Cidofovir

Catalog No.S1516 Synonyms: HPMPC

Cidofovir Chemical Structure

Molecular Weight(MW): 279.19

Cidofovir suppresses virus replication by selective inhibition of viral DNA synthesis.

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2 Customer Reviews

  • Viruses 2015, 7, 2268-2287. . Cidofovir purchased from Selleck.

    Triptolide reduces lytic and latent replication of KSHV in BCBL-1 cells. Uninduced and induced BCBL-1 cells were treated with vehicle control or indicated concentrations of triptolide for 48 h. The whole cell supernatants, genomic DNA and lysates were prepared. (A) The copy numbers of the intracellular viral DNA were quantified by qRT-PCR, each sample was normalized to the amount of the GAPDH gene. *p<0.05, compared to control.

    Int J Oncol, 2016, 48(4):1519-30. . Cidofovir purchased from Selleck.

Purity & Quality Control

Choose Selective DNA/RNA Synthesis Inhibitors

Biological Activity

Description Cidofovir suppresses virus replication by selective inhibition of viral DNA synthesis.
In vitro

Cidofovir inhibits human cytomegalovirus (HCMV) infection in cultured cells. Cidofovir is inhibitory to CMV plaque formation even when added to the cells at 48 hr post infection with IC50 of 0.9 μg/mL for Davis and 1.6 μg/mL for AD-169 strains,respectively. [1] Cidofovir also inhibits herpes simplex virus infection. In addition, Cidofovir blocks cell fusion induced by HSV-1 in monkey kidney cells and blocks the expression of HSV-l-specific proteins and the synthesis of viral DNA. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEL cells M1TFNWZ2dmO2aX;uJIF{e2G7 MYLDc41xd3WwZDD3ZZMhfGW|dHXkJIZweiCjboTpMZZqemGuIHHjeIl3cXS7IHHnZYlve3RiSGPWMVEpU0:VKTDpckBJTUxiY3XscJMtKEWFNUC9NE42PyEQvF2= NWLmWGRPOTR4NEOzNlg>
MRC-5 cells NGjN[GpHfW6ldHnvckBie3OjeR?= MlXQTY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JIN6fG:yYYTobYMh\W[oZXP0JI9nKEiVVj2yLGUhOTl2KTDpckBOWkNvNTDj[YxteyxiSVO1NF0yOCEQvF2= M{i4Ulg3OzJ2M{m=
NHDF cells NWftdpptTnWwY4Tpc44h[XO|YYm= NIPuSoNKdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5QhemWybHnjZZRqd25ib3[gTGNOXiCrbjDOTGRHKGOnbHzzMEBKSzVyPUCuOUDPxE1? M2j5TFg3OzJ2M{m=
HFF cells NF\EdFFHfW6ldHnvckBie3OjeR?= MUHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDWZYNkcW6rYTD2bZJ2eyCFb4Dlcohi\2WwIHnuJGhHTiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ5l1d3CjdHjv[4VvcWOrdImsJGVEPTB;Mz6yJO69VQ>? MX[xOlYxOzN3MR?=
HFF cells NFH0dlNHfW6ldHnvckBie3OjeR?= NWLQcGZpSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS2:5cH;4JJZqenW|IFLybYdpfG:wIHnuJGhHTiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ5l1d3CjdHjv[4VvcWOrdImsJGVEPTB;Nz6xJO69VQ>? M2HDSVE3PjB|M{Wx
HFF cells NFHQOXFHfW6ldHnvckBie3OjeR?= NHLs[YxCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEB3[WOlaX7pZUB3cXK3czDDc5BmdmijZ3XuJI1m[XO3cnXkJIF{KGO7dH;wZZRpd2enbnnjbZR6KGmwIFjGSkBk\WyuczygSWM2OD14Lkmg{txO M{PuZ|E3PzJ{NkW3
bone marrow cells NVHCSWd{S3m2b4TvfIlkcXS7IHHzd4F6 NHvUSJFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBjd26nIH3hdpJwfyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINwdG:weTDmc5JucW6pIIXubZQhd2ZiZ4LhcpVtd2O7dHWvcYFkem:yaHHn[UwhUUN3ME2xNEDPxE1? NIPqSWYyPjhzNEW0OS=>
HFF cells MVHGeY5kfGmxbjDhd5NigQ>? MnTiRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iQ13WJHQzOjRzIHnuJGhHTiClZXzsd{BjgSCVRVHQJIF{e2G7LDDJR|UxRTBwMzFOwG0> M3;IZVE4ODR|MUK4
MRC5 cells NInT[HZHfW6ldHnvckBie3OjeR?= NXfXPXBsSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gR21XKFSxd37lJIlvKE2UQ{WgZ4VtdHNiYomgVHJCNCCLQ{WwQVAvOyEQvF2= M{DHW|E4ODR|MUK4
UC1B cells NUfaZWJ7TnWwY4Tpc44h[XO|YYm= NIjXcmpCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBOfXKrbnWgdI9tgW:vYY\pdpV{KE2QL2LESUBVd3KxboTvJIlvKG2xdYPlJHVEOUJiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGixZ3XubYNqfHluIFXDOVA:OTNizszN M4G1UVE4PDJyMkG0
