- Inhibitory Selectivity
|Catalog No.||Product Name||Solubility(25°C)|
|S1097||BTZ043 Racemate||<1 mg/mL||22 mg/mL||<1 mg/mL|
|S6002||NXY-059 (Disufenton sodium)||76 mg/mL||76 mg/mL||<1 mg/mL|
|S1751||Gadodiamide Hydrate||100 mg/mL||<1 mg/mL||<1 mg/mL|
|S1236||Leucovorin Calcium Pentahydrate||40 mg/mL||<1 mg/mL||<1 mg/mL|
|S1591||Bestatin||<1 mg/mL||0.4 mg/mL||<1 mg/mL|
|S3207||Iopromide||100 mg/mL||100 mg/mL||100 mg/mL|
|S3691||4-Chloro-2-hydroxybenzoic acid, 4-chloro salicylic acid||<1 mg/mL||34 mg/mL||34 mg/mL|
|S3698||Nortriptyline hydrochloride||59 mg/mL||59 mg/mL||59 mg/mL|
|S3687||Urea||12 mg/mL||12 mg/mL||12 mg/mL|
|S3611||(+)-Fangchinoline||<1 mg/mL||40 mg/mL||3 mg/mL|
|S3613||Scoparone||<1 mg/mL||41 mg/mL||41 mg/mL|
|S3629||Syringic acid||1 mg/mL||39 mg/mL||39 mg/mL|
|S3610||Cordycepin||25 mg/mL||50 mg/mL||1 mg/mL|
|S3626||Sesamol||27 mg/mL||27 mg/mL||27 mg/mL|
|S3619||Citicoline sodium||100 mg/mL||<1 mg/mL||<1 mg/mL|
|S8420||R-IMPP||7 mg/mL||77 mg/mL||77 mg/mL|
|S8612||α-cyano-4-hydroxycinnamic acid(α-CHCA)||<1 mg/mL||37 mg/mL||8 mg/mL|
|S8540||Voxelotor(GBT440, GTx011)||<1 mg/mL||67 mg/mL||67 mg/mL|
|S8446||Importazole||<1 mg/mL||63 mg/mL||31 mg/mL|
|S4742||Rebaudioside C||100 mg/mL||100 mg/mL||8 mg/mL|
|S4746||(20S)-Protopanaxadiol||<1 mg/mL||92 mg/mL||33 mg/mL|
|S4739||Oxyresveratrol||1 mg/mL||48 mg/mL||48 mg/mL|
|S2301||Genistin (Genistoside)||<1 mg/mL||86 mg/mL||34 mg/mL|
|S8368||LM10||<1 mg/mL||45 mg/mL||11 mg/mL|
|S1601||Reserpine||<1 mg/mL||13 mg/mL||<1 mg/mL|
|S1627||Nitazoxanide||<1 mg/mL||62 mg/mL||<1 mg/mL|
|S1137||Malotilate||<1 mg/mL||58 mg/mL||58 mg/mL|
|S1428||Risedronate Sodium||2 mg/mL||<1 mg/mL||<1 mg/mL|
|S1271||Acarbose||100 mg/mL||100 mg/mL||8 mg/mL|
|S2757||TH-302||10 mg/mL||90 mg/mL||90 mg/mL|
|S1624||Alendronate sodium trihydrate||20 mg/mL||<1 mg/mL||<1 mg/mL|
|S1311||Pamidronate Disodium||56 mg/mL||<1 mg/mL||<1 mg/mL|
|S2553||5-Aminolevulinic acid HCl||34 mg/mL||34 mg/mL||6 mg/mL|
|S1201||Dimesna||65 mg/mL||65 mg/mL||<1 mg/mL|
|S1732||Mitotane||<1 mg/mL||64 mg/mL||64 mg/mL|
|S2417||20-Hydroxyecdysone||<1 mg/mL||96 mg/mL||96 mg/mL|
|S1326||Edaravone||<1 mg/mL||35 mg/mL||35 mg/mL|
|S1897||Potassium Iodide||33 mg/mL||33 mg/mL||<1 mg/mL|
|S1988||Propylthiouracil||<1 mg/mL||34 mg/mL||19 mg/mL|
|S2586||Dimethyl Fumarate||<1 mg/mL||29 mg/mL||10 mg/mL|
|S1740||Guaifenesin||25 mg/mL||40 mg/mL||40 mg/mL|
|S3038||Fosaprepitant dimeglumine salt||135 mg/mL||201 mg/mL||<1 mg/mL|
|S1698||Torsemide||<1 mg/mL||3 mg/mL||<1 mg/mL|
|S7372||PTC-209||<1 mg/mL||99 mg/mL||<1 mg/mL|
|S7270||SRPIN340||<1 mg/mL||70 mg/mL||70 mg/mL|
|S4067||Deferiprone||1 mg/mL||<1 mg/mL||<1 mg/mL|
|S7272||4μ8C||<1 mg/mL||19 mg/mL||<1 mg/mL|
|S2129||Fudosteine||36 mg/mL||<1 mg/mL||<1 mg/mL|
|S1287||Bumetanide||<1 mg/mL||73 mg/mL||36 mg/mL|
|S8077||RI-1||<1 mg/mL||50 mg/mL||<1 mg/mL|
|S7217||OAC1||<1 mg/mL||47 mg/mL||21 mg/mL|
|S1849||Daidzein||<1 mg/mL||51 mg/mL||<1 mg/mL|
|S2408||Cephalomannine||<1 mg/mL||100 mg/mL||100 mg/mL|
|S2610||Lonidamine||<1 mg/mL||64 mg/mL||<1 mg/mL|
|S7365||AdipoRon||<1 mg/mL||86 mg/mL||50 mg/mL|
|S4059||Sodium Nitroprusside Dihydrate||60 mg/mL||60 mg/mL||<1 mg/mL|
|S7450||FH1(BRD-K4477)||<1 mg/mL||56 mg/mL||<1 mg/mL|
|S2155||LY2608204||<1 mg/mL||112 mg/mL||35 mg/mL|
|S1749||L-Glutamine||29 mg/mL||<1 mg/mL||<1 mg/mL|
|S2901||CCG 50014||<1 mg/mL||63 mg/mL||<1 mg/mL|
|S2035||Epalrestat||<1 mg/mL||3 mg/mL||<1 mg/mL|
|S1917||Crystal Violet||14 mg/mL||82 mg/mL||8 mg/mL|
|S1874||Risedronate||<1 mg/mL||<1 mg/mL||<1 mg/mL|
|S2412||Genipin||<1 mg/mL||45 mg/mL||45 mg/mL|
|S3199||Reboxetine mesylate||82 mg/mL||82 mg/mL||<1 mg/mL|
|S2410||Paeoniflorin||96 mg/mL||96 mg/mL||96 mg/mL|
|S1609||Methimazole||23 mg/mL||23 mg/mL||23 mg/mL|
|S2594||Pramiracetam||<1 mg/mL||54 mg/mL||<1 mg/mL|
|S7369||4EGI-1||<1 mg/mL||90 mg/mL||<1 mg/mL|
|S2388||L-carnitine||32 mg/mL||12 mg/mL||32 mg/mL|
|S1643||Ursodiol||<1 mg/mL||79 mg/mL||79 mg/mL|
|S1647||Adenosine||<1 mg/mL||12 mg/mL||<1 mg/mL|
|S1671||（6-）ε-Aminocaproic acid||26 mg/mL||6 mg/mL||1 mg/mL|
|S1853||Penicillamine||30 mg/mL||<1 mg/mL||<1 mg/mL|
|S1806||Acipimox||<1 mg/mL||31 mg/mL||<1 mg/mL|
|S4217||Liothyronine Sodium||<1 mg/mL||100 mg/mL||<1 mg/mL|
|S1985||ATP||100 mg/mL||<1 mg/mL||<1 mg/mL|
|S3148||Ibandronate sodium||72 mg/mL||<1 mg/mL||<1 mg/mL|
|S3150||Articaine HCl||64 mg/mL||64 mg/mL||64 mg/mL|
|S1875||Tranexamic Acid||31 mg/mL||<1 mg/mL||<1 mg/mL|
|S3000||Carbazochrome sodium sulfonate (AC-17)||3 mg/mL||64 mg/mL||<1 mg/mL|
|S2599||L-Thyroxine||<1 mg/mL||100 mg/mL||<1 mg/mL|
|S1610||Metolazone||<1 mg/mL||73 mg/mL||8 mg/mL|
|S4020||Sodium Picosulfate||96 mg/mL||96 mg/mL||3 mg/mL|
|S4129||Sevelamer HCl||<1 mg/mL||0.005 mg/mL||<1 mg/mL|
|S2381||D-Mannitol||36 mg/mL||36 mg/mL||<1 mg/mL|
|S2393||Sorbitol||36 mg/mL||36 mg/mL||<1 mg/mL|
|S1641||Chlorothiazide||<1 mg/mL||59 mg/mL||<1 mg/mL|
|S2293||DL-Carnitine HCl||40 mg/mL||40 mg/mL||<1 mg/mL|
|S2305||Grape Seed Extract||<1 mg/mL||94 mg/mL||<1 mg/mL|
|S1715||Glipizide||<1 mg/mL||89 mg/mL||<1 mg/mL|
|S4095||Difluprednate||<1 mg/mL||100 mg/mL||25 mg/mL|
|S2032||Rebamipide||<1 mg/mL||74 mg/mL||<1 mg/mL|
|S1928||Alibendol||<1 mg/mL||50 mg/mL||50 mg/mL|
|S1735||Mesna||7 mg/mL||33 mg/mL||<1 mg/mL|
|S4566||DL-Panthenol||41 mg/mL||41 mg/mL||41 mg/mL|
|S2411||Geniposide||78 mg/mL||78 mg/mL||<1 mg/mL|
|S4567||Eprodisate disodium||49 mg/mL||<1 mg/mL||<1 mg/mL|
|S2409||10-Deacetylbaccatin-III||<1 mg/mL||109 mg/mL||<1 mg/mL|
|S3209||Amidopyrine||10 mg/mL||46 mg/mL||46 mg/mL|
|S7382||Phosphoramidon Disodium Salt||100 mg/mL||100 mg/mL||<1 mg/mL|
|S7589||N6022||<1 mg/mL||82 mg/mL||5 mg/mL|
|S7922||Tiplaxtinin (PAI-039)||<1 mg/mL||72 mg/mL||18 mg/mL|
|S4577||Terpin hydrate||<1 mg/mL||38 mg/mL||38 mg/mL|
|S1511||Lactulose||68 mg/mL||68 mg/mL||<1 mg/mL|
|S1708||Hydrochlorothiazide||0 mg/mL||0 mg/mL||0 mg/mL|
|S2596||Clindamycin palmitate HCl||140 mg/mL||140 mg/mL||140 mg/mL|
