Home Metabolism P450 (e.g. CYP17)

P450 (e.g. CYP17) Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S2394 Naringenin Naringenin (NSC 34875, S-Dihydrogenistein, NSC 11855, Salipurol) is a natural predominant flavanone derived from plant food, which is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator.
Molecules, June 23, 2023, 4947
Theranostics, February 18, 2026, 4804-4820
Theranostics, 2026, 4804-4820
Verified customer review of Naringenin
S2900 Cobicistat Cobicistat is a potent and selective inhibitor of CYP3A with IC50 of 30-285 nM.
Anticancer Research, December 2021, 5987-5996
Antimicrobial Agents and Chemotherapy, April 24, 2017, e01776-16
iScience, 2024, 27(10):110862
Verified customer review of Cobicistat
S1952 Methoxsalen Methoxsalen (Xanthotoxin, NCI-C55903) is a naturally occurring photoactive substance found in the seeds of the Ammi majus (Umbelliferae) plant, used in the diagnosis and treatment of psoriasis; this compound is a CYP2A5/6 inhibitor.
Communications Medicine, October 2025, 1136
J Pers Med, 2022, 12(2)258
Hum Cell, 2022, 10.1007/s13577-022-00671-y
S2555 Clarithromycin Clarithromycin (A-56268) is a macrolide antibiotic and a CYP3A4 inhibitor, used to treat a number of bacterial infections.
Circulation, 2024, 150(7):563-576
Microorganisms, 2022, 10(7)1421
Cell Biol Toxicol, 2021, 10.1007/s10565-021-09646-5
S2526 Alizarin Alizarin is a red coloring mordant dye extracted from the roots of madder plants (Rubia tinctorum L). This compound strongly inhibits P450 isoform CYP1A1, CYP1A2, and CYP1B1 with IC50 of 6.2 μM, 10.0 μM, and 2.7 μM, respectively in an enzymatic assay. There are also literature reports this chemical increases the CYP1A1 enzymatic activity and acts as an agonist to the AHR receptor in HepG2 cells.
Journal of Enzyme Inhibition and Medicinal Chemistry, 2025, 2579675
Journal of Enzyme Inhibition and Medicinal Chemistry, 2025, 2579675
Chem Res Toxicol, 2023, 36(8):1361-1373
S2380 Diosmetin Diosmetin (Luteolin 4-methyl ether) is a bioflavonoid found in spearmint, oregano, and many other plants.
Life Sciences, 2023, 122060
Research Square, 2023, Version 1
Mol Med Rep, 2020, 22(2):1335-1341
S5266 Stiripentol (BCX 2600) Stiripentol (BCX2600) is a third-generation anti-epileptic drug that enhances GABAergic neurotransmission. It is an inhibitor of cytochrome P450.
Haematologica, 2025, Online ahead of print
Chinese Medicine, 2025, 122
Chin Med, 2025, 20(1):122
S5416 Metyrapone Metyrapone (NSC-25265, SU-4885) is an inhibitor of the enzyme steroid 11-beta-monooxygenase (CYP11B1) that inhibits adrenal steroid synthesis.
Investigative Ophthalmology & Visual Science, 2026, 15
Investigative Ophthalmology & Visual Science, 2025, 53
Investigative Ophthalmology & Visual Science, 2025, 50
S1195 Orteronel Orteronel(TAK-700) is a potent and highly selective human 17,20-lyase inhibitor with IC50 of 38 nM, exhibits >1000-fold selectivity over other CYPs (e.g. 11-hydroxylase and CYP3A4). This compound is an androgen biosynthesis inhibitor. Phase 3.
Toxicol Appl Pharmacol, 2023, 475:116638
Drug Metab Dispos, 2017, 45(6):635-645
Biochem Biophys Res Commun, 2016, 477(4):1005-10
S2401 Sodium Danshensu Sodium Danshensu is a mono sodium of danshensu, which is a natural phenolic acid of caffeic acid derivatives isolated from Salvia miltiorrhiza.