african green monkey Vero cells MW\GeY5kfGmxbjDhd5NigQ>? MnvBRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMhOSCIIHnu[oVkfGWmIHnuJIFnemmlYX6g[5Jm\W5ibX;ub4V6KF[ncn:gZ4VtdHNiYYPz[ZN{\WRiYYOgdIxieXWnIILl[JVkfGmxbjDh[pRmeiB|NjD0c{A1QCCqcoOsJGVEPTB;MUSuOEDPxE1? MYSxO|Q{QDB4MR?=
HEL cells NHjl[Y9HfW6ldHnvckBie3OjeR?= NYrjT|RzOyCmYYnz MmrURY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGNOXiCDREG2PUBqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImgZYZ1\XJiMzDkZZl{NCCHQ{WwQVAvPDFizszN NFvvd2oyPzl4MUi1NS=>
HEL cells MU\GeY5kfGmxbjDhd5NigQ>? NYnDU4liOyCmYYnz M2\YdmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhEVVZiRHH2bZMhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5JIFnfGW{IEOg[IF6eyxiRVO1NF0xNjRzIN88US=> Mne1NVc6PjF6NUG=
HFF cells NWnYV2xSTnWwY4Tpc44h[XO|YYm= NEj6VXFCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBEgXSxbXXnZYxwfmm{dYOgR21XKFR{MkGxJIlv\mWldHXkJIlvKEiIRjDj[YxteyCkeTDTSWFRKHKncH;yeIVzKGenbnWgZZN{[XluIFXDOVA:OC5{MjFOwG0> NIjWUZkyPzdyOUS2PC=>
HEL cells NUXaR2h6TnWwY4Tpc44h[XO|YYm= NWDTNZVISW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh\2GwY3njcI93cXJvcnXzbZN1[W62IFjDUXYhSURzNkmgZ4xwdmViNDDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXPpeJktKEWFNUC9NE44PCEQvF2= NH3VSWkyQTJ{NkG0NC=>
HEL cells NE\TRWpHfW6ldHnvckBie3OjeR?= MYjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIR21XKESjdnnzJIlv\mWldHXkJIlvKGi3bXHuJGhGVCClZXzsd{Bie3Onc4Pl[EBqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[2m2eTDh[pRmeiB5IHThfZMheG:|dHnu[oVkfGmxbjygSWM2OD1yLkWg{txO NFjZenkyQTJ{NkG0NC=>
HEL cells MY\GeY5kfGmxbjDhd5NigQ>? Moj5RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGNOXiCDREG2PUBqdm[nY4Tl[EBqdiCqdX3hckBJTUxiY3XscJMh[XO|ZYPz[YQhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWOrdImgZYZ1\XJiNzDkZZl{KHCxc4TpcoZm[3Srb36sJGVEPTB;MD6zJO69VQ>? MkT5NVkzOjZzNEC=
HEL cells M2XGOWZ2dmO2aX;uJIF{e2G7 NWT3cGlESW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh\m:|Y3HycoV1NXKnc3nzeIFvfCCKQ13WJGFFOTZ7IHPsc45mKENiaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlaYT5MEBKSzVyPUCuNFQ2KM7:TR?= NGfDZ2QyQTJ{NkG0NC=>
HFF MXfQdo9tcW[ncnH0bY9vKGG|c3H5 MnHCN{Bl[Xm| NET1OnpCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JGhHTiCjZoTldkA{KGSjeYOgZpkh[2:3bITldkBkd3WwdHXyJIF{e2G7LDDFR|UxRTFwOTFOwG0> M2rwOVE6ODJ7M{Ky
HeLaS3 cells MX3GeY5kfGmxbjDhd5NigQ>? NXK4dmttOy13IHThfZM> NYLTZY1NSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhXmGlY3nubYEhfmm{dYOgTWhFNUpiQWTDR{BXWi1zNU[gbY5n\WO2ZXSgbY4hUGWOYWOzJINmdGy|IHHmeIVzKDNidH:gOUBl[Xm|IHL5JJBt[XG3ZTDhd5NigSxiRVO1NF0yQC55NDFOwG0> Mn3oNVg5PTJ{N{G=
HSB2 cells MY\GeY5kfGmxbjDhd5NigQ>? NFnJPWE4KGSjeYO= NGLocZdCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDo[ZJx\XO4aYL1d{A3KEeVIHnu[oVkfGWmIHnuJIh2dWGwIFjTRlIh[2WubIOgZZN{\XO|ZXSgZZMh\GWlcnXhd4UhcW5idnnyZYwhTE6DIHHjZ5VufWyjdHnvckBi\nSncjC3JIRigXNuIFXDOVA:Oi55IN88US=> MliyNVk4PzB{N{S=
A549 cells MknYSpVv[3Srb36gZZN{[Xl? MVjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCjZHXuc5ZqenW|IIT5dIUhOTGyIIPsc4JqfHOtaTDpcoZm[3SnZDDpckBCPTR7IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhTE6DIILldIxq[2G2aX;uJIJ6KFGSQ2KgZZN{[XluIFXDOVA:OTZwNTFOwG0> MWCyNFU5PTFzMh?=
HFF cells NGrmdYNHfW6ldHnvckBie3OjeR?= NV3mfIQzSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS2:5cH;4JJZqenW|IDjCdolocHSxbjDS[YQqKGmwZnXjeIVlKGmwIHj1cYFvKEiIRjDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hfmm{YXytbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDifUBv\XW2cnHsJJJm\CC3cIThb4Uh[XO|YYmsJGVEPTB;Nj63JO69VQ>? Mm[zNlE{PzZ2Mkm=

