Calcium Channel Inhibitors

Cat.No.	Product Name	Information	Product Use Citations
S4202	Verapamil HCl	Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent. Verapamil inhibits both permeability-glycoprotein (P-gp) and CYP3A4.	Cancer Cell, 2025, 43(4):776-796.e14 Nat Commun, 2025, 16(1):7115 Blood Sci, 2025, 7(2):e00236
S2403	Tetrandrine	Tetrandrine, a bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, is a calcium channel blocker.	PLoS Pathog, 2025, 21(8):e1013342 Pharmacol Res, 2024, 207:107314 mBio, 2024, e0228723.
S1905	Amlodipine	Amlodipine (UK-48340) is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.	J Immunother Cancer, 2024, 12(11)e009805 Cancer Medicine, 2024, e7291 Cancer Med, 2024, 13(11):e7291
S1808	Nifedipine	Nifedipine is a dihydropyridine calcium channel blocker, used to lower hypertension and to treat angina.	Dis Model Mech, 2025, 18(6)dmm052220 J Immunother Cancer, 2024, 12(11)e009805 Laryngoscope Investig Otolaryngol, 2023, 8(5):1390-1400
S1293	Cilnidipine	Cilnidipine is a unique L-type and N-type calcium channel blocker, used for high blood pressure treatment.	J Immunother Cancer, 2024, 12(11)e009805 Antioxidants, 2024, 38 Nat Commun, 2021, 12(1):3907
S2721	Nilvadipine	Nilvadipine (ARC029, FR34235,FK235) is a potent calcium channel blocker with an IC50 of 0.03 nM.	Cell Death Differ, 2024, 10.1038/s41418-024-01418-y J Immunother Cancer, 2024, 12(11)e009805 Nat Commun, 2022, 13-1:6117
S2030	Flunarizine 2HCl	Flunarizine 2HCl (KW-3149, R14950) is a dihydrochloride salt form which is a calcium channel blocker with a K_i of 68 nM.	Science Advances, 2023, eadf2695 Sci Adv, 2023, 9(15):eadf2695 Science Advances, 2022, eabk2376
S1356	Levetiracetam (UCB-L059)	Levetiracetam (UCB-L059, SIB-S1) is an anticonvulsant medication used to treat epilepsy and an agonist of muscarinic acetylcholine receptors (mAChR). This compound also modulates the presynaptic P/Q-type voltage-dependent calcium (Ca2+) channel.	Communications Medicine, 2025, 420 The Journal of Neuroscience, 2025, e2297242025 Front Neurosci, 2023, 17:1336026
S1813	Amlodipine Besylate	Amlodipine Besylate is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.	Clin Exp Hypertens, 2025, 47(1):2515924 Function, 2023, zqad047 Front Pharmacol, 2022, 13:902305
S1748	Nisoldipine	Nisoldipine (Sular, BAY K 5552) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Ca_v1.2 with IC50 of 10 nM.	J Immunother Cancer, 2024, 12(11)e009805 Biomed Pharmacother, 2022, 145:112432 iScience, 2022, 25(10):105068
S8380	YM-58483 (BTP2)	YM-58483 (BTP2) is a blocker of store-operated Ca2+ entry (SOCE), which regulates the activation of non-excitable cells such as lymphocytes.	Mol Metab, 2025, 95:102114 Cell Death Discov, 2023, 9(1):100 bioRxiv, 2023, 10.1101/2023.07.31.551242
S1425	Ranolazine 2HCl	Ranolazine 2HCl (RS-43285,RS 43285-193,Ranexa, renolazine,Ranolazine dihydrochloride) is a calcium uptake inhibitor via the sodium/calcium channal, used to treat chronic angina.	Autophagy, 2025, 1-20 J Immunother Cancer, 2024, 12(11)e009805 Cardiovascular Research, 2023, 2469–2481
S1885	Felodipine	Felodipine (CGH-869) is a selective L-type Ca²⁺ channel blocker with IC50 of 0.15 nM.	J Immunother Cancer, 2024, 12(11)e009805 Bioactive Materials, 2022, 272-289 Bioact Mater, 2022, 14:272-289
