HomeAll New Products Listed Chronologically

All New Products Listed Chronologically

Catalog No. Product Name Information Isotype
E1637 ALKBH5 inhibitor 1 (compound 3) Sep 19 2024
E1785 PF-06952229 Sep 19 2024
E4700 ML-099 Sep 19 2024
E1972 AZD8421 Sep 18 2024
E1834 iMDK Sep 18 2024
E4930 Asenapine Sep 18 2024
E4949 Eslicarbazepine Sep 18 2024
E4918 BecloMethasone Sep 18 2024
E4964 ATP (disodium trihydrate) ATP disodium trihydrate, is the primary energy currency of the cell, essential for intracellular energy metabolism. It regulates extracellular biological processes, including cardiac function, neurotransmission, muscle contraction, vasodilation, bone and liver glycogen metabolism, and inflammation. It also plays a crucial role in initiating immune responses during infections. Sep 13 2024
E4661 dWIZ-2 dWIZ-2, is a molecular glue degrader of the WIZtranscription factor degrading WIZ with a DC50 of 32 nM. It also robustly induces fetal hemoglobin (HbF) in erythroblasts with an EC50 of 202 nM. Sep 13 2024
E4914 Cabozantinib hydrochloride Cabozantinib hydrochloride(XL184; BMS-907351 hydrochloride) is a potent small-molecule kinase inhibitor of c-MET and VEGFR2 with an IC50 of 1.3 nM, 0.035 nM respectively. It also inhibits RET, KIT, AXL, Tie2 and FLT3 with an IC50's of 5.2 nM, 4.6 nM, 7 nM, 14.3 nM, 11.3nM respectively. It can be promising agent for inhibiting tumor angiogenesis and metastasis in cancers with dysregulated MET and VEGFR signaling. Sep 13 2024
E4876 Lisinopril Lisinopril(MK-521) is a potent inhibitor of angiotensin-1 converting enzyme (sACE-1) with an IC50 of 1.9 nM. It demonstrates significant efficacy in the management of hypertension and heart failure, potentially improving cardiovascular outcomes. Sep 13 2024
E4960 L-Lysine hydrate L-Lysine hydrate is a first-limiting, essential amino acid with important roles in connective tissues and carnitine synthesis, energy production, growth in children, and maintenance of immune functions. It also ameliorates vascular calcification by modifying several key pathways and attenuates pancreatic tissue injury induced by L-arginine by inhibiting the release of the inflammatory cytokine IL-6. Sep 13 2024
E1302 Braco-19 trihydrochloride Braco-19 trihydrochloride(BRAC-O19; BRACO19 3HCl) is a G-quadruplex-stabilizing agent and an inhibitor of telomere/telomerase. It establishes antiviral activity against HIV-1 and anticancer effects by inhibiting telomerase capping and catalytic functions. Sep 13 2024
E1948 ZT-1a ZT-1a is a potent and selective, non-ATP-competitive inhibitor of STE20/SPS1-related proline-alanine-rich kinase (SPAK) with an IC50 of 44.3 μM. It can exhibit therapeutic potential for brain disorders linked to impaired ionic homeostasis in research. Sep 13 2024
E4677 PKUMDL-LC-101-D04 PKUMDL-LC-101-D04(GPX4-Activator-1d4) is a potent allosteric activator of Glutathione peroxidase 4 (GPX4) effectively suppressing ferroptosis and inflammation. It enhances GPX4 activity by 150% at 20 µM in a cell-free assay and 61 µM in cell extracts, also providing protection against cholesterol hydroperoxide (ChOOH)-induced damage. Sep 13 2024
E4639 FIDAS-5 FIDAS-5 is a potent and orally active inhibitor of methionine S-adenosyltransferase 2A (MAT2A) with an IC50 value of 2.1 μM, respectively. FIDAS-5 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-5 also demonstrates anticancer activity. Sep 12 2024
E4622 RP-102124 RP-102124 is a first-in-class allosteric inhibitor of multi-Rac with activity against oncogenic Rac1b. RP-102124 is orally bioavailable and exhibits dose-dependent inhibition of tumor growth in xenograft models. It exhibits potent inhibition of phenotypic characteristics of Rac signaling such as cell migration and cytoskeletal rearrangements. Sep 12 2024
