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Swertiamarin

Name: Swertiamarin
Brand: Selleck Chemicals
SKU: S3927
Rating: 5 (1 reviews)

Synonyms: Swertiamaroside

Catalog No.S3927 Purity: 99.76%

Swertiamarin (Swertiamaroside) is a common secoiridoid found among the members of Gentianaceae with anti-inflammatory, anticancer, hypoglycemic and hypolipidemic activities.

Swertiamarin Chemical Structure

CAS: 17388-39-5

Selleck's Swertiamarin has been cited by 1 publication

Purity & Quality Control

Batch: S392701 DMSO] 74 mg/mL] false] ] ] false] ] ] false Purity: 99.76%

99.76

Swertiamarin Related Products

Biological Activity

Description	Swertiamarin (Swertiamaroside) is a common secoiridoid found among the members of Gentianaceae with anti-inflammatory, anticancer, hypoglycemic and hypolipidemic activities.

In Vivo
In vivo	Pharmacokinetic analysis shows that Swertiamarin is absorbed very fast, with very short plasma half-life of 1.3 h, and is completely eliminated from systemic circulation after 4-5 h. Swertiamarin treatment has no significant effect on adipogenesis, or the mRNA expression of PPAR-g and GLUT-4; however, there is a significant increase in the mRNA expression of adiponectin^[1]. On treatment, the compound exerts an antiinflammatory effect on macrophages and neutrophils by suppressing the release of free radicals, iNOS expression, and proinflammatory cytokines. Swertiamarin acts as an anti-inflammatory agent by suppressing proinflammatory mediators (Th1) and inducing anti-inflammatory mediators (Th2)^[2]. Swertiamarin decreases serum cholesterol levels and reduces the oxidation of LDL. In addition, swertiamarin has also shown to have the ability in increasing the HDL levels and reduction in the ratio of LDL/HDL cholesterol. Swertiamarin has shown to modulate 5-HT2 receptor and hypolipidemic potential in animal models of depression, diabetes and obesity^[3].
Animal Research	Animal Models	Swiss albino mice
	Dosages	2, 5, and 10 mg/kg b.w.
	Administration	orally

References

Chemical Information & Solubility

Molecular Weight	374.34	Formula	C₁₆H₂₂O₁₀
CAS No.	17388-39-5	SDF	--
Smiles	C=CC1C(OC=C2C1(CCOC2=O)O)OC3C(C(C(C(O3)CO)O)O)O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 74 mg/mL ( (197.68 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

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In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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