| S1442 |
Voriconazole
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Voriconazole is a new triazole derivative similar to fluconazole and itraconazole that acts by inhibiting fungal cytochrome P-450-dependent, 14-alpha-sterol demethylase-mediated synthesis of ergosterol.
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J Adv Res, 2025, S2090-1232(25)00065-7
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PLoS Pathog, 2025, 21(5):e1013220
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mSphere, 2025, 10(1):e0070324
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| S4741 |
Danshensu
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Danshensu (Salvianic acid A), a herbal preparation used in traditional Chinese medicine, possesses potential antitumor and anti‑angiogenesis effects. This compound inhibits CYP2E1 and CYP2C9 with IC50 of 36.63 and 75.76 μm, respectively.
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Stem Cell Res Ther, 2025, 16(1):40
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J Immunother Cancer, 2024, 12(11)e009805
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| S3833 |
Amentoflavone
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Amentoflavone (Didemethyl Ginkgetin) is a biflavonoid originally isolated from Selaginella with antibacterial, antioxidant, antiviral, antidiabetic, and neuroprotective activities.
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Front Plant Sci, 2021, 12:740923
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Viruses, 2019, 11(5)E466
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| S6790 |
Ellipticine hydrochloride
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Ellipticine Hydrochloride (NSC 71795, PZE) is a potent inhibitor of DNA topoisomerase II and forms covalent DNA adducts mediated by its oxidation with cytochromes P450 (CYP) and peroxidases. Ellipticine Hydrochloride is a natural product isolated from the Australian evergreen tree of the Apocynaceae family with antineoplastic activity.
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Viruses, 2022, 15(1)105
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| S4155 |
Chlorzoxazone
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Chlorzoxazone(Chlorzoxazon,Paraflex) is a muscle-relaxing drug, and this compound is a probe for human liver cytochrome P-450IIE1.
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