Name: Deferiprone
Brand: Selleck Chemicals
SKU: S4067
Rating: 5 (11 reviews)

Deferiprone (CP20) is a chelating agent with an affinity for ferric ion (iron III)，binds with ferric ions to form neutral 3:1 (deferiprone:iron) complexes that are stable over a wide range of pH values.

Deferiprone Chemical Structure

CAS: 30652-11-0

Selleck's Deferiprone has been cited by 11 publications

Purity & Quality Control

Batch: Purity: 99.97%

99.97

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Biological Activity

Description	Deferiprone (CP20) is a chelating agent with an affinity for ferric ion (iron III)，binds with ferric ions to form neutral 3:1 (deferiprone:iron) complexes that are stable over a wide range of pH values.
Features	Possesses 10-fold higher cytotoxicity than maltol in both HL-60 and HSC-2 cell lines.

In vitro
In vitro	Deferiprone (100 μM) is able to protect myocytes from doxorubicin-induced lactate dehydrogenase release. Deferiprone (300 μM) quickly and efficiently removes iron(III) from its complex with doxorubicin. Deferiprone (300 μM) rapidly enters myocytes and displaces iron from a fluorescence-quenched trapped intracellular iron-calcein complex, suggesting that in the myocyte, deferiprone should also be able to displace iron from its complex with doxorubicin. Deferiprone (3 mM) also greatly reduces hydroxyl radical production by the iron(III)-doxorubicin complex in the xanthine oxidase/xanthine superoxide generating system. ^[1] Deferiprone (0.5 mM) increases removal of RBC membrane free iron in a time and dose dependent manner. ^[2] Deferiprone (0.3 mM) is effective in inhibiting radioactive iron mobilization from iron-loaded heart cells and protecting or restoring mitochondrial respiratory enzyme activity. Deferiprone (1 mM) results in a sharp decrease in complex I-III activity in iron-loaded heart cells. ^[3] Deferiprone shows cytotoxic effect of human tumor cell lines HSC-2, HSC-3 and HL-60 with IC50 of 13.5 μg/mL, 9.9 μg/mL and 10.6 μg/mL, the cytotoxic activity of HK1 against HL-60 and HSC-2 cells is reduced in the presence of FeCl₃. Deferiprone (100 μg/mL) induces internucleosomal DNA fragmentation in HL-60 cells, but the addition of FeCl₃ inhibits the DNA fragmentation. Deferiprone (100 μg/mL) activates the caspase 3, 8 and 9 in HSC-2 cells. ^[4]

In Vivo
In vivo	Deferiprone (100 mg/kg) reduces the mean basilar artery cross-sectional areas by 24% in rabbits. Deferiprone (100 mg/kg) combined with subarachnoid hemorrhage(SAH) shows a variable amount of corrugation of the internal elastic lamina in rabbits. ^[5]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT02878538	Withdrawn	Mild Cognitive Impairment	The University of Texas Health Science Center at San Antonio	January 2018	Early Phase 1
NCT02728843	Completed	Parkinson''s Disease	ApoPharma	October 12 2016	Phase 2
NCT02477631	Completed	Myelodysplastic Syndrome With Low-grade Lesions\|Iron Overload Due to Repeated Red Blood Cell Transfusions	Sheba Medical Center\|Hadassah Medical Organization\|Tel Aviv Medical Center\|Kaplan Medical Center\|Ziv Medical Center	February 2016	Phase 2

References

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Chemical Information & Solubility

Molecular Weight	139.15	Formula	C₇H₉NO₂
CAS No.	30652-11-0	SDF	Download Deferiprone SDF
Smiles	CC1=C(C(=O)C=CN1C)O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

Water : 27 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
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In vivo Formulation Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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