|S4298||Amifostine||42 mg/mL||<1 mg/mL||<1 mg/mL|
|S7909||Dp44mT||<1 mg/mL||57 mg/mL||47 mg/mL|
|S7913||MCB-613||<1 mg/mL||60 mg/mL||60 mg/mL|
|S4299||Dicoumarol||<1 mg/mL||67 mg/mL||67 mg/mL|
|S4017||Allylthiourea||<1 mg/mL||23 mg/mL||23 mg/mL|
|S2830||Clindamycin||<1 mg/mL||85 mg/mL||85 mg/mL|
|S7914||Isoxazole 9 (ISX-9)||<1 mg/mL||46 mg/mL||13 mg/mL|
|S2589||Miglitol||<1 mg/mL||3 mg/mL||<1 mg/mL|
|S4512||Aceglutamide||37 mg/mL||37 mg/mL||<1 mg/mL|
|S2518||NAD+||100 mg/mL||<1 mg/mL||<1 mg/mL|
|S4015||Cyclamic acid||36 mg/mL||36 mg/mL||36 mg/mL|
|S4514||Acetylleucine||<1 mg/mL||34 mg/mL||34 mg/mL|
|S7209||GSK650394||<1 mg/mL||76 mg/mL||<1 mg/mL|
|S1730||Indapamide||<1 mg/mL||73 mg/mL||73 mg/mL|
|S7363||BRD7552||<1 mg/mL||100 mg/mL||100 mg/mL|
|S4115||Hydroxypropyl Cellulose||<1 mg/mL||4 mg/mL||<1 mg/mL|
|S7976||SBC-115076||<1 mg/mL||33 mg/mL||<1 mg/mL|
|S2053||Cytidine||49 mg/mL||49 mg/mL||<1 mg/mL|
|S8284||Fatostatin HBr||<1 mg/mL||7 mg/mL||25 mg/mL|
|S8234||RS-1||<1 mg/mL||100 mg/mL||<1 mg/mL|
|S4128||Troxipide||<1 mg/mL||18 mg/mL||3 mg/mL|
|S4134||Sevelamer Carbonate||<1 mg/mL||0.05 mg/mL||<1 mg/mL|
|S2008||Taurine||20 mg/mL||<1 mg/mL||<1 mg/mL|
|S4583||Butamben||38 mg/mL||38 mg/mL||38 mg/mL|
|S4137||Eprazinone 2HCl||18 mg/mL||1 mg/mL||<1 mg/mL|
|S2060||Bromhexine HCl||<1 mg/mL||6 mg/mL||5 mg/mL|
|S4138||Dropropizine||11 mg/mL||47 mg/mL||47 mg/mL|
|S7370||4E1RCat||<1 mg/mL||96 mg/mL||<1 mg/mL|
|S2252||(+)-Usniacin||<1 mg/mL||4 mg/mL||<1 mg/mL|
|S2253||3-Indolebutyric acid (IBA)||<1 mg/mL||41 mg/mL||41 mg/mL|
|S2424||Hypoxanthine||<1 mg/mL||0.4 mg/mL||<1 mg/mL|
|S2374||5-hydroxytryptophan (5-HTP)||4 mg/mL||44 mg/mL||<1 mg/mL|
|S2442||Inosine||47 mg/mL||53 mg/mL||<1 mg/mL|
|S2256||4-Methylumbelliferone (4-MU)||<1 mg/mL||35 mg/mL||35 mg/mL|
|S2258||Esculin||2 mg/mL||68 mg/mL||13 mg/mL|
|S3071||Vanillin||<1 mg/mL||30 mg/mL||30 mg/mL|
|S4040||Norethindrone||<1 mg/mL||60 mg/mL||5 mg/mL|
|S2260||Amygdalin||<1 mg/mL||91 mg/mL||<1 mg/mL|
|S2379||Dioscin||<1 mg/mL||100 mg/mL||22 mg/mL|
|S7771||STF-083010||<1 mg/mL||63 mg/mL||<1 mg/mL|
|S4153||D-Phenylalanine||1 mg/mL||<1 mg/mL||<1 mg/mL|
|S7635||Lomitapide||<1 mg/mL||100 mg/mL||100 mg/mL|
|S2383||Gastrodin||<1 mg/mL||50 mg/mL||<1 mg/mL|
|S4154||Cholesterol||<1 mg/mL||0.03 mg/mL||<1 mg/mL|
|S2384||Hematoxylin||61 mg/mL||61 mg/mL||61 mg/mL|
|S8128||BAY 41-2272||<1 mg/mL||35 mg/mL||4 mg/mL|
|S2267||Azomycin||<1 mg/mL||22 mg/mL||<1 mg/mL|
|S2387||Lappaconite HBr||<1 mg/mL||28 mg/mL||<1 mg/mL|
|S2883||4-Aminohippuric Acid||3 mg/mL||39 mg/mL||2 mg/mL|
|S2884||Acesulfame Potassium||40 mg/mL||40 mg/mL||<1 mg/mL|
|S7594||Abscisic Acid (Dormin）||<1 mg/mL||52 mg/mL||52 mg/mL|
|S8135||Riociguat (BAY 63-2521)||<1 mg/mL||84 mg/mL||<1 mg/mL|
|S4652||Sulisobenzone||61 mg/mL||61 mg/mL||61 mg/mL|
|S2270||Bergenin||<1 mg/mL||66 mg/mL||<1 mg/mL|
|S4653||L-Ornithine||26 mg/mL||<1 mg/mL||<1 mg/mL|
|S4161||Benzoic Acid||<1 mg/mL||24 mg/mL||24 mg/mL|
|S2273||β-Sitosterol||<1 mg/mL||<1 mg/mL||<1 mg/mL|
|S2392||Sesamin||<1 mg/mL||70 mg/mL||<1 mg/mL|
|S2276||Bilobalide||<1 mg/mL||65 mg/mL||65 mg/mL|
|S2277||Caffeic Acid||<1 mg/mL||36 mg/mL||<1 mg/mL|
|S4047||Bisacodyl||<1 mg/mL||72 mg/mL||<1 mg/mL|
|S2280||Chlorogenic Acid||18 mg/mL||71 mg/mL||71 mg/mL|
|S4048||Carbimazole||<1 mg/mL||38 mg/mL||15 mg/mL|
|S2281||Chrysin||<1 mg/mL||51 mg/mL||<1 mg/mL|
|S4606||Glutathione||61 mg/mL||<1 mg/mL||<1 mg/mL|
|S2422||Ipriflavone (Osteofix)||<1 mg/mL||56 mg/mL||2 mg/mL|
|S4608||L-Tyrosine||<1 mg/mL||0.1 mg/mL||<1 mg/mL|
|S4166||Chlorpropamide||<1 mg/mL||55 mg/mL||55 mg/mL|
|S7213||Thiamet G||50 mg/mL||50 mg/mL||12 mg/mL|
|S4633||Isosorbide Mononitrate||38 mg/mL||38 mg/mL||38 mg/mL|
|S7633||Lomitapide Mesylate||<1 mg/mL||100 mg/mL||100 mg/mL|
|S2290||Dihydroartemisinin (DHA)||<1 mg/mL||56 mg/mL||11 mg/mL|
|S7763||D-Luciferin||<1 mg/mL||56 mg/mL||1 mg/mL|
|S4640||Lesinurad||<1 mg/mL||80 mg/mL||54 mg/mL|
|S2292||Diosmin||<1 mg/mL||6 mg/mL||<1 mg/mL|
|S4173||1-Hexadecanol||68 mg/mL||68 mg/mL||68 mg/mL|
|S1974||Meglumine||39 mg/mL||39 mg/mL||<1 mg/mL|
|S4174||Sodium Gluconate||44 mg/mL||<1 mg/mL||<1 mg/mL|
|S2396||Salidroside||60 mg/mL||60 mg/mL||4 mg/mL|
|S4057||Methyclothiazide||<1 mg/mL||72 mg/mL||4 mg/mL|
|S4177||Uracil||<1 mg/mL||22 mg/mL||22 mg/mL|
|S2397||Palmatine chloride||5 mg/mL||77 mg/mL||14 mg/mL|
|S4657||Eslicarbazepine Acetate||<1 mg/mL||59 mg/mL||11 mg/mL|
|S2299||Formononetin||<1 mg/mL||54 mg/mL||<1 mg/mL|
|S2398||Coenzyme Q10 (CoQ10)||<1 mg/mL||<1 mg/mL||1 mg/mL|
|S2300||Ferulic Acid||<1 mg/mL||39 mg/mL||39 mg/mL|
|S2402||Cyclovirobuxin D||<1 mg/mL||<1 mg/mL||20 mg/mL|
|S2304||Gramine||<1 mg/mL||35 mg/mL||35 mg/mL|
|S7447||ZLN005||<1 mg/mL||37 mg/mL||2 mg/mL|
|S4624||5,5-Dimethyloxazolidine-2,4-dione||84 mg/mL||84 mg/mL||84 mg/mL|
|S2306||Gynostemma Extract||<1 mg/mL||189 mg/mL||189 mg/mL|
|S4185||Tiratricol||<1 mg/mL||100 mg/mL||100 mg/mL|
|S7443||AP-III-a4 (ENOblock)||9 mg/mL||100 mg/mL||100 mg/mL|
|S2309||Hesperidin||<1 mg/mL||100 mg/mL||<1 mg/mL|
|S2404||Isoliquiritigenin||<1 mg/mL||12 mg/mL||26 mg/mL|
|S4186||Domiphen Bromide||83 mg/mL||83 mg/mL||83 mg/mL|
|S2405||Sophocarpine||6 mg/mL||49 mg/mL||49 mg/mL|
|S2311||Hyodeoxycholic acid (HDCA)||<1 mg/mL||78 mg/mL||78 mg/mL|
|S4189||Cyclandelate||<1 mg/mL||55 mg/mL||55 mg/mL|
|S4190||Cinchophen||<1 mg/mL||50 mg/mL||5 mg/mL|
|S4658||Hydroquinidine||<1 mg/mL||65 mg/mL||<1 mg/mL|
|S4070||Guanidine HCl||19 mg/mL||19 mg/mL||6 mg/mL|
|S4664||Molsidomine||9 mg/mL||48 mg/mL||48 mg/mL|
|S4670||Sucralfate||<1 mg/mL||0.01 mg/mL||<1 mg/mL|
|S4691||Oxybenzone||<1 mg/mL||45 mg/mL||45 mg/mL|
|S4077||Mequinol||25 mg/mL||25 mg/mL||25 mg/mL|
|S7451||FPH1 (BRD-6125)||<1 mg/mL||78 mg/mL||<1 mg/mL|
|S7929||BEC HCl||45 mg/mL||45 mg/mL||45 mg/mL|
|S4263||Efaproxiral Sodium||73 mg/mL||73 mg/mL||73 mg/mL|
|S7339||AZD3965||<1 mg/mL||100 mg/mL||100 mg/mL|