S1747	Nimodipine	Nimodipine (BAY E 9736) is a dihydropyridine calcium channel blocker and an autophagy inhibitor, used in the treatment of high blood pressure.	Theranostics, 2025, 15(6):2624-2648 J Immunother Cancer, 2024, 12(11)e009805 Eye Vis (Lond), 2024, 11(1):37
S1865	Diltiazem HCl	Diltiazem (Tiazac, RG 83606) HCl is a benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions.	J Immunother Cancer, 2024, 12(11)e009805 Function, 2023, zqad047 Anticancer Research, 2021, 6179-6190
S1662	Isradipine	Isradipine (PN 200-110) is a potent and selective L-type voltage-gated calcium channel blocker, used to treat high blood pressure.	Cancer Res Commun, 2025, 10.1158/2767-9764.CRC-24-0433 J Cell Sci, 2022, 135(14)jcs260249 Environ Toxicol Chem, 2021, 10.1002/etc.5018
S2482	Manidipine 2HCl	Manidipine 2HCl (CV-4093) is a HCl salt form of Manidipine, which is a calcium channel blocker with IC50 of 2.6 nM, used clinically as an antihypertensive. Phase 4.	Cell Death Differ, 2024, 10.1038/s41418-024-01418-y Adv Sci (Weinh), 2023, 10(11):e2205500 Front Microbiol, 2023, 14:1177391
S2481	Manidipine	Manidipine(CV-4093,(±)-Manidipine) is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive.	J Immunother Cancer, 2024, 12(11)e009805 Frontiers of Medicine, 2022, 467-482 Antiviral Research, 2018, 130-136
S2080	Clevidipine Butyrate	Clevidipine Butyrate(Cleviprex) is a dihydropyridine calcium channel blocker, uses as an agent for the reduction of blood pressure.	Cell Death Differ, 2024, 10.1038/s41418-024-01418-y J Immunother Cancer, 2024, 12(11)e009805 UNIVERSITY OF PÉCS, 2023,
S2017	Benidipine HCl	Benidipine HCl (KW-3049,(±)- Benidipine) is a hydrochloride salt form of benidipine which is a dihydropyridine calcium channel blocker.	J Immunother Cancer, 2024, 12(11)e009805 Cell Discov, 2020, 6(1):96 ACS Infect Dis, 2020, acsinfecdis.0c00486
S2491	Nitrendipine	Nitrendipine (Bayotensin) is a dihydropyridine calcium channel blocker with an IC50 of 95 nM.	Biochem Biophys Res Commun, 2025, 786:152756 Nat Commun, 2024, 15(1):8708 Cell Death Differ, 2024, 10.1038/s41418-024-01418-y
S3053	Azelnidipine	Azelnidipine (UR-12592) is a dihydropyridine calcium channel blocker. This compound is used for the treatment of hypertension.	Cellular and Molecular Gastroenterology and Hepatology, 2022, 483-500 Cell Mol Gastroenterol Hepatol, 2021, S2352-345X(21)00196-X Environ Toxicol Chem, 2021, 10.1002/etc.5018
S4648	Dantrolene sodium hemiheptahydrate	Dantrolene sodium hemiheptahydrate (Dantrium) is a skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber.	Cardiovasc Res, 2021, 117(4):1091-1102 Oxid Med Cell Longev, 2021, 2021:8810698 Oxidative Medicine and Cellular Longevity, 2021, 8810698
S1799	Ranolazine	Ranolazine (CVT 303, RS 43285-003) is a calcium uptake inhibitor via the sodium/calcium channel, used to treat chronic angina.	Sci Rep, 2023, 10.1038/s41598-023-47540-8 Cancer Cell, 2022, S1535-6108(22)00312-9
S1994	Lacidipine	Lacidipine (GX-1048, GR-43659X, SN-305) is a L-type calcium channel blocker, used for treating high blood pressure.	Cell Death Differ, 2024, 10.1038/s41418-024-01418-y J Immunother Cancer, 2024, 12(11)e009805