Molecules, 2023, 28(4)1551
Front Pharmacol, 2022, 13:946668
J Med Virol, 2019, 91(8):1440-1447
S3673 Sulfaphenazole Sulfaphenazole (Depocid, Depotsulfonamide, Plisulfan, Raziosulfa) is an inhibitor of CYP2C9 with Ki value of 0.3 μM and demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki values of 63 and 29 μM for CYP2C8 and CYP2C18, respectively, and no activity at CYP1A1, CYP1A2, CYP3A4, CYP2C19).
UNIVERSITY OF APPLIED SCIENCES, 2023,
Chem Biol Interact, 2022, 353:109801
Chem Biol Interact, 2022, 365:110070
S2329 Naringin Naringin (Naringoside) is a flavanone glycoside, which exerts a variety of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer activity, and inhibition of cytochrome P450 enzymes.
Ecotoxicol Environ Saf, 2025, 302:118542
American Journal of Translational Research, 2021, 6330-6341
Am J Transl Res, 2021, 6330-6341
S4221 Benzbromarone Benzbromarone(Desuric) is a CYP2C9 inhibitor, it binds to CYP2C9 with Ki value of 19.3 nM.
Commun Biol, 2025, 8(1):1403
J Immunother Cancer, 2024, 12(11)e009805
Hum Mol Genet, 2020, ddaa244
S9250 Isosilybin Isosilybin (Silymarin, Isosilybinin, Q-100795) is a flavanolignan found in the extract of S. marianum fruits with antioxidant and anticancer activities. This compound inhibits CYP3A4 induction with an IC50 of 74 μM.
International Journal of Molecular Sciences, May 29, 2023, 9424
Viruses, August 15, 2023, 1739
S4741 Danshensu Danshensu (Salvianic acid A), a herbal preparation used in traditional Chinese medicine, possesses potential antitumor and anti‑angiogenesis effects. This compound inhibits CYP2E1 and CYP2C9 with IC50 of 36.63 and 75.76 μm, respectively.
Stem Cell Res Ther, 2025, 16(1):40
J Immunother Cancer, 2024, 12(11)e009805
S3833 Amentoflavone Amentoflavone (Didemethyl Ginkgetin) is a biflavonoid originally isolated from Selaginella with antibacterial, antioxidant, antiviral, antidiabetic, and neuroprotective activities.
Front Plant Sci, 2021, 12:740923
Viruses, 2019, 11(5)E466
S3777 Gentiopicroside Gentiopicroside (GE, Gentiopicrin), a naturally occurring iridoid glycoside, inhibits CYP2A6 and CYP2E1 with IC50 values of 21.8μg/ml and 594μg/ml, respectively in human liver microsomes, and this compound does not inhibit CYP2C9, CYP2D6, CYP1A2 or CYP3A4 activities.
International Journal of Molecular Sciences, May 29, 2023, 9424
European Journal of Medical Research, January 11, 2024, 47
BMC Cancer, 2023, 731
S3766 Tanshinone IIA sulfonate sodium Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of tanshinone IIA isolated as the main pharmacologically active natural compound from a traditional Chinese herbal medicine, the dried root of Salvia miltiorrhiza Bunge known as Danshen. Sodium tanshinone IIA sulfonate (STS) is a potent negative allosteric modulator of the human purinergic receptor P2X7. Sodium tanshinone IIA sulfonate (STS) inhibits the activity of CYP3A4 and store-operated Ca2+ entry (SOCE) through store-operated Ca2+ channels (SOCC) via downregulating the expression of transient receptor potential canonical proteins (TRPC).
Journal of Inflammation Research, 2022, 6293-6306
J Inflamm Res, 2022, 15:6293-6306
Molecular Medicine Reports, 2017, 1612-1618
S3917 Tetrahydrocurcumin Tetrahydrocurcumin (Tetrahydrodiferuloylmethane, Tetrahydro Curcumin), a major metabolite of curcumin, possesses strong antioxidant and cardioprotective properties. This compound is a Curcuminoid found in turmeric (Curcuma longa) that is produced by the reduction of Curcumin. It inhibits CYP2C9 and CYP3A4.
