L-Mimosine

Catalog No.S7446 Synonyms: Leucenol

L-Mimosine Chemical Structure

Molecular Weight(MW): 198.18

L-Mimosine is a non-protein amino acid, and acts as an iron chelator.

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Biological Activity

Description L-Mimosine is a non-protein amino acid, and acts as an iron chelator.
In vitro

L-Mimosine arrests the cell cycle at the G1 phase in PC-3 cells and at the S phase in LNCaP cells, thus attenuating cell proliferation. [1] L-Mimosine, as a prolyl hydroxylase (PHD) inhibitor, stimulates VEGF production, and increases their proangiogenic capacity in dental pulp-derived cells. [2]

In vivo L-mimosine (50 mg/kg i.p.) substantially upregulates HIF-1alpha expression in the kidneys, and remarkably enhances the natriuretic response to renal perfusion pressure in Sprague-Dawley rats. [3]

Protocol

Cell Research:[1]
+ Expand
  • Cell lines: PC-3 and LNCaP cells
  • Concentrations: ~800 μM
  • Incubation Time: 48 hours
  • Method: Cell proliferation in response to L-mimosine is measured using a [3H]thymidine incorporation assay. In this assay, 1 × 104 cells are cultured in each well of a 12-well plate in RPMI-1640 medium with 10% FCS and different concentrations (0–800 μM) of L-mimosine. After the required incubation periods (24 and 48 h), 0.5 μCi/ml of [3H]thymidine is added to each well of the 12-well plate. The cells are then incubated at 37°C in a humidified 5% CO2 atmosphere for 4 h. Cells are then washed twice with cold phosphate-buffered saline (PBS) and then with cold 5% trichloroacetic acid. Cells are lysed by adding 0.5 ml of 0.5 N NaOH. Then 400 μl of the solubilized cell solution are mixed with 4 ml of scintillation cocktail and counted in a liquid scintillation analyzer . Each sample was tested in quadruplicate.
    (Only for Reference)
Animal Research:[3]
+ Expand
  • Animal Models: Sprague-Dawley rats
  • Formulation: Na2CO3 solution, pH 8.5
  • Dosages: ~50 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro 10% NaHCO3 (aq) 38 mg/mL warmed (191.74 mM)
DMSO 0.01 mg/mL (0.05 mM)
Water <1 mg/mL
In vivo

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 198.18
Formula

C8H10N2O4

CAS No. 500-44-7
Storage powder
in solvent
Synonyms Leucenol

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID