Guanfacine Hydrochloride

Synonyms: Guanfacine, Tenex, Intuniv

Guanfacine Hydrochloride (Tenex, Intuniv) is a selective α2A-adrenoceptor agonist with anti-hypertensive effect.

Guanfacine Hydrochloride Chemical Structure

Guanfacine Hydrochloride Chemical Structure

CAS: 29110-48-3

Purity & Quality Control

Batch: S469301 DMSO] 56 mg/mL] false] Ethanol] 56 mg/mL] false] Water] 30 mg/mL] false Purity: 99.98%
99.98

Guanfacine Hydrochloride Related Products

Choose Selective Adrenergic Receptor Inhibitors

Biological Activity

Description Guanfacine Hydrochloride (Tenex, Intuniv) is a selective α2A-adrenoceptor agonist with anti-hypertensive effect.
Targets
α2A-adrenoceptor [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04866030 Completed
Attention Deficit Hyperactivity Disorder (ADHD)
Shire|Takeda
March 11 2019 --
NCT05870605 Completed
Attention Deficit Hyperactivity Disorder (ADHD)
Shire|Takeda
November 15 2018 --
NCT01904526 Completed
Smoking
Yale University|National Institute on Drug Abuse (NIDA)
July 2013 Phase 2

Chemical Information & Solubility

Molecular Weight 282.55 Formula

C9H9Cl2N3O.HCl

CAS No. 29110-48-3 SDF Download Guanfacine Hydrochloride SDF
Smiles C1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 56 mg/mL ( (198.19 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 56 mg/mL

Water : 30 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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