Ribociclib succinate

For research use only.

Catalog No.S5188 Synonyms: LEE011 succinate, Kisqali

5 publications

Ribociclib succinate Chemical Structure

CAS No. 1374639-75-4

Ribociclib (LEE011) succinate (Kisqali) is a highly specific dual inhibitor of CDK4 and CDK6 with IC50 of 10 nM and 39 nM, respectively.

Selleck's Ribociclib succinate has been cited by 5 publications

Purity & Quality Control

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Biological Activity

Description Ribociclib (LEE011) succinate (Kisqali) is a highly specific dual inhibitor of CDK4 and CDK6 with IC50 of 10 nM and 39 nM, respectively.
Targets
CDK4 [1]
(Cell-free assay)
CDK6 [1]
(Cell-free assay)
10 nM 39 nM

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (180.95 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 552.63
Formula

C27H36N8O5

CAS No. 1374639-75-4
Storage powder
in solvent
Synonyms LEE011 succinate, Kisqali

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Step 2: Enter the in vivo formulation ()
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Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03056833 Active not recruiting Drug: ribociclib|Drug: Paclitaxel|Drug: Carboplatin Ovarian Cancer|Fallopian Tube Cancer|Peritoneal Carcinoma Ronald Buckanovich|University of Pittsburgh June 10 2017 Phase 1
NCT02934568 Recruiting Drug: LEE011 Continued Access to Study Treatment(s) Cancers With a Mass Bulky Tumor Nodule Lump Advanced Cancer Advanced Solid Tumors Advanced Solid Malignancies Novartis Pharmaceuticals|Novartis December 15 2016 Phase 2
NCT02734615 Active not recruiting Drug: LSZ102|Drug: LEE011|Drug: BYL719 Advanced or Metastatic ER+ Breast Cancer Novartis Pharmaceuticals|Novartis June 14 2016 Phase 1
NCT02431481 Completed Drug: LEE011 Normal Renal Function|Impaired Renal Function Novartis Pharmaceuticals|Novartis October 23 2015 Phase 1
NCT02422615 Active not recruiting Drug: Ribociclib|Drug: fulvestrant|Drug: Ribociclib placebo Advanced Breast Cancer Novartis Pharmaceuticals|Novartis June 9 2015 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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CDK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID