Metronidazole

Catalog No.S1907

Metronidazole is a nitroimidazole antibiotic medication used particularly for anaerobic bacteria and protozoa.

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Metronidazole  Chemical Structure

Metronidazole Chemical Structure
Molecular Weight: 171.15

Validation & Quality Control

Quality Control & MSDS

Related Compound Libraries

Metronidazole is available in the following compound libraries:

Product Information

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Product Description

Biological Activity

Metronidazole(Flagyl)is a nitroimidazole antibiotic medication used particularly for anaerobic bacteria and protozoa. Metronidazole, taken up by diffusion, is selectively absorbed by anaerobic bacteria and sensitive protozoa. Once taken up by anaerobes, it is non-enzymatically reduced by reacting with reduced ferredoxin, which is generated by pyruvate oxido-reductase. This reduction causes the production of toxic products to anaerobic cells, and allows for selective accumulation in anaerobes. [1]

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesBaboonDogMonkeyRabbitGuinea pigRatHamsterMouse
Weight (kg)121031.80.40.150.080.02
Body Surface Area (m2)0.60.50.240.150.050.0250.020.007
Km factor202012128653
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)

Clinical Trial Information( data from http://clinicaltrials.gov, updated on 2014-09-20)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT02186145 Not yet recruiting Bacterial Vaginosis|Fungal Vaginal Infections Marjan Industria e Comercio ltda May 2015 Phase 3
NCT02154061 Not yet recruiting Vaccine Nadine Rouphael|Emory University February 2015 --
NCT02236403 Not yet recruiting Chronic Blepharitis Universidad Nacional de Colombia October 2014 Phase 3
NCT02237950 Recruiting Bacterial Vaginosis Starpharma Pty Ltd September 2014 Phase 3
NCT02236156 Recruiting Bacterial Vaginosis Starpharma Pty Ltd September 2014 Phase 3

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Chemical Information

Download Metronidazole SDF
Molecular Weight (MW) 171.15
Formula

C6H9N3O3

CAS No. 443-48-1
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Synonyms
Solubility (25°C) * In vitro DMSO 34 mg/mL (198 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Research Area

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Tel: +1-832-582-8158 Ext:3

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