Procarbazine HCl

Synonyms: NSC-77213 HCl

Procarbazine HCl (NSC-77213) is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound, used for the treatment of Hodgkin's lymphoma.

Procarbazine HCl Chemical Structure

Procarbazine HCl Chemical Structure

CAS: 366-70-1

Selleck's Procarbazine HCl has been cited by 9 publications

Purity & Quality Control

Batch: Purity: 99.7%
99.7

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Biological Activity

Description Procarbazine HCl (NSC-77213) is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound, used for the treatment of Hodgkin's lymphoma.
In vitro
In vitro

Procarbazine plus Cu(II) induce piperidine-labile and formamidopyrimidine-DNA glycosylase-sensitive lesions at the 5'-ACG-3' sequence, complementary to a hotspot of the p53 gene, and the 5'-TG-3' sequence. Procarbazine causes DNA damage through non-enzymatic formation of the Cu(I)-hydroperoxo complex and methyl radicals. [1] Procarbazine has a strong clastogenic effect in hematopoietic cells and is mutagenic in a variety organs after high dose treatment. [2]

In Vivo
In vivo

Procarbazine causes significant decrease in testicular and epididymal weight and a drastic reduction in haploid cells and spermatogenic arrest, demonstrating variation among the test golden hamster. [3] Procarbazine produces a dose-dependent potentiation of MAO A in brown adipose tissue, the elevation being more pronounced following monomethylhydrazine, with activity rising to 350% of that in control homogenates in rats. Procarbazine or monomethylhydrazine reduces metabolism of this amine by a similar degree as had been determined ex-vivo in blood vessel homogenates. [4] Procarbazine is mutagenic, clastogenic and teratogenic in a wide range of test systems of varying complexity and a wide-spectrum carcinogen in rodents and monkeys, causing tumours of the haemopoietic system, the mammary gland, the lung and the nervous system. Procarbazine in vivo undergoes a complex series of metabolic changes that result in the generation of a number of chemically reactive species, including methylating agents and free radicals. [5]

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00003564 Withdrawn
Brain and Central Nervous System Tumors
M.D. Anderson Cancer Center|National Cancer Institute (NCI)
Phase 3

Chemical Information & Solubility

Molecular Weight 257.76 Formula

C12H19N3O.HCl

CAS No. 366-70-1 SDF Download Procarbazine HCl SDF
Smiles CC(C)NC(=O)C1=CC=C(C=C1)CNNC.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 51 mg/mL ( (197.85 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 51 mg/mL

Ethanol : 34 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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