S2573	Tetracaine HCl	Tetracaine HCl (Amethocaine hydrochloride) is a hydrochloride salt form of tetracaine which is a potent local anaesthetic and a channel function allosteric inhibitor.	PLoS Pathogens, 2023, e1011295 PLoS Pathog, 2023, 19(3):e1011295
S5255	Nicardipine	Nicardipine is a potent calcium channel blockader with marked vasodilator action.	Front Pharmacol, 2025, 16:1539032 Cell Chem Biol, 2021, S2451-9456(21)00442-6
S4626	Ethosuximide	Ethosuximide(Zarontin) is a succinimide anticonvulsant, used mainly in absence seizures; A calcium channel blocker.	Nature, 2018, 554(7692):317-322 Brain, 2017, 669-683
S4597	Lercanidipine hydrochloride	Lercanidipine is a calcium channel blocker of the dihydropyridine class.	J Immunother Cancer, 2024, 12(11)e009805 J Phys Chem B, 2013, 117(23):6868-73
S4977	Efonidipine	Efonidipine (NZ-105) is an L- and T-type calcium channel blocker leading to vasodilation and decreased automaticity of the heart. It also suppresses aldosterone secretion from the adrenal.	Biomol Ther (Seoul), 2022, 30(5):455-464 Biomolecules & Therapeutics, 2022, 455-464
S4084	Lomerizine 2HCl	Lomerizine dihydrochloride (KB-2796) is a relatively new L- and T-type calcium channel blocker used in the treatment of migraine.	Sci Rep, 2025, 15(1):11355 Nat Commun, 2024, 15(1):8708
S3674	Levamlodipine	Levamlodipine (S-amlodipine) is a pharmacologically active enantiomer of amlodipine which belongs to the dihydropyridine group of calcium channel blocker. It acts on the L-type of calcium channels and its treatment results in vasodilation and a fall in blood pressure.	Oncogene, 2021, 40(6):1128-1146 Open Access Macedonian Journal of Medical Sciences, 2021, 505-509
S4727	Cinnarizine	Cinnarizine (Stugeron, Dimitronal, Stutgin, Cinarizine) is a medication derivative of piperazine, and characterized as an antihistamine and a calcium channel blocker.	Science Advances, 2022, eabk2376 Sci Adv, 2022, 8(15):eabk2376
S3045	Cinepazide maleate	Cinepazide maleate is a maleate salt form of cinepazide which is a vasodilator.	J Immunother Cancer, 2024, 12(11)e009805
S5966	Amlodipine maleate	Amlodipine (Amvaz, UK-48340) maleate is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.	Front Pharmacol, 2022, 13:902305
S6834	Zegocractin (CM-4620)	Zegocractin (CM 4620) is an inhibitor of calcium-release activated calcium-channel (CRAC channel). CM4620 inhibits Orai1/STIM1-mediated Ca2+ currents and Orai2/STIM1-mediated currents with IC50 of near 120 nM and 900 nM, respectively.	Elife, 2023, 12e81288
S5514	Lanthanum(III) chloride heptahydrate	Lanthanum(III) chloride is the inorganic compound used in biochemical research to block the activity of divalent cation channels, mainly calcium channels.	J Surg Res, 2021, 263:236-244
S6473	Pinaverium bromide	Pinaverium bromide (Icosapentaenoic acid) acts as a calcium channel blocker and is useful for functional gastrointestinal disorders.	Cell Rep, 2024, 43(11):114952
S9842	MCU-i4	MCU-i4 is a negative modulator of the mitochondrial calcium uniporter (MCU) complex that directly binds a specific cleft in MICU1 and decreases mitochondrial Ca2+ influx.	PLoS Pathog, 2025, 21(1):e1012872
S0000	Cav 2.2 blocker 1	Cav 2.2 blocker 1 (compound 9) is a N-type calcium channel (Cav 2.2) blocker for the treatment of pain with IC50 of 0.001 μM.
