Molecular Weight(MW): 582.96
Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity.
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(C) MGC-803 cells were treated with the control (DMEM culture), 1% alcohol (DMEM culture medium with 1% alcohol) and AG-120 (40, 60, 80 and 100 µM) for 24, 48 or 72 h.
Oncol Rep, 2017, 38(6):3583-3591. Ivosidenib (AG-120) purchased from Selleck.
MGC-803 cells were treated with the control (DMEM culture), 1% alcohol (DMEM culture medium with 1% alcohol) and AG-120 (40, 60, 80 and 100 μM) for 24, 48 or 72 h. The MTT assay was performed to determine cell viability and values are expressed as the mean ± SD of three separate experiments. *p<0.05 vs. control.
ONCOLOGY REPORTS, 2017, 38: 3583-3591. Ivosidenib (AG-120) purchased from Selleck.
Purity & Quality Control
Choose Selective Dehydrogenase Inhibitors
|Description||Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity.|
TF-1 cells or primary human AML patient samples expressing mutant IDH1 are treated with AG-120.Treatment with AG-120 decreases intracellular 2-HG levels, inhibites growth factor independent proliferation and restores erythropoietin (EPO)-induced differentiation in TF-1 IDH1-R132H cells. Similarly, pharmacological inhibition of mutant IDH1 enzyme with AG-120 in primary human blast cells cultured ex vivo provides an effective way to lower intracellular 2-HG levels and induces myeloid differentiation.
|In vitro||DMSO||100 mg/mL (171.53 mM)|
|Ethanol||100 mg/mL (171.53 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2
Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03564821||Recruiting||Drug: Ivosidenib||IDH1 Mutation Myeloid Neoplasms||Massachusetts General Hospital|Agios Pharmaceuticals Inc.||January 16 2019||Phase 1|
|NCT03343197||Active not recruiting||Drug: AG-120|Drug: AG881||Glioma||Agios Pharmaceuticals Inc.||March 20 2018||Phase 1|
|NCT02831972||Completed||Drug: AG120|Drug: Itraconazole||Healthy||Agios Pharmaceuticals Inc.||June 2016||Phase 1|
|NCT02489513||Completed||Drug: [14C]-AG-120||Healthy Volunteers||Agios Pharmaceuticals Inc.||June 2015||Phase 1|
|NCT02074839||Active not recruiting||Drug: AG-120||Relapsed or Refractory Acute Myeloid Leukemia (AML)|Untreated AML|Other IDH1-mutated Positive Hematologic Malignancies||Agios Pharmaceuticals Inc.||March 2014||Phase 1|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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