|S4264||Etofibrate||<1 mg/mL||73 mg/mL||73 mg/mL|
|S4265||Nicaraven||57 mg/mL||57 mg/mL||57 mg/mL|
|S8185||FPS-ZM1||<1 mg/mL||65 mg/mL||65 mg/mL|
|S7517||AZD7545||<1 mg/mL||95 mg/mL||95 mg/mL|
|S4646||Ciclesonide||<1 mg/mL||100 mg/mL||100 mg/mL|
|S2021||Chlormezanone||<1 mg/mL||55 mg/mL||26 mg/mL|
|S4194||Azaguanine-8||<1 mg/mL||6 mg/mL||<1 mg/mL|
|S2316||Kinetin||<1 mg/mL||8 mg/mL||<1 mg/mL|
|S8321||MLR-1023||<1 mg/mL||40 mg/mL||23 mg/mL|
|S2317||L-(+)-Rhamnose Monohydrate||36 mg/mL||36 mg/mL||36 mg/mL|
|S7453||MSDC-0160||<1 mg/mL||0.01 mg/mL||<1 mg/mL|
|S8299||HA15||<1 mg/mL||93 mg/mL||45 mg/mL|
|S4092||Pramoxine HCl||66 mg/mL||66 mg/mL||66 mg/mL|
|S4204||Isosorbide||29 mg/mL||29 mg/mL||29 mg/mL|
|S2124||Xylose||30 mg/mL||30 mg/mL||<1 mg/mL|
|S4205||Dibenzothiophene||<1 mg/mL||37 mg/mL||1 mg/mL|
|S8199||LTX-315||100 mg/mL||-1 mg/mL||-1 mg/mL|
|S2323||Methyl-Hesperidin||100 mg/mL||100 mg/mL||<1 mg/mL|
|S2538||Acetanilide||<1 mg/mL||27 mg/mL||27 mg/mL|
|S4206||Cysteamine HCl||23 mg/mL||23 mg/mL||23 mg/mL|
|S4208||Chromocarb||<1 mg/mL||38 mg/mL||<1 mg/mL|
|S7606||RBC8||<1 mg/mL||84 mg/mL||<1 mg/mL|
|S7534||BAPTA-AM||<1 mg/mL||20 mg/mL||<1 mg/mL|
|S2609||Inulin||104 mg/mL||10 mg/mL||<1 mg/mL|
|S1904||Avobenzone||<1 mg/mL||62 mg/mL||9 mg/mL|
|S4214||Sucralose||80 mg/mL||80 mg/mL||<1 mg/mL|
|S2324||Sodium Monensin||<1 mg/mL||<1 mg/mL||100 mg/mL|
|S1825||Erdosteine||<1 mg/mL||50 mg/mL||10 mg/mL|
|S4101||Voglibose||74 mg/mL||74 mg/mL||<1 mg/mL|
|S7446||L-Mimosine||<1 mg/mL||0.01 mg/mL||<1 mg/mL|
|S2325||Morin Hydrate||<1 mg/mL||64 mg/mL||2 mg/mL|
|S7539||PTC-209 HBr||<1 mg/mL||100 mg/mL||<1 mg/mL|
|S2439||Guanosine||<1 mg/mL||56 mg/mL||<1 mg/mL|
|S4104||Diminazene Aceturate||100 mg/mL||19 mg/mL||<1 mg/mL|
|S8196||ML264||<1 mg/mL||76 mg/mL||<1 mg/mL|
|S7852||Eliglustat||<1 mg/mL||80 mg/mL||80 mg/mL|
|S2331||Neohesperidin Dihydrochalcone (Nhdc)||<1 mg/mL||100 mg/mL||100 mg/mL|
|S4108||Clodronate Disodium||72 mg/mL||<1 mg/mL||<1 mg/mL|
|S4680||Protirelin||72 mg/mL||72 mg/mL||72 mg/mL|
|S2335||Oridonin||<1 mg/mL||72 mg/mL||28 mg/mL|
|S2336||Orotic acid (6-Carboxyuracil)||<1 mg/mL||2 mg/mL||<1 mg/mL|
|S4689||Deoxycholic acid||<1 mg/mL||78 mg/mL||60 mg/mL|
|S2337||Osthole||<1 mg/mL||49 mg/mL||49 mg/mL|
|S2338||Oxymatrine||53 mg/mL||53 mg/mL||53 mg/mL|
|S4607||2,2′-Dihydroxy-4-methoxybenzophenone||<1 mg/mL||48 mg/mL||48 mg/mL|
|S4224||Erythritol||24 mg/mL||24 mg/mL||<1 mg/mL|
|S4701||2-Deoxy-D-glucose||32 mg/mL||32 mg/mL||1 mg/mL|
|S7452||FPH2 (BRD-9424)||<1 mg/mL||70 mg/mL||<1 mg/mL|
|S4703||Choline bitartrate||50 mg/mL||<1 mg/mL||<1 mg/mL|
|S4704||D-(+)-Cellobiose||68 mg/mL||3 mg/mL||<1 mg/mL|
|S3100||2-Thiouracil||<1 mg/mL||26 mg/mL||<1 mg/mL|
|S3102||Creatinine||23 mg/mL||<1 mg/mL||<1 mg/mL|
|S2347||Quercetin Dihydrate||<1 mg/mL||67 mg/mL||21 mg/mL|
|S4508||2,2,2-Tribromoethanol||56 mg/mL||56 mg/mL||56 mg/mL|
|S4233||Zoxazolamine||<1 mg/mL||34 mg/mL||34 mg/mL|
|S4510||4-Aminobenzoic acid||<1 mg/mL||27 mg/mL||27 mg/mL|
|S3106||Pidotimod||10 mg/mL||49 mg/mL||<1 mg/mL|
|S3104||Moguisteine||<1 mg/mL||68 mg/mL||68 mg/mL|
|S4515||Ademetionine disulfate tosylate||79 mg/mL||79 mg/mL||<1 mg/mL|
|S2066||Moxonidine||<1 mg/mL||24 mg/mL||2 mg/mL|
|S4519||Citric acid trilithium salt tetrahydrate||56 mg/mL||56 mg/mL||<1 mg/mL|
|S4530||i-Inositol||36 mg/mL||36 mg/mL||<1 mg/mL|
|S2074||Mecarbinate||<1 mg/mL||47 mg/mL||<1 mg/mL|
|S3138||Methylthiouracil||<1 mg/mL||28 mg/mL||<1 mg/mL|
|S4532||Iopamidol||100 mg/mL||100 mg/mL||<1 mg/mL|
|S4535||Methylene Blue||63 mg/mL||63 mg/mL||10 mg/mL|
|S2916||ML161||<1 mg/mL||72 mg/mL||<1 mg/mL|
|S7498||DDR1-IN-1||<1 mg/mL||100 mg/mL||4 mg/mL|
|S4543||Trimetazidine dihydrochloride||67 mg/mL||67 mg/mL||67 mg/mL|
|S8269||CFSE||<1 mg/mL||100 mg/mL||<1 mg/mL|
|S4546||Xylitol||30 mg/mL||30 mg/mL||<1 mg/mL|
|S8251||Necrosulfonamide||<1 mg/mL||92 mg/mL||<1 mg/mL|
|S3190||N6-methyladenosine (m6A)||14 mg/mL||47 mg/mL||2 mg/mL|
|S8181||SBI-0640756||<1 mg/mL||80 mg/mL||<1 mg/mL|
|S7548||Rilmenidine Phosphate||55 mg/mL||1 mg/mL||<1 mg/mL|
|S2354||Sclareol||<1 mg/mL||61 mg/mL||24 mg/mL|
|S2355||Sclareolide||<1 mg/mL||50 mg/mL||50 mg/mL|
|S4509||4-Aminoantipyrine||40 mg/mL||40 mg/mL||40 mg/mL|
|S4544||Urethane||17 mg/mL||17 mg/mL||17 mg/mL|
|S2356||Shikimic Acid||35 mg/mL||35 mg/mL||<1 mg/mL|
|S2357||Silibinin||<1 mg/mL||96 mg/mL||<1 mg/mL|
|S1900||Talc||<1 mg/mL||0.1 mg/mL||<1 mg/mL|
|S8358||WNK463||<1 mg/mL||92 mg/mL||92 mg/mL|
|S2358||Silymarin||<1 mg/mL||96 mg/mL||1 mg/mL|
|S2359||Sinomenine||65 mg/mL||65 mg/mL||7 mg/mL|
|S7814||AI-10-49||<1 mg/mL||100 mg/mL||100 mg/mL|
|S7777||Coelenterazine||<1 mg/mL||84 mg/mL||1 mg/mL|
|S4548||Aminoguanidine hydrochloride||22 mg/mL||22 mg/mL||<1 mg/mL|
|S4549||Antimonyl potassium tartrate trihydrate||100 mg/mL||<1 mg/mL||<1 mg/mL|
|S4551||Bisoctrizole||<1 mg/mL||0.01 mg/mL||<1 mg/mL|
|S4728||3,3'-Diindolylmethane||<1 mg/mL||49 mg/mL||18 mg/mL|
|S4554||Bucetin||<1 mg/mL||44 mg/mL||6 mg/mL|
|S4721||L-Glutamic acid monosodium salt||33 mg/mL||<1 mg/mL||<1 mg/mL|
|S4556||Carzenide||<1 mg/mL||40 mg/mL||12 mg/mL|
|S2036||Aspartame||4 mg/mL||33 mg/mL||<1 mg/mL|
|S7685||SecinH3||<1 mg/mL||92 mg/mL||1 mg/mL|
|S4558||Citiolone||31 mg/mL||31 mg/mL||31 mg/mL|
|S2370||Ursolic Acid||<1 mg/mL||91 mg/mL||<1 mg/mL|
|S2371||Vanillylacetone||10 mg/mL||38 mg/mL||38 mg/mL|
|S2372||Xanthone||<1 mg/mL||39 mg/mL||1 mg/mL|
|S7608||UM171||<1 mg/mL||45 mg/mL||<1 mg/mL|
|S4561||Danthron||<1 mg/mL||4 mg/mL||<1 mg/mL|
|S4562||Dehydrocholic acid||<1 mg/mL||80 mg/mL||15 mg/mL|
|S7873||Disodium (R)-2-Hydroxyglutarate||38 mg/mL||<1 mg/mL||<1 mg/mL|
- Others Inhibitors (335)
- New Others Products
|Catalog No.||Information||Product Use Citations||Product Validations|
BTZ043 racemate is a decaprenylphosphoryl-β-D-ribose 2'-epimerase (DprE1) inhibitor acting as a new antimycobacterial agent that kill Mycobacterium tuberculosis.
NXY-059 is a novel nitrone, shows efficacious neuroprotective effects. Phase 3.
Gadodiamide Hydrate, a nonionic Gd3+ chelate, is frequently injected i.v. into magnetic resonance imaging (MRI) to enhance contrast.
Leucovorin is a derivative of folic acid, which can be used to increase levels of folic acid under conditions favoring folic acid inhibition.
Bestatin is a potent aminopeptidase-B and leukotriene (LT) A4 hydrolase inhibitor, used in the treatment of acute myelocytic leukemia.
The aminopeptidase-N inhibitor, bestatin (C), showed an inhibitory effect on cell proliferation that predominated in mixed-IHCCA. *p< 0.05 mucin vs mixed, N experiments = 5-7.
Iopromide is a water soluble, hydrophilic and nonionic iodinated contrast agent for x-ray imaging.
Chondroitin sulfate is a kind of sulfated glycosaminoglycan (GAG) which is composed of a chain of alternating sugars including N-acetylgalactosamine and glucuronic acid.
4-Chlorosalicylic acid was used in sensitive spectrofluorometric determination of terbium in mixed rare earths and preparation of poly(4-chlorosalicylic acid-formaldehyde) via condensation with formaldehyde.
Nortriptyline Hydrochloride is the hydrochloride salt form of nortriptyline, a tricyclic antidepressant agent used for short-term treatment of various forms of depression.
Urea is a highly soluble organic compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.
Phenethyl alcohol is an antimicrobial, antiseptic, and disinfectant that is used also as an aromatic essence and preservative in pharmaceutics and perfumery.
Fangchinoline is a phytochemical that has been shown to elicit anti-cancer effects in prostate and breast cancer cell lines via inducing G1 cell cycle arrest. It has also been shown to possess neuroprotective activity.
Scoparone is a natural organic compound discovered from Chinese herb Artemisia scoparia with anticoagulant, hypolipidemic, vasorelaxant, antioxidant, and anti-inflammatory actions.
Syringic acid (SYRA) is a potential antioxidant used in traditional Chinese medicine and is an emerging nutraceutical. It has potential anti-angiogenic, anti-glycating, anti-hyperglycaemic, neuroprotective, and memory-enhancing properties.
Cordycepin is an adenosine analogue, which is readily phosphorylated to its mono-, di-, and triphosphate intracellularly. It has a very potent anti-cancer, anti-oxidant and anti-inflammatory activities.
Sesamol, a natural organic compound, is regarded as a major antioxidant component in the oil with chemoprevention, antimutagenic, and antihepatotoxic activities. It induces apoptosis of cancer and cardiovascular cells.
Citicoline is an essential intermediate in the synthesis of the major phospholipid of the cell membranes, phosphatidylcholine (PtdCho). It increases plasma adrenocorticotropic hormone (ACTH) levels and potentiates serum thyrotrophin (TSH) levels by activating the central cholinergic system.
R-IMPP is an inhibitor of PCSK9 secretion, half maximal inhibitory concentration [IC50] = 4.8 μM.
4-Chloro-α-cyanocinnamic acid (α-CHCA) is a classic monocarboxylate transporters (MCT) inhibitor. α-cyano-4-hydroxycinnamate (CHC) has a 10-fold selectivity for MCT1 compared to other MCTs.
Voxelotor(GBT440, GTx011) is a novel small molecule hemoglobin modifier which increases hemoglobin oxygen affinity.
Importazole is a small molecule inhibitor of the transport receptor importin-β specifically blocking importin-β-mediated nuclear import.
Rebaudioside C belongs to the family of Steviol Glycosides. It is a natural constituent of the plant Stevia rebaudiana Bertoni and used as natural sweeteners to diabetics and others on carbohydrate-controlled diets.
20(S)-Protopanaxadiol (PPD), the main intestinal metabolite of ginsenosides, is one of the active ingredients in ginseng.
Oxyresveratrol, a naturally occurring compound particularly found in Morus alba L., exhibits a potent inhibitory effect on dopa oxidase activity of tyrosinase which catalyzes rate-limiting steps of melanin biosynthesis.
Genistin(Genistoside) is an isoflavone found in a number of dietary plants like soy and kudzu.
LM10 is a selective tryptophan 2,3-dioxygenase (TDO) inhibitor with IC50 values of 0.62 and 2 μM for human and mouse TDO, respectively.
Reserpine is an inhibitor of multidrug efflux pumps, used as an antipsychotic and antihypertensive drug.
(A) Changes of cAMP levels measured by the cAMP-Glo assay (Promega). Gpr52 siRNAs were tranfected for 3 days, whereas the compound treatment (forskolin: 1 μM; reserpine: 10 μM) lasts for 24 hr; statistical analyses performed by the twotailed Mann-Whitney U test. (B) Htt level measured by the 2B7/2166 HTRF upon treatment of different doses of the Gpr52 agonist reserpine for 48 hr, with transfection of Gpr52 siRNA (Gpr52_si1) vs the non-targeting control (Neg_si), n = 4.
Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent. (IC50 for canine influenza virus ranges from 0.17 to 0.21 μM)
Malotilate, diisopropyl 1,3-dithiol-2-ylidenemalonate, is a drug used for the treatment of liver cirrhosis.
Risedronate Sodium, a nitrogen-containing bisphosphonate, inhibits osteoclast-mediated bone resorption and modulates bone metabolism, used in the treatment of osteoporosis.
Acarbose is an inhibitor of intestinal alpha-glucosidase, used to treat type 2 diabetes mellitus.
TH-302 is selective hypoxia-activated prodrug targeting hypoxic regions of solid tumors with IC50 of 19 nM, demonstrates 270-fold enhanced cytotoxicity under hypoxia versus their potency under aerobic conditions, stable to cytochrome P450 metabolism.
Alendronate sodium trihydrate, a nitrogen-containing bisphosphonate, is a potent inhibitor of bone resorption used for the treatment and prevention of osteoporosis.
Pamidronate Disodium is a nitrogen containing bisphosphonate, used to prevent osteoporosis.
5-Aminolevulinic Acid HCl is an intermediate in the porphyrin synthesis pathway, used as a photosensitizing agent and a antineoplastic agent.
Dimesna is an uroprotective agent used to decrease urotoxicity.
Mitotane, is an antineoplastic medication used in the treatment of adrenocortical carcinoma.
20-Hydroxyecdysone (Ecdysterone, 20E) is a naturally occurring ecdysteroid hormone which controls the ecdysis (moulting) and metamorphosis of arthropods.
Edaravone is a novel potent free radical scavenger that has been clinically used to reduce the neuronal damage following ischemic stroke.
Potassium Iodide is used to treat overactive thyroid and to protect the thyroid gland from the effects of radiation from inhaled or swallowed radioactive iodine.
Propylthiouracil is a thyroperoxidase and 5'-deiodinase inhibitor, used to treat hyperthyroidism.
Dimethyl fumarate is the methyl ester of fumaric acid, used to treat people with relapsing forms of multiple sclerosis.
DMF enhances proteasome inhibitor toxicity in tumor cells. (A) GBM5/6/12/14 cells were treated with DMF (5 μM), velcade (10 nM) or the drug combination. Cells were isolated 24 h after treatment and viability determined by trypan blue exclusion assay (n = 3, +/− SEM) *P < 0.05 greater than DMF alone.
Guaifenesin is an expectorant used to relieve chest congestion.
Fosaprepitant is a water-soluble phosphoryl prodrug for Aprepitant which is a NK1 antagonist.
Torsemide is a pyridyl sulfonylurea with a chemical structure between that of traditional loop diuretics and Cl- channel blockers, used to treat hypertension.
PTC-209 is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM in HEK293T cell line, and results in irreversible reduction of cancer-initiating cells (CICs).
Immunoblot analysis of BMI-1 and H2AK119Ub levels following 72 h treatment with 10 µM PTC-209. β-actin and total H2A served as loading controls.
SRPIN340 is a selective SRPK inhibitor with Ki of 0.89 μM for SRPK1, showing no significant inhibitory activity against more than 140 other kinases..
Deferiprone is a chelating agent with an affinity for ferric ion (iron III)，binds with ferric ions to form neutral 3:1 (deferiprone:iron) complexes that are stable over a wide range of pH values.
4μ8C is a potent and selective IRE1 Rnase inhibitor with IC50 of 76 nM.
Fudosteine is a cysteine derivative and a MUC5AC mucin hypersecretion inhibitor, used as a muco-active agent with indications for chronic respiratory diseases.
Bumetanide (Bumex) is a loop diuretic of the sulfamyl category to treat heart failure.
RI-1 is a RAD51 inhibitor with IC50 ranging from 5 to 30 μM.
Inhibition of Rad51 sensitizes PTEN-WT BT549 cells to olaparib. A. Immunofluorescence showed the foci of γH2AX in PTEN-WT BT549 cells treated with 5 μM olaparib (OLA), 5 μM RI-1, and their combination. B. The quantification of immunofluorescenct results. *p ≤ 0.05, ** p ≤ 0.01, ***p ≤ 0.001. C. MTT analysis of PTEN-WT BT549 treated with olaparib or olaparib in combining with RI-1. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001. D. MTT analysis of PTEN-WT BT549 treated with IR-1 for 48 h.
OAC1 (Oct4-activating compound 1) can enhance the efficiency of reprogramming.
Daidzein is a natural isoflavone phytoestrogen found in Leguminosae, used as a component of foods and dietary supplements.
Cephalomannine is an active anti-cancer agent obtained from Taxus yunnanensis and has an antineoplastic effect on tumors found in mice.
Lonidamine is an orally administered small molecule hexokinase inactivator.
AdipoRon is a novel, and orally bioavailable adiponectin receptor agonist with KD of 1.8 and 3.1 μM for AdipoR1 and AdipoR2, respectively.
Sodium Nitroprusside Dihydrate is a potent vasodilator working through releasing NO spontaneously in blood.
FH1 (BRD-K4477) is a small molecule, which promotes differentiation of iPS-derived hepatocytes.
LY2608204 activates glucokinase (GK) with EC50 of 42 nM. Phase 2.
ELISA measurements of secreted human insulin at 2 and 20 mM glucose for a subset of cell lines treated with the anti-diabetic drugs Tolbutamide (sulfonylurea), Liraglutide (GLP-1 R agonist) and LY2608204 (GCK activator). n = 4 measurements for each line. *P<0.05 and **P<0.01 comparing drug treatment with no treatment at the same glucose concentration (two-sided unpaired t-test). Data shown as mean±s.e.m. Samples taken after 10-17 days in Stage 6. Act A, activin A; Alk5i, Alk5 receptor inhibitor II; CHIR, CHIR9901; KGF, keratinocyte growth factor; LDN, LDN193189; PdbU, phorbol 12,13-dibutyrate; RA, retinoic acid; T3, triiodothyronine; Y, Y27632.
L-Glutamine (Gln) is one of the 20 amino acids encoded by the standard genetic code and also a major respiratory fuel and substrate for nucleic acid synthesis in mammalian intestinal cells.
CCG 50014 is a potent and selective inhibitor of RGS4 with IC50 of 30 nM.
Epalrestat is an aldose reductase inhibitor with IC50 of 72 nM.
Crystal violet is a triarylmethane dye.
Risedronate is a bisphosphonate used to strengthen bone, treat or prevent osteoporosis, and treat Paget's disease of bone.
Genipin is an active aglycone derived from an iridoid glycoside called geniposide, which is found in the fruit of Gardenia jasminoides Ellis.
(A) IL-1β secretion in BMDMs stimulated with the indicated doses of genipin and ATP (5 mM, 1 h)
Reboxetine is a norepinephrine reuptake inhibitor with Ki of 8.2 nM.
Paeoniflorin is a herbal constituent extracted from the root of Paeonia albiflora Pall.
Methimazole is an antithyroid medicine.
Pramiracetam is a more potent nootropic drug derived from piracetam.
4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor by binding to eIF4E with KD of 25 μM.
(C) C200 cells were treated with indicated concentrations of cisplatin in the absence and presence of 4egi-1 for 48 h. The numbers above the lines are combination indexes for the combination of cisplatin and 4egi-1.
L-carnitine is constituent of striated muscle and liver. It is used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemias.
Ursodiol reduces cholesterol absorption and is used to dissolve (cholesterol) gallstones. (IC50=0.22 μM)
Adenosine is a nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a β-N9-glycosidic bond.
（6-）ε-Aminocaproic acid is a derivative and analogue of the amino acid lysine.
Penicillamine is used as an antirheumatic and as a chelating agent in Wilson’s disease.
Acipimox is a niacin derivative used as a hypolipidemic agent.
Liothyronine Sodium is the most potent form of thyroid hormone acting on the body to increase the basal metabolic rate, affect protein synthesis.
ATP Disodium is a disodium salt form of adenosine-triphosphate that is used in cells as a coenzyme.
Ibandronate is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis.
Articaine is a dental local anesthetic which contains an additional ester group that is metabolized by estearases in blood and tissue.
Tranexamic Acid is an antifibrinolytic for blocking lysine-binding sites of plasmin and elastase-derived plasminogen fragments with IC50 of 5 mM.
Carbazochrome sodium sulfonate (AC-17) is an antihemorrhagic for use in the treatment of hemorrhoids.
L-Thyroxine is a synthetic form of thyroxine and a hormone replacement drug.
Metolazone is a diuretic that primarily used to treat congestive heart failure and high blood pressure.
Sodium Picosulfate inhibits absorption of water and electrolytes, and increases their secretion.
Sevelamer HCl is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption.
D-Mannitol is an osmotic diuretic agent and a weak renal vasodilator.
Sorbitol is a sugar alcohol and a sugar substitute.
Chlorothiazide is a diuretic and antihypertensive. (IC50=3.8 mM)
DL-Carnitine HCl is a quaternary ammonium compound biosynthesized from the amino acids lysine and methionine.
Grape Seed Extract are industrial derivatives from whole grape seeds that have a great concentration of vitamin E, flavonoids, linoleic acid, and OPCs.
Glipizide is used to treat high blood sugar levels caused by a type of diabetes mellitus called type 2 diabetes.
Difluprednate (difluoroprednisolone butyrate acetate, or DFBA) is a synthetic difluorinated prednisolone derivative, it is originally developed for dermatologic applications.
Rebamipide is a cholecystokinin type 1 (CCK1) receptor inhibitor for inhibiting [125I]BH-CCK-8S with IC50 of 37.7 μM.
Alibendol is an antispasmodic,choleretic, and cholekinetic.
Mesna, a sulfhydryl compound that is used to reduce the incidence of hemorrhagic cystitis associated with certain chemotherapeutic agents.
DL-panthenol is a racemic mixture of D and L form of panthenol,a provitamin of B5.
Geniposide is an iridoid glycoside isolated from the fruit of Gardenia jasminoides Ellis.
Eprodisate Disodium is the orally available disodium salt form of Eprodisate, a small-molecule, orally bioavailable, inhibitor of AA-amyloid fibrillogenesis.
Fostamatinib inhibits activation of Syk and BTK BCWM.1 and MWCL-1 cells treated with either vehicle or fostamatinib at the indicated concentrations for two hours were harvested and lysed, and protein extracts were analyzed by Western blotting. The activation status of Syk (A, B) and BTK (C) was probed with phospho-specific antibodies using β-Actin as well as the levels of total, non-phosphorylated Syk and BTK as controls. Data shown are representative of one of three independent experiments.
Ethylvanillin is the organic flavorant. It is about three times as potent as vanillin and used in the production of chocolate.
10-Deacetylbaccatin-III is an antineoplastic agent and an anti-cancer intermediate.
Halothane is a general inhalation anesthetic used for induction and maintenance of general anesthesia.
Amidopyrine is a white crystalline substance used as an analgesic and antipyretic.
Phosphoramidon Disodium Salt is a metalloendopeptidase inhibitor, widely used as a biochemical tool.
N6022 is a selective, and reversible inhibitor of S-nitrosoglutathione reductase (GSNOR) with IC50 of 8 nM and Ki of 2.5 nM. Phase 1/2.
Tiplaxtinin(PAI-039) is an orally efficacious and selective plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC50 of 2.7 μM.
Terpin hydrate is an expectorant, commonly used to loosen mucus in patients presenting with acute or chronic bronchitis, and related conditions.
Lactulose, a disaccharide composed of galactose and fructose, is a stimulator of health-promoting bacterium growth in the gastrointestinal tract, used to treat chronic constipation and hepatic encephalopathy.
Tyloxapol is a nonionic liquid polymer of the alkyl aryl polyether alcohol type, used as a surfactant to aid liquefaction, removal of mucopurulent and bronchopulmonary secretions. It also blocks plasma lipolytic activity, and thus the breakdown of triglyceride-rich lipoproteins.
Hydrochlorothiazide is a first line diuretic compound of the thiazide class.
Clindamycin palmitate HCl is a water soluble hydrochloride salt of the ester of clindamycin and palmitic acid and a lincosamide antibiotic.
Amifostine is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.
Dp44mT is a potent iron chelator, which shows selective antitumor activity.
MCB-613 is a potent steroid receptor coactivator (SRC) stimulator.
Dicoumarol is a competitive NADPH quinone oxidoreductase (NQO1) inhibitor,and used as an anticoagulant by interfering with the metabolism of vitamin K.
Allylthiourea is a metabolic inhibitor that selective inhibits ammonia oxidation.
Clindamycin inhibits protein synthesis by acting on the 50S ribosomal, used for the treatment of bacterial infections.
Isoxazole 9 (Isx-9) is a synthetic promotor of adult neurogenesis by triggering neuronal differentiation of adult neural stem/precursor cells (NSPCs).
Miglitol is an oral anti-diabetic drug.
Aceglutamide is a psychostimulant, nootropic agent which functions as a prodrug to glutamine with improved potency and stability.
NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.
Cyclamic acid in the form of its sodium or calcium salt is one of the most widely used artificial sweeteners.
Acetylleucine is a drug used in the treatment of vertigo.
GSK650394 is a serum- and glucocorticoid-regulated kinase-1 inhibitor with IC50 of 62 nM and 103 nM for SGK1 and SGK2, respectively.
GSK650394 treatment reduces steady state levels of BoHV-1 proteins. Cells were grown prior to infection. Three hours prior to infection 25 nM of GSK650394 was added to the designated cultures. CRIB cells were infected withBoHV-1 (moi=2) and then stripped FBS added. At the designated times after infection (hours), whole cell lysate (50 ug protein) was prepared and Western Blots performedusing the designated antibodies directed against a viral protein. Arrows denote the position of bICP0 (97 kD), bICP4 (178 kD), bICP22 (45 kD), VP16 (65 kD), and the bracketdenotes various gE forms. Tubulin was used as a loading control. The lane marked M are molecular weight markers: numbers to left are the approximate size of the respectivebands. These results are representative of 4 independent experiments. The relative levels of the respective BoHV-1 proteins were estimated by comparing the intensity ofthe bands to tubulin using a BioRad ChemiDoc MP and PMI System. The value of the respective viral protein that was first detected after infection was set at 10 and the othervalues normalized to this value. ND refers to those lanes in which the viral protein was not detected. These results are representative of three independent experiments.
Indapamide is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure.
BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression.
Hydroxypropyl cellulose (HPC) is a derivative of cellulose with both water solubility and organic solubility, it is used as food additive and sieving matrix for DNA separations.
SBC-115076 is a potent extracellular proprotein convertase subtilisin kexin type 9 (PCSK9) antagonist.
Cytidine is a nucleoside molecule that is formed when cytosine is attached to a ribose ring, cytidine is a component of RNA.
Fatostatin is an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2.
RS-1 is a RAD51-stimulatory compound, which increases the DNA binding activity of RAD51. It is an HDR(homology-directed repair) enhancer.
Troxipide is a novel systemic non-antisecretory gastric cytoprotective agent with anti-ulcer, anti-inflammatory and mucus secreting properties irrespective of pH of stomach or duodenum.
Sevelamer carbonate is a non-absorbed phosphate binding crosslinked polymer, with the same polymeric structure as sevelamer hydrochloride, in which carbonate replaces chloride as the counterion.
Taurine is an organic acid widely distributed in animal tissues.
Butamben is a long-duration local anesthetic used for the treatment of chronic pain.
Eprazinone is a mucolytic.
Bromhexine HCl is a medication prescribed for coughs which works by dissolving hard phlegm.
Dropropizine is a racemic non-opiate antitussive agent, it is used as a cough suppressant.
4E1RCat is a dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction, and inhibits the binding of eIF4G to eIF4E with IC50 of 3.2 μM.
(+)-Usniacin is a naturally occurring dibenzofuran derivative found in several lichen species.
Guanosine hydrate plays important roles in various biochemical processes such as synthesis of nucleic acids and proteins, photosynthesis, muscle contraction and intracellular signal transduction (cGMP).
3-Indolebutyric acid(IBA) is a plant hormone in the auxin family and is an ingredient in many commercial plant rooting horticultural products.
Hypoxanthine, a naturally occurring purine derivative, an intermediate product of uric acid synthesis, formed from adenylic acid and itself a precursor of xanthine.
5-Hydroxytryptophan (5-HTP), also known as oxitriptan (INN), is a naturally occurring amino acid and chemical precursor for the treatment of depression.
Inosine is a nucleoside that is formed when hypoxanthine is attached to a ribose ring via a β-N9-glycosidic bond.
4-Methylumbelliferone is a hyaluronic acid (HA) synthesis inhibitor with an IC50 of 0.4 mM.
Benzyl benzoate is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei.
Esculin is a glucoside found in horse chestnuts.
Benzyl alcohol is used as a local anesthetic. Also, it is used in the manufacture of other benzyl compounds, as a pharmaceutic aid, and in perfumery and flavoring.
Vanillin, 4-hydroxy-3-methoxybenzaldehyde, is a food additive.
Norethindrone is a synthetic progestin, which mimic the actions of the endogenous ovarian hormone progesterone.
Amygdalin is a glycoside initially isolated from the seeds of the tree Prunus dulcis, also known as bitter almonds.
Dioscin is a saponin extracted and isolated from Polygonatum Zanlanscianense Pamp, showing antitumor activities.
STF-083010 is a specific IRE1α endonuclease inhibitor without affecting its kinase activity.
The effect of TUDCA and STF-083010 on mouse decidualization.(B) The average weight of implantation sites on day 8 under TUDCA treatment.(D) The effect of TUDCA treatment on the weight of deciduoma. (F) The average weight of implantation sites on day 8 under STF-083010 treatment. (H) The effect of STF-083010 treatment on the weight of deciduoma. (I) The effect of TUDCA on the mRNA expression of Dtprp in vitro decidualization. (J) The effect of STF-083010 on the mRNA expression of Dtprp in vitro decidualization. Data are presented as the mean ± SD, *p < 0.05.
D-Phenylalanine, a carboxypeptidase A, endorphinase and enkephalinase inhibitor, enhances endorphin production and diminishes pain.
Lomitapide is a potent microsomal triglyceride transfer protein (MTP) inhibitor, used in the treatment of familial hypercholesterolemia.
Gastrodin, an anti-inflammatory polyphenol extracted from Chinese natural herbal Gastrodia elata Blume., benefits neurodegenerative diseases.
Cholesterol is the principal sterol of all higher animals required to build and maintain membranes.
Hematoxylin (Hydroxybrazilin) is a compound that forms strongly colored complexes with certain metal ions, notably Fe(III) and Al(III) salts and a kind of stain in histology.
BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator.
Azomycin is an antimicrobial antibiotic produced by a strain of Nocardia mesenterica.
Lappaconite Hydrobromide is a kind of alkaloid extracted from Aconitum sinomontanum Nakai and has anti-inflammatory effects.
4-Aminohippuric acid is a typical substrate of organic anion transport systems.
Acesulfame potassium is a non-nutritive sweetener.
Abscisic Acid is a plant hormone, which is involved in many plant developmental processes, modulates ion homeostasis and metabolism, and inhibits germination and seedling growth.
Riociguat (BAY 63-2521) is an oral soluble guanylate cyclase (GC) stimulator, used in the treatment of ipulmonary hypertension.
Sulisobenzone is an ingredient in some sunscreens which protects the skin from damage.
Bergenin is trihydroxybenzoic acid glycoside and the C-glycoside of 4-O-methyl gallic acid.
L-ornithine has an antifatigue effect by increasing the efficiency of energy consumption and promoting the excretion of ammonia. It is one of the key reactants in the urea cycle.
Benzoic acid is a colorless crystalline solid and a simple aromatic carboxylic acid, used as a food preservative.
β-Sitosterol is one of several phytosterols (plant sterols) with chemical structures similar to that of cholesterol.
Sesamin, a lignan isolated from the bark of Fagara plants and from sesame oil, exhibits various health benefits.
Bilobalide is a biologically active terpenic trilactone present in Ginkgo biloba.
Caffeic acid is a hydroxycinnamic acid, a naturally occurring organic compound.
Validation of caffeic acid phenethyl ether (CAPE) activity in LPS cells. T778 cells were transfected with either HOXA5 expression vector or empty vector control. Cells were treated with 25 μg/ml CAPE 9 h after transfection, incubated for an additional 15 h, and subjected to Western blotting. Representative images are shown. HNRNPA1 and TUBA4A (α-tubulin) were used as loading control for nuclear (N) and cytoplasmic (C) fraction of cells, respectively. Numbers indicate relative band intensity of RELA normalized to the intensity of the genes in control (1.0) for each fraction.
Bisacodyl (INN) is a stimulant laxative drug that works directly on the colon to produce a bowel movement.
Chlorogenic acid is a hydroxycinnamic acid and a member of a family of naturally occurring organic compounds.
Carbimazole is an imidazole antithyroid agent.
Chrysin is a naturally occurring flavone chemically extracted from the blue passion flower (Passiflora caerulea).
Glutathione acts as an antioxidant, a free radical scavenger and a detoxifying agent. It is a tripeptide comprised of three amino acids (cysteine, glutamic acid, and glycine) present in most mammalian tissue.
Ipriflavone (7-Isopropoxyisoflavon) is used to inhibit bone resorption.
L-tyrosine is a non-essential amino acid. In animals it is synthesized from Ephenylalanine.
Chlorpropamide is a sulfonylurea class drug for type 2 diabetes mellitus.
Thiamet G is a potent, selective O-GlcNAcase inhibitor with Kiof 21 nM, while exhibiting 37,000-fold selectivity over human lysosomal –hexosaminidase.
Hca-P and Hca-F were transfected with scrambled miRNA, miR-24-1 mimic or miR-24-1 inhibitor for 48 h, or treated with 1μM of MG132 (MG), 5μM of Thiamet G (Th) or 50μM of OSMI-1 (OS) for 48 h. c-Myc immunoprecipitations were performed, and immunoprecipitated fractions were analyzed by Western blotting for O-GlcNAcylation and c-Myc
Isosorbide mononitrate is a Nitrate Vasodilator, dilating the blood vessels so as to reduce the blood pressure.
Lomitapide Mesylate is a potent microsomal triglyceride transfer protein (MTP) inhibitor, used in the treatment of familial hypercholesterolemia.
Dihydroartemisinin (DHA) is a semi-synthetic derivative of artemisinin and isolated from the traditional Chinese herb Artemisia annua.
(D) Western Blot analysis of TCTP in cell lysates of MDA cells after 24, 48 and 72 h of exposition to DHA. β-actin was used as loading control.
D-Luciferin is a popular bioluminescent substrate of luciferase in the presence of ATP, used in luciferase-based bioluminescence imaging and cell-based high-throughput screening applications.
Lesinurad is a selective uric acid reabsorption inhibitor (SURI) under investigation for treatment of gout in combination with xanthine oxidase inhibitors.
Diosmin is a semisynthetic phlebotropic agent and a member of the flavonoid family.
1-Hexadecanol is a fatty alcohol used to make other chemicals.
Meglumine is an amino sugar derived from sorbitol for THP-1 cells with IC50 of 22 μg/mL.
Sodium gluconate is the sodium salt of gluconic acid widely used in food and pharmaceutical industry.
Salidroside, a phenylpropanoid glycoside isolated from Rhodiola rosea, has been reported to have a broad spectrum of pharmacological properties.
Methyclothiazide is a substituted benzothiadiazide, used to treat high blood pressure and fluid retention caused by various conditions including heart disease.
Uracil is one of the four nucleobases in the nucleic acid of RNA can be used for drug delivery and as a pharmaceutical.
Palmatine hydrochloride (Palmatine chloride (6CI,7CI); Fibrauretin) is a hydrochloride salt of palmatine which is a protoberberine alkaloid.
Eslicarbazepine acetate is an antiepileptic drug.
Formononetin is a phytoestrogen from the root of Astragalus membranaceus and an O-methylated isoflavone.
Coenzyme Q10 (ubiquinone, ubidecarenone, coenzyme Q) is a component of the electron transport chain and participates in aerobic cellular respiration.
Ferulic Acid is a hydroxycinnamic acid and a type of organic compound found in the Ferula assafoetida L. or Ligusticum chuanxiong.
Cyclovirobuxine D is an active compound extracted from Buxus microphylla, which has been used for treating acute myocardial ischemia.
Gramine is a naturally occurring indole alkaloid present in several plant species.
ZLN005 is a potent and tissue-specific PGC-1α transcriptional activator.
ZLN005 increased Sirt1 protein expression in cardiomyocytes.
Dimethadione is an anticonvulsant that is the active metabolite of trimethadione.
Gynostemma Extract is a saponins extract derived from the Gynostemma pentaphyllum.
