Molecular Weight(MW): 198.22
Guaifenesin is an expectorant used to relieve chest congestion.
Purity & Quality Control
|Description||Guaifenesin is an expectorant used to relieve chest congestion.|
|In vivo||Guaifenesin (200 mg/kg, intravenously) combined with ketamine (50 mg/kg, intramuscularly) produces effective and safe surgical anesthesia for over 30 minutes in New Zealand white rabbits. Guaifenesin (200 mg/kg, intravenously) combined with ketamine (50 mg/kg, intramuscularly) mildly depresses respiratory rate but heart rate and arterial blood pressure are not significantly affected. Guaifenesin (200 mg/kg, intravenously) is combined with sodium pentobarbital (20 mg/kg, intravenously) to produce surgical anesthesia for a period of more than 30 minutes.  Guaifenesin (50 mg/mL) combined Xylazine (0.1 mg/mL) and Ketamine (1.0 mg/mL) results in excellent anesthetic induction and maintenance with cardiopulmonary alterations similar to those associated with isoflurane in mechanically ventilated calves.  Guaifenesin (150 mg/kg) decreases spectral edge frequency (SEF) and total power in pigs.  Guaifenesin prevents adverse anesthetic induction events caused by Propofol in horse. Guaifenesin (90 mg/kg) followed by Propofol (3 mg/kg) should be sufficient to immobilize > 99% of calm healthy adult horses.  Guaifenesin (100 mg/kg) produces moderate behavioral changes in the social conflict test in mice. Guaifenesin (200 mg/kg) combined with Paracetamol (200 mg/kg) causes significantly more pronounced analgesic effects that the corresponding doses of paracetamol alone in mice. |
-  Olson ME, et al. Can J Vet Res, 1987, 51(3), 383-386.
-  Kerr CL, et al. Am J Vet Res, 2007, 68(12), 1287-1293.
-  Haga HA, et al. Am J Vet Res, 2000, 61(12), 1599-1601.
|In vitro||DMSO||40 mg/mL (201.79 mM)|
|Ethanol||40 mg/mL (201.79 mM)|
|Water||25 mg/mL (126.12 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
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Instructions to calculate molar mass (molecular weight) of a chemical compound:
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02656914||Not yet recruiting||Flu Symptoms||EMS||July 2017||Phase 3|
|NCT02656888||Not yet recruiting||Flu Symptoms||EMS||July 2017||Phase 3|
|NCT02902640||Recruiting||Bronchitis||Hoffmann-La Roche||November 2016||--|
|NCT02879981||Not yet recruiting||Bronchitis||Hoffmann-La Roche||August 2016||--|
|NCT02572375||Completed||Cough.||Nexgen Pharma, Inc|Pharmaceutical Research Unit, Jordan||October 2014||Phase 1|
|NCT01257243||Unknown status||Cough||EMS||February 2013||Phase 3|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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