Guaifenesin

Catalog No.S1740

Guaifenesin  Chemical Structure

Molecular Weight(MW): 198.22

Guaifenesin is an expectorant used to relieve chest congestion.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
USD 310 In stock
USD 647 In stock
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Purity & Quality Control

Biological Activity

Description Guaifenesin is an expectorant used to relieve chest congestion.
In vivo Guaifenesin (200 mg/kg, intravenously) combined with ketamine (50 mg/kg, intramuscularly) produces effective and safe surgical anesthesia for over 30 minutes in New Zealand white rabbits. Guaifenesin (200 mg/kg, intravenously) combined with ketamine (50 mg/kg, intramuscularly) mildly depresses respiratory rate but heart rate and arterial blood pressure are not significantly affected. Guaifenesin (200 mg/kg, intravenously) is combined with sodium pentobarbital (20 mg/kg, intravenously) to produce surgical anesthesia for a period of more than 30 minutes. [1] Guaifenesin (50 mg/mL) combined Xylazine (0.1 mg/mL) and Ketamine (1.0 mg/mL) results in excellent anesthetic induction and maintenance with cardiopulmonary alterations similar to those associated with isoflurane in mechanically ventilated calves. [2] Guaifenesin (150 mg/kg) decreases spectral edge frequency (SEF) and total power in pigs. [3] Guaifenesin prevents adverse anesthetic induction events caused by Propofol in horse. Guaifenesin (90 mg/kg) followed by Propofol (3 mg/kg) should be sufficient to immobilize > 99% of calm healthy adult horses. [4] Guaifenesin (100 mg/kg) produces moderate behavioral changes in the social conflict test in mice. Guaifenesin (200 mg/kg) combined with Paracetamol (200 mg/kg) causes significantly more pronounced analgesic effects that the corresponding doses of paracetamol alone in mice. [5]

Protocol

Solubility (25°C)

In vitro DMSO 40 mg/mL (201.79 mM)
Ethanol 40 mg/mL (201.79 mM)
Water 25 mg/mL (126.12 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 198.22
Formula

C10H14O4

CAS No. 93-14-1
Storage powder
Synonyms N/A

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02656914 Not yet recruiting Flu Symptoms EMS July 2017 Phase 3
NCT02656888 Not yet recruiting Flu Symptoms EMS July 2017 Phase 3
NCT02902640 Recruiting Bronchitis Hoffmann-La Roche November 2016 --
NCT02879981 Not yet recruiting Bronchitis Hoffmann-La Roche August 2016 --
NCT02572375 Completed Cough. Nexgen Pharma, Inc|Pharmaceutical Research Unit, Jordan October 2014 Phase 1
NCT01257243 Unknown status Cough EMS February 2013 Phase 3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID