Carteolol HCl

Catalog No.S4278

Carteolol HCl is a β-adrenoceptor antagonist, used for the treatment of glaucoma.

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Carteolol HCl Chemical Structure

Carteolol HCl Chemical Structure
Molecular Weight: 328.83

Validation & Quality Control

Quality Control & MSDS

Related Compound Libraries

Carteolol HCl is available in the following compound libraries:

Product Information

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Product Description

Biological Activity

Description Carteolol HCl is a β-adrenoceptor antagonist, used for the treatment of glaucoma.
Targets β-adrenergic receptor [1]
In vitro
In vivo
Features

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)0.020.151.80.40.0810
Body Surface Area (m2)0.0070.0250.150.050.020.5
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

References

Clinical Trial Information( data from http://clinicaltrials.gov, updated on 2016-07-23)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT02108288 Completed Glaucoma|Ocular Hypertension Otsuka Pharmaceutical Co., Ltd. April 2014 Phase 1
NCT02105285 Completed Glaucoma|Ocular Hypertension Otsuka Pharmaceutical Co., Ltd. April 2014 Phase 3
NCT00972426 Completed Glaucoma Taiwan Otsuka Pharm. Co., Ltd October 2009 Phase 4

Chemical Information

Download Carteolol HCl SDF
Molecular Weight (MW) 328.83
Formula

C16H25ClN2O3

CAS No. 51781-21-6
Storage 3 years -20℃powder
6 months-80℃in solvent
Synonyms N/A
Solubility (25°C) * In vitro DMSO 65 mg/mL (197.67 mM)
Water 65 mg/mL (197.67 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 5-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-3,4-dihydro-2(1H)-quinolinone,hydrochloride (1:1)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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