... Click to View More Cell Line Experimental Data

In vivo Cidofovir (5 mg/kg/day) subcutaneously for 5 days significantly reduces average virus infectivity titer in blood, spleen, lung and salivary gland in infected guinea pigs. Cidofovir significantly reduces lymphocytosis and average tissue indexe of spleen in infected animals. [2]. Cidofovir suppresses all manifestations (skin lesions, paralysis of the hind legs, and mortality) of hairless mice infected intracutaneously with HSV-1 or HSV-2. The most remarkable feature of Cidofovir is that a single administration of the compound, even as late as 4 days after infection, conferees significant protection against HSV-1 or HSV-2 infection. [4] Cidofovir inhibits growth of the highly aggressive melanoma tumor arising from mouse melanoma B16 cells grafted subcutaneously in C57B16/J mice. [5]

Protocol

Solubility (25°C)

In vitro DMSO Insoluble
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 279.19
Formula

C8H14N3O6P

CAS No. 113852-37-2
Storage powder
in solvent
Synonyms HPMPC

Bio Calculators

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Dilution Calculator

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02567149 Not yet recruiting Warts University of Minnesota - Clinical and Translational Science Institute July 2016 Phase 2
NCT02555800 Recruiting Recurrent Respiratory Papillomatosis Centro de Investigación en. Enfermedades Infecciosas, Mexico December 2014 Phase 2
NCT01816646 Completed Blood And Marrow Transplantation M.D. Anderson Cancer Center|Gilead Sciences September 2013 Phase 1
NCT01946009 Completed HIV Fundacion SEIMC-GESIDA September 2013 --
NCT02976987 Completed High Grade Cervical Epithelial Neoplasia (CIN2+) Brugmann University Hospital February 2013 Phase 2
NCT00956176 Withdrawn Cystitis|Bladder Diseases M.D. Anderson Cancer Center|Gilead Sciences September 2012 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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DNA/RNA Synthesis Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID