4TpeoUh[2:wY3XueJJifGmxbjDy[ZF2cXKnZDD0c{BqdmirYnn0JJZiemmlZXzsZUB7d3O2ZYKgeolzfXNicnXwcIlk[XSrb36gbY4hUE[IIHPlcIx{NCCHQ{WwQVEvPiEQvF2= M{HWb|E2PjN2MECz
HFF cells NGLGcWFHfW6ldHnvckBie3OjeR?= M{XRSmVn\mWldHn2[UBkd26lZX70doF1cW:wIILldZVqemWmIITvJIlvcGmkaYSgbIVzeGW|IIPpcZBt\XhidnnyeZMhOSCrbjDISmYh[2WubIOgbY4h[3m2b4DheIhq[yCnZn\lZ5QhMEOSRTmgZZN{[XluIFXDOVA:OC57IN88US=> NVnFUHR[OTV4M{SwNFM>
Daudi cells NWnvOGxqTnWwY4Tpc44h[XO|YYm= MXLJcohq[mm2aX;uJI9nKEWEVjDy[ZBtcWOjdHnvckBqdiCGYYXkbUBk\WyuczDifUB3cXKjbDDjZZB{cWRiYX70bYdmdi2HTFnTRUwhTUN3ME2wMlM{KM7:TR?= MnvKNVcxODR5Mk[=
african green monkey Vero cells M1zGcmZ2dmO2aX;uJIF{e2G7 NUjVcFR4PDhiaB?= NVPUZpFRSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFOYMjDzeJJicW5iM{OzJIlv\mWldHXkJIlvKGGocnnjZY4h\3KnZX6gcY9vc2W7IG\ldo8h[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDjfZRweGG2aHnjJIVn\mWldDDh[pRmeiB2ODDodpMh[nlicHzhdZVmKHKnZIXjeIlwdiCjc4PhfUwhTUN3ME2xMlg4KM7:TR?= M3zSOFIzPzB2OEmw
WI-38 cell NX7qclVjTnWwY4Tpc44h[XO|YYm= M4PFS2FvfGlidnnyZYwh[WO2aY\peJkh[WejaX7zeEBXYlZqcIDscIEhe3S{YXnuLUBqdiCZST2zPEBk\WyuIH3vco9t[XmncoOsJGlFPTB;NDFOwG0> MYOxN|E3QTZ4
HEL cells MYrGeY5kfGmxbjDhd5NigQ>? MkixOEBl[Xm| NFzxcnBCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJW1ZzIFvPV{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5JIFnfGW{IESg[IF6eyxiRVO1NF0xNjJizszN MmrONlI1PTl6N{[=
HEL cells M{npe2Z2dmO2aX;uJIF{e2G7 M2HDOGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXjFiS1;TJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SsJGVEPTB;MD6xOEDPxE1? NUWwSoZ7OjNyOUmwPVc>
African green monkey Vero 76 cells NFLaXJlEgXSxdH;4bYNqfHliYYPzZZk> MV60PE06PiCq NFLienJEgXSxdH;4bYNqfHliYXfhbY5{fCCDZoLpZ4FvKGe{ZXXuJI1wdmuneTDW[ZJwKDd4IHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwhfmmjYnnsbZR6KGGodHXyJFQ5KHSxIEm2JIhzeyCkeTDjdpl{fGGuII\pc4xmfCC|dHHpcolv\yxiQ1O1NF0yOyEQvF2= M2H5flI3OTF7OUmy

... Click to View More Cell Line Experimental Data

In vivo low-dose oral acyclovir may be effective in the prevention of HSV infection during OKT3 treatment of seropositive patients. Continuation of acyclovir prophylaxis for two to four weeks following the conclusion of OKT3 therapy may prevent occurrence of delayed infections[3].

Protocol

Solubility (25°C)

In vitro DMSO 45 mg/mL (199.82 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 225.2
Formula

C8H11N5O3

CAS No. 59277-89-3
Storage powder
Synonyms Acyclovir

Bio Calculators

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03004183 Not yet recruiting Metastatic Non-small Cell Lung Cancer|Metastatic Triple-negative Breast Cancer Jenny C. Chang, MD|Merck Sharp & Dohme Corp.|The Methodist Hospital System January 2017 Phase 2
NCT02977533 Recruiting Progressive Multiple Sclerosis Sanofi December 2016 Phase 1
NCT02997982 Recruiting Alzheimer Disease|Mild Cognitive Impairment|Herpes Simplex Hugo Lovheim|Umeå University December 2016 Phase 2
NCT02738229 Recruiting Herpetic Gingivostomatitis St. Justines Hospital|Canadian Association of Emergency Physicians July 2016 Phase 2
NCT02768363 Recruiting Prostate Cancer Advantagene, Inc. May 2016 Phase 2|Phase 3
NCT02629809 Recruiting Leukemia|Chronic Lymphocytic Leukemia M.D. Anderson Cancer Center|Genentech, Inc.|Pharmacyclics LLC. March 2016 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID