Metronidazole

Catalog No.S1907

Metronidazole  Chemical Structure

Molecular Weight(MW): 171.15

Metronidazole, a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
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Biological Activity

Description Metronidazole, a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa.
Targets
DNA synthesis [1]
In vitro

Metronidazole is relatively inactive until it is metabolized within host or microbial cells. Metronidazole is activated when it receives an electron from ferredoxin or fla vodoxin that is reduced by POR in anaerobic or microaerophilic bacteria or luminal parasites. Metronidazole damages cells by forming protein and DNA adducts. [1] Metronidazole has activity against protozoans like Entamoeba histolytica, Giardia lamblia and Trichomonas vaginalis, for which the drug is first approved as an effective treatment. The activity of metronidazole against anaerobic bowel flora has been used for prophylaxis and treatment of patients with Crohn's disease who might develop an infectious complication. Metronidazole has played an important role in anaerobic-related infections.   Metronidazole has notable effectiveness in treating anaerobic brain abscesses. [2] Metronidazole resistance tends to result from de novo mutation in the resident rdxA gene, rather than from lateral transfer of mutant rdxA (or other) genes from unrelated but Mtzr strains. Metronidazole partially inhibits growth stimulate forward mutation to rifampin resistance in rdxA(+) (Metronidazole(s)) and also in rdxA (Metronidazole(r)) H. pylori strains, and that expression of rdxA in Escherichia coli results in equivalent Mtz-induced mutation. [3] Metronidazole leads to apoptosis-like features in growing cultures of axenic B. hominis, including key morphological and biochemical features of programmed cell death (PCD), viz. nuclear condensation and nicked DNA in nucleus, reduced cytoplasmic volume, externalization of phosphatidylserine and maintenance of plasma membrane integrity with increasing permeability. [4]

Protocol

Solubility (25°C)

In vitro DMSO 34 mg/mL (198.65 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 171.15
Formula

C6H9N3O3

CAS No. 443-48-1
Storage powder
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02942485 Not yet recruiting GIARDIASIS Helsinki University Central Hospital December 2017 Phase 4
NCT02561117 Not yet recruiting Appendicitis Ahmed Nasr|Childrens Hospital of Eastern Ontario June 2017 Phase 4
NCT02935010 Not yet recruiting Helicobacter Pylori Infection Shanghai Jiao Tong University School of Medicine February 2017 Phase 4
NCT03046758 Not yet recruiting Appendicitis Herlev Hospital|Jacob Rosenberg (Sponsor)|Barbara Juliane Holzknecht (Investigator)|Magnus Arpi (Investigator)|Johan Juhl Weisser (Partner, data analysis) February 2017 Phase 2
NCT02682485 Not yet recruiting Anastomotic Leak|Rectal Cancer University of Chicago January 2017 Phase 2
NCT02686645 Not yet recruiting Clostridium Difficile Infection Queen Elizabeth II Health Sciences Centre December 2016 Phase 2|Phase 3

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID