Catalog No.S7534

BAPTA-AM Chemical Structure

Molecular Weight(MW): 764.68

2 Customer Reviews

  • (A) Representative fluorescent images of co-localization of NLRP3 and mitochondria in NP cells as described in Figure 6C. Red and green fluorescence indicated NLRP3 and mitochondria signals, respectively. Cell nuclei are stained by DAPI. Representative fluorescent images of caspase-1 activity (B) in NP cells.

    J Cell Mol Med, 2017. BAPTA-AM purchased from Selleck.

    ER stress is necessary for MHBs-induced p38/NF-κB activation and an increase in IL-6. Huh7, L-02 and SMMC-7721 cells were transfected with MHB or GFP, the cells were treated with BAPTA-AM. (a) The phosphorylation of p38 MAPK and degradation of Iκ-B were detected by western blot.

    PLoS One, 2016, 11(7):e0159089.. BAPTA-AM purchased from Selleck.

Purity & Quality Control

Biological Activity

Description BAPTA-AM is a selective, membrane-permeable calcium chelator.
In vitro

BAPTA-AM, as an intracellular calcium chelator, induces delayed necrosis by lipoxygenase-mediated free radicals in mouse cortical cultures. [1] BAPTA-AM exerts an open channel blocking effect on hERG, hKv1.3 and hKv1.5 channels with IC50 of 1.3, 1.45 and 1.23 μM in HEK 293 cells. [2]

In vivo BAPTA-AM abolishes the UDCA- and TUDCA-induced increases in Ca2+ levels or Ca2+-Dependent PKC-α phosphorylation, and neutralizes the cytoprotective effects of UDCA and TUDCA on the vagotomy-induced damage of the biliary tree in the BDL rats. [3]


Animal Research:[3]
+ Expand
  • Animal Models: BDL rats
  • Formulation: 0.1% DMSO
  • Dosages: ~6 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 20 mg/mL (26.15 mM)
Water slightly soluble or insoluble
Ethanol slightly soluble or insoluble
In vivo Add solvents individually and in order:

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 764.68


CAS No. 126150-97-8
Storage powder
in solvent
Synonyms N/A

Bio Calculators

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID