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Pemetrexed (Alimta) Chemical Structure
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Biological Activity
Pemetrexed (Alimta) is a thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide formyltransferase inhibitor with an IC50 of 25, 34, 220 nM for CCRF-CEM, GC3/cl1, HCT-8, respectively.Prevention of pemetrexed disodium (Alimta, Rolazar, Tifolar, MTA) growth inhibition by thymidine and/or hypoxanthine was investigated in two human lung (A549, COR L23) and two breast (MCF7, T47D) tumour cell lines, and the effect of the nucleoside/base transport inhibitor dipyridamole (DP) on thymidine and hypoxanthine rescue defined. MTA IC50 values (continuous exposure three population doublings) were 640, 28, 52 and 46 nM for A549, COR L23, MCF7, T47D. Thymidine (1 µM) completely prevented growth inhibition at the MTA IC50 in all cell lines. At 10×IC50, growth inhibition was only partially reversed by thymidine (≤10 µM); both thymidine and hypoxanthine (30 µM) being required for complete reversal, reflecting the multi-targeted nature of pemetrexed disodium (Alimta, Rolazar, Tifolar, MTA). [1][2][3]
Chemical Information
| Molecular Weight (WM): | 471.37 |
|---|---|
| Formula: | C20H19N5Na2O6 |
| CAS No.: | 150399-23-8 |
| Synonyms: |
LY-231514
|
| Dissolve in (25°C): | DMSO ≥22mg/mL |
| Water ≥22mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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