Sodium Picosulfate

Catalog No.S4020

Sodium Picosulfate inhibits absorption of water and electrolytes, and increases their secretion.

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In DMSO USD 130 In stock
USD 97 In stock
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Sodium Picosulfate Chemical Structure

Sodium Picosulfate Chemical Structure
Molecular Weight: 481.41

Validation & Quality Control

MSDS

Product Information

Product Description

Biological Activity

Description Sodium Picosulfate inhibits absorption of water and electrolytes, and increases their secretion.
In vitro Sodium Picosulfate displays cytotoxic effects on cultured liver cells. 800 and 1600 mg/mL induces dose-dependently vacuolic and fatty change as well as necrosis combined with a lowered mitotic activity and a slight increase in LDH values of the rapidly growing cultured liver cells of rabbit. Comparable but less severe effects are observed in 4-day old liver cell cultures of rat, while liver cells cultured for 6 to 11 days tolerate 1600 mg/mL Sodium Picosulfate. In human liver cultures the number of cells is slightly lowered at 800 and 1600 mg/mL and the number of nuclei in division is decreased dependent on dose. [1]
In vivo Sodium Picosulphate treatment for long-term has no effects on neuropeptide content of the rat colon. Over a 6-month period, daily doses (10 mg/kg/day) or twice-weekly doses (7.5 mg/kg/day) of Sodium Picosulphate do not affect the level of Vasoactive intestinal polypeptide (VIP), somatostatin, and substance P in mucosa, submucosa, or muscularis externa. [2] Sodium Picosulphate has no major influence on ileal and colonic epithelial cell proliferation. In a 12 weeks study, 10 mg/kg Sodium Picosulphate continuously treatment does not influence the labeling index of Brdu (LI) in the ileum and induces no statistically significant increase of the LI when the treated groups are compared with the control group. The proliferative pattern along the crypts remains unchanged with sodium picosulphate treatment throughout the study. [3] Sodium Picosulphate does not induce chronic changes in colonic motility in rats under long-term treatment. 10mg/kg/day Sodium Picosulphate pretreated for 23 weeks does not induce any significant change in the duration of long spike bursts (LSB) which are associated with phasic contractions, or in LSB frequency in the fasted state or after a 3-gram meal. [4]
Features

Protocol(Only for Reference)

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesBaboonDogMonkeyRabbitGuinea pigRatHamsterMouse
Weight (kg)121031.80.40.150.080.02
Body Surface Area (m2)0.60.50.240.150.050.0250.020.007
Km factor202012128653
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

References

[1] Nishikawa J, et al. Arzneimittelforschung, 1981, 31(2), 321-325.

[2] Tzavella K, et al. Eur J Gastroenterol Hepatol, 1995, 7(1), 13-20.

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Clinical Trial Information( data from http://clinicaltrials.gov, updated on 2014-12-13)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT01984008 Recruiting Bowel Preparation Before Colonoscopy Universal Integrated Corp. October 2013 Phase 3
NCT01685970 Recruiting Colonoscopy Inje University September 2012 Phase 3
NCT01627171 Recruiting Endoscopy|Bowel Preparation Solutions St. Josephs Healthcare Hamilton|McMaster University September 2012 Phase 4
NCT01554111 Active, not recruiting Cathartic Colon Queens University March 2012 Phase 4
NCT02211911 Completed Healthy Boehringer Ingelheim February 2008 Phase 1

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Chemical Information

Download Sodium Picosulfate SDF
Molecular Weight (MW) 481.41
Formula

C18H15NO8S2.2Na

CAS No. 10040-45-6
Storage 3 years -20℃Powder
6 months-80℃in solvent (DMSO, water, etc.)
Synonyms
Solubility (25°C) * In vitro DMSO 96 mg/mL (199.41 mM)
Water 96 mg/mL (199.41 mM)
Ethanol 3 mg/mL (6.23 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name Phenol, 4,4'-(2-pyridinylmethylene)bis-, 1,1'-bis(hydrogen sulfate), sodium salt (1:2)

Research Area

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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