Sodium Picosulfate

Catalog No.S4020

Sodium Picosulfate Chemical Structure

Molecular Weight(MW): 481.41

Sodium Picosulfate inhibits absorption of water and electrolytes, and increases their secretion.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock

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Purity & Quality Control

Biological Activity

Description Sodium Picosulfate inhibits absorption of water and electrolytes, and increases their secretion.
In vitro

Sodium Picosulfate displays cytotoxic effects on cultured liver cells. 800 and 1600 mg/mL induces dose-dependently vacuolic and fatty change as well as necrosis combined with a lowered mitotic activity and a slight increase in LDH values of the rapidly growing cultured liver cells of rabbit. Comparable but less severe effects are observed in 4-day old liver cell cultures of rat, while liver cells cultured for 6 to 11 days tolerate 1600 mg/mL Sodium Picosulfate. In human liver cultures the number of cells is slightly lowered at 800 and 1600 mg/mL and the number of nuclei in division is decreased dependent on dose. [1]

In vivo Sodium Picosulphate treatment for long-term has no effects on neuropeptide content of the rat colon. Over a 6-month period, daily doses (10 mg/kg/day) or twice-weekly doses (7.5 mg/kg/day) of Sodium Picosulphate do not affect the level of Vasoactive intestinal polypeptide (VIP), somatostatin, and substance P in mucosa, submucosa, or muscularis externa. [2] Sodium Picosulphate has no major influence on ileal and colonic epithelial cell proliferation. In a 12 weeks study, 10 mg/kg Sodium Picosulphate continuously treatment does not influence the labeling index of Brdu (LI) in the ileum and induces no statistically significant increase of the LI when the treated groups are compared with the control group. The proliferative pattern along the crypts remains unchanged with sodium picosulphate treatment throughout the study. [3] Sodium Picosulphate does not induce chronic changes in colonic motility in rats under long-term treatment. 10mg/kg/day Sodium Picosulphate pretreated for 23 weeks does not induce any significant change in the duration of long spike bursts (LSB) which are associated with phasic contractions, or in LSB frequency in the fasted state or after a 3-gram meal. [4]

Protocol

Solubility (25°C)

In vitro DMSO 96 mg/mL (199.41 mM)
Water 96 mg/mL (199.41 mM)
Ethanol 3 mg/mL (6.23 mM)
In vivo

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 481.41
Formula

C18H15NO8S2.2Na

CAS No. 10040-45-6
Storage powder
in solvent
Synonyms N/A

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03017235 Not yet recruiting Bowel Preparation Ferring Pharmaceuticals January 2017 Phase 3
NCT02979223 Recruiting Bowel Preperation|Sodium Picosulfate and Magnesium Citrate|Polyethylene Glycol With Ascorbic Acid National Cancer Center, Korea November 2016 Phase 2
NCT02956057 Not yet recruiting Colonoscopy Tomas Bata Hospital, Czech Republic|Brno University Hospital|Faculty Hospital Kralovske Vinohrady November 2016 Phase 4
NCT02386449 Completed Bowel Preparation Ferring Pharmaceuticals February 2015 Phase 4
NCT01984008 Unknown status Bowel Preparation Before Colonoscopy Universal Integrated Corp. October 2013 Phase 3
NCT01685970 Unknown status Colonoscopy Inje University September 2012 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID