Pritelivir (BAY 57-1293)
Catalog No.S7546 Synonyms: AIC316
Molecular Weight(MW): 402.49
Pritelivir (BAY 57-1293) is a potent helicase primase inhibitor, exhibiting antiviral effect on herpes simplex virus (HSV) with IC50 of 20 nM for both HSV-1 and HSV-2.
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|Description||Pritelivir (BAY 57-1293) is a potent helicase primase inhibitor, exhibiting antiviral effect on herpes simplex virus (HSV) with IC50 of 20 nM for both HSV-1 and HSV-2.|
The mechanism of action is that BAY 57-1293 directly inhibits the ATPase activity of the viral helicase-primase enzyme complex in a dose-dependent manner. BAY 57-1293 also shows potent antiviral activity against acyclovir resistant HSV mutants.  BAY 57-1293 reduces Aβ and P-tau induced by herpes simplex virus type 1 in vero cells. 
|In vivo||BAY 57-1293 (p.o.) shows profound antiviral activity in murine and rat lethal challenge models of disseminated herpes (0.5 mg/kg), in a murine zosteriform spread model of cutaneous disease (15 mg/kg), and in a murine ocular herpes model. |
|In vitro||DMSO||80 mg/mL (198.76 mM)|
* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
C18 H18 N4 O3 S2
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