Benzoic Acid

Catalog No.S4161

Benzoic acid is a colorless crystalline solid and a simple aromatic carboxylic acid, used as a food preservative.

Price Stock Quantity  
USD 97 In stock
Bulk Inquiry

Massive Discount Available

Free Overnight Delivery on all orders over $ 500.

Benzoic Acid Chemical Structure

Benzoic Acid Chemical Structure
Molecular Weight: 122.12

Validation & Quality Control

Quality Control & MSDS

Product Information

Product Description

Biological Activity

Description Benzoic acid is a colorless crystalline solid and a simple aromatic carboxylic acid, used as a food preservative.
In vitro Benzoic acid transports through human skin membranes with the mean maximum absorption rate of 16.54 μg/cm2/h, while the amount in the receptor fluid after 24 hours is 70.6% of the dose applied. The transport of [14C]benzoic acid is significantly inhibited carbonylcyanide p-trifluoromethoxyphenylhydrazone and nigericin, the direct driving force for benzoic acid transport is suggested to be the inwardly directed proton gradient. [1] Benzoic acid enters the diet as a natural constituent in plants, with high amounts found in fruits and berries and as a result of the widespread use of monosodium benzoate as a food preservative. Benzoic acid and para-t-butylbenzoate are most potent and acetyl CoA carboxylase (EC appeared to be the target of inhibition. Benzoic acid readily enters the cell to undergo intracellular ionization with a substantial lowering of cytosolic pH and ATP levels under acidic growth conditions. Benzoic acid is oxidized by hydroxy radicals produced by stimulated polymorphonuclear cells oxidize. [2] The photometabolism of Benzoic and 4-hydroxybenzoic acids by whole cells is inhibited by the presence of exogenous fatty acids. Benzoic acid enters the anaerobic degradation as follow: initial activation to form benzoyl-Coenzyme A, reduction of the aromatic nucleus--a reaction that has only recently been demonstrated in vitro--and the subsequent degradation of the alicyclic intermediates. [3] For Benzoic acid, there is no differences between the mean absorption through human skin and the one rat study, and skin thickness only slightly influences the absorption of Benzoic acid. [4]
In vivo

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)
Body Surface Area (m2)0.0070.0250.
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)


[1] Tsuji A, et al. Pharm Res, 1994, 11(1), 30-37.

[2] Tremblay GC, et al. Pharmacol Ther, 1993, 60(1), 63-90.

view more

Chemical Information

Download Benzoic Acid SDF
Molecular Weight (MW) 122.12


CAS No. 65-85-0
Storage 3 years -20℃powder
2 years -80℃in solvent
Synonyms FEMA 2131
Solubility (25°C) * In vitro DMSO 24 mg/mL (196.52 mM)
Ethanol 24 mg/mL (196.52 mM)
Water <1 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name Benzoic acid

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

* Indicates a Required Field

Related Others Products

  • CB-839

    CB-839 is a potent, selective, and orally bioavailable glutaminase inhibitor with IC50 of 24 nM for recombinant human GAC. Phase 1.

  • GKT137831

    GKT137831 is a potent, dual NADPH oxidase NOX1/NOX4 inhibitor with Ki of 110 nM and 140 nM, respectively. Phase 2.

  • LB-100

    LB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor. Phase 1.

  • Puromycin 2HCl

    Puromycin 2HCl is an aminonucleoside antibiotic, which acts as a protein synthesis inhibitor.

  • Cyclosporin A

    Cyclosporin A is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, widely used in organ transplantation to prevent rejection.

  • Cyclophosphamide Monohydrate

    Cyclophosphamide Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA.

  • Ganciclovir

    Ganciclovir is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM in a cell-free assay.

  • Calcitriol

    Calcitriol is the hormonally active form of vitamin D.

  • Ribavirin

    Ribavirin, a synthetic guanosine analogue, possesses a broad spectrum of activity against DNA and RNA viruses.


    BAPTA-AM is a selective, membrane-permeable calcium chelator.

Recently Viewed Items

Tags: buy Benzoic Acid | Benzoic Acid ic50 | Benzoic Acid price | Benzoic Acid cost | Benzoic Acid solubility dmso | Benzoic Acid purchase | Benzoic Acid manufacturer | Benzoic Acid research buy | Benzoic Acid order | Benzoic Acid mouse | Benzoic Acid chemical structure | Benzoic Acid mw | Benzoic Acid molecular weight | Benzoic Acid datasheet | Benzoic Acid supplier | Benzoic Acid in vitro | Benzoic Acid cell line | Benzoic Acid concentration | Benzoic Acid nmr
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Contact Us