Catalog No.S4067 Synonyms: CP20
Molecular Weight(MW): 139.15
Deferiprone is a chelating agent with an affinity for ferric ion (iron III)，binds with ferric ions to form neutral 3:1 (deferiprone:iron) complexes that are stable over a wide range of pH values.
Purity & Quality Control
|Description||Deferiprone is a chelating agent with an affinity for ferric ion (iron III)，binds with ferric ions to form neutral 3:1 (deferiprone:iron) complexes that are stable over a wide range of pH values.|
|Features||Possesses 10-fold higher cytotoxicity than maltol in both HL-60 and HSC-2 cell lines.|
Deferiprone (100 μM) is able to protect myocytes from doxorubicin-induced lactate dehydrogenase release. Deferiprone (300 μM) quickly and efficiently removes iron(III) from its complex with doxorubicin. Deferiprone (300 μM) rapidly enters myocytes and displaces iron from a fluorescence-quenched trapped intracellular iron-calcein complex, suggesting that in the myocyte, deferiprone should also be able to displace iron from its complex with doxorubicin. Deferiprone (3 mM) also greatly reduces hydroxyl radical production by the iron(III)-doxorubicin complex in the xanthine oxidase/xanthine superoxide generating system.  Deferiprone (0.5 mM) increases removal of RBC membrane free iron in a time and dose dependent manner.  Deferiprone (0.3 mM) is effective in inhibiting radioactive iron mobilization from iron-loaded heart cells and protecting or restoring mitochondrial respiratory enzyme activity. Deferiprone (1 mM) results in a sharp decrease in complex I-III activity in iron-loaded heart cells.  Deferiprone shows cytotoxic effect of human tumor cell lines HSC-2, HSC-3 and HL-60 with IC50 of 13.5 μg/mL, 9.9 μg/mL and 10.6 μg/mL, the cytotoxic activity of HK1 against HL-60 and HSC-2 cells is reduced in the presence of FeCl3. Deferiprone (100 μg/mL) induces internucleosomal DNA fragmentation in HL-60 cells, but the addition of FeCl3 inhibits the DNA fragmentation. Deferiprone (100 μg/mL) activates the caspase 3, 8 and 9 in HSC-2 cells. 
|In vivo||Deferiprone (100 mg/kg) reduces the mean basilar artery cross-sectional areas by 24% in rabbits. Deferiprone (100 mg/kg) combined with subarachnoid hemorrhage(SAH) shows a variable amount of corrugation of the internal elastic lamina in rabbits. |
-  Barnab?N, et al. Free Radic Biol Med, 2002, 33(2), 266-275.
-  Shalev O, et al. Blood, 1995, 86(5), 2008-2013.
-  Link G, et al. J Lab Clin Med, 1999, 133(2), 179-188.
|In vitro||Water||1 mg/mL (7.18 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02882477||Not yet recruiting||Diabetes Mellitus|Iron Metabolism Disorders|Gastroduodenal Ulcer|Optic Atrophy|Sensorineural Hearing Loss|Platelet Dysfunction||Hadassah Medical Organization||December 2016||Phase 2|Phase 3|
|NCT02878538||Not yet recruiting||Mild Cognitive Impairment||The University of Texas Health Science Center at San Antonio||September 2016||--|
|NCT02980458||Completed||Bioequivalence||SocraTec R&D GmbH|SocraMetrics GmbH||August 2016||Phase 1|
|NCT02728843||Recruiting||Parkinsons Disease||ApoPharma||July 2016||Phase 2|
|NCT02477631||Recruiting||Myelodysplastic Syndrome With Low-grade Lesions|Iron Overload Due to Repeated Red Blood Cell Transfusions||Sheba Medical Center|Hadassah Medical Organization||February 2016||Phase 2|
|NCT02655315||Recruiting||Parkinson Disease||University Hospital, Lille|European Commission|ApoPharma||February 2016||Phase 2|
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