Eflornithine hydrochloride hydrate

For research use only.

Catalog No.S4582 Synonyms: Difluoromethylornithine hydrochloride hydrate

1 publication

Eflornithine hydrochloride hydrate Chemical Structure

CAS No. 96020-91-6

Eflornithine(Difluoromethylornithine) inhibits polyamine biosynthesis by the selective, irreversible inhibition of ornithine decarboxylase (ODC). A chemoprotective agent that blocks angiogenesis. Its biological half-life is 8 hours.

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Selleck's Eflornithine hydrochloride hydrate has been cited by 1 publication

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Biological Activity

Description Eflornithine(Difluoromethylornithine) inhibits polyamine biosynthesis by the selective, irreversible inhibition of ornithine decarboxylase (ODC). A chemoprotective agent that blocks angiogenesis. Its biological half-life is 8 hours.
Targets
Orn decarboxylase [2]
In vitro

When cultured cells are treated with α-difluoromethyl-Orn, an inhibitor of polyamine biosynthesis, production of hydrogen peroxide is suppressed and programmed cell death did not occur[1].

Protocol

Cell Research:

[1]

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  • Cell lines: BY2 cell
  • Concentrations: 2 mM
  • Incubation Time: 48 h
  • Method:

    BY2 cells are treated with or without cryptogein in the presence or absence of DFMO(Difluoromethylornithine) and monitered the effect of chemicals on cell growth.


    (Only for Reference)

Solubility (25°C)

In vitro Water 47 mg/mL (198.61 mM)
DMSO Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 236.64
Formula

C6H12F2N2O2.HCl.H2O

CAS No. 96020-91-6
Storage powder
in solvent
Synonyms Difluoromethylornithine hydrochloride hydrate
Smiles C(CC(C(F)F)(C(=O)O)N)CN.O.Cl

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID