Home Neuronal Signaling Adrenergic Receptor agonist Clonidine HCl

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Clonidine HCl Adrenergic Receptor agonist

Cat.No.S2458

Clonidine HCl(Kapvay) is a direct-acting α2 adrenergic agonist with an ED50 of 0.02±0.01 mg/kg.
Clonidine HCl Adrenergic Receptor agonist Chemical Structure

Chemical Structure

Molecular Weight: 266.5

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Quality Control

Batch: S245801 DMSO]53 mg/mL]false]Water]53 mg/mL]false]Ethanol]53 mg/mL]false Purity: 99.97%
99.97

Solubility

In vitro
Batch:

DMSO : 53 mg/mL (198.87 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 53 mg/mL

Ethanol : 53 mg/mL

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In vivo
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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Chemical Information, Storage & Stability

Molecular Weight 266.5 Formula

C9H9Cl2N3.HCl

 Storage (From the date of receipt)
CAS No. 4205-91-8 Download SDF Storage of Stock Solutions

Synonyms Kapvay Smiles C1CN=C(N1)NC2=C(C=CC=C2Cl)Cl.Cl

Mechanism of Action

Targets/IC50/Ki
α2-adrenergic receptor

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05943613 Not yet recruiting
Postoperative Pain
Assiut University
 December 1 2023 Phase 1
NCT05091242 Recruiting
Emergence Delirium
Rigshospitalet Denmark
 October 25 2021 Phase 2|Phase 3
NCT05029401 Unknown status
Opiate Withdrawal Syndrome
DemeRx IB Inc.|MAC Clinical Research|ERT: Clinical Trial Technology Solutions|Hammersmith Medicines Research
 April 1 2021 Phase 1|Phase 2
NCT03537612 Terminated
Scoliosis
Dr. Jean A. Ouellet MD FRCSC|Shriners Hospitals for Children
 June 22 2018 Phase 3

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