J Gerontol A Biol Sci Med Sci, 2022, 77-8:1485-1493
Investigative Ophthalmology & Visual Science, 2022, 26
Invest Ophthalmol Vis Sci, 2022, 63(6):26
S3660 Uniconazole (S 3307D) Uniconazole (S 3307D, XE 1019D) is a well known inhibitor of cytochrome P450 monooxygenase that prevents the biosynthesis of trans-zeatin. It targets CYP735As with Ki of 22 μM.
Nat Microbiol, 2022, 10.1038/s41564-022-01072-5
Nat Biotechnol, 2021, 10.1038/s41587-021-00860-4
S2344 Piperine Piperine (1-Piperoylpiperidine) is the alkaloid responsible for the pungency of black pepper and long pepper, which has also been used in some forms of traditional medicine and as an insecticide.
iScience, 2024, 27(10):110862
Int J Mol Med, 2015, 36(5):1369-76
International Journal of Molecular Medicine, 2015, 1369-1376
Verified customer review of Piperine
S2571 Quinidine Quinidine is a pharmaceutical agent that acts as a class I antiarrhythmic agent.
Anticancer Research, December 2021, 6179-6190
Journal of Biomedical Research, 2021, 395-407
S6594 Liarozole dihydrochloride Liarozole Dihydrochloride is identified as a modest inhibitor of P450 with IC50 of 2.2–6.0 μM and 260 nM for CYP26 and rat CYP17 respectively.
Journal of Cancer, 2025, 2476-2491
bioRxiv, 2023, 10.1101/2023.05.23.542015
S1739 Thiabendazole Thiabendazole inhibits the mitochondrial helminth-specific enzyme, fumarate reductase, with anthelminthic property, used as an anthelmintic and fungicide agent. It is a potent inhibitor of cytochrome P450 1A2 (CYP1A2).
bioRxiv, 2023, 2023.07.12.548707
S0721 Ticlopidine Ticlopidine (Yuclid, Ticlopidinum, Ticlopidina,PCR 5332) is an orally active inhibitor of platelet aggregation induced by adenosine diphosphate (ADP). This compound is also an inhibitor of CYP2B6 with Ki of 0.2 μM.
Nature, 2026, 423-431
Nature, 2025, 10.1038/s41586-025-09755-9
S6790 Ellipticine hydrochloride Ellipticine Hydrochloride (NSC 71795, PZE) is a potent inhibitor of DNA topoisomerase II and forms covalent DNA adducts mediated by its oxidation with cytochromes P450 (CYP) and peroxidases. Ellipticine Hydrochloride is a natural product isolated from the Australian evergreen tree of the Apocynaceae family with antineoplastic activity.
Viruses, 2022, 15(1)105
Viruses, 2022, 105
S9442 Bergaptol Bergaptol (5-Hydroxypsoralen, 5-Hydroxyfuranocoumarin) is a natural furanocoumarin found in the essential oils of citrus including lemon and bergamot. This compound is a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 μM.
Molecules, 2024, 29(3)713
S5380 7-Hydroxyflavone 7-Hydroxyflavone is a potent inhibitor of CYP1A1 with a Ki value of 0.015 μM and exhibits 6-fold greater selectivity for CYP1A1 over CYP1A2. It also has excellent antioxidant properties and great potential to be applied as medicines.
International Journal of Molecular Sciences, May 29, 2023, 9424
S0230 NVP-VID-400 NVP-VID-400 (SDZ285428) is an inhibitor of CYP51. This compound inhibits T. cruzi and T. brucei with I/E2a(5 min) of both <1 and I/E2(60 min) of 9 and 35, respectively.
Research Square, November 2021, nan
S2067 Ozagrel HCl Ozagrel HCl (OKY-046) is a selective thromboxane A(2) (TXA(2)) synthetase inhibitor with IC50 of 11 nM for rabbit platelet, used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral ischaemia.
S4155 Chlorzoxazone Chlorzoxazone(Chlorzoxazon,Paraflex) is a muscle-relaxing drug, and this compound is a probe for human liver cytochrome P-450IIE1.
E1816 Lorundrostat Lorundrostat (MT-4129) is a highly selective inhibitor of CYP11B2 (aldosterone synthase), with inhibition constant (Ki) values of 1.27 nM for hCYP11B2 and 475 nM for hCYP11B1. It demonstrates potential as a safe and effective treatment for aldosterone-dependent uncontrolled hypertension, including cases of treatment-resistant hypertension.
S5169 2,6-Dihydroxyanthraquinone 2,6-Dihydroxyanthraquinone (Anthraflavic acid, Anthraflavin) is a potent and specific inhibitor of cytochrome P-448 activity.
S0922 Salvianolic acid C Salvianolic acid C is a non-competitive Cytochrome P4502C8 (CYP2C8) inhibitor and a moderate mixed inhibitor of Cytochrome P45022J2 (CYP2J2).
S2921 PF-4981517 PF-4981517 (CYP3cide, PF-04981517) is a potent and selective inhibitor of CYP3A4 (P450) with IC50 of 0.03 μM, and this compound exhibits >500-fold selectivity over CYP3A5 and CYP3A7.
S5252 Ozagrel sodium Ozagrel sodium (KCT-0809, Cataclot, Xanbo) is a thromboxane A2 synthase (CYP5) inhibitor with neuroprotective properties.
E1650 Opevesostat (ODM208) Opevesostat (ODM208) is the first-in-class, selective, nonsteroidal, oral CYP11A1 inhibitor. It exhibits a rapid, complete, durable, and reversible inhibition of the steroid hormone biosynthesis in an adrenocortical carcinoma cell model in vitro, in adult noncastrated male mice and dogs, and in patients with CRPC.
S0541 Dazoxiben hydrochloride Dazoxiben hydrochloride (HCl) is a potent, selevtive and orally active inhibitor of thromboxane (TX) synthase. Dazoxiben inhibits TXB2 production in clotting human whole blood with IC50 of 0.3 μM and causes parallel enhancement of PGE2 production.
S6606 CDD3505 CDD3505 is used for elevating high density lipoprotein cholesterol (HDL) by inducing hepatic cytochrome P450IIIA (CYP3A) activity.
S9257 Acetylshikonin Acetylshikonin is a biologically active compound with anti-cancer and anti-inflammatory activity, which is isolated from the roots of Lithospermum erythrorhizoma. It is a novel general P450 inhibitor with IC50 values of 1.4-4.0 μM for all tested P450s.
Journal of Orthopaedic Research, 2024, 172-182
E0214 Pachymic acid Pachymic acid(3-O-Acetyltumulosic acid) inhibits the activity of CYP2C9 with the IC50 of 21.25 µM.
S4938 Cedrol Cedrol, a natural occuring sesquiterpene alcohol, is a potent competitive inhibitor of CYP2B6-mediated bupropion hydroxylase with inhibition constant (Ki) value of 0.9 μM. It also inhibits CYP3A4-mediated midazolam hydroxylation with a Ki value of 3.4 μM while this compound only weakly inhibits CYP2C8, CYP2C9, and CYP2C19 activities.
S2389 Naringin Dihydrochalcone Naringin Dihydrochalcone(Naringin DC) is a new-style sweetening agent and an artificial sweetener derived from naringin and also an inhibitor of CYP enzymes.
Charles University, 2021,
E4855 Sertaconazole Sertaconazole (FI-7045) is an imidazole-type antifungal agent that inhibits ergosterol biosynthesis by inhibiting the cytochrome P450-dependent 14α-lanosterol demethylase or Erg11p. This inhibition disrupts fungal cell membrane integrity, ultimately leading to fungal cell death. This compound is used in the topical treatment of superficial mycoses.
E6401New Vicadrostat Vicadrostat (compound 29 A) is a potent and selective inhibitor of aldosterone synthase(CYP11B2) with an IC50 of 16 nM. It exhibits potential in renal disease, diabetic nephropathy, cardiovascular diseases and fibrotic disorder research.
S9299 Ginsenoside F1 Ginsenoside F1, a pharmaceutical component of ginseng, is known to have antiaging, antioxidant, anticancer, and keratinocyte protective effects. This compound exhibits competitive inhibition of the activity of CYP3A4 with Ki values of 67.8 ± 16.2 μM. It also exhibited a weaker inhibition of the activity of CYP2D6.
S4963 Purpurin Purpurin (1,2,4-Trihydroxyanthraquinone, Hydroxylizaric acid, Verantin) is one of the natural colorants extracted from madder roots and other Rubiaceae family plants. It exhibits anti-angiogenic, antifungal, antibiotic, and antioxidative activities. This compound strongly inhibits the activities of CYP1A1, CYP1A2 and CYP1B1.
E0531 TMS TMS ((E)-2,3',4,5'-tetramethoxystilbene) is a selective and competitive human cytochrome P450s B1 (CYP1B1) inhibitor with an IC50 of 6 nM.
S5969 Dicloxacillin Sodium hydrate Dicloxacillin Sodium hydrate (DLX, Dycill, Dynapen, Pathocil), a narrow-spectrum β-Lactam antibiotic of the penicillin class, induces drug-metabolizing CYP enzymes to a clinically relevant extent.
S4831 Piperonyl butoxide Piperonyl butoxide (PBO, Butacide, Ethanol butoxide, Pyrenone 606,ENT-14250) is a man-made pesticide synergist, working with insect killers to increase their effectiveness.This compound is an inhibitor of cytochrome P450 monooxygenases(P450s).
E1830 Baxdrostat Baxdrostat(CIN-107) is a selective and potent inhibitor of aldosterone synthase(CYP11B2), a rate-limiting enzyme in the pathway of aldosterone synthesis, with the potential to treat resistant hypertension. It also inhibits the function of multidrug and toxin extrusion 1 (MATE1) and MATE2-K with IC50 values of 1.34 µM and 2.67 µM, respectively.
E2912 MEHP MEHP (Phthalic acid mono-2-ethylexyl ester) is a competitive inhibitor of CYP2C9 with IC50 of 6.37 μM.
S0175 DMU2105 DMU2105 is a potent and specific inhibitor of CYP1B1 with IC50 of 10 nM.
S0176 DMU2139 DMU2139 is a potent and specific inhibitor of CYP1B1 with IC50 of 9 nM.
S0418 Ezutromid Ezutromid (SMT C1100,BMN 195,VOX-C1100) is a first-in-class, orally active benzoxazole utrophin modulator with an EC50 of 0.91 μM which can be used for the research Duchenne muscular dystrophy (DMD), also inhibits CYP1A2 enzymic activity in human liver microsomes (HLM) with an IC50 of 5.4 μM.
S3719 Topiroxostat Topiroxostat is a xanthine oxidoreductase (XOR) inhibitor and used for treatment of gout and hyperuricemia. This compound exhibits weak CYP3A4-inhibitory activity (18.6%). It has the potential for hyperuricemia treatment.
S6886 1-Aminobenzotriazole 1-Aminobenzotriazole (ABT, 3-Aminobenzotriazole, 1-Benzotriazolylamine, NSC 114498, NSC 656987) is a nonselective and irreversible inhibitor of cytochrome P450 (CYP) enzymes. This compound is also a substrate and inhibitor of N-acetyltransferase (NAT).
S5529 Galangin Galangin (3,5,7-trihydroxyflavone; Norizalpinin), a naturally occuring flavonoid found in herbs, is a well-known antioxidant and also an inhibitor of CYP1A1 activity and an agonist/antagonist of the aryl hydrocarbon receptor.
S4784 Phloracetophenone Phloracetophenone, or 2,4,6-trihydroxyacetophenone (THA), the aglycone component of phloracetophenone glucoside, is a naturally occurring compound obtained from the rhizome of Curcuma comosa (Family Zingiberaceae). This compound can stimulate CYP7A1 activity. It induces cholestasis in rats mediated through Mrp2.
S9241 Polygalaxanthone III Polygalaxanthone III is a natural product with the efficacy of tranquilization, glaangal, eliminating sputum and detumescence. This compound inhibits chlorzoxazone 6-hydroxylation catalyzed by CYP2E1 with an IC50 of 50.56 μM.
S9163 Rhapontigenin Rhapontigenin (Protigenin), produced from rhapontin isolated from a methanol extract of Rheum undulatum roots by enzymatic transformation, is a selective inactivator of cytochrome P450 1A1 (IC50 = 400 nM).
S3227 5,7-Dimethoxyflavone 5,7-Dimethoxyflavone (5,7-DMF) is an inhibitor of cytochrome P450 (CYP) 3As that markedly decreases the expression of CYP3A11 and CYP3A25 in the liver. This compound is also a potent Breast Cancer Resistance Protein (BCRP, ABCG2) inhibitor. It is one of the major components of Kaempferia parviflora with anti-obesity, anti-inflammatory, and antineoplastic effects.
S6437 Oxolamine Citrate Oxolamine (SKF-9976, AF-438) citrate, a cough suppressant, is an inhibitor of CYP2B1/2. Oxolamine citrate also exhibits anti-inflammatory effect.
S1185 Ritonavir Ritonavir is a Cytochrome P450 3A and Protease Inhibitor; Also inhibits Cytochrome P450 2D6, P-Glycoprotein and induces Cytochrome P450 2C19, Cytochrome P450 1A2, Cytochrome P450 2C9, Cytochrome P450 2B6 and UDP Glucuronosyltransferases. This compound induces apoptosis.
Nature, 2025, 10.1038/s41586-025-09755-9
Vet Parasitol, 2025, 337:110471
Cell Chem Biol, 2024, S2451-9456(24)00396-9
Verified customer review of Ritonavir
S2476 Itraconazole Itraconazole is a relatively potent inhibitor of CYP3A4 with IC50 of 6.1 nM, used as a triazole antifungal agent. This compound is a potent antagonist of the Hedgehog (Hh) signaling pathway. It also suppresses the growth of glioblastoma through induction of autophagy.
Cell Rep Med, 2025, S2666-3791(25)00272-1
Infect Drug Resist, 2025, 18:783-789
Toxicol Appl Pharmacol, 2025, 502:117404
Verified customer review of Itraconazole
S4202 Verapamil HCl Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent. Verapamil inhibits both permeability-glycoprotein (P-gp) and CYP3A4.
Cancer Cell, 2025, 43(4):776-796.e14
Nat Commun, 2025, 16(1):7115
Blood Sci, 2025, 7(2):e00236
Verified customer review of Verapamil HCl
S2187 Avasimibe (CI-1011) Avasimibe inhibits ACAT with IC50 of 3.3 μM, also inhibits human P450 isoenzymes CYP2C9, CYP1A2 and CYP2C19 with IC50 of 2.9 μM, 13.9 μM and 26.5 μM, respectively.
J Lipid Res, 2025, 66(8):100854
Hepatol Commun, 2025, 9(6)e0714
Nat Commun, 2024, 15(1):8301
Verified customer review of Avasimibe (CI-1011)
S1794 Fenofibrate Fenofibrate is a compound of the fibrate class and fibric acid derivative. This compound is a selective agonist of PPARα with EC50 of 30 μM. It binds to and inhibits cytochrome P450 epoxygenase (CYP)2C with IC50 of 0.2 μM, 0.7 μM and 9.7 μM for CYP2C19, CYP2B6 and CYP2C9, respectively. This chemical induces autophagy.
J Cell Mol Med, 2025, 29(7):e70524
J Immunother Cancer, 2024, 12(11)e009805
Heliyon, 2024, 10(11):e31861
Verified customer review of Fenofibrate
S4662 Atazanavir Atazanavir (Latazanavir, Zrivada, Reyataz, BMS-232632) is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents. This compound is a substrate and inhibitor of cytochrome P450 isozyme 3A (CYP3A4) and an inhibitor and inducer of P-glycoprotein.
Anticancer Research, July 15, 2019, 3757-3765
Journal of Virology, April 17, 2019, e00077-19
Int J Mol Sci, 2022, 23(23)15380
S2271 Berberine chloride Berberine chloride is a quaternary ammonium salt from the group of isoquinoline alkaloids. This compound activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. It decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. This chemical induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. It is a dual topoisomerase I and II inhibitor. It is also a potential autophagy modulator.
J Cardiovasc Dev Dis, 2025, 12(7)278
Adv Healthc Mater, 2023, e2300591.
Transl Oncol, 2023, 35:101712
S2803 Galeterone Galeterone (TOK-001) is a selective CYP17 inhibitor and androgen receptor (AR) antagonist with IC50 of 300 nM and 384 nM, respectively, and is a potent inhibitor of human prostate tumor growth. Phase 2.
ChemMedChem, 2022, 17(9):e202200043
ChemMedChem, 2022, e202200043
Cancer Chemother Pharmacol, 2020, 10.1007/s00280-020-04195-w
Verified customer review of Galeterone
S3931 Ginsenoside Rd Ginsenoside Rd (Panaxoside Rd, Sanchinoside Rd), a minor ginseng saponin, has several pharmacological activities such as immunosuppressive activity, anti-inflammatory activity, immunological adjuvant, anti-cancer activity and wound-healing activity. This compound inhibits TNFα-induced NF-κB transcriptional activity with an IC50 of 12.05±0.82 μM in HepG2 cells. It inhibits expression of COX-2 and iNOS mRNA. This chemical also inhibits Ca2+ influx. It inhibits CYP2D6, CYP1A2, CYP3A4, and CYP2C9, with IC50s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively.
British Journal of Pharmacology, 2024 Dec, 4822-4844
The American Journal of Chinese Medicine, 2023, 91-105
Journal of Ginseng Research, 2022 Sep, 700-709
S5658 Omeprazole Sodium Omeprazole Sodium is the sodium salt form of omeprazole, which is a proton pump inhibitor and suppresses gastric acid secretion. This compound is a metabolism-dependent inhibitor (MDI) of CYP2C19.
Theranostics, 2021, 11(5):2364-2380
J Virol, 2021, JVI.00190-21
Biosci Rep, 2021, BSR20200842
S6868 Furmonertinib Mesylate (AST2818, Alflutinib) Alflutinib (Furmonertinib) mesylate is a third-generation epidermal growth factor receptor (EGFR) inhibitor that inhibits both EGFR-sensitive mutations and T790M mutations. Alflutinib (AST2818), primarily metabolized by CYP3A4, is also a potent CYP3A4 inducer with EC50 of 0.25 μM.
Cells, 2025, 14(17)1386
Biomedicines, 2024, 12(7)1412
Int J Mol Sci, 2023, 24(18)13972
S3874 Curcumenol Curcumenol, a sesquiterpene isolated from Curcuma zedoaria, is known to possess a variety of health and medicinal values which includes neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities. It inhibits NF-κB activation by suppressing the nuclear translocation of the NF-κB p65 subunit and blocking IκBα phosphorylation and degradation.
Frontiers in Pharmacology, 2022, 905966
Front Pharmacol, 2022, 13:905966
J Bone Miner Res, 2021, 10.1002/jbmr.4328
S5967 Berberine chloride hydrate Berberine (Natural Yellow 18) chloride hydrate is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.
Front Biosci (Landmark Ed), 2022, 27(8):242
Front Pharmacol, 2021, 12:632201
S3273 Hypericin Hypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. This compound has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450).
Eur J Pharmacol, 2021, 900:174071
S2496 Ozagrel Ozagrel (OKY-046) is a selective thromboxane A(2) (TXA(2)) synthetase inhibitor with IC50 of 11 nM for rabbit platelet, used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral ischaemia.
S3291 Myristicin Myristicin (Myristicine), a terpene-like active component in Nutmeg which is the seed of Myristica fragrans, is a weak inhibitor of monamine oxidase (MAO) and a mechanism-based inhibitor of CYP1A2.
S0110 APD597 APD-597 (JNJ-38431055) is a potent and selective G protein-coupled receptor 119 (GPR119) agonist with EC50 of 46 nM for hGPR119 and an inhibitor of Cytochrome P450 2C9 (CYP2C9) with IC50 of 5.8 μM. APD-597 (JNJ-38431055) is developed for treating Type 2 diabetes (T2D).