Capecitabine (Xeloda)

M.Wt: 359.35
Formula: C₁₅H₂₂FN₃O₆
Solubility: DMSO
Purity: >99%
Storage: at -20℃ 2 years
CAS No.: 154361-50-9

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Applications & Customer's Feedback of Capecitabine (Xeloda):

Biological Activity of Capecitabine (Xeloda):

Capecitabine (Xeloda) is an orally-administered chemotherapeutic agent (IC50 = 0.7~5 mM) and prodrug of 5-fluorouracil which is a DNA synthesis inhibitor with an IC50 for 5.0 ± 1.8 μM. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, FdUMP and FUTP by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand. Capecitabine is a chemotherapy drug that is given as a treatment for many types of cancer, including bowel cancer, breast cancer|, stomach cancer and oesophageal cancer. ^{[1][2][3][4][5]}

References on Capecitabine (Xeloda):

[1] Kolinsky K, et al.Mol Cancer Ther. 2009 Jan;8(1):75-82

[2] Lechleider RJ et al. Clin Cancer Res. 2008 Jul 15;14(14):4378-84

[3] Siegel-Lakhai WS et al. Br J Cancer. 2008 Apr 22;98(8):1320-6

[4] Dell’Erba C et al. Pharmacol Res. 2005 Sep;52(3):271-82.

[5] http://en.wikipedia.org/wiki/Capecitabine

MSDS
Batch S115601: H-NMR  HPLC  COA
Batch S115602: H-NMR  HPLC  COA
Batch S115604: H-NMR  HPLC  COA

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