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All New Products Listed Chronologically
| Cat.No. | Product Name | Information | Added |
|---|---|---|---|
| S2752 | HER2-Inhibitor-1 | ARRY-380 is a potent and selective HER2 inhibitor with IC50 of 8 nM, equipotent against truncated p95-HER2, 500-fold more selective for HER2 versus EGFR. Phase 1. | Jul 13 2017 |
| S8520 | Senexin A | Senexin A is a potent and selective inhibitor of CDK8 and its nearest relative, CDK19 with Kd values of 0.83 μM and 0.31 μM for CDK8 and CDK19 ATP site binding, respectively. | Jul 11 2017 |
| S8570 | RXDX-106 (CEP-40783) | RXDX-106 (CEP-40783) is an orally-available, potent and selective TAM(TYRO3, AXL, MER)/MET inhibitor displaying low nanomolar biochemical activity and slow (T1/2 >120 min) inhibitor off-rate in peptide phosphorylation assays and in vitro kinase binding assays, respectively. | Jul 11 2017 |
| S8549 | AUNP-12 | AUNP-12, a new immune checkpoint modulator, is an inhibitor of the PD-1 pathway. | Jul 11 2017 |
| S8517 | Lixisenatide | Lixisenatide is a once-daily short-acting glucagon-like peptide-1 (GLP-1) receptor agonist (GLP-1RA) with an IC50 of 1.4 nM for the human GLP-1 receptor in receptor binding studies. | Jul 11 2017 |
| S8157 | GDC-0326 | GDC-0326 is a potent and selective inhibitor of PI3Kα with Ki value of 0.2 nM; remarkably selective over the other class I isoforms in enzymatic assays. | Jul 11 2017 |
| S8559 | INF39 | INF39 is a nontoxic, irreversible NLRP3 inhibitor that counteracts NLRP3 activation through direct irreversible interaction with NLRP3 and partial inhibition of LPS-driven pro-inflammatory gene expression. | Jul 11 2017 |
| S8565 | Omarigliptin (MK-3102) | Omarigliptin (MK-3102) is a competitive, reversible inhibitor of DPP-4 (IC50 = 1.6 nM, Ki = 0.8 nM). It is highly selective over all proteases tested (IC50 > 67 μM), including QPP, FAP, PEP, DPP8, and DPP9 and has weak ion channel activity (IC50 > 30 μM at IKr, Caγ1.2, and Naγ1.5). | Jul 11 2017 |
| S8340 | SGC2085 | SGC2085 is a potent and selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) inhibitor with an IC50 value of 50 nM and >100-fold selective over other PRMTs. | Jul 03 2017 |
| S8518 | AD80 | AD80, a multikinase inhibitor, shows strong activity against human RET, BRAF, S6K, and SRC but were much less active than either AD57 or AD58 against mTOR. The IC50 value for RET is 4 nM. | Jul 03 2017 |
| S7983 | A-196 | A-196 is a potent and selective inhibitor of SUV420H1 and SUV420H2 with IC50 values of 0.025 and 0.144 μM, respectively; more than 100-fold selective over other histone methyltransferases and non-epigenetic targets. | Jul 03 2017 |
| S8564 | Verubecestat (MK-8931) | Verubecestat (MK-8931) is a potent and selective beta-secretase inhibitor and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor. | Jun 29 2017 |
| S7901 | Ac-DEVD-CHO | Ac-DEVD-CHO is a potent aldehyde inhibitor of Group II caspases with Ki values of 0.2 nM and 0.3 nM for for caspase-3 and caspase-7, respectively. Weak inhibition for caspase-2. | Jun 29 2017 |
| S7178 | Prexasertib (LY2606368) | Prexasertib (LY2606368) is an ATP-competitive CHK1 inhibitor with a Ki value of 0.9 nmol/L. For CHK2 and RSK, its IC50 values are 8 nM and 9 nM respectively in cell-free assay. | Jun 29 2017 |
| S7609 | GW4869 | GW4869 is a neutral, noncompetitive inhibitor of sphingomyelinase (SMase) with an IC50 of 1 μM. It is selective for N-SMase, and does not inhibit acid SMase at up to at least 150 μM. | Jun 21 2017 |
| S7362 | AZD5582 | AZD5582, a novel small-molecule IAP inhibitor, binds potently to the BIR3 domains of cIAP1, cIAP2, and XIAP with IC50 values of 15, 21, and 15 | Jun 13 2017 |
| S8366 | CRT0066101 | CRT0066101 is a small molecule PKD family specific inhibitor which specifically blocks PKD1/2 activity and does not suppress PKCα/PKCβ/PKCε activity in multiple. | Jun 13 2017 |
| S8427 | LTURM34 | LTURM34 is a specific DNA-PK inhibitor, 170-fold more selective for DNA-PK activity compared to PI3K activity, with IC50 value of 0.034 μM. | Jun 13 2017 |
| S8156 | ARS-853 (ARS853) | ARS-853 is a selective, covalent inhibitor of KRAS(G12C) that inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein and preventing activation. | Jun 05 2017 |
| A2000 | Cetuximab | Cetuximab, a novel molecular-targeted agent,is an inhibitor of EGFR monoclonal humanized antibody interacting with the extracellular binding site of EGFR to block ligand stimulation. MW : 145.781 KD. | Jun 02 2017 |
| Cat.No. | Product Name | Information | Added |
|---|---|---|---|
| A2001 | Ipilimumab | Ipilimumab is an immunomodulatory monoclonal antibody directed against the cell surface antigen CTLA-4 and also a type of immune checkpoint inhibitor. MW : 148 kD. | Jun 02 2017 |
| A2002 | Nivolumab | Nivolumab is a genetically engineered, fully human immunoglobulin (Ig) G4 monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed death-1 (PD-1,PCD-1) with immune checkpoint inhibitory and antineoplastic activities. MW : 143.597 KD. | Jun 02 2017 |
| A2004 | Atezolizumab | Atezolizumab is a fully humanized, IgG1 monoclonal antibody that blocks the interaction of PD-L1 with both PD-1 and B7.1, but not the interaction of PD-L2 with PD-1. MW : 145 KD. | Jun 02 2017 |
| A2005 | Pembrolizumab | Pembrolizumab is a potent, highly selective, fully humanized immunoglobulin (Ig) G4-kappa monoclonal antibody against PD-1 with potential immune checkpoint inhibitory and antineoplastic activities. MW : 146.286 KD. | Jun 02 2017 |
| S8539 | TAS-102 | TAS-102 is an orally administered combination of a thymidine-based nucleic acid analogue, trifluridine, and a thymidine phosphorylase inhibitor, tipiracil hydrochloride. | Jun 01 2017 |
| S7682 | SAR405 | SAR405 is a low-molecular-mass kinase inhibitor of Vps34 (KD 1.5 nM) showing high selectivity and not be active up to 10 μM on class I and class II PI3Ks as well as on mTOR. | Jun 01 2017 |
| S8397 | Eltanexor (KPT-8602) | Eltanexor(KPT-8602) is a second-generation, orally bioavailable XPO1 inhibitor with IC50 values of 20−211 nM in 10 AML lines after 3 days exposure. | Jun 01 2017 |
| S8522 | Compstatin | Compstatin binds to complement component C3 and inhibits complement activation with IC50 of 12 μM. | Jun 01 2017 |
| S4753 | Ganoderic acid A | Ganoderic acid A (GAA), a representative active triterpenoid from Ganoderma lucidum, has been reported to exhibit antinociceptive, antioxidative, cytotoxic, hepatoprotective and anticancer activities. | Jun 01 2017 |
| S8278 | SHP099 dihydrochloride | SHP099 is a highly potent, selective and orally bioavailable small-molecule SHP2 inhibitor with an IC50 value of 0.071 μM and shows no activity against SHP1. | May 19 2017 |
| S8288 | VLX1570 | VLX1570 is a competitive inhibitor of proteasome DUB activity, with an IC50 of ~10 μM in vitro. | May 19 2017 |
| S8501 | DAPTA | DAPTA is a water soluble potent, selective CCR5 antagonist which potently inhibits specific CD4-dependent binding of gp120 Bal (IC50 = 0.06 nM) and CM235 (IC50 = 0.32 nM) to CCR5. | May 19 2017 |
| S8229 | Brigatinib (AP26113) | Brigatinib (AP26113) is a potent and selective ALK (IC50, 0.6 nM) and ROS1 (IC50, 0.9 nM) inhibitor. It also inhibits ROS1, FLT3, and mutant variants of FLT3 (D835Y) and EGFR with lower potentcy. | May 10 2017 |
| S8141 | Cl-amidine | Cl-amidine is an irreversible pan-peptidylarginine deiminase (PAD) inhibitor with IC50 values of 5.9 ± 0.3 μM, 0.8 ± 0.3 μM, 6.2 ± 1.0 μM for PAD4, PAD1 and PAD3, respectively. | May 10 2017 |
| S8452 | BAY-876 | BAY-876 is a potent and selective GLUT1 inhibitor (IC50=0.002 μM) with a selectivity factor of >100 against GLUT2, GLUT3, and GLUT4. | May 10 2017 |
| S8344 | AZD5153 | AZD5153 is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor with pKi of 8.3 for BRD4. | May 10 2017 |
| S8367 | GSK2193874 | GSK2193874 is an orally active, potent, and selective blocker of transient receptor potential vanilloid 4 (TRPV4) with IC50 values of 0.04 and 0.002 μM for hTRPV4 and rTRPV4, respectively. | May 10 2017 |
| S8379 | YU238259 | YU238259 is a novel inhibitor of homology-dependent DNA repair(HDR), but does not inhibit non-homologous end-joining (NHEJ), in cell-based GFP reporter assays. | May 10 2017 |
| S7985 | PIM447 (LGH447) | PIM447 is a novel pan-PIM kinase inhibitor with Ki values of 6 pM, 18 pM, 9 pM for PIM1, PIM2, PIM3 respectively. It also inhibits GSK3β, PKN1, and PKCτ, but at a significantly lower potency with IC50 between 1 and 5 μM (>105-fold differential relative to the Ki on PIMs). | May 05 2017 |
| S7552 | CFI-400945 | CFI-400945 is an orally active, potent and selective polo-like kinase 4(PLK4) inhibitor with Ki value of 0.26 nM. | May 05 2017 |
| Cat.No. | Product Name | Information | Added |
|---|---|---|---|
| S8432 | Troglitazone (CS-045) | Troglitazone is a potent agonist for the peroxisome proliferator-activated receptor-(PPAR) that is a ligand activated transcription factor regulating cell differentiation and growth. | Apr 27 2017 |
| S8265 | GSK6853 | GSK6853 is a selective benzimidazolone BRPF1 inhibitor with pIC50 of 8.1(TR-FRET) showing greater than 1600-fold selectivity over all other bromodomains tested. | Apr 27 2017 |
| S8496 | EED226 | EED226 is a potent, selective, and orally bioavailable a novel allosteric Polycomb repressive complex 2 (PRC2) inhibitor with an IC50 of 23.4 nM when the H3K27me0 peptide was used as substrate and an IC50 of 53.5 nM when the mononucleosome was used as the substrate. It directly binds to the H3K27me3 binding pocket of EED. | Apr 27 2017 |
| S8489 | GSK180736A (GSK180736) | GSK180736A, developed as a Rho-associated, coiled-coil-containing protein kinase inhibitor, binds to GRK2(G protein-coupled receptor kinase 2) with logIC50 pf -6.6 (logIC50 -4.0 for GRK5 and >-3 for GRK1); ≥400-fold selective for GRK2 over both GRK1 and GRK5. | Apr 27 2017 |
| S8481 | SRT3025 HCl | SRT3025 is an orally available small molecule activator of the SIRT1 enzyme. | Apr 27 2017 |
| S8523 | GSK2256098 | GSK2256098 is a potent, selective, reversible, and ATP competitive FAK kinase inhibitor with apparent Ki of 0.4 nM. | Apr 27 2017 |
| S7648 | OTS964 | OTS964 is a potent TOPK inhibitor with high affinity and selectivity and IC50 value is 28 nM. | Apr 21 2017 |
| S8490 | Tanzisertib(CC-930) | CC-930 is kinetically competitive with ATP in the JNK-dependent phosphorylation of the protein substrate c-Jun and potent against all isoforms of JNK (Ki(JNK1) = 44 ± 3 nM, IC50(JNK1) = 61 nM, Ki(JNK2) = 6.2 ± 0.6 nM, IC50(JNK2) = 5 nM, IC50(JNK3) = 5 nM) and selective against MAP kinases ERK1 and p38a with IC50 of 0.48 and 3.4 μM respectively. | Apr 21 2017 |
| S8434 | B02 | B02 is a small-molecule inhibitor of human RAD51 with an IC50 of 27.4 μM, but does not inhibit its E. coli homologue RecA (IC50 > 250 μM). | Apr 21 2017 |
| S7824 | Nazartinib (EGF816, NVS-816) | Nazartinib (EGF816, NVS-816) is a covalent, irreversible, mutant-selective EGFR inhibitor that has nanomolar inhibitory potency against activating mt (L858R, ex19del) and T790M mt, with up to 60-fold selectivity over wild type (wt) EGFR in vitro. | Apr 21 2017 |
| S8426 | 10074-G5 | 10074-G5 is a c-Myc inhibitor that binds to and distorts the bHLH-ZIP domain of c-Myc (Kd = 2.8 µM), thereby inhibiting c-Myc/Max heterodimer formation and inhibiting its transcriptional activity (IC50 = 146 µM). | Apr 21 2017 |
| S8503 | BLU-554 (BLU554) | BLU-554 is a potent, highly-selective, oral FGFR4 inhibitor with an IC50 value of 5 nM. The IC50s for FGFR1-3 is 624-2203 nM. | Apr 21 2017 |
| S8493 | PD-166866 (PD166866) | PD-166866 is a synthetic molecule inhibiting the tyrosin kinase action of FGFR1, shows a very high selectivity towards FGFR1 and inhibits the auto-phosphorylation activity of FGRF1. | Apr 21 2017 |
| S8363 | NMS-P118 | NMS-P118 is a potent, orally available, and highly selective PARP-1 inhibitor endowed with excellent ADME and pharmacokinetic profiles, showing 150-fold selectivity for PARP-1 over PARP-2 (Kd 0.009 μM vs 1.39 μM, respectively). | Apr 21 2017 |
| S8474 | LF3 | LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 with an IC50 less than 2 μM. | Apr 21 2017 |
| S7942 | Bioymifi | Bioymifi, a small-molecule death receptor 5 (DR5) agonist, binds to the extracellular domain(ECD) of DR5 with a Kd of 1.2 μM but showed little binding affinity to the DR4 ECD. It induces DR5 clustering and aggregation, leading to apoptosis. | Apr 12 2017 |
| S8192 | SUN11602 | SUN11602 is a small synthetic compound that mimics the neuroprotective activities of bFGF and activates key molecules in the FGF receptor-1-mitogen-activated protein kinase/extracellular signal-regulated kinase-1/2 kinase (FGFR-1-MEK/ERK) signaling pathway. | Apr 12 2017 |
| S8443 | MK-8617 | MK-8617 is an orally active pan-inhibitor of Hypoxia-inducible factor prolyl hydroxylase 1−3 (HIF PHD1−3), inhibiting PHD1, 2, 3 with IC50s of 1.0, 1.0 and 14 nM, respectively. | Apr 12 2017 |
| S8194 | TGR-1202 | TGR-1202, a novel, next generation PI3Kδ inhibitor, inhibits PI3Kδ activity in enzyme and cell based assays with IC50 and EC50 values of 22.2 & 24.3 nM, respectively. | Apr 12 2017 |
| S8410 | MG-132(R) | MG-132(R) is a potent, reversible, and cell permeable proteasome inhibitor with IC50 of 0.22 μM. | Apr 12 2017 |
| Cat.No. | Product Name | Information | Added |
|---|---|---|---|
| S7992 | LDC4297 (LDC044297) | LDC4297 is a novel CDK7 inhibitor (IC50=0.13±0.06 nM for CDK7 versus IC50s between 10 nM and 10,000 nM for all other analyzed CDKs). | Mar 31 2017 |
| S7958 | Lificiguat(YC-1) | YC-1 is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha). | Mar 31 2017 |
| S7892 | Avadomide(CC-122) | Avadomide(CC-122), a new chemical entity termed pleiotropic pathway modifier, is a novel agent for Diffuse large B-cell lymphoma(DLBCL) with antitumor and immunomodulatory activity. Its molecular target is the protein cereblon (CRBN), a substrate receptor of the cullin ring E3 ubiquitin ligase complex CRL4CRBN. | Mar 31 2017 |
| S8464 | Citarinostat (ACY-241) | Citarinostat (ACY-241) is an orally available selective HDAC6 inhibitor with IC50 of 2.6 nM and 46 nM for HDAC6 and HDAC3, respectively. It has 13 to 18-fold selectivity towards HDAC6 in comparison to HDAC1-3. | Mar 31 2017 |
| S7954 | CP21R7 (CP21) | CP21R7, also known CP21, is a potent and selective GSK-3β inhibitor that can potently activate canonical Wnt signalling. | Mar 31 2017 |
| S8253 | CCT245737 | CCT245737 is an orally active CHK1 inhibitor with The IC50 of 1.4 nM. It exhibits >1,000-fold selectivity against CHK2 and CDK1. | Mar 31 2017 |
| S8215 | BAY 1217389 | BAY 1217389 is an orally bioavailable, selective inhibitor of the serine/threonine kinase monopolar spindle 1 (Mps1) with IC50 values below 10 nmol/L while showing an excellent selectivity profile. | Mar 31 2017 |
| S8415 | PACAP 1-38 | PACAP 1-38 is a highly potent PACAP receptor agonist (Kd = 100 pM). It stimulates adenylate cyclase and phagocytosis. | Mar 31 2017 |
| S8416 | PACAP 6-38 | PACAP 6-38 is a PACAP (pituitary adenylate cyclase-activating polypeptide) non-stimulating competitive antagonist with an IC50 value of 2 nM. It also acts as a functional CARTp antagonist in vivo. | Mar 31 2017 |
| S8390 | LXR-623 (WAY-252623) | LXR-623 is a novel liver X-receptor(LXR) agonist with IC50 values of 179 nM and 24 nM for LXR-α and LXR-β, respectively. It is orally bioavailable and readily passes the blood-brain barrier. | Mar 31 2017 |
| S7817 | MI-503 | MI-503 is a potent and selective Menin-MLL inhibitor with IC50 of 14.7 nM. It shows pronounced growth suppressive activity in a panel of human MLL leukemia cell lines(GI50 at 250 nM-570 nM range), but only a minimal effect in human leukemia cell lines without MLL translocations. | Mar 31 2017 |
| S8412 | Naquotinib(ASP8273) | Naquotinib(ASP8273) is an orally available, irreversible, mutant-selective, epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. | Mar 31 2017 |
| S8245 | Thiomyristoyl | Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. It inhibits SIRT1 with an IC50 value of 98 μM and does not inhibit SIRT3 even at 200 μM. | Mar 31 2017 |
| S8460 | Salermide | Salermide is a reverse amide with a strong in vitro inhibitory effect on Sirt1 and Sirt2. Compared with Sirt1, Salermide is even more efficient at inhibiting Sirt2. | Mar 31 2017 |
| S8400 | Mivebresib(ABBV-075) | Mivebresib(ABBV-075) is a novel BET family bromodomain inhibitor. It binds bromodomains of BRD2/4/T with similar affinities (Ki of 1-2.2 nM) and highly selective for 18 bromodomain proteins tested (Kd > 1 μM; more than 600-fold selectivity vs. BRD4), but exhibits roughly 10-fold weaker potency towards BRD3 (Ki of 12.2 nM) and has moderate activity towards CREBBP (Kd = 87 μM; 54-fold selectivity vs. BRD4). | Mar 31 2017 |
| S8208 | Hydroxyfasudil (HA-1100) HCl | Hydroxyfasudil (HA-1100), an active metabolite of fasudil hydrochloride, is a specific Rho-kinase(ROCK) inhibitor with IC50 values of 0.73 μM and 0.72 μM for ROCK1 and ROCK2, respectively. | Mar 31 2017 |
| S8419 | E7449 | E7449 is an orally bioavailable, brain penetrable, small molecule dual inhibitor of PARP1/2 that also inhibits PARP5a/5b, otherwise known as tankyrase1 and 2 (TNKS1/2), important regulators of canonical Wnt/β-catenin signaling. It has IC50 values of 1.0 and 1.2 nM for PARP1 and 2, respectively. | Mar 31 2017 |
| S4748 | Ondansetron Hydrochloride Dihydrate | Ondansetron is a highly specific and selective serotonin 5-HT3 receptor antagonist (Ki=6.16 nM), with low affinity for dopamine receptors. | Mar 31 2017 |
| S4749 | Citalopram HBr | Citalopram HBr, an antidepressant, is an orally administered selective serotonin reuptake inhibitor (SSRI) with IC50 of 1.8 nM. | Mar 31 2017 |
| S4750 | Sulfacetamide sodium salt hydrate | Sulfacetamide is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase(DHPS) with IC50 of 9.5 μM. Sulfacetamide is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. | Mar 31 2017 |
| Cat.No. | Product Name | Information | Added |
|---|---|---|---|
| S4751 | Cisapride hydrate | Cisapride acts directly as a selective serotonin 5-HT4 receptor agonist with IC50 of 0.483 μM. And It also acts indirectly as a parasympathomimetic. | Mar 31 2017 |
| S4752 | Corticosterone | Corticosterone, the major stress hormone, is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. | Mar 31 2017 |
| S8291 | Atractylenolide I | Atractylenolide I is the major sesquiterpenoid of the rhizome of A. macrocephala and shows a wide spectrum of pharmacological activities such as antiinflammatory, digestion promoting, and antioxidant effects. | Mar 31 2017 |
| S8392 | NCB-0846 | NCB-0846 is a novel, orally small-molecule Wnt inhibitor that inhibits TNIK (TRAF2 and NCK-Interacting Kinase) with an IC50 value of 21 nM. | Mar 31 2017 |
| S8166 | ONO-4059 (GS-4059) hydrochloride | ONO-4059 (GS-4059) is highly potent and selective BTK inhibitor with an IC50 of 2.2 nM. | Mar 31 2017 |
| S7182 | JTE 013 | JTE 013 is a potent and selective S1P2 antagonist with IC50 of 17.6 nM. | Mar 31 2017 |
| S7511 | LY2857785 | LY2857785 is a type I reversible and competitive ATP kinase inhibitor against CDK9(IC50=0.011 μM) and also inhibits other transcription kinases CDK8(IC50=0.016 μM) and CDK7 (IC50=0.246 μM). | Mar 30 2017 |
| S8177 | BH3I-1 | BH3I-1 is a Bcl-XL-BH3 domain interaction inhibitor with Ki of 2.4 μM (by fluorescence polarization ).It is a selective inhibitor of Bcl-2 family proteins. | Mar 30 2017 |
| S2879 | AMD3465 hexahydrobromide | AMD3465 is a monomacrocyclic CXCR4 antagonist with IC50 of 0.75 nM. | Mar 22 2017 |
| S4742 | Rebaudioside C | Rebaudioside C belongs to the family of Steviol Glycosides. It is a natural constituent of the plant Stevia rebaudiana Bertoni and used as natural sweeteners to diabetics and others on carbohydrate-controlled diets. | Mar 02 2017 |
| S4743 | Wogonin | Wogonin, a natural and biologically-active flavonoid found in plants, is an inhibitor of CDK9 and does not inhibit CDK2, CDK4 and CDK6 at doses that inhibit CDK9 activity; Also inhibits N-acetyltransferase. | Mar 02 2017 |
| S8429 | PNU-74654 | PNU-75654 disrupts the Wnt signaling pathway via inhibition of the interaction (KD50=450 nM) between β-catenin and Tcf4. | Mar 02 2017 |
| S8405 | RRx-001 | RRx-001 is a novel epigenetic modulator with potential radiosensitizing activity. It inhibits glucose 6-phosphate dehydrogenase(G6PD) in human tumor cells, binds hemoglobin and drives RBC-mediated redox reactions under hypoxia. | Mar 02 2017 |
| S7816 | MI-463 | MI-463 is a potent inhibitor of Menin-MLL interaction with an IC50 value of 15.3 nM. | Mar 02 2017 |
| S8446 | Importazole | Importazole is a small molecule inhibitor of the transport receptor importin-β specifically blocking importin-β-mediated nuclear import. | Mar 02 2017 |
| S7923 | SH5-07 (SH-5-07) | SH5-07 is a robust hydroxamic acid-based STAT3 inhibitor, which induce antitumor cell effects in vitro and antitumor response in vivo against human glioma and breast cancer models. | Mar 02 2017 |
| S8457 | UK-371804 HCl | UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin). | Mar 02 2017 |
| S7743 | CCT196969 | CCT196969 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. It also inhibits SRC, LCK, and the p38 MAPKs. | Mar 02 2017 |
| S8275 | eFT-508 (eFT508) | eFT-508 (eFT508) is a potent and selective MNK1/2 inhibitor with IC50s of 2.4 nM and 1 nM, respectively. It potentially results in decreased tumor cell proliferation and tumor growth. | Mar 02 2017 |
| S8402 | KRIBB11 | KRIBB11 abolishes the heat shock-induced luciferase activity with an IC50 of 1.2 μM. It is an inhibitor of the transcription factor Heat Shock Factor 1 (HSF1). | Feb 22 2017 |
| Cat.No. | Product Name | Information | Added |
|---|---|---|---|
| S7740 | SAR-020106 | SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC50 of 13.3 nM. | Feb 22 2017 |
| S8414 | PACAP 1-27 | Pituitary adenylate cyclase activating polypeptide (PACAP 1-27) is a potent PACAP receptor antagonist. | Feb 22 2017 |
| S8456 | VPS34 inhibitor 1 (Compound 19, PIK-III analogue) | VPS34 inhibitor 1 (Compound 19, PIK-III analogue) is a potent and selective inhibitor of VPS34 with an IC50 of 15 nM. | Feb 22 2017 |
| S7652 | OTS514 hydrochloride | OTS514 is a highly potent TOPK(T-LAK cell-originated protein kinase) inhibitor with an IC50 value of 2.6 nM. | Feb 22 2017 |
| S7769 | BP-1-102 | BP-1-102 is a potent, orally bioavailable and selective STAT3 inhibitor, binds Stat3 with an affinity Kd of 504 nM and blocks Stat3-phospho-tyrosine (pTyr) peptide interactions and Stat3 activation at 4-6.8 μM. | Feb 22 2017 |