E4916 Bestatin hydrochloride Bestatin hydrochloride is an inhibitor of aminopeptidase N and enkephalinase that elevates the levels of angiotensin II and angiotensin III. It also acts as a non-competitive inhibitor (α > 1) of porcine DPP-IV with a Ki value of 75 μM. It reduces DPP-IV activity, decreases cell viability, and increases DNA fragmentation in vitro. It has the potential to treat skin conditions like acne, psoriasis and keloids. Sep 12 2024
S5707 Aripiprazole lauroxil Aripiprazole lauroxil(Aripiprazole lauroxil) is an extended-release prodrug of aripiprazole designed for intramuscular injection and approved for the treatment of schizophrenia. It acts as a dopamine-serotonin system stabilizer, with a potent partial agonist for dopamine D2 and serotonin 5-HT1A receptors while an antagonist for serotonin 5-HT2A receptors. Sep 12 2024
E4891 Fostemsavir Tris Fostemsavir Tris(BMS-663068 Tris) is a phosphonooxymethyl prodrug of BMS-626529, formulated as a tris(hydroxymethyl)aminomethane salt. It inhibits human immunodeficiency virus type 1 (HIV-1) by binding to the gp120 protein, preventing the virus from attaching to CD4+ T-cells. Sep 12 2024
E4910 Cariprazine Cariprazine(RGH-188; MP-214) is an atypical antipsychotic medication that mainly functions as a partial agonist at dopamine receptors, with pKi values of 10.07 for D3, 9.16 for D2L, and 9.31 for D2S receptors. It also acts as an antagonist forserotonin receptors, with pKi of 9.24, 8.59, 7.73, and 6.87 for5-HT2B,5-HT1A, 5-HT2A, and 5-HT2C receptors, respectively. Cariprazine is used to treat schizophrenia and bipolar mania. Sep 12 2024
E4929 (S)-Clopidogrel (S)-Clopidogrel is an inhibitor of P2Y12 and exerts anticoagulant effects. It is metabolized into an active form that binds to the P2Y12 receptor, blocking ADP and preventing platelet aggregation. It also exhibits anti-inflammatory and antifibrotic properties in chronic kidney disease (CKD) and liver fibrosis. Sep 12 2024
E4897 Estramustine Estramustine(NSC-89201; LEO275) is used to treat hormone-resistant prostate cancer and stabilize microtubule dynamics. It acts as an anti-mitotic and anti-microtubule agent and disrupts microtubule disassembly. It inhibits the binding of MAPs 1 and 2 to taxol-stabilized microtubules, hinders microtubule assembly, and promotes the disassembly of MAP-2-associated microtubules. Sep 12 2024
E4920 Baclofen hydrochloride Baclofen hydrochloride is an agonist of the GABAB receptor that mimics the action of GABA, leading to slow presynaptic inhibition via the GABAB receptor. It improves the function of the ubiquitin-proteasome system (UPS) and enhances cell survival in both in vitro and in vivo models of Huntington's disease (HD). Sep 12 2024
E4961 Rutin (trihydrate) Rutin trihydrate is a bioflavonoid composed of the flavonol quercetin and the disaccharide rutinose. It exhibits anti-inflammatory and antiproliferative properties. It also acts as an antioxidant by scavenging reactive oxygen species (ROS). It lowers ROS levels, which in turn reduces oxidative stress in neurons, thereby controlling neuropathy (including auditory neuropathy) in patients with diabetes. Sep 12 2024
P1243 Fetuin, Fetal Bovine Serum Fetuin, Fetal Bovine Serum, a prevalent protein found in fetal bovine plasma, is the bovine equivalent of human α2HS glycoprotein (α2HS), commonly used as a supplement in various serum-free media. It inhibits trypsin activity and enhances cellular attachment, growth, and differentiation in culture systems. Sep 12 2024
E4597 Avitinib maleate Avitinib maleate(Abivertinib maleate; AC0010 maleate; AC0010MA) is a third-generation, irreversible, and orally active selective inhibitor of EGFR. It displays IC50 values of 0.18 nM, 0.18 nM, 7.68 nM and against EGFR L858R, EGFR T790M, and wild-type EGFR. Avitinib maleate also acts as an inhibitor of BTK that induces apoptosis of BTK in mantle cell lymphoma. Sep 10 2024
