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Sucralose

Cat.No.S4214

Sucralose (E955,Trichloro Sucrose) is an artificial and noncaloric sweetener, not broken down by the body.
Sucralose Chemical Structure

Chemical Structure

Molecular Weight: 397.63

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Quality Control

Batch: S421401 DMSO]80 mg/mL]false]Water]80 mg/mL]false]Ethanol]Insoluble]false Purity: 100.0%
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100.0

Solubility

In vitro
Batch:

DMSO : 80 mg/mL (201.19 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 80 mg/mL

Ethanol : Insoluble

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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g
μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 397.63 Formula

C12H19Cl3O8

 Storage (From the date of receipt)
CAS No. 56038-13-2 Download SDF Storage of Stock Solutions

Synonyms E955,Trichloro Sucrose Smiles C(C1C(C(C(C(O1)OC2(C(C(C(O2)CCl)O)O)CCl)O)O)Cl)O

Mechanism of Action

In vitro

Combining pea with sucrose and sucralose induced even higher levels of CCK and GLP-1. Synchronous addition of pea and sucralose to enteroendocrine cells induced higher levels of CCK and GLP-1 than addition of each compound alone.
In vivo

Effects of sucralose sweetener on blood constituents labelled with technetium-99m ((99m)Tc) on red blood cell (RBC) morphology, sodium pertechnetate (Na(99m)TcO(4)) and diethylenetriaminepentaacetic acid labeled with (99m)Tc ((99m)Tc-DTPA) biodistribution in rats are evaluated. There is no alteration on RBC blood constituents and morphology %ATI. Sucralose sweetener is capable of altering %ATI/g of the radiopharmaceuticals in different organs. These findings are associated to the sucralose sweetener in specific organs.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05124886 Recruiting
Enteric Hyperoxaluria
NYU Langone Health|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
 November 10 2022 Not Applicable
NCT05579392 Recruiting
Inflammatory Bowel Disease
Rush University Medical Center
 September 22 2022 Not Applicable
NCT05379270 Active not recruiting
Breastfeeding
George Washington University
 February 28 2022 Not Applicable

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