Catalog No.S1807 Synonyms: Acyclovir
Molecular Weight(MW): 225.2
Aciclovir is a synthetic nucleoside analogue active against herpesviruses.
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(A) HONE1 and (B) HK1-EBV cells were treated with TPA (40 ng/ml) and SB (3 mM) for EBV induction. After 3 h, uninduced and induced HONE1 and HK1-EBV cells were treated with the vehicle control (0.006% DMSO) or indicated concentrations of berberine for 48 h. Subsequently, the culture medium was harvested for quantitative-PCR analysis with EBNA1 primers. Each sample was normalized to the amount of the GAPDH gene; *p<0.05, compared with the control group.
Oncol Rep, 2017, 37(4):2109-2120. Aciclovir purchased from Selleck.
Purity & Quality Control
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|Description||Aciclovir is a synthetic nucleoside analogue active against herpesviruses.|
Acyclovir sensitivity of herpes simplex virus isolates is determined in a plaque-reduction assay in Vero cells. IC50 Values are consistently 2-3 fold lower in B2 compared with the H strain of Vero cells. HSV Type 2 strains are 2-10-fold less sensitive than Type 1 strains.
|In vivo||low-dose oral acyclovir may be effective in the prevention of HSV infection during OKT3 treatment of seropositive patients. Continuation of acyclovir prophylaxis for two to four weeks following the conclusion of OKT3 therapy may prevent occurrence of delayed infections.|
|In vitro||DMSO||45 mg/mL (199.82 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2
Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03004183||Not yet recruiting||Metastatic Non-small Cell Lung Cancer|Metastatic Triple-negative Breast Cancer||Jenny C. Chang, MD|Merck Sharp & Dohme Corp.|The Methodist Hospital System||January 2017||Phase 2|
|NCT02977533||Recruiting||Progressive Multiple Sclerosis||Sanofi||December 2016||Phase 1|
|NCT02997982||Recruiting||Alzheimer Disease|Mild Cognitive Impairment|Herpes Simplex||Hugo Lovheim|Umeå University||December 2016||Phase 2|
|NCT02738229||Recruiting||Herpetic Gingivostomatitis||St. Justines Hospital|Canadian Association of Emergency Physicians||July 2016||Phase 2|
|NCT02768363||Recruiting||Prostate Cancer||Advantagene, Inc.||May 2016||Phase 2|Phase 3|
|NCT02629809||Recruiting||Leukemia|Chronic Lymphocytic Leukemia||M.D. Anderson Cancer Center|Genentech, Inc.|Pharmacyclics LLC.||March 2016||Phase 2|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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