E1969 ADT-007 ADT-007 is a potent and orally active pan-RAS inhibitor. ADT-007 effectively targets and suppresses the proliferation of cancer cells harboring mutated or hyper-activated wild-type RAS isozymes. ADT-007 exhibits potent anti-cancer effects. Sep 09 2024
S9911 Chlorin e6 Chlorin e6 is a photosensitizer characterized by strong absorption peaks at 402 nm and 662 nm and intense fluorescence at 668 nm. It possesses antimicrobial and anticancer activities. It activates caspase-3 and induces apoptosis in cells, making it valuable for cancer research. Sep 09 2024
E4651 HRS-4642 HRS-4642 is a selective inhibitor of KRAS G12D with a Kd value of 0.083 nM. It exhibits robust anti-cancer activity against KRAS G12D-mutant cancers both in vitro and in vivo. Sep 09 2024
E4615 GLPG0187 GLPG0187 is a broad-spectrum antagonist of integrin receptor. It inhibits αvβ1-integrin with an IC50 value of 1.3 nM. GLPG0187 also inhibits migrasome biogenesis without cytotoxicity. GLPG0187 exhibits potent antitumor activity. Sep 09 2024
E1701 Vanzacaftor Vanzacaftor(VX-121) is an orally active corrector of Cystic fibrosis transmembrane conductance regulator (CFTR). Vanzacaftor improves the processing and trafficking of CFTR protein and increases chloride transport in combination with Tezacaftor and Deutivacaftor. Sep 09 2024
E4919 Barnidipine hydrochloride Barnidipine hydrochloride(Mepirodipine hydrochloride; YM-09730-5) is an antagonist of L-type calcium (CaA). It displays a high affinity for [3H] initrendipine binding sites with a Ki value of 0.21 nmol/l. Barnidipine hydrochloride also acts as an antihypertensive agent. Sep 09 2024
E4903 Dalasetron Mesylate Hydrate Dolasetron Mesylate hydrate(MDL-73147EF hydrate) is an antagonist of serotonin 5-HT3 receptor. It is used in the treatment of patients with nausea and vomiting following chemotherapy. Sep 08 2024
E1827 ECC5004(AZD5004) ECC5004(AZD5004; GLP-1 agonist (Eccogene)) is a small molecule GLP-1 receptor agonist (GLP-1RA) used to treat digestive system diseases and endocrine and metabolic diseases. ECC5004 has the potential to be used to treat obesity, type 2 diabetes and metabolic dysfunction-associated steatohepatitis (MASH) disease. Sep 08 2024
E1971 Rezatapopt Rezatapopt(PC14586) is a first-in-class p53 reactivator. It selectively binds to the mutated p53 Y220C protein and restores its wild-type activity. It can also be used to inhibit solid tumor with p53 mutation. Sep 05 2024
E4686 DCZ0415 DCZ0415 is a potent inhibitor of TRIP13. DCZ0415 impairs nonhomologous end joining repair and inhibits NF-κB activity. It triggers anti-myeloma effects both in vitro, and in vivo, and primary cells obtained from myeloma patients resistant to drugs. Sep 05 2024
E1836 Cevidoplenib dimesylate Cevidoplenib dimesylate(SKI-O-703 dimesylate) is an orally available inhibitor of spleen tyrosine kinase (Syk) with potential anti-inflammatory and immunomodulating activities. It attenuates the progression of autoantibody-mediated autoimmune diseases by inhibiting both autoantibody-producing and autoantibody-sensing cells. Sep 05 2024
E1508 APG-2449 APG-2449 is an orally active inhibitor of ALK/ROS1/FAK. APG-2449 exerts potent and durable antitumor activity in human non-small-cell lung cancer (NSCLC) and ovarian tumor models. Sep 04 2024
E4662 CK-586 CK-586(CK-4021586) is an inhibitor of cardiac myosin used to treat obstructive hypertrophic cardiomyopathy (oHCM). It effectively reduces left ventricular outflow tract obstruction (LVOTO) in a dose-dependent manner. Sep 03 2024
E4695 OPB-171775 OPB-171775 functions as a molecular glue, promoting the formation of a complex between phosphodiesterase 3A (PDE3A) and Schlafen family member 12 (SLFN12). This interaction triggers multiple cellular stresses, ultimately leading to cell death. It also demonstrates significant anticancer activity in patient-derived xenograft (PDX) models of Gastrointestinal stromal tumor (GIST). Sep 03 2024
