Research Area
Product Type
United States ( Change Country )
Triciribine Chemical Structure
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Biological Activity
Triciribine is a synthetic tricyclic nucleoside which acts as a specific inhibitor of the Akt signaling pathway. It selectively inhibits the phosphorylation and activation of Akt1, -2 and -3 but does not inhibit Akt kinase activity nor known upstream Akt activators such as PI 3-Kinase and PDK1. It inhibits cell growth and induces apoptosis preferentially in cells that express aberrant Akt. This agent is shown≥ 80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p. [1,2]
References on Triciribine
- [1] J Med Chem 2000 Jun 15;43(12):2438-48
- [2] Nucleosides Nucleotides Nucleic Acids 2004;23(1-2):31-9
Chemical Information
| Molecular Weight (WM): | 320.3 |
|---|---|
| Formula: | C13H16N6O4 |
| CAS No.: | 35943-35-2 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
Research Area
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