Capecitabine

Catalog No.S1156
1 Reviews

Capecitabine is a tumor-selective fluoropyrimidine carbamate which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU.

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In DMSO USD 480 In stock
USD 97 In stock
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Capecitabine  Chemical Structure

Capecitabine Chemical Structure
Molecular Weight: 359.35

Validation & Quality Control

Customer Reviews(1)

Quality Control & MSDS

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Product Information

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Product Description

Biological Activity

Description Capecitabine is a tumor-selective fluoropyrimidine carbamate which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU.
Targets
IC50
In vitro Both LS174T WT and LS174T-c2 cells show significantly greater sensitivity to Capecitabine when cultivated in the same plates as HepG2 hepatoma with IC50 values of 890 and 630 μM in LS174T WT alone and cultivated with HepG2, respectively. In addition, for the LS174T-C2 subline, the IC50 falls from 330 ± 4 down to 89 ± 6 μm when cultivated in the same plates as hepatoma cells. Furthermore, Capecitabine induces apoptosis in a Fas-dependent manner, and shows a 7-fold higher cytotoxicity and markedly stronger apoptotic potential in thymidine phosphorylase (TP)-transfected LS174T-c2 cells. [1]
In vivo In the human cancer xenograft models studied, Capecitabine is more effective in a wider dose range and has a broader spectrum of antitumor activity than 5-FU, UFT or its intermediate metabolite 5'-DFUR, which can be correlated with tumor dThdPase levels. [2] Capecitabine inhibits tumor growth and metastatic recurrence after resection of human hepatocellular carcinoma (HCC) in highly metastatic nude mice model which is attributed to the high expression of platelet-derived endothelial cell growth factor in tumors. [3]
Features A tumor-selective fluoropyrimidine carbamate.

Protocol(Only for Reference)

Cell Assay: [1]

Cell lines HepG2, LS174T WT and LS174T-c2 cells
Concentrations ~1 mM
Incubation Time 72 hours
Method HepG2 and either LS174T WT or LS174T-c2 cells are seeded, respectively, in the top and bottom chambers of 8-well strip membranes in 96-well plates. The exponentially growing cells are exposed to increasing concentrations of capecitabine. The medium is supplemented with 750 ng/mL ZB4 MoAB or 100 ng/mL BR17 MoAB when the latter are used in the experiments. After 72 hours of continuous exposure, LS174T viability is assessed using the classic colorimetric MTT test.

Animal Study: [2]

Animal Models BALB/c nu/nu mice are inoculated s.c. with small pieces of CXF280 xenograft tissues
Dosages ≤1.5 mM/kg/day
Administration Administered via p.o.
Solubility 30% propylene glycol, 5% Tween 80, 65% D5W, 30 mg/mL
1

References

Chemical Information

Download Capecitabine SDF
Molecular Weight (MW) 359.35
Formula

C15H22FN3O6

CAS No. 154361-50-9
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Syonnyms Captabin
Solubility (25°C) * In vitro DMSO 72 mg/mL (200 mM)
Water 6 mg/mL (16 mM)
Ethanol 72 mg/mL (200 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W, 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name pentyl 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-methyl-tetrahydrofuran-2-yl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-ylcarbamate

Preparing Stock Solutions

Stock Solution (1ml DMSO) 1mM 10mM 20mM 30mM
Mass(mg) 0.35935 3.5935 7.187 10.7805

Research Area

Customer Reviews (1)


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Rating
Source Dr. Helen Sadik of Johns Hopkins University. Capecitabine purchased from Selleck
Method MTT assay
Cell Lines MCF7 cells, MCF10A cells
Concentrations 0.001-100 μM
Incubation Time 48 h
Results Capecitabine potently inhibited the survival of MCF10A cells and MCF7 cells in a dose-dependent manner.

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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