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Xylometazoline HCl

Name: Xylometazoline HCl
Brand: Selleck Chemicals
SKU: S2576
Rating: 5 (1 reviews)

Catalog No.S2576 Purity: 99.71%

Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α_2B-adrenoceptor subtype with EC50 of 99 μM.

Xylometazoline HCl Chemical Structure

CAS: 1218-35-5

Purity & Quality Control

Batch: S257601 Water] 56 mg/mL] false] Ethanol] 56 mg/mL] false] DMSO] 27 mg/mL] false Purity: 99.71%

99.71

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Signaling Pathway

Adrenergic Receptor Signaling Pathway

Choose Selective Adrenergic Receptor Inhibitors

Biological Activity

Description

Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α_2B-adrenoceptor subtype with EC50 of 99 μM.

Targets

adrenoceptor α1A ^[1]	adrenoceptor α2C ^[1]	adrenoceptor α1D ^[1]	adrenoceptor α1B ^[1]	adrenoceptor α2A ^[1]	Click to View More Targets
80 nM	220 nM	450 nM	560 nM	980 nM	Click to View More Targets

In vitro
In vitro	Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α_2B-adrenoceptor subtype with EC50 of 99 μM. Xylometazoline binds at adrenoceptor subtypeα_1A, α_1B, α_1D, α_2A, α_2B, α_2C with IC50 of 0.08, 0.56, 0.45, 0.98, 1.8, 0.22μM, repectively. ^[1]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT00452270	Completed	Common Cold	Novartis	March 2007	Phase 3

References

[1] Haenisch B, Fundam Clin Pharmacol, 2010, 24(6), 729-739.

Chemical Information & Solubility

Molecular Weight	280.84	Formula	C₁₆H₂₄N₂.HCl
CAS No.	1218-35-5	SDF	Download Xylometazoline HCl SDF Download Xylometazoline HCl SDF
Smiles	CC1=CC(=CC(=C1CC2=NCCN2)C)C(C)(C)C.Cl
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

Water : 56 mg/mL

Ethanol : 56 mg/mL

DMSO : 27 mg/mL ( (96.14 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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