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Naftopidil Dihydrochloride Chemical Structure
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Biological Activity
Naftopidil is a selective α1-adrenergic receptor antagonist or alpha blocker with IC50 of 22.2 ± 4.0 µM and 33.2 ± 1.1 µM for androgen-sensitive LNCaP cells and androgen-insensitive PC-3 cells, respectively.[1] In vivo, oral administration of naftopidil to nude mice inhibited the growth of PC-3 tumors as compared to vehicle-treated controls. These results suggest that naftopidil may be useful in the chemoprevention of prostate cancer and the intervention of hormone refractory prostate cancer. [2]
References on Naftopidil Dihydrochloride
- [1] http://en.wikipedia.org/wiki/Naftopidil ;
- [2] Int J Cancer. 2008 Jan 15;122(2):444-51.
Chemical Information
| Molecular Weight (WM): | 465.41 |
|---|---|
| Formula: | C24H28N2O3.2HCl |
| CAS No.: | 57149-08-3 |
| Synonyms: |
Flivas, KT-611, Avishot
|
| Dissolve in (25°C): | DMSO ≥93mg/mL |
| Water <1mg/mL | |
| Ethanol ≥2mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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