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Calcium Channel Antagonists

Cat.No. Product Name Information Product Use Citations Product Validations
S3809 Imperatorin Imperatorin (Ammidin, Marmelosin, Pentosalen, 8-Isoamylenoxypsoralen), a naturally occurring psoralen-type furanocoumarin, is a potent myorelaxant agent and acts as a calcium antagonist on vascular smooth muscle.
Pharmaceuticals, 2023, 1595
Pharmaceuticals (Basel), 2023, 10.3390/ph16111595
Life, 2023, 1112
E4980 Verapamil Verapamil(Iproveratril,Dilacoran), is a phenylalkylamine derivative which is an antagonist of calcium influx and also an inhibitor P-gp and CYP3A4. It exhibits potency in treatment for angina, cardiac arrhythmias, cardiomyopathies and hypertension.
Nat Commun, 2025, 16(1):8069
J Am Heart Assoc, 2025, 14(1):e037400
Pharmaceuticals (Basel), 2025, 18(2)181
E7160 Diltiazem Diltiazem (Dilzen, CRD-401) is a benzothiazepine, an antagonist of Ca2+ channel inhibiting L-type Ca²⁺ currents via CaV1.2 channels in cardiac and vascular smooth muscle. It can be used in research of cardiac arrhythmia, hypertension, and angina pectoris.
Clin Exp Hypertens, 2025, 47(1):2515924
Biochem Biophys Res Commun, 2025, 786:152756
Function, 2023, zqad047
S4931 Propiverine hydrochloride Propiverine is an anticholinergic drug used for the treatment of overactive bladder and urinary incontinence. Propiverine is a muscarinic receptor antagonist possessing additional properties, i.e., block of L-type Ca2+ channels.
S0870 Barnidipine Barnidipine (Libradin, Mepirodipine, Vasexten, YM-09730-5, Cyress, Hypoca, Oldeca) is an antihypertensive drug that belongs to the dihydropyridine (DHP) group of calcium antagonist (CaA) with Ki of 0.21 nM for [3H]nitrendipine binding sites.
E4919 Barnidipine hydrochloride Barnidipine hydrochloride(Mepirodipine hydrochloride; YM-09730-5) is an antagonist of L-type calcium (CaA). It displays a high affinity for [3H] initrendipine binding sites with a Ki value of 0.21 nmol/l. This compound also acts as an antihypertensive agent.
E1705 Mibefradil dihydrochloride Mibefradil dihydrochloride (Ro 40-5967 dihydrochloride) is a nondihydropyridine antagonist of Ca++ channel, it reversibly inhibits the T-type and L-type currents with IC50 values of 2.7 μM and 18.6 μM, respectively. It increases coronary blood flow during ischemia and decreases smooth muscle proliferation after vascular injury, making it useful for congestive heart failure research.
E0945 BIA BIA (TMBIM6 antagonist BIA), a potential TMBIM6 antagonist, is an inhibitor of the interaction between TMBIM6 (Transmembrane B cell lymphoma 2-associated X protein (BAX) inhibitor motif-containing 6) and mTORC2, which ultimately blocks AKT activation and cancer progression.
E0777 Z944 Z944 is a highly selective antagonist for T-type calcium channel with IC50s of 50, 160, 110 nM for hCaV3.1, hCaV3.2, and hCaV3.3.
S2436 Pranidipine Pranidipine (Acalas, OPC 13340) is a new 1,4-dihydropyridine calcium channel blocker. This compound can enhance cyclic GMP-independent nitric oxide-induced relaxation of the rat aorta.
E1410 Fluspirilene Fluspirilene (R 6218; Redeptin) is a non-competitive antagonist of L-type calcium channels with an IC50 of 0.03 μM in cell-free assays. This compound is a long-acting injectable depot antipsychotic agent used for schizophrenia.
S5861 Lercanidipine Lercanidipine is a vasoselective dihydropyridine calcium antagonist used for the treatment of essential hypertension.
E7819 TTA-A2 TTA-A2 is a potent and selective antagonist of T-type calcium channel with an IC50 of 9.4 nM, and reduced PXR activation, promoting slow-wave sleep in mice. It shows strong efficacy in rodent models of epilepsy and sleep, making it a valuable preclinical tool for the research of a variety of human neurological diseases.