| S7169 | LY3039478 | LY3039478 is an oral Notch inhibitor with an IC50 of 0.41 nM. | Feb 10 2017 |
| S8261 | GSK583 | GSK583 is a highly potent and selective inhibitor of RIP2 kinase with an IC50 of 5 nM. | Feb 09 2017 |
| S7456 | LCI699 | LCI699(Osilodrostat) is a potent inhibitor of 11β-hydroxylase, an enzyme catalyzing the final step of cortisol synthesis. | Feb 09 2017 |
| S8339 | Miransertib (ARQ 092) HCl | ARQ 092 is a novel, orally bioavailable and selective AKT pathway inhibitor exhibiting a manageable safety profile among patients with advanced solid tumors. | Feb 09 2017 |
| S8404 | S49076 | S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3 with IC50 values below 20 nmol/L. | Feb 09 2017 |
| S8137 | Capsazepine | Capsazepine acts as a competitive antagonist of capsaicin and a transient receptor potential vanilloid type 1(TRPV1) antagonist. | Feb 09 2017 |
| S7820 | EPZ020411 2HCl | EPZ020411 is a potent and selective small molecule PRMT6 inhibitor with an IC50 of 10 nM. | Feb 09 2017 |
| S8337 | 1400W 2HCl | 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase(iNOS). | Feb 09 2017 |
| S8459 | TAK-063 | TAK-063 is a novel and selective phosphodiesterase 10A(PDE10A) inhibitor with an IC50 of 0.30 nM. | Feb 09 2017 |
| S4741 | Danshensu | Danshensu, a herbal preparation used in traditional Chinese medicine, possesses potential antitumor and anti‑angiogenesis effects. | Feb 09 2017 |
| S8071 | UNC0638 | UNC0638 is a potent, selective and cell-penetrant chemical probe for G9a and GLP with IC50 of <15 nM and 19 nM, respectively, shows selectivity over a wide range of epigenetic and non-epigenetic targets. | Jan 24 2017 |
| S7549 | THZ1 2HCl | THZ1 is a covalent CDK7 inhibitor which has the unprecedented ability to target a remote cysteine residue located outside of the canonical kinase domain, providing an unanticipated means of achieving selectivity for CDK7. | Jan 24 2017 |
| S8270 | SRT2183 | SRT2183 is a small-molecule activator of the sirtuin subtype SIRT1, currently being developed by Sirtris Pharmaceuticals. | Jan 24 2017 |
| S7940 | NSC12 | NSC12 is an orally available pan-FGF trap able to inhibit FGF2/FGFR interaction and endowed with promising antitumor activity. | Jan 24 2017 |
| S8193 | AZD3293 (LY3314814) | AZD3293, also known as LY3314814 is an oral beta-secretase 1 cleaving enzyme (BACE) inhibitor. | Jan 24 2017 |
| Cat.No. | Product Name | Information | Added |
|---|---|---|---|
| S8439 | Monastrol | Monastrol is a cell-permeable small molecule inhibitor of kinesin-5(KIF11) which is essential for maintaining separation of the half-spindles. | Jan 24 2017 |
| S4737 | Psoralen | Psoralen is a naturally occurring furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division. | Jan 24 2017 |
| S4738 | Arctiin | Arctiin acts on an agonists of the adiponectin receptor 1 with anti-cancer effects. | Jan 24 2017 |
| S4739 | Oxyresveratrol | Oxyresveratrol, a naturally occurring compound particularly found in Morus alba L., exhibits a potent inhibitory effect on dopa oxidase activity of tyrosinase which catalyzes rate-limiting steps of melanin biosynthesis. | Jan 24 2017 |
| S4740 | Sodium ferulate | Sodium ferulate (SF), the sodium salt of ferulic acid, is a drug used in traditional Chinese medicine for treatment of cardiovascular and cerebrovascular diseases and to prevent thrombosis. | Jan 24 2017 |
| S4746 | (20S)-Protopanaxadiol | 20(S)-Protopanaxadiol (PPD), the main intestinal metabolite of ginsenosides, is one of the active ingredients in ginseng. | Jan 24 2017 |
| S4747 | Jervine | Jervine is an inhibitor of Hedgehog signaling (IC50=500-700 nM) that inhibits the sonic hedgehog (shh) pathway by interacting with smoothened. | Jan 24 2017 |
| S8129 | Salinomycin (from Streptomyces albus) | Salinomycin, traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects. | Jan 24 2017 |
| S7937 | GSK2269557 | Nemiralisib, also known as GSK-2269557, is a potent and selective PI3Kδ inhibitor(pKi = 9.9). | Jan 24 2017 |
| S8274 | STO-609 | STO-609 is a specific inhibitor of the Ca2+/Calmodulin-dependent protein kinase kinase(CaM-KK) that inhibits the activities of recombinant CaM-KKα and CaM-KKβ isoforms, with Ki values of 80 and 15 ng/ml, respectively, and also inhibits their autophosphorylation activities. | Jan 19 2017 |
| S8328 | CeMMEC1 HCl | CeMMEC1 is an N-methylisoquinolinone derivative that inhibits the second bromodomain of TAF1 (IC50=0.9 μM). | Jan 19 2017 |
| S8147 | MS049 | MS049 is a potent and selective inhibitor of PRMT4 and PRMT6 with IC50s of 34 nM and 43 nM, respectively. | Jan 19 2017 |
| S8448 | ZINC00881524 (ROCK inhibitor) | ZINC00881524 is a ROCK inhibitor. | Jan 19 2017 |
| S4736 | Trapidil | Trapidil is a PDGF antagonist that can inhibit the proliferation of the PDGF-producing glioma cells. | Jan 19 2017 |
| S7724 | APR-246 (PRIMA-1MET) | APR-246, also known as PRIMA-1MET, is a small organic molecule that has been shown to restore tumour-suppressor function primarily to mutant p53 and also to induce cell death in various cancer types. | Jan 19 2017 |
| S2301 | Genistin (Genistoside) | Genistin(Genistoside) is an isoflavone found in a number of dietary plants like soy and kudzu. | Jan 17 2017 |
| S8334 | XMU-MP-1 | XMU-MP-1 is an inhibitor of MST1/2 with IC50 values of 71.1±12.9 nM and 38.1±6.9 nM against MST1 and MST2, respectively. | Jan 16 2017 |
| S7935 | Y-39983 HCl | Y-39983 is a selective rho-associated protein kinase(ROCK) inhibitor with an IC50 of 3.6 nM. | Jan 16 2017 |
| S8368 | LM10 | LM10 is a selective tryptophan 2,3-dioxygenase (TDO) inhibitor with IC50 values of 0.62 and 2 μM for human and mouse TDO, respectively. | Jan 16 2017 |
| S8272 | XMD8-87 | XMD8-87 is a novel tyrosine kinase nonreceptor 2(TNK2) inhibitor with IC50s of 38 nmol/L and 113 nmol/L for the D163E and R806Q mutations. | Jan 16 2017 |
| Cat.No. | Product Name | Information | Added |
|---|---|---|---|
| S8273 | XMD16-5 | XMD16-5 is a novel tyrosine kinase nonreceptor 2(TNK2) inhibitor with IC50s of 16 nmol/L and 77 nmol/L for the D163E and R806Q mutations. | Jan 16 2017 |
| S8365 | Apoptozole | Apoptozole is an inhibitor of heat shock protein 70(HSP70) and Hsc70. It induces caspase-dependent apoptosis. | Jan 16 2017 |
| S8401 | Erdafitinib (JNJ-42756493) | Erdafitinib (JNJ-42756493) is a potent and selective orally bioavailable, pan fibroblast growth factor receptor (FGFR) inhibitor with potential antineoplastic activity. | Jan 16 2017 |
| S4733 | Retigabine | Retigabine(free base) is a novel anticonvulsant with activity in a broad range of seizure models. The mechanism of action involves opening of neuronal K(V)7.2-7.5 (formerly KCNQ2-5) voltage-activated K(+) channels. | Jan 16 2017 |
| S7865 | 740 Y-P (PDGFR 740Y-P) | 740 Y-P is cell-permeable phosphopeptide activator of PI3K. | Jan 16 2017 |
| S7420 | CA-074 methyl ester (CA-074 Me) | CA-074 Me is a membrane-permeable derivative of CA-074 and acts as an irreversible cathepsin B inhibitor. | Jan 09 2017 |
| S8244 | Etomoxir (Na salt) | Etomoxir is an irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1) on the outer face of the inner mitochondrial membrane. | Jan 09 2017 |
| S7891 | CC-115 | CC-115 is a dual inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR), with potential antineoplastic activity. | Jan 09 2017 |
| S8403 | MX69 | MX69 is a MDM2/XIAP inhibitor, used for cancer treatment. | Jan 09 2017 |
| S8359 | UNC3866 | UNC3866 is a potent antagonist of the methyllysine (Kme) reading function of the Polycomb CBX and CDY families of chromodomains. UNC3866 binds the chromodomains of CBX4 and CBX7 most potently, with a K(d) of ∼100 nM for each, and is 6- to 18-fold selective as compared to seven other CBX and CDY chromodomains. | Jan 09 2017 |
| S8163 | GDC-0084 | GDC-0084 is a brain penetrant inhibitor of PI3K and mTOR. | Jan 09 2017 |
| S7014 | Merestinib (LY2801653) | LY2801653 is a type-II ATP competitive, slow-off inhibitor of MET tyrosine kinase with a dissociation constant (Ki) of 2 nM, a pharmacodynamic residence time (Koff) of 0.00132 min(-1) and t1/2 of 525 min. | Jan 09 2017 |
| S8388 | ML-7 HCl | ML-7 is an inhibitor of smooth muscle myosin light chain kinase (MLCK) with a Ki value of 0.3 µM and displays reversible, ATP-competitive inhibition of Ca2+-calmodulin-dependent and -independent smooth muscle MLCKs. | Jan 09 2017 |
| S8433 | NS-398 (NS398) | NS-398 is a selective inhibitor of cyclooxygenase-2 (COX-2). The IC50 values for human recombinant COX-1 and -2 are 75 and 1.77 μM, respectively. | Jan 09 2017 |
| S8298 | CZ415 | CZ415, a potent ATP-competitive mTOR inhibitor with very good cell permeability. | Jan 09 2017 |
| S4734 | Retigabine 2HCl | Retigabine is a novel anticonvulsant with activity in a broad range of seizure models. The mechanism of action involves opening of neuronal K(V)7.2-7.5 (formerly KCNQ2-5) voltage-activated K(+) channels. | Jan 09 2017 |
| S4735 | Salvianolic acid B | Salvianolic acid B (Sal B), an antioxidant and free radical scavenging compound, is the most abundant bioactive compound extracted from the root of Salvia miltiorrhiza Bunge. | Jan 09 2017 |
| S7286 | RO9021 | RO9021 potently inhibits SYK kinase activity with an average IC50 of 5.6 nM and suppresses B-cell receptor signaling. | Dec 29 2016 |
| S8158 | PD-1/PD-L1 Inhibitor 3 | PD-1/PD-L1 Inhibitor 3（Programmed Death-1/Programmed Death-Ligand 1 Inhibitor 3）is a Macrocyclic inhibitor of PD-1/PD-L1 interaction with IC50 of 5.6 nM | Dec 29 2016 |
| S8376 | Rbin-1 | Rbin-1(ribozinoindole-1) is a potent chemical inhibitor of eukaryotic ribosome assembly. It inhibits recombinant full-length Mdn1's ATPase activity in vitro. | Dec 29 2016 |
| Cat.No. | Product Name | Information | Added |
|---|---|---|---|
| S8226 | Netarsudil (AR-13324) 2HCl | Netarsudil (a.k.a. AR-13324) is ROCK inhibitor with Ki value of 0.2-10.3 nM. It is currently in clinical trials for the treatment of glaucoma and ocular hypertension. | Dec 29 2016 |
| S8370 | BGP-15 2HCl | BGP-15, is a nicotinic amidoxime derivative with PARP inhibitory activity. It has been demonstrated that BGP-15 protects against ischemia-reperfusion injury. | Dec 29 2016 |
| S8287 | CPI-455 HCl | CPI-455 is a specific KDM5 inhibitor, elevating global levels of H3K4 trimethylation (H3K4me3) and decreased the number of DTPs in multiple cancer cell line models treated with standard chemotherapy or targeted agents. | Dec 29 2016 |
| S8380 | YM-58483 (BTP2) | YM-58483/BTP2 is a blocker of store-operated Ca2+ entry (SOCE), which regulates the activation of non-excitable cells such as lymphocytes. | Dec 29 2016 |
| S4729 | Tamsulosin hydrochloride | Tamsulosin is a potent and selective α1a adrenergic receptor antagonist. | Dec 29 2016 |
| S8362 | Irbinitinib (ARRY-380, ONT-380) | ARRY-380 (ONT-380) is an orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity. | Dec 29 2016 |
| S8249 | HPI-4 (Ciliobrevin A) | HPI-4 (Ciliobrevin A) is a hedgehog (Hh) pathway antagonist. It blocks Sonic hedgehog (Shh)-induced Hh pathway activation (IC50 = 7 μM) downstream of Smo. | Dec 29 2016 |
| S8228 | NT157 | NT157, a selective inhibitor of IRS-1/2(insulin receptor substrate), has the potential to inhibit IGF-1R and STAT3 signaling pathways in cancer cells and stroma cells of TME leading to a decrease in cancer cell survival. | Dec 15 2016 |
| S8353 | CPI-1205 | CPI-1205 is an orally available selective inhibitor of the histone lysine methyltransferase EZH2, with potential antineoplastic activity. | Dec 08 2016 |
| S7687 | GSK269962 HCl | GSK269962 is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively. | Dec 08 2016 |
| S8188 | BFH772 | BFH772 is a novel potent oral VEGFR2 inhibitor, targeting VEGFR2 kinase with IC50 of 3 nM. | Dec 08 2016 |
| S7875 | NVP-CGM097 | NVP-CGM097 is a highly potent and selective MDM2 inhibitor. It binds to the p53 binding-site of the Mdm2 protein, disrupting the interaction between both proteins, leading to an activation of the p53 pathway. | Dec 08 2016 |
| S8372 | AZD9496 | AZD9496 is an oral estrogen receptor inhibitor that blocks the growth of ER-positive and ESR1 mutant breast tumours in preclinical models. | Dec 08 2016 |
| S8345 | ONO-7300243 | ONO-7300243 is a novel, potent LPA1(Lysophosphatidic Acid Receptor) antagonist with an IC50 of 160 nM. | Dec 08 2016 |
| S8126 | MK571 | MK-571 is a selective, orally active CysLT1 receptor(Cysteinyl leukotriene receptor) antagonist. | Dec 08 2016 |
| S2741 | Niraparib (MK-4827) | Niraparib (MK-4827) is a selective inhibitor of PARP1/2 with IC50 of 3.8 nM/2.1 nM, with great activity in cancer cells with mutant BRCA-1 and BRCA-2. It is >330-fold selective against PARP3, V-PARP and Tank1. Phase 3. | Dec 08 2016 |
| S8190 | CPI-637 | CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor. | Dec 01 2016 |
| S7853 | CPI-0610 | CPI-0610 is a potent and selective benzoisoxazoloazepine BET bromodomain inhibitor and currently undergoing human clinical trials for hematological malignancies. | Dec 01 2016 |
| S8189 | BAW2881 (NVP-BAW2881) | BAW2881 (NVP-BAW2881) is a novel vascular endothelial growth factor (VEGF) receptor tyrosine-kinase inhibitor that potently inhibits VEGFR1-3 at 1.0-4.3 nanomolar (nM) concentrations and inhibits PDGFRβ, c-Kit, and RET at 45-72 nM concentrations. | Dec 01 2016 |
| S8301 | AS101 | AS101, a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme. | Dec 01 2016 |
| Cat.No. | Product Name | Information | Added |
|---|---|---|---|
| S7849 | BDA-366 | BDA-366 is a small-molecule Bcl2-BH4 domain antagonist and binds BH4 with high affinity and selectivity. | Dec 01 2016 |
| S8382 | ML390 | ML390 is a human DHODH inhibitor that induces differentiation in acute myeloid leukemia. | Dec 01 2016 |
| S8125 | Pamapimod (R-1503, Ro4402257) | Pamapimod (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase. It inhibits p38α and p38β enzymatic activity with IC50 values of 0.014±0.002 and 0.48± 0.04 microM, respectively with no activity against p38delta or p38gamma isoforms. | Dec 01 2016 |
| S7833 | OICR-9429 | OICR-9429 is a potent antagonist of the interaction of WDR5 with peptide regions of MLL and Histone 3 and reduces viability of acute myeloid leukemia cells in vitro. | Dec 01 2016 |
| S7466 | GGTI 298 TFA salt | GGTI 298 is a geranylgeranyltransferase I inhibitor with ability to arrest human tumor cells in the G1 phase of the cell cycle and induce apoptosis. | Dec 01 2016 |
| S4732 | MPTP hydrochloride | MPTP hydrochloride is a dopaminergic neurotoxin and cause selective destruction of dopaminergic neurons in animal models of parkinsonism. | Dec 01 2016 |
| S8318 | Alantolactone | Alantolactone, a naturally occurring eudesmane-type sesquiterpene lactone (SL), could induce activin/SMAD3 signaling and disrupt Cripto-1/activin receptor type II A interaction. | Dec 01 2016 |
| S8306 | Leukadherin-1 | Leukadherin-1 (LA1) is a small molecule agonist that enhances CD11b/CD18-dependent cell adhesion to its ligand ICAM-1(an agonist for the complement receptor 3 (CD11b/CD18)). | Dec 01 2016 |
| S8320 | SKL2001 | SKL2001 is a novel agonist of the Wnt/β-catenin pathway that disrupts the Axin/β-catenin interaction. | Dec 01 2016 |
| S4731 | Perphenazine | Perphenazine is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties. | Nov 23 2016 |
| S4631 | Prochlorperazine dimaleate salt | Prochlorperazine dimaleate is a dopamine (D2) receptor antagonist. | Nov 23 2016 |
| S8324 | ZK756326 2HCl | ZK756326 is a full agonist of CCR8（Chemokine receptor 8） with an IC50 of 1.8 μM, dose-responsively eliciting an increase in intracellular calcium and cross-desensitizing the response of the receptor to CCL1. | Nov 21 2016 |
| S7221 | GS-9620 | GS-9620 is a potent and selective orally active small molecule agonist of Toll-like receptor 7. | Nov 21 2016 |
| S7144 | BMS-911543 | BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1 nM, ~350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively. Phase 1/2. | Nov 21 2016 |
| S7575 | LLY-507 | LLY-507 is a cell-active, potent, and selective inhibitor of protein-lysine Methyltransferase SMYD2. | Nov 21 2016 |
| S4701 | 2-Deoxy-D-glucose | 2-Deoxy-D-glucose, an analog of glucose, is a glycolytic inhibitor with antiviral activity. | Nov 21 2016 |
| S4702 | Sarcosine | Sarcosine is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist. | Nov 21 2016 |
| S4703 | Choline bitartrate | Choline bitartrate is a form of the nutrient choline which is found in foods. Choline is necessary for normal liver and kidney function and a component of the neurotransmitter acetylcholine, a chemical that facilitates communication between the nerves and muscles. | Nov 21 2016 |
| S4707 | Oleic Acid | Oleic acid is a fatty acid that occurs naturally in various animal and vegetable fats and oils. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. | Nov 21 2016 |
| S4700 | 4-Aminobutyric acid | Gamma-Aminobutyric Acid is a naturally occurring neurotransmitter with central nervous system (CNS) inhibitory activity. | Nov 21 2016 |
| Cat.No. | Product Name | Information | Added |
|---|---|---|---|
| S4709 | Latanoprost | Latanoprost is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect. Latanoprost increases uveoscleral outflow and thereby reduces intraocular pressure. | Nov 21 2016 |
| S8312 | NSC228155 | NSC228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyrosine phosphorylation. | Nov 21 2016 |
| S8269 | CFSE | Carboxyfluorescein succinimidyl ester (CFSE) is a fluorescent cell staining dye. CFSE is cell permeable and covalently couples, via its succinimidyl group, to intracellular molecules, notably, to intracellular lysine residues and other amine sources. | Nov 21 2016 |
| S8355 | APS-2-79 HCl | APS-2-79 is a MAPK antagonist that modulating KSR-dependent MAPK signalling by antagonizing RAF heterodimerization as well as the conformational changes required for phosphorylation and activation of KSR-bound MEK. | Nov 21 2016 |
| S8375 | AZD0156 | AZD0156 is a potent and selective inhibitors of ATM kinase, with potential chemo-/radio-sensitizing and antineoplastic activities. | Nov 21 2016 |
| S8132 | Deguelin | Deguelin, a natural product isolated from plants in the Mundulea sericea family, is an PI3K/AKT Inhibitor. | Nov 21 2016 |
| S4710 | Picolinamide | Picolinamide is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells. | Nov 21 2016 |
| S4722 | (+)-Catechin | Cianidanol is an antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms. | Nov 21 2016 |
| S4723 | (-)Epicatechin | (−)Epicatechin is a flavonoid present in cocoa, green tea and red wine. It is a strong antioxidant, has insulin mimic action and improves heart health. | Nov 21 2016 |
| S2105 | Pantoprazole | Pantoprazole is a proton pump inhibitor used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. | Nov 09 2016 |
| S4726 | Lauric Acid | Lauric Acid is a saturated medium-chain fatty acid with a 12-carbon backbone. Lauric acid is found naturally in various plant and animal fats and oils, and is a major component of coconut oil and palm kernel oil. | Nov 03 2016 |
| S8279 | Shikonin | Shikonin is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay. | Nov 03 2016 |
| S7006 | BAY-61-3606 | BAY-61-3606 is a potent and selective inhibitor of Syk kinase (Ki = 7.5 nM). | Nov 03 2016 |
| S8309 | ATI-2341 | ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4), is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. | Nov 03 2016 |
| S8251 | Necrosulfonamide | Necrosulfonamide is a very specific and potent necrosis inhibitor and blocks mixed lineage kinase domain-like protein (MLKL). | Nov 03 2016 |
| S7966 | AZD8835 | AZD8835 ia a novel mixed inhibitor of PI3Kα and PI3Kδ with IC50 of 6.2 nM and 5.7 nM, respectively, also with selectivity against PI3Kβ (IC50=431 nM) and PI3Kγ (IC50=90 nM). | Nov 03 2016 |
| S8327 | KYA1797K | KYA1797K is a highly potent and selective Wnt/β-catenin inhibitor with IC50 of 0.75 µM (TOPflash assay). | Nov 03 2016 |
| S8118 | RHPS 4 methosulfate | RHPS4 is a potent inhibitor of Telomerase at submicromolar. | Nov 03 2016 |
| S8329 | CeMMEC13 | CeMMEC13 is an isoquinolinone that selectively inhibits the second bromodomain of TAF1 (IC50 = 2.1 µM). | Nov 03 2016 |
| S7960 | Larotrectinib (LOXO-101) sulfate | Larotrectinib (LOXO-101) sulfate is an oral potent and selective ATP-competitive inhibitor of tropomyosin receptor kinases (TRK). | Nov 03 2016 |
| Cat.No. | Product Name | Information | Added |
|---|---|---|---|
| S8358 | WNK463 | WNK463 is a pan-WNK-kinase inhibitor. It potently inhibits the in vitro kinase activity of all four WNK family members (WNK1, WNK2, WNK3, and WNK4). | Nov 03 2016 |
| S8246 | RK-33 | RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells. | Nov 03 2016 |
| S4699 | Etretinate | Etretinate is an oral aromatic retinoid acid which is effective in psoriasis and other dermatological syndromes. It activates retinoid receptors, causing an induction of cell differentiation, inhibition of cell proliferation, and inhibition of tissue infiltration by inflammatory cells. | Nov 03 2016 |
| S4725 | Benzenesulfonamide | Benzenesulfonamide ia an inhibitor of carbonic anhydrases. | Nov 03 2016 |
| S4704 | D-(+)-Cellobiose | D-(+)-Cellobiose is a substrate of β-glucosidase. | Oct 26 2016 |
| S7989 | FRAX1036 | FRAX-1036 is a potent and selective PAK1 inhibitor. | Oct 26 2016 |
| S8242 | EAI045 | EAI045 is an allosteric inhibitor that targets selected drug-resistant EGFR mutants but spares the wild-type receptor. | Oct 26 2016 |
| S8113 | BI-9564 | BI-9564 is a selective inhibitor of BRD9 and BRD7 bromodomains with the IC50 of 75 nM and 3.4 µM, respectively. | Oct 26 2016 |
| S7801 | A-1331852 | A-1331852 is a potent and selectiveBCL-XL inhibitor and may be useful in the treatment of cancer, immune and autoimmune diseases. | Oct 26 2016 |
| S4719 | Kynurenic acid | Kynurenic acid, a natural metabolite of tryptophan via the kynurenine pathway, is a broad-spectrum excitatory amino acid antagonist; It proved to be an antagonist at NMDA, kainate and AMPA receptors. | Oct 26 2016 |
| S4714 | (-)-Menthol | (-)-Menthol is a levo isomer of menthol and used as a cooling agent that strongly activates TRPM8. | Oct 26 2016 |
| S4711 | Esculetin | Esculetin is a coumarin derivative found in various natural plant products with various biological and pharmaceutical properties including anti-edema, anti-inflammatory and anti-tumour effects. It inhibits lipoxygenases (LOs). | Oct 26 2016 |
| S4712 | Diethylmaleate | Diethylmaleate is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NFkB. | Oct 26 2016 |
| S4715 | Benzamide | Benzamide, an inhibitor of poly(ADP-ribose) polymerase, is a derivative of benzoic acid. | Oct 26 2016 |
| S4717 | Isatin | Isatin is an endogenous MAO inhibitor and more active against MAO-B than MAO-A | Oct 26 2016 |
| S4728 | 3,3'-Diindolylmethane | 3,3'-Diindolylmethane(DIM) is a major digestive product of indole-3-carbinol, a potential anticancer component of cruciferous vegetables. | Oct 26 2016 |
| S4716 | Evans Blue | Evans Blue is a potent inhibitor of the uptake of L-glutamate into synaptic vesicles, also an AMPA/kainate receptor antagonist. | Oct 26 2016 |
| S4718 | Acetylcholine iodide | Acetylcholine iodide is a neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. | Oct 26 2016 |
| S4721 | L-Glutamic acid monosodium salt | L-Glutamic acid monosodium salt is the sodium salt of glutamic acid, found naturally in tomatoes, cheese and other foods. | Oct 26 2016 |
| S4727 | Cinnarizine | Cinnarizine is a medication derivative of piperazine, and characterized as an antihistamine and a calcium channel blocker. | Oct 26 2016 |
| Cat.No. | Product Name | Information | Added |
|---|---|---|---|
| S4708 | Palmitoylethanolamide | Palmitoylethanolamide(PEA) is an endogenous fatty acid amide and selectively activates PPAR-α in vitro with an EC50 value of 3.1±0.4 μM. | Oct 26 2016 |
| S8200 | MK-4101 | MK-4101, a potent inhibitor of the Hedgehog pathway, shows anti-tumor activity through the inhibition of proliferation and induction of extensive apoptosis in tumor cells. | Oct 20 2016 |
| S7959 | SIS3 HCl | SIS3, a novel specific inhibitor of Smad3, inhibits TGF-β and activin signaling by suppressing Smad3 phosphorylation without affecting the MAPK/p38, ERK, or PI3-kinase signaling pathways. | Oct 20 2016 |
| S8266 | Melphalan | Melphalan is a phenylalanine derivative of nitrogen mustard with antineoplastic activity. | Oct 20 2016 |
| S8174 | VO-Ohpic trihydrate | VO-Ohpic is a potent inhibitor of PTEN (phosphatase and tensin homolog) with IC50 of 35 nM. | Oct 20 2016 |
| S7800 | A-1155463 | A-1155463, a highly potent and selective BCL-XL inhibitor, shows picomolar binding affinity to BCL-XL, and >1000-fold weaker binding to BCL-2 and related proteins BCL-W(Ki=19 nM) and MCL-1(Ki>440 nM). | Oct 20 2016 |
| S1634 | Acetaminophen | Acetaminophen is a COX inhibitor for COX-1 and COX-2 with IC50 of 113.7 μM and 25.8 μM, respectively. | Oct 11 2016 |
| S8173 | Verubecestat (MK-8931) Trifluoroacetat | Verubecestat (MK-8931) is a potent and selective beta-secretase inhibitor and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor. | Oct 10 2016 |
| S7807 | FRAX486 | FRAX486 is a potent p21-activated kinase (PAK) inhibitor with IC50 values of 14, 33, 39 and 575 nM for PAK1, PAK2, PAK3 and PAK4 respectively. | Oct 10 2016 |
| S7723 | PRIMA-1 | PRIMA-1 is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53. | Oct 10 2016 |
| S8326 | Saccharin 1-methylimidazole (SMI) | SMI is considered a general-purpose activator for DNA and RNA synthesis. | Oct 10 2016 |
| S8256 | Liraglutide | Liraglutide is a long-acting glucagon-like peptide-1(GLP-1) receptor agonist. | Oct 10 2016 |
| S7663 | LY333531 HCl | LY333531 is a β-specific protein kinase C inhibitor. It competitively and reversibly inhibits PKCβ1 and PKCβ2 with IC50 values of 4.7 and 5.9 nM respectively. | Oct 10 2016 |
| S8283 | SQ22536 | SQ22536 is an inhibitor of adenylyl cyclase with an IC50 of 1.4 μM. It can inhibit PGE1-stimulated increases in cAMP levels in intact human platelets. | Oct 10 2016 |
| S4673 | Etonogestrel | Etonogestrel is a synthetic form of the naturally occurring female sex hormone progesterone. It binds to the cytoplasmic progesterone receptors in the reproductive system and subsequently activates progesterone receptor mediated gene expression. | Oct 10 2016 |
| S4678 | Povidone iodine | Povidone iodine is a stable chemical complex of polyvinylpyrrolidone (povidone, PVP) and elemental iodine. It is used as topical antiseptic in surgery and for skin and mucous membrane infections, also as aerosol. | Oct 10 2016 |
| S4690 | Escin | Escin is a mixture of saponins with anti-inflammatory, vasoconstrictor and vasoprotective effects found in Aesculus hippocastanum(the horse chestnut). | Oct 10 2016 |
| S8182 | NSC87877 | NSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively. It also inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation. | Oct 10 2016 |
| S2352 | Salinomycin | Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug. | Sep 29 2016 |
| S7314 | Z-IETD-FMK | Z-IETD-FMK is a specific Caspase-8 inhibitor. | Sep 21 2016 |
| Cat.No. | Product Name | Information | Added |
|---|---|---|---|
| S7312 | Z-DEVD-FMK | Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor, and also shows potent inhibition on caspase-6, caspase-7, caspase-8, and caspase-10. | Sep 21 2016 |
| S8292 | Selonsertib (GS-4997) | GS-4997 is a highly selective and potent once-daily oral ASK1 inhibitor with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. | Sep 21 2016 |
| S8284 | Fatostatin HBr | Fatostatin is an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2. | Sep 21 2016 |
| S7625 | Niraparib (MK-4827) tosylate | Niraparib (MK-4827) tosylate is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM. | Sep 21 2016 |
| S8281 | CCF642 | CCF642 is a novel PDI-inhibiting compound with antimyeloma activity. | Sep 21 2016 |
| S1395 | Polymyxin B sulphate | Polymyxin B is an antibiotic primarily used for resistant gram-negative infections. | Sep 21 2016 |
| S7775 | Emricasan | Emricasan is a potent irreversible pan-caspase inhibitor. | Sep 21 2016 |
| S8319 | 7,8-Dihydroxyflavone | 7,8-Dihydroxyflavone acts as a potent and selective small-molecule agonist of the TrkB receptor (Kd ≈ 320 nM), the main signaling receptor of brain-derived neurotrophic factor (BDNF). | Sep 21 2016 |
| S2315 | Kanamycin sulfate | Kanamycin sulfate(Kanamycin monosulfate) is an aminoglycoside antibiotic, available in oral, intravenous, and intramuscular forms, and used to treat a wide variety of infections. | Sep 21 2016 |
| S7762 | TRx0237 (LMTX) mesylate | TRx 0237 (LMTX™) mesylate is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. | Sep 21 2016 |
| S8302 | SR-12813 | SR-12813 is a pregnane X receptor (PXR) agonist and HMG-CoA reductase inhibitor with an IC50 of 850 nM. | Sep 21 2016 |
| S1789 | Tetrabenazine (Xenazine) | Tetrabenazine(Nitoman, Xenazine) acts primarily as a reversible high-affinity inhibitor of mono-amine uptake into granular vesicles of presynaptic neurons by binding selectively to VMAT-2; Also blocks dopamine D2 receptors, but this affinity is 1,000-fold lower than its affinity for VMAT-2. | Sep 21 2016 |
| S8322 | LY3023414 | LY3023414 is an oral ATP competitive inhibitor of the class I PI3K isoforms, mTOR and DNA-PK. | Sep 21 2016 |
| S8323 | ITSA-1 (ITSA1) | ITSA-1 (ITSA1) is an HDAC activator via TSA suppression, but shows no activity towards other HDAC inhibitors. | Sep 21 2016 |
| S8321 | MLR-1023 | MLR-1023 is a chemical compound which inhibits acid secretion in animal models and also acts as a bronchodilator in histamine-challenged animals. | Sep 21 2016 |
| S8299 | HA15 | HA15 is a molecule that targets specifically BiP/GRP78/HSPA5. HA15 displays anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors. | Sep 21 2016 |
| S4685 | Efavirenz | Efavirenz is a synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity. | Sep 21 2016 |
| S4696 | CarbinoxaMine Maleate | Carbinoxamine maleate is a histamine-H1 receptor blocking agent with antihistamine and anticholinergic properties. | Sep 21 2016 |
| S4688 | Perampanel | Perampanel is an orally active, non-competitive, and selective alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor antagonist, with anti-epileptic activity. | Sep 21 2016 |
| S4669 | Benzocaine hydrochloride | Benzocaine hydrochloride is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. | Sep 21 2016 |
| Cat.No. | Product Name | Information | Added |
|---|---|---|---|
| S4668 | Procaine | Procaine is a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. | Sep 21 2016 |
| S4667 | Lidocaine hydrochloride | Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmia agent. | Sep 21 2016 |
| S4697 | Saxagliptin hydrate | Saxagliptin H2O is a selective and reversible DPP4 inhibitor with IC50 of 26 nM. | Sep 21 2016 |
| S4636 | Teneligliptin hydrobromide | Teneligliptin is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50 values of approximately 1 nM. | Sep 21 2016 |
| S4671 | Cefradine | Cephradine is a semi-synthetic cephalosporin antibiotic. | Sep 21 2016 |
| S4662 | Atazanavir | Atazanavir is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents. | Sep 21 2016 |
| S4686 | Vitamin E | Vitamin E is a fat-soluble vitamin with potent antioxidant properties. It is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription. | Sep 21 2016 |
| S4689 | Deoxycholic acid | Deoxycholic acid is a cytolytic agent. The physiologic effect of deoxycholic acid is by means of decreased cell membrane integrity. | Sep 21 2016 |
| S4706 | Eugenol | Eugenol is a naturally occuring scent chemical found in clove oil and other plants. The physiologic effect of eugenol is by means of increased Histamine Release, and cell-mediated Immunity. | Sep 21 2016 |
| S4687 | Rivastigmine | Rivastigmine is a cholinesterase inhibitor with IC50 of 5.5 μM. It inhibits acetylcholinesterase (IC50 = 4.15 µM) and butyrylcholinesterase (IC50 = 37 nM). | Sep 21 2016 |
| S4655 | Sulpiride | Sulpiride is a dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid. | Sep 20 2016 |
| S4658 | Hydroquinidine | Hydroquinidine is an antiarrhythmic agent. | Sep 20 2016 |
| S4659 | Nandrolone | Nandrolone is a synthetic, anabolic steroid analog of testosterone. | Sep 20 2016 |
| S4660 | Glycopyrrolate | Glycopyrrolate is a muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with some anesthetics. | Sep 20 2016 |
| S4661 | Tiagabine hydrochloride | Tiagabine Hydrochloride is the hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. A selective gamma-aminobutyric acid (GABA) reuptake inhibitor. | Sep 20 2016 |
| S4664 | Molsidomine | Molsidomine is an orally active, long acting vasodilating drug. Molsidomine is metabolized in the liver to the active metabolite linsidomine. Linsidomine is an unstable compound that releases nitric oxide (NO) upon decay as the actual vasodilating compound. | Sep 20 2016 |
| S4666 | Sivelestat sodium tetrahydrate | Sivelestat sodium tetrahydrate is a competitive inhibitor of human neutrophil elastase, also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse. | Sep 20 2016 |
| S4670 | Sucralfate | Sucralfate is a sucrose sulfate-aluminium complex that binds to the ulcer, creating a physical barrier that protects the gastrointestinal tract from stomach acid and prevents the degradation of mucus. | Sep 20 2016 |
| S4682 | Loxoprofen | Loxoprofen is a non-steroidal anti-inflammatory drug in the propionic acid derivatives group. | Sep 20 2016 |
| S4695 | D panthenol | Dexpanthenol is an alcoholic analogue of D-pantothenic acid and cholinergic agent. | Sep 20 2016 |
| Cat.No. | Product Name | Information | Added |
|---|---|---|---|
| S4691 | Oxybenzone | Oxybenzone is a benzophenone derivative used as a sunscreen agent. | Sep 20 2016 |
| S4693 | Guanfacine Hydrochloride | Guanfacine Hydrochloride is a selective α2A-adrenoceptor agonist with anti-hypertensive effect. | Sep 20 2016 |
| S4694 | Alosetron Hydrochloride | Alosetron Hydrochloride is the hydrochloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist. | Sep 20 2016 |
| S4683 | Sildenafil Mesylate | Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5. | Sep 20 2016 |
| S4684 | Sildenafil | Sildenafil is a Phosphodiesterase 5 Inhibitor with IC50 of 5.22 nM. | Sep 20 2016 |
| S4674 | Hydroxyprogesterone caproate | Hydroxyprogesterone Caproate is a synthetic progestational agent. It binds to and activates nuclear progesterone receptors in the reproductive system and inhibits ovulation and an alteration in the cervical mucus and endometrium. | Sep 20 2016 |
| S4675 | Tiagabine | Tiagabine is an anti-convulsive medication and a selective gamma-aminobutyric acid (GABA) reuptake inhibitor. | Sep 20 2016 |
| S4677 | Fluoxymesterone | Fluoxymesterone is an Androgen. The mechanism of action of fluoxymesterone is as an Androgen Receptor Agonist. | Sep 20 2016 |
| S4679 | Terazosin HCl | Terazosin is a selective alpha-1 antagonist used for treatment of symptoms of an enlarged prostate (BPH). It works by blocking the action of adrenaline on smooth muscle of the bladder and the blood vessel walls. | Sep 20 2016 |
| S4637 | Prasugrel Hydrochloride | Prasugrel hydrochloride is a piperazine derivative and pletelet aggregation inhibitor that is used to prevent thrombosis in patients with acute coronary syndrome. | Sep 20 2016 |
| S4646 | Ciclesonide | Ciclesonide is a glucocorticoid used to treat obstructive airway diseases. | Sep 20 2016 |
| S4648 | Dantrolene sodium hemiheptahydrate | Dantrolene sodium hemiheptahydrate ia a skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. | Sep 20 2016 |
| S4651 | Etoricoxib | Etoricoxib is a new COX-2 selective inhibitor with anti-inflammatory, antipyretic, analgesic, and potential antineoplastic properties. | Sep 20 2016 |
| S4654 | Netupitant | Netupitant is a selective neurokinin 1 (NK1) receptor antagonist with potential antiemetic activity. | Sep 20 2016 |
| S4663 | Fusidate Sodium | Fusidate Sodium is a sodium salt form of fusidic acid, a bacteriostatic antibiotic derived from the fungus Fusidium coccineum and used as a topical medication to treat skin infections. | Sep 20 2016 |
| S4665 | Rebeprazole sodium | Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. | Sep 20 2016 |
| S4680 | Protirelin | Protirelin is a tripeptide that stimulates the release of thyrotropin and prolactin. | Sep 20 2016 |
| S4601 | Clioquinol | Clioquinol is an orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potential antitumor activities. | Sep 20 2016 |
| S4607 | 2,2′-Dihydroxy-4-methoxybenzophenone | Dioxybenzone (benzophenone-8) is an organic compound used in sunscreen to block UVB and short-wave UVA (ultraviolet) rays. | Sep 20 2016 |
| S4515 | Ademetionine disulfate tosylate | Ademetionine Disulfate Tosylate is the disulfate-tosylate mixed salt of a mixture of diastereoisomers of the ademetionine ions. Ademetionine possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. | Sep 20 2016 |
| Cat.No. | Product Name | Information | Added |
|---|---|---|---|
| S4550 | Azelaic acid | Azelaic acid is an organic compound produced by the ozonolysis of oleic acid and possesses antibacterial, keratolytic, comedolytic, and anti-oxidant activity. | Sep 20 2016 |
| S4562 | Dehydrocholic acid | Dehydrocholic acid is a semisynthetic bile acid made from cholic acid. It is used as a cholagogue, hydrocholeretic, diuretic, and as a diagnostic aid. | Sep 20 2016 |
| S8280 | IMR-1 | IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μmol/L. | Sep 08 2016 |
| S8234 | RS-1 | RS-1 is a RAD51-stimulatory compound, which increases the DNA binding activity of RAD51. It is an HDR(homology-directed repair) enhancer. | Sep 08 2016 |
| S8314 | 5-Iodotubercidin | 5-Iodotubercidin is a potent adenosine kinase inhibitor with IC50 of 26 nM. It inhibits nucleoside transporter, CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC. | Sep 08 2016 |
| S4652 | Sulisobenzone | Sulisobenzone is an ingredient in some sunscreens which protects the skin from damage. | Sep 08 2016 |
| S4588 | Docusate Sodium | Docusate Sodium is a laxative used to treat constipation, for constipation due to the use of opiates it maybe used with a stimulant laxative, can be taken by mouth or rectally. | Sep 08 2016 |
| S4647 | Cefmenoxime hydrochloride | Cefmenoxime, a potent inhibitor of Enterobacteriaceae, is a cephalosporin antibiotic that is administered intravenously or intramuscularly. | Sep 08 2016 |
| S4602 | Acetohydroxamic acid | Acetohydroxamic acid is an Urease Inhibitor. In the urine, it acts as an antagonist of the bacterial enzyme urease. | Sep 08 2016 |
| S4606 | Glutathione | Glutathione acts as an antioxidant, a free radical scavenger and a detoxifying agent. It is a tripeptide comprised of three amino acids (cysteine, glutamic acid, and glycine) present in most mammalian tissue. | Sep 08 2016 |
| S4608 | L-Tyrosine | L-tyrosine is a non-essential amino acid. In animals it is synthesized from Ephenylalanine. | Sep 08 2016 |
| S4634 | Sodium sulfadiazine | Sodium Sulfadiazine is a sodium salt form of sulfadiazine, an intermediate-acting bacteriostatic, synthetic sulfanilamide derivative. | Sep 08 2016 |
| S4641 | Tedizolid Phosphate | Tedizolid is an oxazolidinone-class antibiotic. Tedizolid phosphate is a phosphate ester prodrug of the active compound tedizolid. | Sep 08 2016 |
| S4642 | Dolutegravir Sodium | Dolutegravir is a HIV integrase inhibitor with IC50 of 2.7 nM. | Sep 08 2016 |
| S4644 | Zolpidem | Zolpidem is a benzodiazepine agonist with high selectivity for α1-subunit-containing GABAA receptors. | Sep 08 2016 |
| S4645 | Armodafinil | Armodafinil is the R-enantiomer of the racemic synthetic agent modafinil with central nervous system (CNS) stimulant and wakefulness-promoting activities. | Sep 08 2016 |
| S4649 | Atipamezole hydrochloride | Atipamezole is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug. Atipamezole hydrochloride is hydrochloride form of atipamezole. | Sep 08 2016 |
| S4650 | Atipamezole | Atipamezole is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug. | Sep 08 2016 |
| S4657 | Eslicarbazepine Acetate | Eslicarbazepine acetate is an antiepileptic drug. | Sep 08 2016 |
| S4541 | Triclosan | Triclosan is a diphenyl ether derivative used in cosmetics and toilet soaps as an antiseptic. It has some bacteriostatic and fungistatic action. | Sep 08 2016 |
| Cat.No. | Product Name | Information | Added |
|---|---|---|---|
| S1717 | Fomepizole | Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites. | Sep 08 2016 |
| S8248 | IQ-1 | IQ-1 enables Wnt/β-catenin-driven expansion of mouse ESCs and prevents spontaneous differentiation, Maintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells and prevents PP2A/Nkd interaction. | Sep 08 2016 |
| S8294 | Olmutinib (HM61713, BI 1482694) | Olmutinib is a novel third-generation epidermal growth factor receptor (EGFR) mutation-specific tyrosine kinase inhibitor (TKI). Also a potent inhibitor of Bruton's tyrosine kinase. | Sep 07 2016 |
| S8236 | MK-886 (L-663,536) | MK-886 is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist. | Sep 07 2016 |
| S8303 | Kobe0065 | Kobe0065 is H-Ras-cRaf1 interaction inhibitor, exhibiting potent activity to competitively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 46 ± 13 μM. | Sep 07 2016 |
| S4653 | L-Ornithine | L-ornithine has an antifatigue effect by increasing the efficiency of energy consumption and promoting the excretion of ammonia. It is one of the key reactants in the urea cycle. | Sep 07 2016 |
| S4656 | Parecoxib | Parecoxib is a selective COX2 inhibitor. | Sep 07 2016 |
| S4609 | Diflunisal | Diflunisal is a difluorophenyl derivate of salicylic acid and a nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic and anti-inflammatory properties. The mechanism of action of diflunisal is as a Cyclooxygenase Inhibitor. | Sep 07 2016 |
| S4603 | Gallic acid | Gallic acid is an organic acid found in a variety of foods and herbs that are well known as powerful antioxidants. | Sep 07 2016 |
| S4604 | Levofloxacin hydrate | Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. It acts by inhibiting DNA gyrase (bacterial topoisomerase II). | Sep 07 2016 |
| S4605 | Folic acid | Folic acid, a B vitamin, plays an important role in cell division and in the synthesis of amino acids and nucleic acids like DNA. | Sep 07 2016 |
| S4610 | Mebendazole | Mebendazole is a synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake. | Sep 07 2016 |
| S4612 | Dapson | Dapsone, also known as diaminodiphenyl sulfone (DDS), is an antibiotic commonly used in combination with rifampicin and clofazimine for the treatment of leprosy. | Sep 07 2016 |
| S4633 | Isosorbide Mononitrate | Isosorbide mononitrate is a Nitrate Vasodilator, dilating the blood vessels so as to reduce the blood pressure. | Sep 07 2016 |
| S4635 | Cyproheptadine hydrochloride | Cyproheptadine hydrochloride is non-selective 5HT2 antagonist with IC50 of 0.6 nM. Also a SETD7/9 inhibitor. | Sep 07 2016 |
| S4640 | Lesinurad | Lesinurad is a selective uric acid reabsorption inhibitor (SURI) under investigation for treatment of gout in combination with xanthine oxidase inhibitors. | Sep 07 2016 |
| S4615 | Modafinil | Modafinil is a mood-brightening and memory-enhancing psychostimulant which enhances wakefulness and vigilance. | Sep 07 2016 |
| S4638 | Desogestrel | Desogestrel is a synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents. | Sep 07 2016 |
| S4639 | Brexpiprazole | Brexpiprazole is a novel D2 dopamine and serotonin 1A partial agonist, called serotonin-dopamine activity modulator (SDAM), and a potent antagonist of serotonin 2A receptors, noradrenergic alpha 1B and 2C receptors. | Sep 07 2016 |
| S4582 | Eflornithine hydrochloride hydrate | Eflornithine(Difluoromethylornithine) inhibits polyamine biosynthesis by the selective, irreversible inhibition of ornithine decarboxylase (ODC). A chemoprotective agent that blocks angiogenesis. Its biological half-life is 8 hours. | Sep 07 2016 |
| Cat.No. | Product Name | Information | Added |
|---|---|---|---|
| S4624 | 5,5-Dimethyloxazolidine-2,4-dione | Dimethadione is an anticonvulsant that is the active metabolite of trimethadione. | Sep 07 2016 |
| S4574 | Piperazine | Piperazine, GABA receptor agonist, is an anthelmintic used in the treatment of the intestinal nematodes Ascaris lumbricoides and Enterobius vermicularis. | Aug 30 2016 |
| S4575 | Pralidoxime chloride | Pralidoxime is an antidote to organophosphate pesticides and chemicals; An acetylcholinesterase (AChE) reactivator. | Aug 30 2016 |
| S4576 | Sulfabenzamide | Sulfabenzamide is an antibacterial/antimicrobial which also exhibit their antitumor effects through multiple mechanisms including inhibition of membrane bound carbonic anhydrases, prevention of microtubule assembly, cell cycle arrest, and inhibition of angiogenesis. | Aug 30 2016 |
