Catalog No.S1516 Synonyms: HPMPC
Molecular Weight(MW): 279.19
Cidofovir suppresses virus replication by selective inhibition of viral DNA synthesis.
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Triptolide reduces lytic and latent replication of KSHV in BCBL-1 cells. Uninduced and induced BCBL-1 cells were treated with vehicle control or indicated concentrations of triptolide for 48 h. The whole cell supernatants, genomic DNA and lysates were prepared. (A) The copy numbers of the intracellular viral DNA were quantified by qRT-PCR, each sample was normalized to the amount of the GAPDH gene. *p<0.05, compared to control.
Int J Oncol, 2016, 48(4):1519-30. . Cidofovir purchased from Selleck.
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|Description||Cidofovir suppresses virus replication by selective inhibition of viral DNA synthesis.|
Cidofovir inhibits human cytomegalovirus (HCMV) infection in cultured cells. Cidofovir is inhibitory to CMV plaque formation even when added to the cells at 48 hr post infection with IC50 of 0.9 μg/mL for Davis and 1.6 μg/mL for AD-169 strains,respectively.  Cidofovir also inhibits herpes simplex virus infection. In addition, Cidofovir blocks cell fusion induced by HSV-1 in monkey kidney cells and blocks the expression of HSV-l-specific proteins and the synthesis of viral DNA. 
|In vivo||Cidofovir (5 mg/kg/day) subcutaneously for 5 days significantly reduces average virus infectivity titer in blood, spleen, lung and salivary gland in infected guinea pigs. Cidofovir significantly reduces lymphocytosis and average tissue indexe of spleen in infected animals. . Cidofovir suppresses all manifestations (skin lesions, paralysis of the hind legs, and mortality) of hairless mice infected intracutaneously with HSV-1 or HSV-2. The most remarkable feature of Cidofovir is that a single administration of the compound, even as late as 4 days after infection, conferees significant protection against HSV-1 or HSV-2 infection.  Cidofovir inhibits growth of the highly aggressive melanoma tumor arising from mouse melanoma B16 cells grafted subcutaneously in C57B16/J mice. |
-  Snoeck R, et al, Antimicrob Agents Chemother, 1988, 32(12), 1839-1844.
-  Li SB, et al. Antiviral Res, 1990, 13(5), 237-252.
-  Chatterjee S, et al. Antiviral Res., 1992, 19(3), 181-192.
|In vitro||DMSO||<1 mg/mL|
* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02567149||Not yet recruiting||Warts||University of Minnesota - Clinical and Translational Science Institute||July 2016||Phase 2|
|NCT02555800||Recruiting||Recurrent Respiratory Papillomatosis||Centro de Investigación en. Enfermedades Infecciosas, Mexico||December 2014||Phase 2|
|NCT01816646||Completed||Blood And Marrow Transplantation||M.D. Anderson Cancer Center|Gilead Sciences||September 2013||Phase 1|
|NCT01946009||Completed||HIV||Fundacion SEIMC-GESIDA||September 2013||--|
|NCT02976987||Completed||High Grade Cervical Epithelial Neoplasia (CIN2+)||Brugmann University Hospital||February 2013||Phase 2|
|NCT00956176||Withdrawn||Cystitis|Bladder Diseases||M.D. Anderson Cancer Center|Gilead Sciences||September 2012||--|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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