E8077	ML218	ML218 is a potent, selective, and orally active inhibitor of T-type Ca²⁺ channels (Cav3.1, Cav3.2, and Cav3.3), with IC50 of 310 nM for Cav3.2 and 270 nM for Cav3.3. It effectively suppresses burst activity in subthalamic nucleus (STN) neurons.
E0778	o-3M3FBS	O-3M3FBS, the negative control of m-3M3FBS, inhibits inward and outward currents via mechanisms independent of PLC acting in an antagonistic manner, reversibly inhibits delayed rectifier K⁺ channels, increases in [Ca²⁺](i) in an agonistic manner with m-3M3FBS.
S0535	FK962	FK962, a derivative of FK960 with putative anti-dementia properties, significantly enhances high K+-evoked somatostatin release from rat hippocampal slices at 1-1000 nM, also significantly reduces somatostatin-induced inhibition of Ca2+ channels at 1-100 nM in single rat hippocampal neurons.
E5930^New	REM127	REM127 is a small molecule that restores calcium homeostasis by stabilizing the septin cytoskeleton, thereby preventing pathological calcium influx in models of tauopathies. It improves synaptic plasticity, reduces tau and Aβ pathology, and rescues memory function in disease models. It exhibits a potential for treating Alzheimer’s disease and frontotemporal dementia.
S5279	Fendiline hydrochloride	Fendiline hydrochloride is the hydrochloride salt form of Fendiline, which is an L-type calcium channel blocker and also a specific inhibitor of K-Ras plasma membrane targeting with no detectable effect on the localization of H- and N-Ras.
S3845	Panaxadiol	Panaxadiol (20(R)-Panaxadiol) is a triterpene sapogenin originally found in species of Panax (ginseng) and exhibits anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities. This compound inhibits Ca2+ channels, decreasing channel open time and open state probability in vitro and displaying anti-arrhythmic potential.
S5898	Efonidipine hydrochloride monoethanolate	Efonidipine (NZ-105) hydrochloride monoethanolate is an L- and T-type calcium channel blocker leading to vasodilation and decreased automaticity of the heart. Efonidipine hydrochloride monoethanolate also suppresses aldosterone secretion from the adrenal.
E1368	PD173212	PD173212(Compound 11) is a selective N-type voltage sensitive calcium channel (VSCC) blocker, with an IC50 of 36 nM in IMR-32 assays.
S9017	Columbianadin	Columbianadin (Zosimin, 2-Butenoic acid), a natural coumarin from Angelica decursiva, is known to have various biological activities including calcium-channel blocking activity, cytotoxic activity against various cancer cell lines, analgesic activities, intestinal absorption and transportation, anti-inflammatory and anti-cancer effects.
S6920	SEA0400	SEA0400 is a selective and potent inhibitor of the Na+-Ca2+ exchanger (NCX) that inhibits Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50 of 33 nM, 5.0 nM and 8.3 nM, respectively. This compound prevents sodium nitroprusside (SNP) from increasing ERK and p38 MAPK phosphorylation and production of reactive oxygen species (ROS) in an extracellular Ca(2+)-dependent manner.
E0826	Levamlodipine Besylate	Levamlodipine Besylate is a powerful dihydropyridine calcium channel blocker, possessing vasodilation properties and used in the treatment of hypertension and angina.
S3682	Ethyl 3-Aminobenzoate methanesulfonate	Ethyl 3-Aminobenzoate (Ethyl m-Aminobenzoate, NSC 93790, Tricaine) can block the generation of action potentials via voltage-dependent Na+-channels and usually used for anesthesia, sedation, or euthanasia of fish.
E0334	BAMB-4	BAMB-4 (ITPKA-IN-C14) is a new type of membrane permeable ITPKA inhibitor, and IC50 is 37 μM in the Kinase ADP-Glo assay.
