Adrenergic Receptor

Signaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S2507 Salbutamol Sulfate 68 mg/mL <1 mg/mL <1 mg/mL
S1324 Doxazosin Mesylate <1 mg/mL 15 mg/mL <1 mg/mL
S1283 Asenapine maleate <1 mg/mL 80 mg/mL <1 mg/mL
S4009 Mirabegron <1 mg/mL 79 mg/mL 8 mg/mL
S2516 Xylazine HCl 12 mg/mL 50 mg/mL 50 mg/mL
S3960 Higenamine hydrochloride -1 mg/mL 61 mg/mL -1 mg/mL
S3643 Amitraz <1 mg/mL 58 mg/mL <1 mg/mL
S3664 Flupenthixol dihydrochloride 100 mg/mL 100 mg/mL 30 mg/mL
S3640 Methoxyphenamine Hydrochloride 43 mg/mL 43 mg/mL 43 mg/mL
S3727 Vilanterol Trifenate <1 mg/mL 100 mg/mL 14 mg/mL
S3656 Piribedil <1 mg/mL 59 mg/mL 59 mg/mL
S1409 Alfuzosin HCl 85 mg/mL 85 mg/mL 85 mg/mL
S3083 Indacaterol Maleate <1 mg/mL 102 mg/mL <1 mg/mL
S2566 Isoprenaline HCl 50 mg/mL 50 mg/mL <1 mg/mL
S2020 Formoterol Hemifumarate <1 mg/mL 80 mg/mL <1 mg/mL
S1613 Silodosin <1 mg/mL 99 mg/mL 99 mg/mL
S1549 Nebivolol HCl <1 mg/mL 88 mg/mL <1 mg/mL
S2521 Epinephrine bitartrate 67 mg/mL 67 mg/mL <1 mg/mL
S2691 BMY 7378 Dihydrochloride 92 mg/mL 92 mg/mL 20 mg/mL
S2458 Clonidine HCl 53 mg/mL 53 mg/mL 53 mg/mL
S1424 Prazosin HCl <1 mg/mL 4 mg/mL <1 mg/mL
S4076 Propranolol HCl 6 mg/mL 59 mg/mL <1 mg/mL
S2038 Phentolamine Mesylate 76 mg/mL 76 mg/mL 76 mg/mL
S3041 Droxidopa <1 mg/mL <1 mg/mL <1 mg/mL
S3075 Dexmedetomidine <1 mg/mL 40 mg/mL 40 mg/mL
S2522 L-Adrenaline <1 mg/mL 4 mg/mL <1 mg/mL
S1206 Bisoprolol fumarate 88 mg/mL 88 mg/mL 88 mg/mL
S1856 Metoprolol Tartrate 100 mg/mL 100 mg/mL 31 mg/mL
S2059 Terazosin HCl Dihydrate <1 mg/mL 26 mg/mL <1 mg/mL
S1387 Naftopidil DiHCl <1 mg/mL 41 mg/mL 2 mg/mL
S2517 Maprotiline HCl <1 mg/mL 63 mg/mL 24 mg/mL
S1831 Carvedilol <1 mg/mL 81 mg/mL 4 mg/mL
S4113 Desvenlafaxine <1 mg/mL 37 mg/mL 3 mg/mL
S2569 Phenylephrine HCl 41 mg/mL 41 mg/mL 41 mg/mL
S2126 Naftopidil <1 mg/mL 79 mg/mL <1 mg/mL
S2499 Phenoxybenzamine HCl 17 mg/mL 68 mg/mL 68 mg/mL
S2509 Sotalol HCl 61 mg/mL 61 mg/mL <1 mg/mL
S4123 Timolol Maleate <1 mg/mL 86 mg/mL 86 mg/mL
S4065 Guanabenz Acetate <1 mg/mL 58 mg/mL 5 mg/mL
S2519 Naphazoline HCl 49 mg/mL 17 mg/mL 22 mg/mL
S2533 Ritodrine HCl 65 mg/mL 65 mg/mL 65 mg/mL
S2438 Synephrine HCl 41 mg/mL 14 mg/mL 4 mg/mL
S2090 Dexmedetomidine HCl <1 mg/mL 48 mg/mL 48 mg/mL
S4010 Acebutolol HCl 75 mg/mL 75 mg/mL 75 mg/mL
S3061 Epinephrine HCl 44 mg/mL 44 mg/mL 7 mg/mL
S3060 Medetomidine HCl 47 mg/mL 12 mg/mL 47 mg/mL
S1437 Tizanidine HCl 15 mg/mL 10 mg/mL <1 mg/mL
S1827 Betaxolol HCl 69 mg/mL 69 mg/mL 69 mg/mL
S2092 Detomidine HCl 45 mg/mL 45 mg/mL 45 mg/mL
S2545 Scopine <1 mg/mL 31 mg/mL <1 mg/mL
S4296 Salmeterol Xinafoate <1 mg/mL 100 mg/mL 4 mg/mL
S2607 Buflomedil HCl 69 mg/mL 31 mg/mL 7 mg/mL
S2523 DL-Adrenaline <1 mg/mL 0.02 mg/mL <1 mg/mL
S4266 Brimonidine Tartrate 75 mg/mL 88 mg/mL <1 mg/mL
S2615 Noradrenaline bitartrate monohydrate 64 mg/mL 64 mg/mL <1 mg/mL
S7974 L755507 <1 mg/mL 100 mg/mL <1 mg/mL
S4729 Tamsulosin hydrochloride 17 mg/mL 88 mg/mL 8 mg/mL
S4124 Tolazoline HCl 39 mg/mL 39 mg/mL 39 mg/mL
S4127 Terbutaline Sulfate 100 mg/mL <1 mg/mL <1 mg/mL
S4135 Clorprenaline HCl 50 mg/mL 50 mg/mL 50 mg/mL
S4043 Tetrahydrozoline HCl 47 mg/mL 12 mg/mL 26 mg/mL
S1642 Methyldopa <1 mg/mL 2 mg/mL <1 mg/mL
S2576 Xylometazoline HCl 56 mg/mL 27 mg/mL 56 mg/mL
S4649 Atipamezole hydrochloride 21 mg/mL 12 mg/mL 49 mg/mL
S4650 Atipamezole <1 mg/mL 42 mg/mL 42 mg/mL
S4693 Guanfacine Hydrochloride 30 mg/mL 56 mg/mL 56 mg/mL
S4679 Terazosin HCl 1 mg/mL 84 mg/mL <1 mg/mL
S4085 Levobetaxolol HCl 69 mg/mL 69 mg/mL 69 mg/mL
S8114 ICI-118551 Hydrochloride 21 mg/mL 62 mg/mL 62 mg/mL
S4100 Esmolol HCl 66 mg/mL 66 mg/mL 66 mg/mL
S4112 Desvenlafaxine Succinate <1 mg/mL 80 mg/mL <1 mg/mL
S4243 Deoxycorticosterone acetate <1 mg/mL 11 mg/mL 6 mg/mL
S2086 Ivabradine HCl 82 mg/mL 101 mg/mL 101 mg/mL
S2091 Betaxolol 62 mg/mL 62 mg/mL <1 mg/mL
S4277 Bambuterol HCl 72 mg/mL 80 mg/mL 28 mg/mL
S4278 Carteolol HCl 65 mg/mL 65 mg/mL <1 mg/mL
S2362 Synephrine <1 mg/mL 33 mg/mL 2 mg/mL
S2113 Cisatracurium Besylate 47 mg/mL 249 mg/mL 249 mg/mL
S2373 Yohimbine HCl <1 mg/mL 12 mg/mL <1 mg/mL
S4291 Labetalol HCl 8 mg/mL 72 mg/mL 7 mg/mL
S3185 Adrenalone HCl 44 mg/mL 44 mg/mL <1 mg/mL

Isoform-specific Inhibitors

Catalog No. Information Product Use Citations Product Validations

Salbutamol Sulfate

Salbutamol Sulfate is a short-acting β2-adrenergic receptor agonist with an IC50 of 8.93 µM.


