Name: Sodium Nitroprusside Dihydrate
Brand: Selleck Chemicals
SKU: S4059
Availability: InStock
Rating: 5 (3 reviews)

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Batch: S405901 DMSO]60 mg/mL]false]Water]60 mg/mL]false]Ethanol]Insoluble]false Purity: 99.7%

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COA
SDS
Datasheet

99.7

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Solubility

In vitro
Batch:

DMSO : 60 mg/mL (201.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 60 mg/mL

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

%

% Tween 80

% ddH₂O

% DMSO

+

%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	297.95	Formula	C₅H₄FeN₆Na₂O₃	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	13755-38-9	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	N/A			Smiles	[C-]#N.[C-]#N.[C-]#N.[C-]#N.[C-]#N.[N-]=O.O.O.[Na+].[Na+].[Fe+4]

Mechanism of Action

Targets/IC₅₀/Ki	guanylate cyclase
In vitro	Sodium Nitroprusside is a potent vasodilator. Sodium nitroprusside has potent vasodilating effects in arterioles and venules. Sodium Nitroprusside breaks down in circulation to release nitric oxide (NO). NO activates guanylate cyclase in vascular smooth muscle and increases intracellular production of cGMP. The end result is vascular smooth muscle relaxation, which allow vessels to dilate. Sodium nitroprusside decreases the proliferation of vascular smooth muscle cells.
In vivo	Sodium nitroprusside (5 mg/kg) significantly reduces the intestinal ischemiareperfusion injury as a nitric oxide donor in rats.
References	[1] http://www.ncbi.nlm.nih.gov/pubmed/?term=8660704 [2] http://www.ncbi.nlm.nih.gov/pubmed/?term=2540223 [3] http://www.ncbi.nlm.nih.gov/pubmed/?term=18568253

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05277922	Completed	Study Vasodilatory Effects of C21	Vicore Pharma AB\|CTC Clinical Trial Consultants AB	April 28 2022	Phase 1
NCT04303689	Completed	Essential Hypertension	University of Copenhagen\|University of Aarhus	August 1 2020	Not Applicable
NCT04321434	Terminated	Coronary Microvascular Disease\|Microvascular Disease\|Ischemic Heart Disease	Université Libre de Bruxelles	December 1 2016	Not Applicable

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Sodium Nitroprusside Dihydrate

Chemical Structure

Molecular Weight: 297.95