S9400	Rhynchophylline	Rhynchophylline (Mitrinermine), an active component isolated from species of the genus Uncaria, acts as a calcium channel blocker and is widely used in traditional Chinese medicine mainly for treating ailments of central nervous and cardiovascular systems, such as lightheadedness, convulsions, numbness, and hypertension.
S5567	Trimethadione	Trimethadione is an oxazolidinedione anticonvulsant and often used to treat epileptic conditions that are resistant to other treatments.
S9566	Bepridil hydrochloride monohydrate	Bepridil hydrochloride monohydrate(CERM 1978) is an anti-anginal drug classified as a calcium channel blocker. It also blocks multiple other ion channels, including sodium and potassium channels.
S0452	NP118809	NP118809(39-1B4) is a potent N-type calcium channel blocker, with an IC50 of 0.11 μM, also less potently inhibits L-type calcium channel with an IC50 of 12.2 μM.
S2975	CarboxyaMidotriazole orotate	Carboxyamidotriazole Orotate (L-651582 Orotate) is the orotate salt form of Carboxyamidotriazole (CAI), an orally bioavailable signal transduction inhibitor. Carboxyamidotriazole Orotate is a cytostatic inhibitor of nonvoltage-operated calcium channels and calcium channel-mediated signaling pathways. Carboxyamidotriazole Orotate inhibits angiogenesis, tumor growth, invasion, and metastasis.
E2984	GSK-7975A	GSK-7975A is a potent and orally available inhibitor of CRAC channel. It reduces FcεRI-dependent Ca2+ influx and reduces the release of histamine, leukotriene C4, and cytokines (IL-5/-8/-13 and TNFα).
E2993	Ruthenium Red	Ruthenium red (Ammoniated ruthenium oxychloride) is a polycationic dye, which is a L-type calcium current (ICa) blocker. It is widely used for electron microscopy (EM) of cells, tissues and vegetative bacteria. Ruthenium red strongly reacts with phospholipids and fatty acids and binds to acidic mucopolysaccharides.
S1573	Fasudil (HA-1077) Hydrochloride	Fasudil HCl, a potent and selective inhibitor of Rho kinase, displays less potent inhibiton over PKA, PKG, PKC and MLCK with Ki of 1.6, 1.6, 3.3, and 36 μM in cell-free assays, respectively. Fasudil is also a calcium channel blocker.	Stem Cell Res Ther, 2025, 16(1):597 Transl Oncol, 2025, 51:102209 J Immunother Cancer, 2024, 12(11)e009805
S1811	Amiloride HCl	Amiloride HCl is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA)(Ki=7 μM).	J Extracell Vesicles, 2024, 13(4):e12426 Virus Res, 2024, 339:199258 J Clin Invest, 2023, 10.1172/JCI163402
S6657	2-APB (2-Aminoethyl Diphenylborinate)	2-Aminoethyl Diphenylborinate (2-APB) is an IP3 receptor inhibitor and regulates IP3-induced calcium release. It also inhibits the SOC channel activity and, at higher concentrations, inhibits TRP channel.	Cell Prolif, 2025, e70120. PLoS Pathog, 2025, 21(1):e1012872 Liver Int, 2025, 45(10):e70341
S3931	Ginsenoside Rd	Ginsenoside Rd (Panaxoside Rd, Sanchinoside Rd), a minor ginseng saponin, has several pharmacological activities such as immunosuppressive activity, anti-inflammatory activity, immunological adjuvant, anti-cancer activity and wound-healing activity. This compound inhibits TNFα-induced NF-κB transcriptional activity with an IC50 of 12.05±0.82 μM in HepG2 cells. It inhibits expression of COX-2 and iNOS mRNA. This chemical also inhibits Ca2+ influx. It inhibits CYP2D6, CYP1A2, CYP3A4, and CYP2C9, with IC50s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively.	The American Journal of Chinese Medicine, 2023, 91-105 Journal of Ginseng Research, 2022, 700-709 Drug Design, Development and Therapy, 2022, 2767-2782
S6847	ML-9 HCl	ML-9 HCl (ML-9 hydrochloride) is a selective and potent inhibitor of Akt kinase, myosin light chain kinase (MLCK) and stromal interaction molecule 1 (STIM1). This compound is also a potent inhibitor of Ca2+-permeable channels. It is a lysosomotropic agent targeting autophagy and cell death.	Cell Mol Life Sci, 2025, 82(1):201 Cellular and Molecular Life Sciences, 2025, 201 PLoS Pathog, 2023, 19(3):e1011295
S2114	Dronedarone HCl	Dronedarone HCl (SR33589) is a multichannel blocker targeting potassium channel, sodium channel and calcium channel, used as an antiarrhythmic drug for treatment of atrial fibrillation (AF).	Cancers (Basel), 2022, 14(19)4883 Chem Res Toxicol, 2021, 10.1021/acs.chemrestox.1c00127 Cell Syst, 2019, 8(2):97-108
S4181	Nicardipine HCl	Nicardipine HCl (RS-69216,YC-93) is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders.	Frontiers in Pharmacology, 2025, 1539032 Cell Discovery, 2020, 96 Cell Discov, 2020, 6(1):96
S3766	Tanshinone IIA sulfonate sodium	Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of tanshinone IIA isolated as the main pharmacologically active natural compound from a traditional Chinese herbal medicine, the dried root of Salvia miltiorrhiza Bunge known as Danshen. Sodium tanshinone IIA sulfonate (STS) is a potent negative allosteric modulator of the human purinergic receptor P2X7. Sodium tanshinone IIA sulfonate (STS) inhibits the activity of CYP3A4 and store-operated Ca2+ entry (SOCE) through store-operated Ca2+ channels (SOCC) via downregulating the expression of transient receptor potential canonical proteins (TRPC).	Journal of Inflammation Research, 2022, 6293-6306 J Inflamm Res, 2022, 15:6293-6306
E1259	DNQX	DNQX is an AMPA receptor antagonist that prevents excess calcium influx via voltage-gated calcium channels.
S3242	Loureirin B	Loureirin B (LB, LrB), a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of PAI-1 with IC50 of 26.10 μM. This compound downregulates p-ERK and p-JNK in TGF-β1-stimulated fibroblasts. It promotes insulin secretion mainly through increasing Pdx-1, MafA, intracellular ATP level, inhibiting the K_ATP current, influx of Ca²⁺ to the intracellular.
S3700	DHBP dibromide	DHBP (1,1'-diheptyl-4,4'-bipyridinium), a viologen for electrochromic memory display agent, inhibits the calcium release induced by 2 mM caffeine and 2 μg/ml polylysine with an IC50 value of 5 μg/ml and 4 μg/ml respectively.
S9315	Praeruptorin A	Praeruptorin A, a naturally existing pyranocumarin, is isolated from the dried root of Peucedanum praeruptorum Dunn. This compound inhibits p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca2+ oscillation. It can significantly upregulates multidrug resistance-associated protein 2 expression via the constitutive androstane receptor-mediated pathway in vitro, and this should be taken as an herb-drug interaction.
S3883	Protopine	Protopine (Corydinine, Fumarine, Biflorine, Macleyine), an alkaloid present in different plants, has been shown to exhibit a number of activities, such as inhibition of calcium influx through both voltage and receptor-operated channels and inhibition of rabbit blood platelet aggregation. It also possesses anti-cholinergic and anti-histaminic as well as anti-bacterial activities.
S0016	SN-6	SN-6 is a selective Na+/Ca2+ exchanger (NCX) inhibitor. This compound inhibits NCX1, NCX2, and NCX3 with IC50 of 2.9 μM, 16 μM and 8.6 μM, respectively. It abolishes acetylcholine (ACh)-induced vasodilation.