IDH-305

For research use only.

Catalog No.S3574

IDH-305 Chemical Structure

CAS No. 1628805-46-8

IDH-305 (Compound 13) is an orally available, mutant-selective and brain-penetrant inhibitor of isocitrate dehydrogenase 1 (IDH1) that targets IDH1(R132) mutation with IC50 of 27 nM, 28 nM and 6.14 μM for IDH1R132H, IDH1R132C and IDH1WT, respectively.

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Biological Activity

Description IDH-305 (Compound 13) is an orally available, mutant-selective and brain-penetrant inhibitor of isocitrate dehydrogenase 1 (IDH1) that targets IDH1(R132) mutation with IC50 of 27 nM, 28 nM and 6.14 μM for IDH1R132H, IDH1R132C and IDH1WT, respectively.
Targets
IDH1R132H [1]
(Cell-free assay)
IDH1R132C [1]
(Cell-free assay)
IDH1WT [1]
(Cell-free assay)
27 nM 28 nM 6.14 μM

Protocol

Solubility (25°C)

In vitro DMSO 98 mg/mL (199.81 mM)
Water Insoluble
Ethanol '98 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 490.45
Formula

C23H22F4N6O2

CAS No. 1628805-46-8
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02987010 Withdrawn Drug: IDH305 Glioma University of Texas Southwestern Medical Center January 2017 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID