Cidofovir

Catalog No.S1516 Synonyms: HPMPC

Cidofovir Chemical Structure

Molecular Weight(MW): 279.19

Cidofovir suppresses virus replication by selective inhibition of viral DNA synthesis.

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2 Customer Reviews

  • The copy numbers of the intracellular viral DNA were directly extracted from cells and were quantified by qPCR using primers specific for the KSHV ORF73 gene. Then each sample was normalized to the amount of the GAPDH gene (C), CDV (20 µM) was used as a positive control. CDV:Cidofovir.

    Viruses 2015, 7, 2268-2287. . Cidofovir purchased from Selleck.

    Triptolide reduces lytic and latent replication of KSHV in BCBL-1 cells. Uninduced and induced BCBL-1 cells were treated with vehicle control or indicated concentrations of triptolide for 48 h. The whole cell supernatants, genomic DNA and lysates were prepared. (A) The copy numbers of the intracellular viral DNA were quantified by qRT-PCR, each sample was normalized to the amount of the GAPDH gene. *p<0.05, compared to control.

    Int J Oncol, 2016, 48(4):1519-30. . Cidofovir purchased from Selleck.

Purity & Quality Control

Choose Selective DNA/RNA Synthesis Inhibitors

Biological Activity

Description Cidofovir suppresses virus replication by selective inhibition of viral DNA synthesis.
In vitro

Cidofovir inhibits human cytomegalovirus (HCMV) infection in cultured cells. Cidofovir is inhibitory to CMV plaque formation even when added to the cells at 48 hr post infection with IC50 of 0.9 μg/mL for Davis and 1.6 μg/mL for AD-169 strains,respectively. [1] Cidofovir also inhibits herpes simplex virus infection. In addition, Cidofovir blocks cell fusion induced by HSV-1 in monkey kidney cells and blocks the expression of HSV-l-specific proteins and the synthesis of viral DNA. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEL cells NYjYR5JKTnWwY4Tpc44h[XO|YYm= NYHReJdVS2:vcH;1coQhf2G|IITld5Rm\CCob4KgZY51cS24aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXi1zKFvPV{khcW5iSFXMJINmdGy|LDDFR|UxRTBwNUeg{txO MX6xOFY1OzN{OB?=
MRC-5 cells NWqw[GlsTnWwY4Tpc44h[XO|YYm= NGLibnhKdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5Qh[3m2b4DheIhq[yCnZn\lZ5Qhd2ZiSGPWMVIpTSBzOUSpJIlvKE2UQz21JINmdGy|LDDJR|UxRTFyIN88US=> NXr2W5l1QDZ|MkSzPS=>
NHDF cells M3KxR2Z2dmO2aX;uJIF{e2G7 NVnkXZY6UW6qaXLpeI9zgSCjY4Tpeol1gSCjZ3HpcpN1KHKncHzpZ4F1cW:wIH;mJGhEVVZiaX6gUmhFTiClZXzsd{whUUN3ME2wMlUh|ryP NYjJVGJXQDZ|MkSzPS=>
HFF cells MnL3SpVv[3Srb36gZZN{[Xl? MYDBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDWZYNkcW6rYTD2bZJ2eyCFb4Dlcohi\2WwIHnuJGhHTiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ5l1d3CjdHjv[4VvcWOrdImsJGVEPTB;Mz6yJO69VQ>? M3voRlE3PjB|M{Wx
HFF cells MWjGeY5kfGmxbjDhd5NigQ>? NG\lO4pCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBEd3eyb4igeolzfXNiQoLp[4h1d25iaX6gTGZHKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDjfZRweGG2aH;n[Y5q[2m2eTygSWM2OD15LkGg{txO NV\rV4tbOTZ4MEOzOVE>
HFF cells NUDNcJdqTnWwY4Tpc44h[XO|YYm= NIra[HFCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEB3[WOlaX7pZUB3cXK3czDDc5BmdmijZ3XuJI1m[XO3cnXkJIF{KGO7dH;wZZRpd2enbnnjbZR6KGmwIFjGSkBk\WyuczygSWM2OD14Lkmg{txO NVPhZ5Y{OTZ5MkK2OVc>
bone marrow cells MYHDfZRwfG:6aXPpeJkh[XO|YYm= NWHhSZhPS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4h[m:wZTDtZZJzd3diY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBkd2yxbomg[o9zdWmwZzD1col1KG:oIHfyZY52dG:leYTlM41i[3KxcHjh[4UtKEmFNUC9NVAh|ryP NIDyXYwyPjhzNEW0OS=>
HFF cells MVzGeY5kfGmxbjDhd5NigQ>? MUTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCFTW[gWFIzPDFiaX6gTGZHKGOnbHzzJIJ6KFOHQWCgZZN{[XluIFnDOVA:OC5|IN88US=> M2fZW|E4ODR|MUK4
MRC5 cells MUPGeY5kfGmxbjDhd5NigQ>? M3e0TWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIFPNWkBVd3ewZTDpckBOWkN3IHPlcIx{KGK7IGDSRUwhUUN3ME2wMlMh|ryP M2fXdFE4ODR|MUK4
UC1B cells NHLqcZBHfW6ldHnvckBie3OjeR?= MYXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDNeZJqdmVicH;sfY9u[X[rcoXzJG1PN1KGRTDUc5JwdnSxIHnuJI1wfXOnIGXDNWIh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJktKEWFNUC9NVMh|ryP MYexO|QzODJzNB?=
african green monkey Vero cells NEexUmRHfW6ldHnvckBie3OjeR?= MWLBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AyKEZiaX7m[YN1\WRiaX6gZYZzcWOjbjDndoVmdiCvb37r[ZkhXmW{bzDj[YxteyCjc4Pld5Nm\CCjczDwcIFyfWVicnXkeYN1cW:wIHHmeIVzKDN4IITvJFQ5KGi{czygSWM2OD1zND60JO69VQ>? Mm\uNVc1OzhyNkG=
HEL cells NGDpN4FHfW6ldHnvckBie3OjeR?= MV2zJIRigXN? MmTSRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGNOXiCDREG2PUBqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImgZYZ1\XJiMzDkZZl{NCCHQ{WwQVAvPDFizszN M2HGbVE4QTZzOEWx
HEL cells NWHXclZGTnWwY4Tpc44h[XO|YYm= MX6zJIRigXN? MVHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIR21XKESjdnnzJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aH;n[Y5q[2m2eTDh[pRmeiB|IHThfZMtKEWFNUC9NE41OSEQvF2= NHLJcYUyPzl4MUi1NS=>
HFF cells MV7GeY5kfGmxbjDhd5NigQ>? M4nvfmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGN6fG:vZXfhcI93cXK3czDDUXYhXDJ{MUGgbY5n\WO2ZXSgbY4hUE[IIHPlcIx{KGK7IGPFRXAhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NF0xNjJ{IN88US=> M2raS|E4PzB7NE[4
HEL cells Ml3FSpVv[3Srb36gZZN{[Xl? MkPtRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4Sg[4Fv[2mlbH;2bZIuemW|aYP0ZY51KEiFTW[gRWQyPjliY3zvcoUhPCCrbn\lZ5Rm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWOrdImsJGVEPTB;MD63OEDPxE1? NVHqWYtJOTl{Mk[xOFA>
HEL cells MYjGeY5kfGmxbjDhd5NigQ>? NEHKNllCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJS02YIFTheol{KGmwZnXjeIVlKGmwIHj1cYFvKEiHTDDj[YxteyCjc4Pld5Nm\CCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirY3n0fUBi\nSncjC3JIRigXNicH;zeIlv\mWldHnvckwhTUN3ME2wMlUh|ryP M2Dnb|E6OjJ4MUSw
HEL cells NIDqN5VHfW6ldHnvckBie3OjeR?= NETFPXBCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJS02YIFHENVY6KGmwZnXjeIVlKGmwIHj1cYFvKEiHTDDj[YxteyCjc4Pld5Nm\CCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirY3n0fUBi\nSncjC3JIRigXNicH;zeIlv\mWldHnvckwhTUN3ME2wMlMh|ryP M1XxeFE6OjJ4MUSw
HEL cells NVnhW3RsTnWwY4Tpc44h[XO|YYm= Mmi2RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4Sg[o9{[2G{bnX0MZJme2m|dHHueEBJS02YIFHENVY6KGOub37lJGMhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkcXS7LDDJR|UxRTBwMES1JO69VQ>? NIDQOVYyQTJ{NkG0NC=>
HFF NIH5b|VRem:uaX\ldoF1cW:wIHHzd4F6 M2f3TlMh\GG7cx?= MmHNRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDISmYh[W[2ZYKgN{Bl[Xm|IHL5JINwfWy2ZYKgZ492dnSncjDhd5NigSxiRVO1NF0yNjlizszN M2rnS|E6ODJ7M{Ky
HeLaS3 cells MV3GeY5kfGmxbjDhd5NigQ>? M4PFOFMuPSCmYYnz Mnu5RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgWoFk[2mwaXGgeolzfXNiSVjEMWohSVSFQzDWVk0yPTZiaX7m[YN1\WRiaX6gTIVN[VN|IHPlcIx{KGGodHXyJFMhfG9iNTDkZZl{KGK7IIDsZZF2\SCjc4PhfUwhTUN3ME2xPE44PCEQvF2= NXjob4RCOTh6NUKyO|E>
HSB2 cells NXPoVJJ5TnWwY4Tpc44h[XO|YYm= MWi3JIRigXN? MlK4RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iaHXydIV{fmm{dYOgOkBIWyCrbn\lZ5Rm\CCrbjDoeY1idiCKU1KyJINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKH[rcnHsJGRPSSCjY3P1cZVt[XSrb36gZYZ1\XJiNzDkZZl{NCCHQ{WwQVIvPyEQvF2= MYKxPVc4ODJ5NB?=
A549 cells MnO0SpVv[3Srb36gZZN{[Xl? MnXsRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iYXTlco93cXK3czD0fZBmKDFzcDDzcI9jcXS|a3mgbY5n\WO2ZXSgbY4hSTV2OTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKESQQTDy[ZBtcWOjdHnvckBjgSCTUFPSJIF{e2G7LDDFR|UxRTF4LkWg{txO MX2yNFU5PTFzMh?=
HFF cells M1W3W2Z2dmO2aX;uJIF{e2G7 NX;yTldTSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhS2:5cH;4JJZqenW|IDjCdolocHSxbjDS[YQqKGmwZnXjeIVlKGmwIHj1cYFvKEiIRjDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hfmm{YXytbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDifUBv\XW2cnHsJJJm\CC3cIThb4Uh[XO|YYmsJGVEPTB;Nj63JO69VQ>? M4Dy[|IyOzd4NEK5

... Click to View More Cell Line Experimental Data

In vivo Cidofovir (5 mg/kg/day) subcutaneously for 5 days significantly reduces average virus infectivity titer in blood, spleen, lung and salivary gland in infected guinea pigs. Cidofovir significantly reduces lymphocytosis and average tissue indexe of spleen in infected animals. [2]. Cidofovir suppresses all manifestations (skin lesions, paralysis of the hind legs, and mortality) of hairless mice infected intracutaneously with HSV-1 or HSV-2. The most remarkable feature of Cidofovir is that a single administration of the compound, even as late as 4 days after infection, conferees significant protection against HSV-1 or HSV-2 infection. [4] Cidofovir inhibits growth of the highly aggressive melanoma tumor arising from mouse melanoma B16 cells grafted subcutaneously in C57B16/J mice. [5]

Protocol

Solubility (25°C)

In vitro Water 12 mg/mL (42.98 mM)
DMSO 2 mg/mL (7.16 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 279.19
Formula

C8H14N3O6P

CAS No. 113852-37-2
Storage powder
Synonyms HPMPC

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02567149 Not yet recruiting Warts University of Minnesota - Clinical and Translational Science Institute July 2016 Phase 2
NCT02555800 Recruiting Recurrent Respiratory Papillomatosis Centro de Investigación en. Enfermedades Infecciosas, Mexico December 2014 Phase 2
NCT01816646 Completed Blood And Marrow Transplantation M.D. Anderson Cancer Center|Gilead Sciences September 2013 Phase 1
NCT01946009 Completed HIV Fundacion SEIMC-GESIDA September 2013 --
NCT02976987 Completed High Grade Cervical Epithelial Neoplasia (CIN2+) Brugmann University Hospital February 2013 Phase 2
NCT00956176 Withdrawn Cystitis|Bladder Diseases M.D. Anderson Cancer Center|Gilead Sciences September 2012 --

Tech Support

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DNA/RNA Synthesis Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID