Name: Metoprolol
Brand: Selleck Chemicals
SKU: S5430
Rating: 5 (2 reviews)

Metoprolol is a cardioselective β1-adrenergic blocking agent with log Kd values of −7.26±0.07, −6.89±0.09, −5.16±0.12 for β1, β2, and β3 adrenoceptors, respectively. It is used for acute myocardial infarction, heart failure, angina pectoris and mild to moderate hypertension.

Metoprolol Chemical Structure

CAS: 51384-51-1

Selleck's Metoprolol has been cited by 2 publications

Purity & Quality Control

Batch: Purity: 99.99%

99.99

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Signaling Pathway

Adrenergic Receptor Signaling Pathway

Choose Selective Adrenergic Receptor Inhibitors

Biological Activity

Description

Metoprolol is a cardioselective β1-adrenergic blocking agent with log Kd values of −7.26±0.07, −6.89±0.09, −5.16±0.12 for β1, β2, and β3 adrenoceptors, respectively. It is used for acute myocardial infarction, heart failure, angina pectoris and mild to moderate hypertension.

Targets

β1-adrenergic receptor ^[1]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT06004453	Recruiting	Heart Failure	Novartis Pharmaceuticals\|Novartis	April 5 2023	--
NCT05368831	Not yet recruiting	Healthy Volunteers	NorthSea Therapeutics B.V.	July 2022	Phase 1
NCT05171985	Unknown status	COVID-19 Pneumonia\|Atrial Fibrillation	Tanta University	January 2022	Not Applicable
NCT04842981	Terminated	Arthritis Rheumatoid\|Interaction	University of Southern Denmark\|Odense University Hospital\|Hospital of South West Jutland\|King Christian X´Hospital for Rheumatic Diseases\|Sygehus Lillebaelt\|Odense Patient Data Explorative Network	May 25 2021	Phase 1\|Phase 2
NCT04840641	Completed	Healthy Volunteers\|Drug Drug Interaction	University of Southern Denmark\|SignaTope GmbH Germany	March 25 2021	Phase 1

References

[1] Jillian G Baker. Br J Pharmacol. 2005, 144(3): 317–322.

Chemical Information & Solubility

Molecular Weight	267.36	Formula	C₁₅H₂₅NO₃
CAS No.	51384-51-1	SDF	--
Smiles	CC(C)NCC(COC1=CC=C(C=C1)CCOC)O
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 53 mg/mL ( (198.23 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 53 mg/mL

Ethanol : 53 mg/mL

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In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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