Doxazosin Mesylate

Doxazosin, a quinazoline-derivative, selectively antagonizes postsynaptic α1-adrenergic receptors, used in the treatment of high blood pressure and urinary retention associated with benign prostatic hyperplasia.


Asenapine maleate

Asenapine maleate is a high-affinity antagonist of serotonin, norepinephrine, dopamine and histamine receptors, used for the treatment of schizophrenia and acute mania associated with bipolar disorder.



Mirabegron is a selective β3-adrenoceptor agonist with EC50 of 22.4 nM.


Xylazine HCl

Xylazine is an α2-Adrenergic receptor agonist, used as a sedative and muscle relaxant.


Higenamine hydrochloride

Higenamine, also known as Norcoclaurine HCl, is a non-selective β2 adrenoceptor agonist which is a chemical compound naturally occurring in a number of plants.



Amitraz is a triazapentadiene, an α2 adrenergic agonist and a member of the amidine chemical family. It is a non-systemic acaricide and insecticide.


Flupenthixol dihydrochloride

Flupentixol, an antipsychotic neuroleptic drug, is a powerful antagonist of both D1 and D2 dopamine receptors and also an alpha-adrenergic receptor antagonist.


Methoxyphenamine Hydrochloride

Methoxyphenamine Hydrochloride is a β-adrenergic receptor agonist of the amphetamine class used as a bronchodilator.


Vilanterol Trifenate

Vilanterol trifenatate is a novel inhaled long-acting beta2 adrenoceptor agonist with inherent 24-hour activity for once daily treatment of COPD and asthma.



Piribedil is a relatively selective dopamine (D2/D3) agonist with moderate antidepressant activity. It also has α2-adrenergic (α2A/α2C) antagonist properties.


Alfuzosin HCl

Alfuzosin HCl is an alpha1 receptor antagonist used to treat benign prostatic hyperplasia (BPH).


Indacaterol Maleate

Indacaterol is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36 for β1-adrenoceptor and pKi of 5.48 for β2-adrenoceptor.


Isoprenaline HCl

Isoprenaline is a non-selective beta-adrenergic receptor agonist, used for the treatment of bradycardia and heart block.


Formoterol Hemifumarate

Formoterol Hemifumarate is a potent, selective and long-acting β2-adrenoceptor agonist used in the management of asthma and chronic obstructive pulmonary disease(COPD).



Silodosin is a highly selective α1A-adrenoceptor antagonist, used in treatment of benign prostatic hyperplasia.


Nebivolol HCl

Nebivolol HCl selectively inhibits β1-adrenoceptor with IC50 of 0.8 nM.


Epinephrine bitartrate

Epinephrine bitartrate is an alpha- and beta-adrenergic receptor stimulator.


BMY 7378 Dihydrochloride

BMY 7378 is a multi-targeted inhibitor of α2C-adrenoceptor and α1D-adrenoceptor with pKi of 6.54 and 8.2, respectively, and acts as a mixed agonist and antagonist for 5-HT1A receptor with pKi of 8.3.


Clonidine HCl

Clonidine HCl is a direct-acting α2 adrenergic agonist with an ED50 of 0.02±0.01 mg/kg.


Prazosin HCl

Prazosin HCl is a competitive alpha-1 adrenoceptor antagonist, used to treat high blood pressure or benign prostatic hyperplasia.


Propranolol HCl

Propranolol HCl is a competitive non-selective beta-adrenergic receptors inhibitor with IC50 of 12 nM.


Phentolamine Mesylate

Phentolamine Mesylate is a reversible and nonselective alpha-adrenergic receptor antagonist, used for the prevention or control of hypertensive episodes.



Droxidopa is a psychoactive drug and acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline).



Dexmedetomidine is a sedative medication used by intensive care units and anesthetists.



L-Adrenaline belongs to a group of the compounds known as catecholamines.


Bisoprolol fumarate

Bisoprolol fumarate is a selective type β1 adrenergic receptor blocker.


Metoprolol Tartrate

Metoprolol Tartrate is a selective β1 receptor blocker medication, used to treat hypertension and heart failure.


Terazosin HCl Dihydrate

Terazosin HCl is a selective α1-adrenoceptor antagonist, used for treatment of symptoms of an enlarged prostate (BPH).


Naftopidil DiHCl

Naftopidil DiHCl is a selective 5-HT1A and α1-adrenergic receptor antagonist with IC50 of 0.1 μM and 0.2 μM, respectively.


Maprotiline HCl

Maprotiline HCl is a selective noradrenalin re-uptake inhibitor, used in the treatment of depression.



Carvedilol is a non-selective beta blocker/alpha-1 blocker, used to treat congestive heart failure (CHF) and high blood pressure.



Desvenlafaxine is a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor with Ki of 40.2 nM and 558.4 nM, respectively.


Phenylephrine HCl

Phenylephrine HCl is a selective α1-adrenergic receptor agonist, used primarily as a decongestant.



Naftopidil is a selective α1-adrenergic receptor antagonist with Ki of 3.7 nM, 20 nM, and 1.2 nM for α1a, α1b, and α1d, respectively, used for the treatment of benign prostatic hyperplasia.


Phenoxybenzamine HCl

Phenoxybenzamine HCl is a non-specific, irreversible alpha antagonist with an IC50 of 550 nM.


Sotalol HCl

Sotalol is a non-selective beta blocker and a potassium channel blocker with an IC50 of 43 μM.


Timolol Maleate

Timolol Maleate is a non-selective, beta-adrenergic receptor antagonist for β1/β2 with Ki of 1.97 nM/2.0 nM.


Guanabenz Acetate

Guanabenz Acetate is an selective agonist of α2a-adrenergic receptor, α2b-adrenergic receptor and α2c-adrenergic receptor with pEC50 of 8.25, 7.01 and ~5, respectively.


Naphazoline HCl

Naphazoline HCl is an ocular vasoconstrictor and imidazoline derivative sympathomimetic amine.


Ritodrine HCl

Ritodrine HCl is a hydrochloride salt of ritodrine which is a β-2 adrenergic receptor agonist.


Synephrine HCl

SynephrineHCl (Oxedrine, p-Synephrine) is a sympathomimetic α-adrenergic receptor (AR) agonist.


Dexmedetomidine HCl

Dexmedetomidine HCl is a highly selective and potent alpha-2 adrenoceptor agonist, which reduces anesthetic requirements for patients by providing significant sedation.


Acebutolol HCl

Acebutolol is a β-adrenergic receptors antagonist used in the treatment of hypertension, angina pectoris and cardiac arrhythmias.


Epinephrine HCl

Epinephrine HCl is a hormone and a neurotransmitter.


Medetomidine HCl

Medetomidine is a selective α2-adrenoceptor agonist, with Ki of 1.08 nM, exhibts 1620-fold selectivity over α1-adrenoceptor.


Tizanidine HCl

Tizanidine HCl is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.


Betaxolol HCl

Betaxolol is a β1 adrenergic receptor blocker with IC50 of 6 μM.


Detomidine HCl

Detomidine HCl produce dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors.



Scopine is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock.


Salmeterol Xinafoate

Salmeterol Xinafoate is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma symptoms and chronic obstructive pulmonary disease (COPD) symptoms.


Buflomedil HCl

Buflomedil HCl is a vasodilator used to treat claudication or the symptoms of peripheral arterial disease; A nonselective alpha adrenergic receptor inhibitor.



DL-Adrenaline is a hormone and a neurotransmitter secreted by the medulla of the adrenal glands.


Brimonidine Tartrate

Brimonidine Tartrate is a highly selective α-adrenergic receptor agonist with EC50 of 0.45 nM for the α2A adrenoreceptor, and used to treat open-angle glaucoma or ocular hypertension.


Noradrenaline bitartrate monohydrate

Noradrenaline bitartrate monohydrate is a direct alpha-adrenergic receptors stimulator.



L-755,507 is characterized as a potent and selective β3 adrenergic receptor partial agonist with EC50 of 0.43 nM. It is also recently identified to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs) and other cell types.


Tamsulosin hydrochloride

Tamsulosin is a potent and selective α1a adrenergic receptor antagonist.


Tolazoline HCl

Tolazoline is a non-selective competitive α-adrenergic receptor antagonist.


Terbutaline Sulfate

Terbutaline Sulfate is a selective β2-adrenergic receptor agonist with IC50 of 53 nM.


Clorprenaline HCl

Clorprenaline HCl is a β2-receptor agonist, it has a significant expansion of the bronchial effect.


Tetrahydrozoline HCl

Tetrahydrozoline HCl is an imidazoline derivative with alpha receptor agonist activity.



Methyldopa (Aldomet) is a DOPA decarboxylase competitive inhibitor with an ED50 of 21.8 mg/kg.


Xylometazoline HCl

Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 99 μM.


Atipamezole hydrochloride

Atipamezole is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug. Atipamezole hydrochloride is hydrochloride form of atipamezole.



Atipamezole is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug.


Guanfacine Hydrochloride

Guanfacine Hydrochloride is a selective α2A-adrenoceptor agonist with anti-hypertensive effect.


Terazosin HCl

Terazosin is a selective alpha-1 antagonist used for treatment of symptoms of an enlarged prostate (BPH). It works by blocking the action of adrenaline on smooth muscle of the bladder and the blood vessel walls.


Levobetaxolol HCl

Levobetaxolol exhibits a higher affinity at cloned human β1 and β2 receptors with Ki value of 0.76 nM and 32.6 nM, respectively.


ICI-118551 Hydrochloride

ICI-118551 is a highly selective β2-adrenergic receptor antagonist with Ki values of 0.7, 49.5 and 611 nM for β2, β1 and β3 receptors, respectively.


Esmolol HCl

Esmolol is a cardioselective b-blocker, used to control rapid heartbeats or abnormal heart rhythms.


Desvenlafaxine Succinate

Desvenlafaxine Succinate is a new serotonin (5-HT) transporter and norepinephrine (NE) transporter reuptake inhibitor with Ki of 40.2 nM and 558.4 nM respectively.


Deoxycorticosterone acetate

Deoxycorticosterone acetate is a steroid hormone used for intramuscular injection for replacement therapy of the adrenocortical steroid.


Ivabradine HCl

Ivabradine HCl, a new If inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent.



Betaxolol is a selective beta1 adrenergic receptor blocker used in the treatment of hypertension and glaucoma.


Bambuterol HCl

Bambuterol HCl is a potent β-adrenoceptor agonist, used in the treatment of asthma.


Carteolol HCl

Carteolol HCl is a β-adrenoceptor antagonist, used for the treatment of glaucoma.



Synephrine, a natural protoalkaloid in the extract of bitter orange and other citrus species, is commonly used for weight loss.


Cisatracurium Besylate

Cisatracurium Besylate is a nondepolarizing neuromuscular blocking agent, antagonizing the action of acetylcholine by inhibiting neuromuscular transmission.


Yohimbine HCl

Yohimbine has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac.


Labetalol HCl

Labetalol HCl is a dual antagonist for both selective alpha1-adrenergic and nonselective beta-adrenergic receptors, used in the treatment of high blood pressure.


Adrenalone HCl

Adrenalone is an adrenergic agonist used as a topical vasoconstrictor and hemostatic, mainly acts on alpha-1 adrenergic receptors.

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