Tiratricol (also known as TRIAC or triiodothyroacetic acid) is a thyroid hormone analogue.
AP-III-a4 (ENOblock) is the first nonsubstrate analogue inhibitor of enolase with IC50 of 0.576 μM.
Hesperidin is a flavanone glycoside found abundantly in citrus fruits.
Isoliquiritigenin, an anti-tumor flavonoid from the root of Glycyrrhiza glabra, inhibits aldose reductase with an IC50 of 320 nM.
Cells expressing wild type EGFR (HCC827 and H1650) or L858R/T790M mutant EGFR (HCC827GR) were treated with different concentration of ILQ for 24 h, and the expression of apoptotic markers was detected by immunoblotting.
Domiphen bromide is a quaternary ammonium antiseptic with actions as a cationic surfactant.
Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
Hyodeoxycholic(HDCA) acid is a secondary bile acid, one of the metabolic byproducts of intestinal bacteria.
Cyclandelate is an effective inhibitor of rat hepatic acycloenzyme A: cholesterol acyltransferase (ACAT) with IC50 of 80 μM.
Cinchophen is an analgesic drug that is frequently used to treat gout.
Hydroquinidine is an antiarrhythmic agent.
Guanidine HCl, the crystalline compound of strong alkalinity formed by the oxidation of guanine, is a normal product of protein metabolism and a protein denaturant.
Molsidomine is an orally active, long acting vasodilating drug. Molsidomine is metabolized in the liver to the active metabolite linsidomine. Linsidomine is an unstable compound that releases nitric oxide (NO) upon decay as the actual vasodilating compound.
Sucralfate is a sucrose sulfate-aluminium complex that binds to the ulcer, creating a physical barrier that protects the gastrointestinal tract from stomach acid and prevents the degradation of mucus.
Oxybenzone is a benzophenone derivative used as a sunscreen agent.
Mequinol (4-Methoxyphenol) is a depigmentation agent.
FPH1 (BRD-6125) is a small molecule, which promotes expansion of iPS-derived hepatocytes.
BEC HCl is a slow-binding, and competitive arginase inhibitor with Ki of 0.31 μM (pH7.5) and 0.4-0.6 μM for Arginase II and rat Arginase I, respectively.
Efaproxiral Sodium is a synthetic allosteric modifier of hemoglobin, used for brain metastases originating from breast cancer.
AZD3965 is a potent, selective and orally available monocarboxylate transporter 1 (MCT1) inhibitor with a binding affinity of 1.6 nM, 6-fold selective over MCT2. Phase 1.
Etofibrate is a combination of clofibrate and niacin, used to treat hyperlipemia.
Nicaraven is a hydroxyl radical scavenger with antivasospastic and neuroprotective effects.
FPS-ZM1 is a blood-brain-barrier permeant, non-toxic, tertiary amide compound which is a high affinity RAGE-specific inhibitor, blocking Aβ binding to the V domain of RAGE.
FPS-ZM1 suppresses S100B promoted migration and invasion abilities. *P < 0.05, **P < 0.01 vs “CM” groups; &P < 0.05, &&P < 0.01 vs “S100B+FPS” groups.
AZD7545 is a potent PDHK inhibitor with IC50 of 36.8 nM and 6.4 nM for PDHK1 and PDHK2, respectively. It failed to inhibit PDHK4 at higher concentrations(>10 nM), AZD7545 stimulates PDHK4 activity.
AZD7545 mediated growth suppression of BRAFV600E mutant and NRASmut melanoma cells. Twenty-four hours after plating, both A375 and IGR37 cell lines (BRAFV600E) (a) and SKMel30, IPC298 and MelJuso cell lines (NRASmut) (b) were treated with 10 μM of AZD7545. The plates were imaged using an IncuCyte ZOOM live cell microscope (Essen BioScience) and images were taken every 3 h for a total of 90 h (BRAFV600E) and 120 h (NRASmut). Results are shown for one representative of three biological replicates
Ciclesonide is a glucocorticoid used to treat obstructive airway diseases.
Chlormezanone，a non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm.
Azaguanine-8 is a purine analogs showing antineoplastic activity by competing with guanine in the metabolism.
Kinetin is a type of cytokinin, a class of plant hormone that promotes cell division.
MLR-1023 is a chemical compound which inhibits acid secretion in animal models and also acts as a bronchodilator in histamine-challenged animals.
L(+)-Rhamnose (Rham) is a naturally-occurring deoxy sugar that is found primarily in plants and some bacteria.
MSDC-0160 is a prototype mTOT-modulating insulin sensitizer being studied to treat diabetes and Alzheimer's disease. Phase 2.
HA15 is a molecule that targets specifically BiP/GRP78/HSPA5. HA15 displays anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors.
Pramoxine is a topical local anesthetic that has been shown to have antipruritic properties.
Isosorbide is a heterocyclic compound that is derived from glucose, used as a diuretic.
Xylose is a sugar first isolated from wood.
Dibenzothiophene (DBT) is a model compound for organic sulfur in fossil fuels.
LTX-315 is the oncolytic peptide that kills cancer cells through Bax/Bak-regulated mitochondrial membrane permeabilization.
Methyl Hesperidin is a flavanone glycoside (flavonoid) (C28H34O15) found abundantly in citrus fruits. Its aglycone form is called hesperetin.
Acetanilide is an aniline derivative and has possess analgesic.
Cysteamine is an agent for the treatment of nephropathic cystinosis and an antioxidant.
Chromocarb is a vasoprotectant.
RBC8 is a selective inhibitor of the GTPases RalA and RalB by inhibiting the binding of Ral to its effector RALBP1, no inhibition on the GTPases Ras and RhoA.
(A) RBC8 inhibits the viability of K562 cells. K562 cells transfected with RalA plasmid, empty vector or blank were treated with different concentrations of RBC8 (1–5 μM) for 48 h, followed by MTT assays. (B) RalA GTPase activity measured by G-LISA™ in K562 and KCL-22 cells compared to normal blood controls. K562 and KCL-22 cells were treated with RBC8 (3 μM) for 48 h, followed by G-LISA™ assays. (C) RBC8 enhances the inhibitory effects of imatinib. K562, KCL-22 and BaF3-P210 cells were treated with different concentrations of RBC8 (1–5 μM) plus imatinib (0.1 μM) for 48 h, followed by MTT assays.
BAPTA-AM is a selective, membrane-permeable calcium chelator.
(A) Representative fluorescent images of co-localization of NLRP3 and mitochondria in NP cells as described in Figure 6C. Red and green fluorescence indicated NLRP3 and mitochondria signals, respectively. Cell nuclei are stained by DAPI. Representative fluorescent images of caspase-1 activity (B) in NP cells.
Inulin(Inulin and sodium chloride), a starch found in the tubers and roots of many plants. Since it is hydrolyzable to fructose, it is classified as a fructosan.
Avobenzone is an oil soluble ingredient used in sunscreen products to absorb the full spectrum of UVA rays and a dibenzoylmethane derivative.
Sucralose is an artificial and noncaloric sweetener, not broken down by the body.
Sodium Monensin, isolated from Streptomyces cinnamonensis, is a well-known representative of naturally polyether ionophore antibiotics.
Erdosteine is a mucolytic which is used in treatment of excessive viscous mucus.
Voglibose is an N-substituted derivative of valiolamine, excellent inhibitory activity against α-glucosidases and its action against hyperglycemia and various disorders caused by hyperglycemia.
L-Mimosine is a non-protein amino acid, and acts as an iron chelator.
Morin hydrate(Aurantica) is a flavonoid isolated from Maclura pomifera (Osage orange), Maclura tinctoria (old fustic) and from leaves of Psidium guajava (common guava).
PTC-209 HBr is the hydrobromide salt of PTC-209, which is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results in irreversible reduction of cancer-initiating cells (CICs).
b Reduced viability 96 h post treatment was observed in all MM cell lines in a dose-dependent manner, but not in BMSCs or PBMCs (c). d Downregulation of CCND1 and MYC as well as upregulation of CDNK1A and CDKN1B was noted 5 h post treatment. e Deregulation of proliferation-associated genes translated into a significant increase of cells in the G1 phase and concurrent decrease in the S and G2M phase of the cell cycle 24 h post treatment. ***P < 0.001, **P < 0.01 and *P < 0.05 vs DMSO control
Guanosine is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond.
Diminazene is a di-amidine also known as 4,4-(1-Triazene–1,3–diyl)bis(benzenecarboximidamide), used as an effective trypanocidal agent.
ML264, a selectively inhibitor of kruppel-like factor 5 (KLF5),potently Inhibits Growth of Colorectal Cancer.
Eliglustat (Tartrate) inhibits glucosylceramide synthase(GCS),thus reducing the load of glucosylceramide influx into the lysosome.
Neohesperidin dihydrochalcone(Nhdc), sometimes abbreviated to neohesperidin DC or simply NHDC, is an artificial sweetener derived from citrus.
Clodronate Disodium, a bisphosphonate, is a potent antiosteolytic agent which inhibits bone resorption.
Protirelin is a tripeptide that stimulates the release of thyrotropin and prolactin.
Oridonin, a diterpenoid purified from Rabdosia rubescens, is an antitumor agent.
Orotic acid(6-Carboxyuracil) is a heterocyclic compound and an acid.
Deoxycholic acid is a cytolytic agent. The physiologic effect of deoxycholic acid is by means of decreased cell membrane integrity.
Osthol is an O-methylated coumarin, which is found in the plants such as Cnidium monnieri, Angelica archangelica and Angelica pubescens.
(G) Kidney in situ ROS production demonstrated by DHE detection.
Oxymatrine is a quinolizidine alkaloid extracted from the root of Sophora flavescens with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway. It is used for the treatment of viral hepatitis, cancer, viral myocarditis, gastrointestinal hemorrhage and skin diseases.
Dioxybenzone (benzophenone-8) is an organic compound used in sunscreen to block UVB and short-wave UVA (ultraviolet) rays.
Erythritol is a sugar alcohol used as low-calorie sweetener.
2-Deoxy-D-glucose, an analog of glucose, is a glycolytic inhibitor with antiviral activity.
FPH2 (BRD-9424) is a small molecule, which promotes differentiation of iPS-derived hepatocytes.
Choline bitartrate is a form of the nutrient choline which is found in foods. Choline is necessary for normal liver and kidney function and a component of the neurotransmitter acetylcholine, a chemical that facilitates communication between the nerves and muscles.
D-(+)-Cellobiose is a substrate of β-glucosidase.
Oleic acid is a fatty acid that occurs naturally in various animal and vegetable fats and oils. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent.
2-Thiouracil is a thiolated uracil derivative that is a known antihyperthyroid agent.
Creatinine is a break-down product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body.
Quercetin, a polyphenolic flavonoid found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine, is utilized in many different cultures for their nervous system and anticancer effects.
After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of Quercetin for 3h,followed by 20-minute stimolation of 100ng/ml EGF.
2,2,2-Tribromoethanol is an organic compound used to anesthetize mice.
Zoxazolamine is a centrally acting myorelaxant, which is formerly used as an antispasmodic and uricosuric.
4-Aminobenzoic acid is an intermediate in the synthesis of tetrahydrofolic acid in many non-mammalian organisms, including bacteria and fungi.
Pidotimod is an immunostimulant.
Moguisteine is a novel peripheral non-narcotic antitussive drug.
Ademetionine Disulfate Tosylate is the disulfate-tosylate mixed salt of a mixture of diastereoisomers of the ademetionine ions. Ademetionine possesses anti-inflammatory activity and has been used in treatment of chronic liver disease.
Moxonidine is a selective agonist at the imidazoline receptor subtype 1, used as antihypertensive agent.
Citric acid trilithium salt tetrahydrate is a pharmaceutical and construction material. It is commonly used in HPLC gradient elution for quantification of amino acids.
i-Inositol, also known as myo-inositol, is a chemical compound which is sugar alcohol. i-Inositol is involved in a number of biological processes including insulin signal transduction, cytoskeleton transduction and so on.
Mecarbinate is a chemical intermediate of arbidol hydrochloride.
Methylthiouracil is an antithyroid preparation.
Iopamidol is a non-ionic, water-soluble radiographic contrast agent.
Methylene Blue is used as a dye in chromoendoscopy. It Inhibits tau filament formation with IC50 of 1.9μM. Also it inhibits soluble guanylyl cyclase.
ML-161 is an allosteric inhibitor of PAR1 with IC50 of 0.26 μM.
Pamidronate is bisphosphonate which binds to the hydroxyapatite in bone and act as an inhibitor of the resorption of bone for the treatment of osteitis deformans and postmenopausal osteoporosis.
DDR1-IN-1 is a potent and selective discoidin domain receptor 1 (DDR1) receptor tyrosine kinase inhibitor with IC50 of 105 nM, about 3-fold selectivity over DDR2.
Trimetazidine dihydrochloride is a kind of drug for treatment of chronic ischemic disorders. It improves myocardial glucose utilization through inhibition of fatty acid metabolism, known as fatty acid oxidation inhibitor.
Carboxyfluorescein succinimidyl ester (CFSE) is a fluorescent cell staining dye. CFSE is cell permeable and covalently couples, via its succinimidyl group, to intracellular molecules, notably, to intracellular lysine residues and other amine sources.
Xylitol is a sugar alcohol derived from XYLOSE by reduction of the carbonyl group. It is as sweet as sucrose and used as a noncariogenic sweetener.
Necrosulfonamide is a very specific and potent necrosis inhibitor and blocks mixed lineage kinase domain-like protein (MLKL).
Sapogenins glycosides are a mixture of triterpene and steroid saponins isolated from medicinal plants such as Aesculus hippocastanum L., Hedera helix L. and Ruscus aculeatus L., which are claimed to be effective for the treatment/prevention of venous insufficiency.
N6-methyladenosine (m6A) is a base modified analog of adenosine and is found as a minor nucleoside in natural RNAs.
(A) Comparison of ribose modification across the RNA species. Modified nucleosides of MRC-5 cells were aligned in terms of modification type and then RNA species. Data are presented as means ± STD, n = 3. (B) tRNA modification profiles of cancer tissues. Data are presented as means ± STD, n = 5.
SBI-0640756 is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. It can also suppress AKT and NF-kB signaling.
Rilmenidine Phosphate is a selective I(1) imidazoline receptor agonist, used for the treatment of hypertension.
Sclareol, a labdane-type diterpene isolated from clary sage (Salvia sclarea), exerts growth inhibition and cytotoxic activity against a variety of human cancer cell lines.
Effects of signal inhibitors on CCN1 expression in UVB irradiated (50 mJ/cm2) CCN1-GFs. a Cell viability was measured using the MTT assay 30 min after UVB irradiation. b CCN1-GFs were pretreated with 10 μM sclareol for 4 h, and further irradiated with UVB (50 mJ/cm2) after 30 min. CCN1 expression was analyzed by real-time PCR. Results are expressed as mean ± standard deviation (SD; n = 3). ¶ P < 0.05 of UVB versus untreated control and **P < 0.05, UVB versus treated control
Sclareolide(Norambreinolide) is a sesquiterpene lactone natural product derived from various plant sources including Salvia sclarea, Salvia yosgadensis, and cigar tobacco.
4-Aminoantipyrine(Ampyrone) is a metabolite of aminopyrine with analgesic, anti-inflammatory, and antipyretic properties. It is used as a reagent for biochemical reactions producing peroxides or phenols.
Urethane is a kind of antineoplastic agent that is also used as a veterinary anesthetic. It is a intermediate in organic synthesis.
Shikimic acid(Shikimate), more commonly known as its anionic form shikimate, is an important biochemical intermediate in plants and microorganisms.
Silibinin, the main flavonoid extracted from the milk thistle Silybum marianum, displays hepatoprotective properties in acute and chronic liver injury.
Growth-inhibiting effects of gefitinib and/or silibinin in hepatocellular carcinoma cells (HCCs). A: Huh7, Huh-BAT, HepG2, SNU475, and SNU761 HCC cell lines were cultured in medium containing 5% fetal bovine serum (FBS) and treated with gefitinib (A, left), silibinin (A, right) for 72 hr. The resulting cell viability was determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay.
Talc is a mineral composed of hydrated magnesium silicate with the chemical formula H2Mg3(SiO3)4 or Mg3Si4O10(OH)2.
2-Aminoheptane is a nasal decongestant drug which is a sympathomimetic stimulant and vasoconstrictor.
WNK463 is a pan-WNK-kinase inhibitor. It potently inhibits the in vitro kinase activity of all four WNK family members (WNK1, WNK2, WNK3, and WNK4).
Silymarin (Silybin B), a polyphenolic flavonoid extracted from the seeds of Silybum marianum or milk thistle, is used in the prevention and treatment of liver diseases and primary liver cancer.
Silymarin improved HFD-induced hepatic injury. Mice were fed with NCD or HFD for 14 weeks, then treated with silymarin for 3 weeks, followed by 12 h fasting. (a) ALT and AST levels in serum were determined. (b) Hematoxylin and eosin staining of liver (400×) was showed. Values are means ± SD (n = 8). *p < 0.05 and **p < 0.01 compared to HFD group.
Sinomenine, a pure alkaloid extracted from the chinese medical plant Sinomenium acutum, is used for the treatment of rheumatism and arthritis.
SINO reduced neuronal loss and apoptosis after MCAO. A-B. Nissl staining and quantitative analysis of neuronal survival at 72 h after MCAO (n = 5). Scale bar = 100 μm. C–D. Western blot and quantitative analysis of cleaved caspase-3 expression in the ischemic hemisphere at 72 h after MCAO (n = 5). Data are means ± SEM, *P < 0.05 and **P < 0.01, vs. sham group; #P < 0.05 and ##P < 0.01 vs. the indicated groups. SINO-10: 10 mg/kg SINO; SINO-20: 20 mg/kg SINO.
AI-10-49 is a selective inhibitor of the binding of CBFβ-SMMHC to RUNX1 with IC50 of 260 nM.
6-Acetamidohexanoic acid is a pharmaceutical intermediate.
Coelenterazine is a luminescent enzyme substrate, used for monitoring reporter genes in BRET, ELISA and HTS techniques.
Aminoguanidine is a diamine oxidase and nitric oxide synthase inhibitor. It acts to reduce levels of advanced glycation end products (AGEs) through interacting with 3-deoxyglucosone.
Antimony potassium tartrate trihydrate is a powerful emetic, also used in the treatment of schistosomiasis and leishmaniasis.
Bisoctrizole is a broad-spectrum ultraviolet radiation absorber, absorbing UVB as well as UVA rays. Also a hybrid UV absorber, reflecting and scattering UV.
3,3'-Diindolylmethane(DIM) is a major digestive product of indole-3-carbinol, a potential anticancer component of cruciferous vegetables.
Bucetin is an analgesic and antipyretice agent with a risk of carcinogenesis.
L-Glutamic acid monosodium salt is the sodium salt of glutamic acid, found naturally in tomatoes, cheese and other foods.
Carzenide is an organic synthesis intermediate, used for synthetic drug.
Aspartame is an artificial, non-saccharide sweetener used as a sugar substitute in some foods and beverages.
SecinH3 is a selective cytohesin inhibitor with IC50 of 2.4 μM, 5.4 μM, 5.4 μM, 5.6 μM, 5.6 μM, and 65 μM for hCyh2, hCyh1, mCyh3, hCyh3, drosophila steppke, and yGea2-S7, respectively.
DU145 and PC3 cells were treated with 20 μM of the indicated Arf1 inhibitors for 24 h, and cell lysates were collected for Western blot with the indicated antibodies
Citiolone is a derivative of the amino acid cysteine, used in liver therapy.
Ursolic acid (Malol) is a pentacyclic triterpene acid, used in cosmetics.
Vanillylacetone is similar in chemical structure to other flavor chemicals such as vanillin and eugenol and is used as a flavor additive in spice oils and in perfumery to introduce spicy aromas.
Xanthone is an organic compound, which can be prepared by the heating of phenyl salicylate.
UM171 is a potent agonist of human hematopoietic stem cell renewal, independently of AhR suppression.
Danthron is an organic substance. It used to be a laxatica and now is currently used as an antioxidant in synthetic lubricants, in the synthesis of experimental antitumor agents, as a fungicide and as an intermediate for making dyes.
Dehydrocholic acid is a semisynthetic bile acid made from cholic acid. It is used as a cholagogue, hydrocholeretic, diuretic, and as a diagnostic aid.
Diatrizoic Acid is an organic, iodinated radiocontrast agent used in diagnostic radiography.
Disodium (R)-2-Hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with Ki of 0.628 mM.