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Ivabradine HCl Adrenergic Receptor inhibitor

Name: Ivabradine HCl
Brand: Selleck Chemicals
SKU: S2086
Availability: InStock
Rating: 5 (3 reviews)

Cat.No.S2086

Ivabradine HCl (S 16257-2,S-18982 D6 hydrochloride), a new I_f inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent.

Chemical Structure

Molecular Weight: 505.05

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Quality Control

Batch: Purity: 99.74%

99.74

Related Targets	AChR 5-HT Receptor COX Calcium Channel Histamine Receptor Dopamine Receptor GABA Receptor TRP Channel Cholinesterase (ChE) GluR
Other Adrenergic Receptor Inhibitors	ICI 118551 Hydrochloride (Zenidolol) L755507 Yohimbine HCl Atipamezole Higenamine hydrochloride Noradrenaline bitartrate monohydrate Fenoterol hydrobromide Medetomidine HCl Isoprenaline L-Adrenaline

Solubility

In vitro
Batch:

DMSO : 101 mg/mL (199.98 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 101 mg/mL

Water : 82 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	5mg/ml (9.90mM)	Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.71mg/ml (1.41mM)	Taking the 1 mL working solution as an example, add 50 μL of 14.2 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	505.05	Formula	C₂₇H₃₆N₂O₅.HCl	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	148849-67-6	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	S 16257-2,S-18982 D6 hydrochloride			SMILES	CN(CCCN1CCC2=CC(=C(C=C2CC1=O)OC)OC)CC3CC4=CC(=C(C=C34)OC)OC.Cl

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC₅₀/Ki	Adrenergic Receptor
References	[1] https://pubmed.ncbi.nlm.nih.gov/8032660/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2025-12-17)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07268170	ENROLLING_BY_INVITATION	Coronary Arterial Disease (CAD); Ischemic Heart Disease (IHD)	Gødstrup Hospital	2025-12-15	PHASE2; PHASE3
NCT07135258	NOT_YET_RECRUITING	Atrial Fibrillation (Permanent); Atrial Fibrillation (AF)	The University of Hong Kong	2025-10-01	PHASE4
NCT07714746	RECRUITING	Cardiogenic Shock Post Myocardial Infarction	National Institute of Cardiovascular Diseases, Pakistan	2026-04-20	PHASE3
NCT07797946	NOT_YET_RECRUITING	Hemodynamic Instability	Minia University	2026-08-01
NCT05882708	RECRUITING	Sepsis; Ivabradine; Hemodynamics; Heart Rate Control	Second Affiliated Hospital of Guangzhou Medical University	2023-06-01	PHASE4
NCT07717710	NOT_YET_RECRUITING	Healthy Adult	University of British Columbia	2026-08-01	EARLY_PHASE1

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Handling Instructions

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