| S4580 | Hydroquinone | Hydroquinone is a Melanin Synthesis Inhibitor. The physiologic effect of hydroquinone is by means of Depigmenting Activity. It also posesses antioxidant properties that can cause toxicity in several organs, notably the kidney. | Aug 30 2016 |
| S8289 | NQDI-1 | NQDI 1, an inhibitor of ASK1(apoptosis signal-regulating kinase 1), attenuates acute ischemic renal injury by modulating oxidative stress and cell death. | Aug 30 2016 |
| S7974 | L755507 | L-755,507 is characterized as a potent and selective β3 adrenergic receptor partial agonist with EC50 of 0.43 nM. It is also recently identified to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs) and other cell types. | Aug 30 2016 |
| S8095 | Tubercidin | Tubercidin, an adenosine analogue, is a nucleoside antibiotic. It is incorporated into DNA and inhibits polymerases, thereby inhibiting DNA replication and RNA and protein synthesis. This agent also exhibits antifungal and antiviral activities. | Aug 30 2016 |
| S4616 | Nandrolone decanoate | Nandrolone Decanoate is a mild form of an anabolic steroid. | Aug 30 2016 |
| S4617 | Dextromethorphan hydrobromide hydrate | Dextromethorphan is an antitussive (cough suppressant) drug of the morphinan class with sedative, dissociative, and stimulant properties (at higher doses). | Aug 30 2016 |
| S4618 | Fenoldopam mesylate | Fenoldopam is a selective dopamine-1 receptor (DA1) agonist with natriuretic/diuretic properties. It lowers blood pressure through arteriolar vasodilation. | Aug 30 2016 |
| S4626 | Ethosuximide | Ethosuximide is a succinimide anticonvulsant, used mainly in absence seizures; A calcium channel blocker. | Aug 30 2016 |
| S4628 | (+/-)-Sulfinpyrazone | Sulfinpyrazone is one of the most studied platelet COX inhibitors, also a uricosuric agent that competitively inhibits uric acid reabsorption in kidney proximal tubules. | Aug 30 2016 |
| S4629 | Chlorotrianisene | Chlorotrianisene is a synthetic, non-steroidal estrogen. It is a selective estrogen receptor modulator. | Aug 30 2016 |
| S4630 | Diazoxide | Diazoxide is a well-known small molecule that activates KATP channels in the smooth muscle of blood vessels and pancreatic beta-cells by increasing membrane permeability to potassium ions. | Aug 30 2016 |
| S4632 | Hexachlorophene | Hexachlorophene is a potent KCNQ1/KCNE1 potassium channel activator with EC50 of 4.61 ± 1.29 μM; It can also attenuate Wnt/beta-catenin signaling through the Siah-1-mediated beta-catenin degradation. | Aug 30 2016 |
| S4583 | Butamben | Butamben is a long-duration local anesthetic used for the treatment of chronic pain. | Aug 30 2016 |
| S4584 | Butylparaben | Butylparaben is a chemical compound commonly used as an antifungal preservative in cosmetic products. | Aug 30 2016 |
| S4585 | Succinylsulfathiazole | Succinylsulfathiazole, a sulfonamide, is an antibiotic. | Aug 30 2016 |
| S4586 | 4-Chloro-DL-phenylalanine | 4-Chloro-DL-phenylalanine is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). 4-Chloro-DL-phenylalanine acts pharmacologically to deplete endogenous levels of serotonin. | Aug 30 2016 |
| Cat.No. | Product Name | Information | Added |
|---|---|---|---|
| S4587 | Pentylenetetrazol | Pentylenetetrazol displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GABA(A) receptor antagonist. | Aug 30 2016 |
| S4589 | Amodiaquine dihydrochloride dihydrate | Amodiaquine is a potent, non-competitive inhibitor of histamine N-methyl transferase in human erythrocytes, also used as an antimalarial and anti-inflammatory agent. | Aug 30 2016 |
| S4591 | Nitroxoline | Nitroxoline is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. It is a fluorquinolone that is active against bacterial gyrases. | Aug 30 2016 |
| S4592 | Captisol (SBE-β-CD) | Captisol (SBE-β-CD) is a novel, chemically modified cyclodextrin with a structure designed to optimize the solubility and stability of drugs. | Aug 30 2016 |
| S4595 | Cefazolin Sodium | Cefazolin Sodium is a semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine. | Aug 30 2016 |
| S4596 | Cefixime | Cefixime is an antibiotic useful for the treatment of a number of bacterial infections. It is a third generation cephalosporin. | Aug 30 2016 |
| S4597 | Lercanidipine hydrochloride | Lercanidipine is a calcium channel blocker of the dihydropyridine class. | Aug 30 2016 |
| S4599 | Benzyl benzoate | Benzyl benzoate is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei. | Aug 30 2016 |
| S4600 | Benzyl alcohol | Benzyl alcohol is used as a local anesthetic. Also, it is used in the manufacture of other benzyl compounds, as a pharmaceutic aid, and in perfumery and flavoring. | Aug 30 2016 |
| S4619 | Itopride hydrochloride | Itopride hydrochloride is an AChE inhibitor. The IC50 of itopride with AChE is 2.04 +/- 0.27 μM. | Aug 30 2016 |
| S4620 | Cefuroxime sodium | Cefuroxime Sodium is a cephalosporin effective against gram-positive and gram-negative bacteria with resistance to β-lactamase. | Aug 30 2016 |
| S4625 | Alcaftadine | Alcaftadine is a high affinity ligand for the H1 receptor, with a pKi (8.5) that is comparable with that of other H1 antihistamines. Alcaftadine is also an antagonist for H2 and H4 receptors with no affinity for the H3 receptor. | Aug 30 2016 |
| S4540 | Sisomicin sulfate | Sisomicin sulfate is an aminoglycoside antibiotic, isolated from the fermentation broth of a new species of the genus Micromonospora. | Aug 30 2016 |
| L3600 | Express-Pick Library | 4208 compounds featured different parent nuclei and structurally diverse respectively. | Aug 29 2016 |
| S4566 | DL-Panthenol | DL-panthenol is a racemic mixture of D and L form of panthenol,a provitamin of B5. | Aug 17 2016 |
| S4568 | Ethylvanillin | Ethylvanillin is the organic flavorant. It is about three times as potent as vanillin and used in the production of chocolate. | Aug 17 2016 |
| S4569 | Fluphenazine dihydrochloride | Fluphenazine dihydrochloride is a phenothiazine-class D1DR and D2DR inhibitor. It also inhibits Histamine H1 Receptor. | Aug 17 2016 |
| S4570 | Halothane | Halothane is a general inhalation anesthetic used for induction and maintenance of general anesthesia. | Aug 17 2016 |
| S4571 | Hexylresorcinol | Hexylresorcinol is an organic compound with local anaesthetic, antiseptic and anthelmintic properties, is a potent inhibitor of mushroom tyrosinase. The IC50 values of hexylresorcinol for monophenolase is 1.24 μM and for diphenolase is 0.85 μM. | Aug 17 2016 |
| S4577 | Terpin hydrate | Terpin hydrate is an expectorant, commonly used to loosen mucus in patients presenting with acute or chronic bronchitis, and related conditions. | Aug 17 2016 |
| Cat.No. | Product Name | Information | Added |
|---|---|---|---|
| S4578 | Tyloxapol | Tyloxapol is a nonionic liquid polymer of the alkyl aryl polyether alcohol type, used as a surfactant to aid liquefaction, removal of mucopurulent and bronchopulmonary secretions. It also blocks plasma lipolytic activity, and thus the breakdown of triglyceride-rich lipoproteins. | Aug 17 2016 |
| S4581 | Triacetin | Triacetin is a triglyceride that is used as an antifungal agent. | Aug 17 2016 |
| S7999 | SKF96365 | SKF96365, originally identified as a blocker of receptor-mediated calcium entry, is widely used diagnostically, as a blocker of transient receptor potential canonical type (TRPC) channels. | Aug 17 2016 |
| S7938 | GSK2292767 | GSK2292767 is a potent and selective PI3Kδ inhibitor. | Aug 17 2016 |
| S8167 | AMG 337 | AMG 337 is an oral, small molecule, ATP-competitive, highly selective inhibitor of the MET receptor. | Aug 17 2016 |
| S8105 | ZM241385 | ZM-241385 is a high affinity antagonist ligand selective for the adenosine A2A receptor. | Aug 17 2016 |
| S4593 | Chlormadinone acetate | Chlormadinone acetate is a steroidal progestin with additional antiandrogen and antigonadotropic effects, used often in combinations as an oral contraceptive. Its half-life is about 34-38 hours. | Aug 17 2016 |
| S4594 | Cephalothin | Cephalothin is a semisynthetic, beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cephalothin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. | Aug 17 2016 |
| S4546 | Xylitol | Xylitol is a sugar alcohol derived from XYLOSE by reduction of the carbonyl group. It is as sweet as sucrose and used as a noncariogenic sweetener. | Aug 17 2016 |
| S4544 | Urethane | Urethane is a kind of antineoplastic agent that is also used as a veterinary anesthetic. It is a intermediate in organic synthesis. | Aug 17 2016 |
| S4516 | (+)-Camphor | Camphor is a waxy, flammable, white or transparent solid with a strong aroma, often used to relieve pain, reduce itching and treat fungal infections. It can activate TRPV1 and TRPV3. | Aug 17 2016 |
| S4520 | 2-Aminoheptane | 2-Aminoheptane is a nasal decongestant drug which is a sympathomimetic stimulant and vasoconstrictor. | Aug 17 2016 |
| S4524 | 2-Ethoxybenzamide | 2-Ethoxybenzamide is a common analgesic and anti-inflammatory drug that is used for the relief of fever, headaches, and other minor aches and pains. | Aug 17 2016 |
| S4534 | 6-Acetamidohexanoic acid | 6-Acetamidohexanoic acid is a pharmaceutical intermediate. | Aug 17 2016 |
| S4547 | 8-Hydroxyquinoline | 8-Hydroxyquinoline is an antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes. | Aug 17 2016 |
| S4549 | Antimonyl potassium tartrate trihydrate | Antimony potassium tartrate trihydrate is a powerful emetic, also used in the treatment of schistosomiasis and leishmaniasis. | Aug 17 2016 |
| S4553 | Bronopol | Bronopol(2-bromo-2-nitropropane-1,3-diol) is antibacterial agent, used as preservative in cosmetic industry. | Aug 17 2016 |
| S4556 | Carzenide | Carzenide is an organic synthesis intermediate, used for synthetic drug. | Aug 17 2016 |
| S4558 | Citiolone | Citiolone is a derivative of the amino acid cysteine, used in liver therapy. | Aug 17 2016 |
| S4559 | Cloxiquine | Cloxiquine is an antibacterial, antifungal, antiaging and antituberculosis drug. | Aug 17 2016 |
| Cat.No. | Product Name | Information | Added |
|---|---|---|---|
| S4565 | Diiodohydroxyquinoline | Diiodohydroxyquinoline is a topical therapeutic agent,a quinoline derivative, with satisfactory antibacterial properties. | Aug 17 2016 |
| S4567 | Eprodisate disodium | Eprodisate Disodium is the orally available disodium salt form of Eprodisate, a small-molecule, orally bioavailable, inhibitor of AA-amyloid fibrillogenesis. | Aug 08 2016 |
| S4573 | m-Tolyl acetate | m-Tolyl acetate is a pharmaceutical intermediate and antiseptic. | Aug 08 2016 |
| S4579 | Resorcinol | Resorcinol is a chemical compound that serves as an antiseptic,an disinfectant, and a chemical intermediate for the production of many other pharmaceuticals. | Aug 08 2016 |
| S4545 | Warfarin | Warfarin is one of the most widely used anticoagulant drugs worldwide, used in the prevention of thrombosis and thromboembolism, the formation of blood clots in the blood vessels and their migration elsewhere in the body. | Aug 08 2016 |
| S4512 | Aceglutamide | Aceglutamide is a psychostimulant, nootropic agent which functions as a prodrug to glutamine with improved potency and stability. | Aug 08 2016 |
| S4514 | Acetylleucine | Acetylleucine is a drug used in the treatment of vertigo. | Aug 08 2016 |
| S4529 | Idramantone | Idramantone is an immune agonist. | Aug 08 2016 |
| S4535 | Methylene Blue | Methylene Blue is used as a dye in chromoendoscopy. It Inhibits tau filament formation with IC50 of 1.9μM. Also it inhibits soluble guanylyl cyclase. | Aug 08 2016 |
| S4537 | Oxolinic acid | Oxolinic acid is a quinolone antibiotic, inhibiting the enzyme DNA gyrase and DNA synthesis.It also acts as a dopamine reuptake inhibitor. | Aug 08 2016 |
| S4538 | Pantoprazole sodium | Pantoprazole is a proton pump inhibitor drug that inhibits gastric acid secretion. It works on gastric parietal cells to irreversibly inhibit (H+/K+)-ATPase function and suppress the production of gastric acid. | Aug 08 2016 |
| S4539 | Salicylic acid | Salicylic acid is a beta hydroxy acid that occurs as a natural compound in plants which is an inhibitor of ethylene biosynthesis and cyclooxygenase activity. | Aug 08 2016 |
| S4542 | Trihexyphenidyl hydrochloride | Trihexyphenidyl hydrochloride is an antiparkinsonian agent of the antimuscarinic class. | Aug 08 2016 |
| S4543 | Trimetazidine dihydrochloride | Trimetazidine dihydrochloride is a kind of drug for treatment of chronic ischemic disorders. It improves myocardial glucose utilization through inhibition of fatty acid metabolism, known as fatty acid oxidation inhibitor. | Aug 08 2016 |
| S4548 | Aminoguanidine hydrochloride | Aminoguanidine is a diamine oxidase and nitric oxide synthase inhibitor. It acts to reduce levels of advanced glycation end products (AGEs) through interacting with 3-deoxyglucosone. | Aug 08 2016 |
| S4551 | Bisoctrizole | Bisoctrizole is a broad-spectrum ultraviolet radiation absorber, absorbing UVB as well as UVA rays. Also a hybrid UV absorber, reflecting and scattering UV. | Aug 08 2016 |
| S4552 | Bithionol | Bithionol is a potent inhibitor of soluble adenylyl cyclase(sAC) and has antibacterial and anthelmintic properties along with algaecide activity. | Aug 08 2016 |
| S4554 | Bucetin | Bucetin is an analgesic and antipyretice agent with a risk of carcinogenesis. | Aug 08 2016 |
| S4555 | Carsalam | Carsalam is a nonsteroidal anti-inflammatory drug. | Aug 08 2016 |
| S4521 | DEET | DEET is a commen active ingredient insect repellent. | Aug 08 2016 |
| Cat.No. | Product Name | Information | Added |
|---|---|---|---|
| S4522 | Dehydroacetic acid | Dehydroacetic acid is an organic compound, used mostly as a fungicide and bactericide. | Aug 08 2016 |
| S4561 | Danthron | Danthron is an organic substance. It used to be a laxatica and now is currently used as an antioxidant in synthetic lubricants, in the synthesis of experimental antitumor agents, as a fungicide and as an intermediate for making dyes. | Aug 08 2016 |
| S4563 | Diatrizoic acid | Diatrizoic Acid is an organic, iodinated radiocontrast agent used in diagnostic radiography. | Aug 08 2016 |
| S4564 | Diethylcarbamazine citrate | Diethylcarbamazine citrate is an inhibitor of arachidonic acid metabolism in filarial microfilaria and is highly specific for several parasites and does not contain any toxic metallic elements. | Aug 08 2016 |
| S8179 | BI-7273 | BI-7273 is a potent, selective, and cell-permeable BRD9 BD Inhibitor. | Aug 05 2016 |
| S7572 | A-366 | A-366 is a potent and selective G9a/GLP histone lysine methyltransferase inhibitor with IC50 of 3.3nM, exhibiting >1000-fold selectivity for G9a/GLP over 21 other methyltransferases. | Aug 05 2016 |
| S8185 | FPS-ZM1 | FPS-ZM1 is a blood-brain-barrier permeant, non-toxic, tertiary amide compound which is a high affinity RAGE-specific inhibitor, blocking Aβ binding to the V domain of RAGE. | Aug 05 2016 |
| S7930 | Ixabepilone (BMS-247550) | Ixabepilone is an orally bioavailable microtubule inhibitor. It binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis. | Aug 05 2016 |
| S8237 | IC261 | IC261 is a novel inhibitor of CK1. The IC50 of IC261 for CK1 was 16 μM and for Cdk5 is 4.5 mM. | Aug 05 2016 |
| S8218 | PF-8380 | PF-8380 is a potent autotaxin inhibitor with IC50 of 2.8nM in an in vitro enzyme assay. | Aug 05 2016 |
| S8187 | ReACp53 | ReACp53 is a cell-penetrating peptide, designed to inhibit p53 amyloid formation, resues p53 function in cancer cell lines and in organoids derived from high-grade serous ovarian carcinomas (HGSOC). | Aug 05 2016 |
| S8197 | APTSTAT3-9R | APTSTAT3-9R is a specific STAT3-binding peptide with addition of a cell-penetrating motif. The treatment of APTSTAT3-9R in various types of cancer cells blocks STAT3 phosphorylation and reduces expression of STAT targets. | Aug 05 2016 |
| S8181 | SBI-0640756 | SBI-0640756 is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. It can also suppress AKT and NF-kB signaling. | Aug 05 2016 |
| S8136 | Sivelestat (ONO-5046) | Sivelestat is a potent and selective inhibitor of neutrophil elastase with IC50 of 44nM. It almost shows no activity at a range of other proteases. | Aug 05 2016 |
| S8276 | FCCP | FCCP is a potent uncoupler of oxidative phosphorylation in mitochondria that disrupts ATP synthesis by transporting protons across cell membranes. | Aug 05 2016 |
| S8201 | BI-78D3 | BI-78D3 is a competitive JNK inhibitor with IC50 of 280nM that displays > 100 fold selectivity over p38α and no activity at mTOR and PI-3K. | Aug 05 2016 |
| S8169 | GSK481 | GSK481 is a RIP1(Receptor Interacting Protein Kinase1) inhibitor. Inhibition of RIP1 has been shown to hinder cell necrotic death. | Aug 05 2016 |
| S7815 | MI-136 | MI-136 can specifically inhibit the menin-MLL interaction. It inhibits DHT-induced expression of androgen receptor (AR) target genes. | Aug 05 2016 |
| S3077 | Tazobactam | Tazobactam is a β-lactamases Inhibitor with antibacterial activity. It also inhibits the class D oxacillinase OXA-2. It is used in combination with piperacillin and other β-lactam antibiotics to broaden their spectrum and enhance their effect. | Jul 28 2016 |
| S4519 | Citric acid trilithium salt tetrahydrate | Citric acid trilithium salt tetrahydrate is a pharmaceutical and construction material. It is commonly used in HPLC gradient elution for quantification of amino acids. | Jul 27 2016 |
| Cat.No. | Product Name | Information | Added |
|---|---|---|---|
| S4525 | Ethylparaben | Ethylparaben is the ethyl ester of p-hydroxybenzoic acid, used as an antifungal preservative and food additive. It is a standardized chemical allergen. The physiologic effect of ethylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity. | Jul 27 2016 |
| S4528 | Furazolidone | Furazolidone is a synthetic nitrofuran derivative with bactericidal or bacteriostatic activity when used against Gram-positive and Gram-negative bacteria. | Jul 27 2016 |
| S4530 | i-Inositol | i-Inositol, also known as myo-inositol, is a chemical compound which is sugar alcohol. i-Inositol is involved in a number of biological processes including insulin signal transduction, cytoskeleton transduction and so on. | Jul 27 2016 |
| S4532 | Iopamidol | Iopamidol is a non-ionic, water-soluble radiographic contrast agent. | Jul 27 2016 |
| S4536 | Nitrofurantoin | Nitrofurantoin is an antibiotic used to treat bladder infections.It inhibits bacterial DNA, RNA, and cell wall protein synthesis. | Jul 27 2016 |
| S4509 | 4-Aminoantipyrine | 4-Aminoantipyrine(Ampyrone) is a metabolite of aminopyrine with analgesic, anti-inflammatory, and antipyretic properties. It is used as a reagent for biochemical reactions producing peroxides or phenols. | Jul 27 2016 |
| S8097 | C-DIM12 | C-DIM12 is Nurr1 activator that stimulates Nurr1 mediated apoptosis axis in bladder cancer cells and tumors and inhibits NF-κB–dependent gene expression in glial cells. | Jul 20 2016 |
| S4510 | 4-Aminobenzoic acid | 4-Aminobenzoic acid is an intermediate in the synthesis of tetrahydrofolic acid in many non-mammalian organisms, including bacteria and fungi. | Jul 20 2016 |
| S4511 | 6-Benzylaminopurine | 6-Benzylaminopurine is a first-generation synthetic cytokinin which could regulate the activities of the antioxidant defense system of plants.Its treatment elicits plant growth and development. | Jul 20 2016 |
| S4517 | Cefotaxime sodium | Cefotaxime sodium salt is a third-generation cephalosporin antibiotic; broad-spectrum antibiotic with activity against numerous Gram-positive and Gram-negative bacteria. | Jul 20 2016 |
| S4518 | Chloroxylenol | Chloroxylenol is a broad-spectrum antimicrobial chemical compound used to control bacteria, algae, fungi and virus. | Jul 20 2016 |
| S4523 | Dihydrostreptomycin sulfate | Dihydrostreptomycin sulfate is an aminoglycoside antibiotic, used to treat bacterial diseases in cattle, pigs and sheep. Dihydrostreptomycin is a derivative of streptomycin. | Jul 20 2016 |
| S4526 | Fenbufen | Fenbufen is an orally active phenylalkanoic derivative with anti-inflammatory, analgesic and antipyretic activity. It is a non-steroidal anti-inflammatory drug. | Jul 20 2016 |
| S4527 | Fenofibric acid | Fenofibric acid is a fibrate that acts as a lipid-lowering agent, decreasing low-density lipoprotein cholesterol and triglycerides. | Jul 20 2016 |
| S7827 | 4-Hydroxytamoxifen | 4-Hydroxytamoxifen is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer. | Jul 14 2016 |
| S8107 | GSK1016790A | GSK1016790A (GSK101) is a novel, potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34nM in choroid plexus epithelial cells. | Jul 14 2016 |
| S7964 | PLX7904 | PLX7904, also known as PB04, is a potent and selective paradox-breaker RAF inhibitor. It is able to efficiently inhibit activation of ERK1/2 in mutant BRAF melanoma cells but does not hyperactivate ERK1/2 in mutant RAS-expressing cells. | Jul 14 2016 |
| S8262 | PRI-724 | PRI-724 is a potent, specific inhibitor of the canonical Wnt signaling pathway in cancer stem cells with potential antineoplastic activity. PRI-724 specifically inhibits the recruiting of beta-catenin with its coactivator CBP. | Jul 14 2016 |
| S8238 | SB366791 | SB-366791 is a novel, potent, and selective, cinnamide TRPV1 antagonist. | Jul 14 2016 |
| S8205 | Enasidenib (AG-221) | AG-221（Enasidenib） is a first-in-class, oral, potent, reversible, selective inhibitor of the IDH2 mutant enzyme with IC50 of 12 nM. | Jul 14 2016 |
| Cat.No. | Product Name | Information | Added |
|---|---|---|---|
| S7752 | SC1 | Pluripotin (SC1) is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP. Maintains embryonic stem cell (ESC) self-renewal. | Jul 14 2016 |
| S8164 | YAP-TEAD Inhibitor 1 (Peptide 17) | Peptide 17 is a inhibitor of this YAP-TEAD protein-protein interaction which has potential usage in treatment of YAP-involved cancers with IC50 of 25nM. | Jul 14 2016 |
| S4506 | Acetazolamide | Acetazolamide, a potent carbonic anhydrase (CA) inhibitor, is commonly used in clinical practice as an immediate and readily available option for acute reduction of intraocular pressure(IOP). | Jul 14 2016 |
| S4507 | 17-Hydroxyprogesterone | 17-Hydroxyprogesterone (17-OHP) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens. | Jul 14 2016 |
| S4508 | 2,2,2-Tribromoethanol | 2,2,2-Tribromoethanol is an organic compound used to anesthetize mice. | Jul 14 2016 |
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