Catalog No.S7446

L-Mimosine is a non-protein amino acid, and acts as an iron chelator.

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L-Mimosine Chemical Structure

L-Mimosine Chemical Structure
Molecular Weight: 198.18

Validation & Quality Control

Quality Control & MSDS

Product Information

Product Description

Biological Activity

Description L-Mimosine is a non-protein amino acid, and acts as an iron chelator.
In vitro L-Mimosine arrests the cell cycle at the G1 phase in PC-3 cells and at the S phase in LNCaP cells, thus attenuating cell proliferation. [1] L-Mimosine, as a prolyl hydroxylase (PHD) inhibitor, stimulates VEGF production, and increases their proangiogenic capacity in dental pulp-derived cells. [2]
In vivo L-mimosine (50 mg/kg i.p.) substantially upregulates HIF-1alpha expression in the kidneys, and remarkably enhances the natriuretic response to renal perfusion pressure in Sprague-Dawley rats. [3]

Protocol(Only for Reference)

Cell Assay: [1]

Cell lines PC-3 and LNCaP cells
Concentrations ~800 μM
Incubation Time 48 hours
Method Cell proliferation in response to L-mimosine is measured using a [3H]thymidine incorporation assay. In this assay, 1 × 104 cells are cultured in each well of a 12-well plate in RPMI-1640 medium with 10% FCS and different concentrations (0–800 μM) of L-mimosine. After the required incubation periods (24 and 48 h), 0.5 μCi/ml of [3H]thymidine is added to each well of the 12-well plate. The cells are then incubated at 37°C in a humidified 5% CO2 atmosphere for 4 h. Cells are then washed twice with cold phosphate-buffered saline (PBS) and then with cold 5% trichloroacetic acid. Cells are lysed by adding 0.5 ml of 0.5 N NaOH. Then 400 μl of the solubilized cell solution are mixed with 4 ml of scintillation cocktail and counted in a liquid scintillation analyzer . Each sample was tested in quadruplicate.

Animal Study: [3]

Animal Models Sprague-Dawley rats
Formulation Na2CO3 solution, pH 8.5
Dosages ~50 mg/kg
Administration i.p.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)
Body Surface Area (m2)0.0070.0250.
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)


[1] Chung LC, et al. Am J Physiol Cell Physiol. 2012, 302(4), C676-685.

[2] Müller HD, et al. J Endod. 2012, 38(11), 1498-1503.

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Chemical Information

Download L-Mimosine SDF
Molecular Weight (MW) 198.18


CAS No. 500-44-7
Storage 3 years -20℃powder
2 years -80℃in solvent
Synonyms Leucenol
Solubility (25°C) * In vitro 10% NaHCO3 (aq) 38 mg/mL warming (191.74 mM)
DMSO 0.01 mg/mL (0.05 mM)
Water <1 mg/mL (<1 mM)
In vivo
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name (S)-2-amino-3-(3-hydroxy-4-oxopyridin-1(4H)-yl)propanoic acid

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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