Catalog No.S4113 Synonyms: WY 45233 Succinate

Desvenlafaxine Chemical Structure

Molecular Weight(MW): 263.38

Desvenlafaxine is a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor with Ki of 40.2 nM and 558.4 nM, respectively.

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In DMSO USD 120 In stock
USD 60 In stock
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Biological Activity

Description Desvenlafaxine is a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor with Ki of 40.2 nM and 558.4 nM, respectively.
Features Desvenlafaxine is a major active metabolite of venlafaxine.
5-HT [1] Norepinephrine (NE) [1]
40.2 nM(Ki) 558.4 nM(Ki)
In vitro

Desvenlafaxine is a serotonin-norepinephrine reuptake inhibitor and is the active metabolite of the antidepressant venlafaxine. Similar to venlafaxine, desvenlafaxine inhibits the neuronal uptake of serotonin and norepinephrine. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter. Desvenlafaxine inhibits [3H]5-HT or [3H]NE uptake for the hSERT or hNET with IC50 of 47.3 and 531.3 nM, respectively.[1] Desvenlafaxine has the potential to inhibit CYP2D6, which could result in increased concentrations of drugs metabolized through this pathway. Induction of CYP3A4 is also possible with desvenlafaxine, which could impact the metabolism of drugs metabolized via this enzyme. [2]

In vivo Desvenlafaxine rapidly penetrates the male rat brain and hypothalamus. Desvenlafaxine significantly increases extracellular NE levels compared with baseline in the male rat hypothalamus but had no effect on DA levels using microdialysis. [1] Desvenlafaxine exhibits a linear and dose-proportional pharmacokinetic single-dose profile in a dose range from 100 to 600 mg/day. The absolute bioavailability of the oral formulation is 80.5%.[2]


Animal Research:[1]
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  • Animal Models: Male Sprague-Dawley rats
  • Formulation: 0.25% Tween 80 and 0.5% methylcellulose
  • Dosages: 30 mg/kg
  • Administration: oral
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 37 mg/mL (140.48 mM)
Ethanol 3 mg/mL (11.39 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
0.5% methylcellulose+0.2% Tween 80
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 263.38


CAS No. 93413-62-8
Storage powder
in solvent
Synonyms WY 45233 Succinate

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03432221 Not yet recruiting Major Depressive Disorder Corporacion Parc Tauli|Pfizer April 3 2018 --
NCT02893371 Enrolling by invitation Bipolar Disorder University of New Mexico|Patient-Centered Outcomes Research Institute|Montana State University|National Alliance on Mental Illness|CGStat LLC|Risk Benefit Statistics LLC September 2016 --
NCT02330679 Unknown status Major Depressive Disorder University of Calgary|University of Alberta December 2014 Phase 4
NCT02200406 Completed Depression|Opioid Dependence|Methadone Treatment Didier Jutras-Aswad|Pfizer|Centre hospitalier de l''Université de Montréal (CHUM) July 2014 Phase 4
NCT01974934 Unknown status Vascular Depression Hotel-Dieu Grace Healthcare December 2013 Phase 4
NCT01977378 Unknown status Major Depressive Disorder Jiangsu Hansoh Pharmaceutical Co. Ltd. October 2013 Phase 2|Phase 3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID