Catalog No.S3041 Synonyms: L-DOPS
Molecular Weight(MW): 213.19
Droxidopa is a psychoactive drug and acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline).
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|Description||Droxidopa is a psychoactive drug and acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline).|
|Features||An artificial amino acid.|
Droxidopa is a pro-drug which has a structure similar to noradrenaline, but with a carboxyl group. Droxidopa can be administered orally, unlike noradrenaline, and after absorption is converted by the enzyme dopa decarboxylase into noradrenaline thus increasing levels of the neurotransmitter which is identical to endogenous noradrenaline.  Droxidopa is well tolerated.  Droxidopa could exert its pressor effect in three different ways: a) as a central stimulator of sympathetic activity; b) as a peripheral sympathetic neurotransmitter; c) as a circulating hormone. Droxidopa taken alone increases standing blood pressure.  Droxidopa can also cross the blood–brain barrier (BBB) where it is converted to norepinephrine and epinephrine from within the brain. 
|In vivo||The acute administration of droxidopa in PVL and BDL rats caused a significant and maintained increase in arterial pressure and mesenteric arterial resistance, with a significant decrease of mesenteric arterial and portal blood flow, without changing portal pressure and renal blood flow. Droxidopa-treated rats also showed a decreased ratio of p-eNOS/eNOS and p-AKT/AKT and increased activity of RhoK in SMA.|
-  Mathias CJ. Clin Auton Res, 2008, 18 Suppl 1, 25-29.
-  Mathias CJ, et al. Clin Auton Res, 2001, 11(4), 235-242.
-  Kaufmann H. Clin Auton Res, 2008, 18 Suppl 1, 19-24.
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02897063||Recruiting||Autonomic Failure|Pure Autonomic Failure|Multiple System Atrophy|Parkinson Disease|Orthostatic Hypotension||Vanderbilt University Medical Center||September 2016||Phase 1|
|NCT02812147||Recruiting||Parkinson Disease||St. Josephs Hospital and Medical Center, Phoenix|Arizona State University, Tempe||May 2016||Phase 2|
|NCT02586623||Recruiting||Symptomatic Neurogenic Orthostatic Hypotension||Lundbeck Northera Ltd.||February 2016||Phase 4|
|NCT02624310||Withdrawn||HSAN Type IV||New York University School of Medicine||January 2016||Phase 2|
|NCT02558972||Recruiting||Postural Tachycardia Syndrome (POTS)|Vasovagal Syncope (VVS)|Fainting||New York Medical College|Lundbeck LLC||September 2015||Phase 2|
|NCT02066571||Enrolling by invitation||Parkinsons Disease|Freezing of Gait|Cognitive Ability, General||Henry Ford Health System||March 2015||Phase 2|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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