For research use only.
CAS No. 1448347-49-6
Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity.
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(C) MGC-803 cells were treated with the control (DMEM culture), 1% alcohol (DMEM culture medium with 1% alcohol) and AG-120 (40, 60, 80 and 100 µM) for 24, 48 or 72 h.
Oncol Rep, 2017, 38(6):3583-3591. Ivosidenib (AG-120) purchased from Selleck.
MGC-803 cells were treated with the control (DMEM culture), 1% alcohol (DMEM culture medium with 1% alcohol) and AG-120 (40, 60, 80 and 100 μM) for 24, 48 or 72 h. The MTT assay was performed to determine cell viability and values are expressed as the mean ± SD of three separate experiments. *p<0.05 vs. control.
ONCOLOGY REPORTS, 2017, 38: 3583-3591. Ivosidenib (AG-120) purchased from Selleck.
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|Description||Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity.|
TF-1 cells or primary human AML patient samples expressing mutant IDH1 are treated with AG-120.Treatment with AG-120 decreases intracellular 2-HG levels, inhibites growth factor independent proliferation and restores erythropoietin (EPO)-induced differentiation in TF-1 IDH1-R132H cells. Similarly, pharmacological inhibition of mutant IDH1 enzyme with AG-120 in primary human blast cells cultured ex vivo provides an effective way to lower intracellular 2-HG levels and induces myeloid differentiation.
|In vitro||DMSO||100 mg/mL (171.53 mM)|
|Ethanol||100 mg/mL (171.53 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04195555||Recruiting||Drug: Ivosidenib||Recurrent Ependymoma|Recurrent Ewing Sarcoma|Recurrent Hepatoblastoma|Recurrent Langerhans Cell Histiocytosis|Recurrent Malignant Germ Cell Tumor|Recurrent Malignant Glioma|Recurrent Malignant Solid Neoplasm|Recurrent Medulloblastoma|Recurrent Neuroblastoma|Recurrent Non-Hodgkin Lymphoma|Recurrent Osteosarcoma|Recurrent Peripheral Primitive Neuroectodermal Tumor|Recurrent Rhabdoid Tumor|Recurrent Rhabdomyosarcoma|Recurrent Soft Tissue Sarcoma|Recurrent WHO Grade II Glioma|Refractory Ependymoma|Refractory Ewing Sarcoma|Refractory Hepatoblastoma|Refractory Langerhans Cell Histiocytosis|Refractory Malignant Germ Cell Tumor|Refractory Malignant Glioma|Refractory Malignant Solid Neoplasm|Refractory Medulloblastoma|Refractory Neuroblastoma|Refractory Non-Hodgkin Lymphoma|Refractory Osteosarcoma|Refractory Peripheral Primitive Neuroectodermal Tumor|Refractory Rhabdoid Tumor|Refractory Rhabdomyosarcoma|Refractory Soft Tissue Sarcoma|Refractory WHO Grade II Glioma|Wilms Tumor||National Cancer Institute (NCI)||June 8 2020||Phase 2|
|NCT03564821||Recruiting||Drug: Ivosidenib||IDH1 Mutation Myeloid Neoplasms||Massachusetts General Hospital|Agios Pharmaceuticals Inc.||January 16 2019||Phase 1|
|NCT03343197||Active not recruiting||Drug: AG-120|Drug: AG881||Glioma||Agios Pharmaceuticals Inc.||March 20 2018||Phase 1|
|NCT02831972||Completed||Drug: AG120|Drug: Itraconazole||Healthy||Agios Pharmaceuticals Inc.||June 2016||Phase 1|
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