Cidofovir

Catalog No.S1516 Synonyms: HPMPC

Cidofovir Chemical Structure

Molecular Weight(MW): 279.19

Cidofovir suppresses virus replication by selective inhibition of viral DNA synthesis.

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2 Customer Reviews

  • The copy numbers of the intracellular viral DNA were directly extracted from cells and were quantified by qPCR using primers specific for the KSHV ORF73 gene. Then each sample was normalized to the amount of the GAPDH gene (C), CDV (20 µM) was used as a positive control. CDV:Cidofovir.

    Viruses 2015, 7, 2268-2287. . Cidofovir purchased from Selleck.

    Triptolide reduces lytic and latent replication of KSHV in BCBL-1 cells. Uninduced and induced BCBL-1 cells were treated with vehicle control or indicated concentrations of triptolide for 48 h. The whole cell supernatants, genomic DNA and lysates were prepared. (A) The copy numbers of the intracellular viral DNA were quantified by qRT-PCR, each sample was normalized to the amount of the GAPDH gene. *p<0.05, compared to control.

    Int J Oncol, 2016, 48(4):1519-30. . Cidofovir purchased from Selleck.

Purity & Quality Control

Choose Selective DNA/RNA Synthesis Inhibitors

Biological Activity

Description Cidofovir suppresses virus replication by selective inhibition of viral DNA synthesis.
In vitro

Cidofovir inhibits human cytomegalovirus (HCMV) infection in cultured cells. Cidofovir is inhibitory to CMV plaque formation even when added to the cells at 48 hr post infection with IC50 of 0.9 μg/mL for Davis and 1.6 μg/mL for AD-169 strains,respectively. [1] Cidofovir also inhibits herpes simplex virus infection. In addition, Cidofovir blocks cell fusion induced by HSV-1 in monkey kidney cells and blocks the expression of HSV-l-specific proteins and the synthesis of viral DNA. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEL cells MVTGeY5kfGmxbjDhd5NigQ>? NUnp[5RFS2:vcH;1coQhf2G|IITld5Rm\CCob4KgZY51cS24aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXi1zKFvPV{khcW5iSFXMJINmdGy|LDDFR|UxRTBwNUeg{txO NF:4U|YyPDZ2M{OyPC=>
MRC-5 cells MU\GeY5kfGmxbjDhd5NigQ>? Mnq1TY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JIN6fG:yYYTobYMh\W[oZXP0JI9nKEiVVj2yLGUhOTl2KTDpckBOWkNvNTDj[YxteyxiSVO1NF0yOCEQvF2= M2GyXVg3OzJ2M{m=
NHDF cells MmjsSpVv[3Srb36gZZN{[Xl? MVzJcohq[mm2b4L5JIFkfGm4aYT5JIFo[Wmwc4SgdoVxdGmlYYTpc44hd2ZiSFPNWkBqdiCQSFTGJINmdGy|LDDJR|UxRTBwNTFOwG0> MUm4OlMzPDN7
HFF cells NF\ZO2NHfW6ldHnvckBie3OjeR?= M4iyTGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JHZi[2OrbnnhJJZqenW|IFPvdIVvcGGpZX6gbY4hUE[IIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBkgXSxcHH0bI9o\W6rY3n0fUwhTUN3ME2zMlIh|ryP NVP1THA1OTZ4MEOzOVE>
HFF cells M1KzTGZ2dmO2aX;uJIF{e2G7 NEHiVWZCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBEd3eyb4igeolzfXNiQoLp[4h1d25iaX6gTGZHKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDjfZRweGG2aH;n[Y5q[2m2eTygSWM2OD15LkGg{txO NYTxZ2tPOTZ4MEOzOVE>
HFF cells NWHXPXVtTnWwY4Tpc44h[XO|YYm= M1fzemFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JJZi[2OrbnnhJJZqenW|IFPvdIVvcGGpZX6gcYVie3W{ZXSgZZMh[3m2b4DheIhw\2WwaXPpeJkhcW5iSF\GJINmdGy|LDDFR|UxRTZwOTFOwG0> M{jmblE3PzJ{NkW3
bone marrow cells MUDDfZRwfG:6aXPpeJkh[XO|YYm= NEDRbmZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBjd26nIH3hdpJwfyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINwdG:weTDmc5JucW6pIIXubZQhd2ZiZ4LhcpVtd2O7dHWvcYFkem:yaHHn[UwhUUN3ME2xNEDPxE1? MVixOlgyPDV2NR?=
HFF cells NU\aZYRDTnWwY4Tpc44h[XO|YYm= NYPtV2ZpSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gR21XKFR{MkSxJIlvKEiIRjDj[YxteyCkeTDTSWFRKGG|c3H5MEBKSzVyPUCuN{DPxE1? M4HTV|E4ODR|MUK4
MRC5 cells NVXQN2Z7TnWwY4Tpc44h[XO|YYm= NE\YUItCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDDUXYhXG:5bnWgbY4hVVKFNTDj[YxteyCkeTDQVmEtKEmFNUC9NE4{KM7:TR?= MmTtNVcxPDNzMki=
UC1B cells NGr2RlVHfW6ldHnvckBie3OjeR?= M1XuNGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JG12emmwZTDwc4x6d22jdnnyeZMhVU5xUlTFJHRwem:wdH:gbY4hdW:3c3WgWWMySiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cG:pZX7pZ4l1gSxiRVO1NF0yOyEQvF2= NH3vTYoyPzR{MEKxOC=>
african green monkey Vero cells M2f3NGZ2dmO2aX;uJIF{e2G7 NUPyZYs5SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUGW{cHXzJJNqdXCuZYigeolzfXNiMTDGJIlv\mWldHXkJIlvKGGocnnjZY4h\3KnZX6gcY9vc2W7IG\ldo8h[2WubIOgZZN{\XO|ZXSgZZMheGyjcYXlJJJm\HWldHnvckBi\nSncjCzOkB1dyB2ODDodpMtKEWFNUC9NVQvPCEQvF2= MnPoNVc1OzhyNkG=
HEL cells MXLGeY5kfGmxbjDhd5NigQ>? NYPTUIJ{OyCmYYnz NHXr[odCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJS02YIFHENVY6KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUBi\nSncjCzJIRigXNuIFXDOVA:OC52MTFOwG0> MkX0NVc6PjF6NUG=
HEL cells NWjwNIpVTnWwY4Tpc44h[XO|YYm= M4O0XVMh\GG7cx?= NHr4ZmxCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJS02YIFTheol{KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUBi\nSncjCzJIRigXNuIFXDOVA:OC52MTFOwG0> NXLZfYtDOTd7NkG4OVE>
HFF cells NU\wdJV7TnWwY4Tpc44h[XO|YYm= M1;VXmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGN6fG:vZXfhcI93cXK3czDDUXYhXDJ{MUGgbY5n\WO2ZXSgbY4hUE[IIHPlcIx{KGK7IGPFRXAhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NF0xNjJ{IN88US=> NGD2OGUyPzdyOUS2PC=>
HEL cells M3ixSmZ2dmO2aX;uJIF{e2G7 MYTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDnZY5kcWOub4\pdk1z\XOrc4ThcpQhUEOPVjDBSFE3QSClbH;u[UA1KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[2m2eTygSWM2OD1yLke0JO69VQ>? MmewNVkzOjZzNEC=
HEL cells MVHGeY5kfGmxbjDhd5NigQ>? NGXLUpdCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJS02YIFTheol{KGmwZnXjeIVlKGmwIHj1cYFvKEiHTDDj[YxteyCjc4Pld5Nm\CCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirY3n0fUBi\nSncjC3JIRigXNicH;zeIlv\mWldHnvckwhTUN3ME2wMlUh|ryP M{LzbFE6OjJ4MUSw
HEL cells M{f6eGZ2dmO2aX;uJIF{e2G7 MnvqRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGNOXiCDREG2PUBqdm[nY4Tl[EBqdiCqdX3hckBJTUxiY3XscJMh[XO|ZYPz[YQhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWOrdImgZYZ1\XJiNzDkZZl{KHCxc4TpcoZm[3Srb36sJGVEPTB;MD6zJO69VQ>? MnroNVkzOjZzNEC=
HEL cells MWPGeY5kfGmxbjDhd5NigQ>? MVjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDmc5Nk[XKwZYStdoV{cXO2YX70JGhEVVZiQVSxOlkh[2yxbnWgR{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYNqfHluIFnDOVA:OC5yNEWg{txO NWTBRZF3OTl{Mk[xOFA>
HFF MYfQdo9tcW[ncnH0bY9vKGG|c3H5 Ml\rN{Bl[Xm| NG\pUFFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JGhHTiCjZoTldkA{KGSjeYOgZpkh[2:3bITldkBkd3WwdHXyJIF{e2G7LDDFR|UxRTFwOTFOwG0> M1XzWFE6ODJ7M{Ky
HeLaS3 cells NH65PGNHfW6ldHnvckBie3OjeR?= NWr0TWE3Oy13IHThfZM> NHPQe|FCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBX[WOlaX7pZUB3cXK3czDJTGQuUiCDVFPDJHZTNTF3NjDpcoZm[3SnZDDpckBJ\UyjU{OgZ4VtdHNiYX\0[ZIhOyC2bzC1JIRigXNiYomgdIxieXWnIHHzd4F6NCCHQ{WwQVE5Njd2IN88US=> MYexPFg2OjJ5MR?=
HSB2 cells MYTGeY5kfGmxbjDhd5NigQ>? M2H6cFch\GG7cx?= MYHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCqZYLw[ZN3cXK3czC2JGdUKGmwZnXjeIVlKGmwIHj1cYFvKEiVQkKgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hfmm{YXygSG5CKGGlY4XteYxifGmxbjDh[pRmeiB5IHThfZMtKEWFNUC9Nk44KM7:TR?= MlzCNVk4PzB{N{S=
A549 cells M{Ltb2Z2dmO2aX;uJIF{e2G7 NHf0V45CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDh[IVvd3[rcoXzJJR6eGViMUHwJJNtd2KrdIPrbUBqdm[nY4Tl[EBqdiCDNUS5JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiRF7BJJJmeGyrY3H0bY9vKGK7IGHQR3Ih[XO|YYmsJGVEPTB;MU[uOUDPxE1? NHPBOpYzODV6NUGxNi=>
HFF cells NXywZoJKTnWwY4Tpc44h[XO|YYm= MnXpRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgR494eG:6II\pdpV{KCiEcnnnbJRwdiCUZXSpJIlv\mWldHXkJIlvKGi3bXHuJGhHTiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6geolz[WxvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCCkeTDu[ZV1emGuIILl[EB2eHSja3WgZZN{[XluIFXDOVA:Pi55IN88US=> MnfjNlE{PzZ2Mkm=

... Click to View More Cell Line Experimental Data

In vivo Cidofovir (5 mg/kg/day) subcutaneously for 5 days significantly reduces average virus infectivity titer in blood, spleen, lung and salivary gland in infected guinea pigs. Cidofovir significantly reduces lymphocytosis and average tissue indexe of spleen in infected animals. [2]. Cidofovir suppresses all manifestations (skin lesions, paralysis of the hind legs, and mortality) of hairless mice infected intracutaneously with HSV-1 or HSV-2. The most remarkable feature of Cidofovir is that a single administration of the compound, even as late as 4 days after infection, conferees significant protection against HSV-1 or HSV-2 infection. [4] Cidofovir inhibits growth of the highly aggressive melanoma tumor arising from mouse melanoma B16 cells grafted subcutaneously in C57B16/J mice. [5]

Protocol

Solubility (25°C)

In vitro Water 12 mg/mL (42.98 mM)
DMSO 2 mg/mL (7.16 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 279.19
Formula

C8H14N3O6P

CAS No. 113852-37-2
Storage powder
Synonyms HPMPC

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02567149 Not yet recruiting Warts University of Minnesota - Clinical and Translational Science Institute July 2016 Phase 2
NCT02555800 Recruiting Recurrent Respiratory Papillomatosis Centro de Investigación en. Enfermedades Infecciosas, Mexico December 2014 Phase 2
NCT01816646 Completed Blood And Marrow Transplantation M.D. Anderson Cancer Center|Gilead Sciences September 2013 Phase 1
NCT01946009 Completed HIV Fundacion SEIMC-GESIDA September 2013 --
NCT02976987 Completed High Grade Cervical Epithelial Neoplasia (CIN2+) Brugmann University Hospital February 2013 Phase 2
NCT00956176 Withdrawn Cystitis|Bladder Diseases M.D. Anderson Cancer Center|Gilead Sciences September 2012 --

Tech Support

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DNA/RNA Synthesis Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID