Catalog No.S1302 Synonyms: NSC109724, Isophosphamide
Molecular Weight(MW): 261.09
Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer.
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Chemotherapeutic response. Ifosfamide was applied at different concentrations on Lipo-DUE1, Lipo246, and PLS-1 for 72 h. Subsequently, cell viability was determined by MTS assay at a wavelength of 490 nm. Values represent the mean±S.D. of triplicates
Tumour Biol, 2016, 37(2):2341-51. Ifosfamide purchased from Selleck.
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|Description||Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer.|
Ifosfamide (50 mM) increases CYP3A4, CYP2C8, and CYP2C9 protein levels in hepatocytes, which thereby enhances their own rates of 4-hydroxylation in the cultured hepatocytes. Ifosfamide only induces CYP3A4 in one human hepatocyte culture that contained the polymorphically expressed CYP3A5 in addition to the more widely expressed CYP3A4.  Ifosfamide is a prodrug metabolised in the liver by cytochrome P450 mixed-function oxidase enzymes to isofosforamide mustard, the active alkylating compound. Ifosfamide has produced favourable response rates in small cell lung cancer, paediatric solid tumours, non-Hodgkin's and Hodgkin's lymphoma, and ovarian cancer.  Ifosfamide is highly cytotoxic to MCF-7 cells following stable transfection of CYP2B1 but exhibits no toxicity to parental tumor cells or to a beta-galactosidase-expressing MCF-7 transfectant, this cytotoxicity could be appreciably blocked by the CYP2B1 inhibitor metyrapone.  Ifosfamide combined with Zoledronic acid is more effective than each agent alone in preventing tumor recurrence, improving tissue repair, and increasing bone formation as revealed by the analysis of trabecular architecture. 
|In vivo||Ifosfamide (100 mg/kg, 200 mg/kg and 400 mg/kg) injected intraperitoneally induces a dose dependent increase in bladder wet weight and Evans blue extravasation in mice. Ifosfamide reveals extensive cystitis characterized by acute inflammation with vascular congestion, edema, hemorrhage and fibrin deposition, neutrophil cell infiltration and epithelial denudation in mice. Ifosfamide shows intense reactivity to inducible nitric oxide synthase in the cytoplasm as well as intense and diffuse necrosis on hematoxylin and eosin staining. |
|In vitro||DMSO||52 mg/mL (199.16 mM)|
|Water||52 mg/mL (199.16 mM)|
|Ethanol||52 mg/mL (199.16 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02432274||Recruiting||Tumors|Solid Malignant Tumors|Osteosarcoma|Differentiated Thyroid Cancer (DTC)||Eisai Limited|Eisai Inc.||December 29, 2014||Phase 1|Phase 2|
|NCT03007147||Not yet recruiting||B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1|BCR-ABL1 Fusion Protein Expression|Minimal Residual Disease|Philadelphia Chromosome Positive|T Acute Lymphoblastic Leukemia|Untreated Adult Acute Lymphoblastic Leukemia|Untreated Childhood Acute Lymphoblastic Leukemia||Childrens Oncology Group|National Cancer Institute (NCI)||July 2017||Phase 3|
|NCT03016871||Not yet recruiting||CD (Cluster of Differentiation) 30-Positive Neoplastic Cells Present|Recurrent Hodgkin Lymphoma|Refractory Hodgkin Lymphoma||City of Hope Medical Center|National Cancer Institute (NCI)||June 2017||Phase 2|
|NCT02808247||Not yet recruiting||Sarcoma, Soft Tissue||European Organisation for Research and Treatment of Cancer - EORTC|Boehringer Ingelheim||January 2017||Phase 2|
|NCT03034304||Not yet recruiting||Advanced Cancer|Bladder Cancer|Soft Tissue Sarcoma||SYZ Cell Therapy Co..|HRYZ (ShenZhen) Biotech Co.||January 2017||Phase 1|
|NCT02732015||Recruiting||Sarcoma||M.D. Anderson Cancer Center|Tesaro, Inc.||October 2016||Phase 2|
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