E4679 Bleximenib oxalate Bleximenib oxalate(Menin-MLL inhibitor 24 oxalate) is an inhibitor of menin-mixed-lineage leukemia 1 (menin-MLL) . It can be used for the research of cancer. Sep 03 2024
E4659 Pyr3 Pyr3 is a selective and potent inhibitor of transient receptor potential canonical channel 3 (TRPC3). It inhibits TRPC3-mediated Ca2+ influx in a dose-dependent manner with the IC50 value of 0.7 μM. It holds potential for treating TRPC3-related diseases like cardiac hypertrophy. Sep 03 2024
E1556 GSK-3484862 GSK-3484862 is a non-covalent, potent and selective inhibitor of DNMT1 with an IC50 of 0.23 μM. It demonstrates efficacy in acute myeloid leukemia. Sep 03 2024
E4660 TAC(TERT activator compound) TAC(TERT activator compound) is an activator of TERT, that upregulates TERT transcription via the MEK/ERK/AP-1 cascade. It enhances telomere synthesis, reduces aging markers, inflammation, and senescence, and preserves brain function, highlighting TERT's potential in combating aging and related diseases. Sep 03 2024
E4624 Tradipitant Tradipitant(VLY-686, LY686017) is the 2nd generation antagonist of neurokinin-1 (NK-1). It exhibits potential for treating chemotherapy-induced nausea, depression, alcoholism, social anxiety disorder, and for developing imaging ligands. Sep 03 2024
E4872 Mefloquine Mefloquine(Lariam；WR-142490) is a quinoline antimalarial drug and an antagonist of K+ channel (KvQT1/minK) with an IC50 of ~1 μM. It is widely used in both the treatment and prophylaxis of Plasmodium falciparum malaria, and can prolong cardiac repolarization. Sep 03 2024
E4888 Guanabenz hydrochloride Guanabenz hydrochloride(NE56490) is a small molecule, antihypertensive agonist of α2-adrenoceptor. It also inhibits eIF2α and GADD34, showing potential for treating cardiac hypertrophy, heart failure, atherosclerosis, and ischemic heart disease. Sep 03 2024
E4845 Ulipristal Ulipristal(Deacetyl CDB-2914; CDB-3236) is a selective modulator of progesterone receptors used in a single dose as an emergency postcoital contraceptive. Sep 03 2024
E4902 Dantrolene Dantrolene is an antagonist of ryanodine receptor (RYR) and a postsynaptic skeletal muscle relaxant that reduces calcium release from the sarcoplasmic reticulum (SR), leading to a dose-dependent decrease in myoplasmic free calcium levels. It is used to treat and control the accelerated hypermetabolism of skeletal muscle that leads to a malignant hyperthermia crisis. Sep 01 2024
E4673 AMTB hydrochloride AMTB hydrochloride is a blocker of the transient receptor potential melastatin 8 (TRPM8) ion channel. It reduces the activation of TRPM8 channels induced by icilin, as assessed through a Ca2+ influx assay, with a pIC50 of 6.23. It is used as a tool to evaluate the role of this channel in bladder rhythmic contraction. Sep 01 2024
E4904 Dacomitinib hydrate Dacomitinib hydrate(PF-00299804; PF-804) is an orally administered, highly selective irreversible inhibitor targeting pan-ERBB receptors, with an IC50 of 6.0 nM for EGFR, 45.7 nM for ERBB2, and 73.7 nM for ERBB4. It also demonstrates anti-tumor activity. Sep 01 2024
E4905 Cyclizine hydrochloride Cyclizine hydrochloride is an antagonist of the H1 histamine receptor used for the treatment and prevention of vertigo and motion sickness. It also exhibits antihistaminic properties. Sep 01 2024
F2160 Lumican Rabbit mAb Aug 30 2024
E4885 Dopamine Dopamine is a catecholamine neurotransmitter in the mammalian brain. It plays role as a modulator of cardiovascular function, catecholamine release, hormone secretion, vascular tone, renal function, and gastrointestinal motility. Aug 28 2024
E4674 Cu(II)GTSM Cu(II)GTSM is a potent cell-permeable inhibitor of GSK3β that also inhibits Aβ oligomers and reduces tau phosphorylation. It shows potential as an anticancer and antimicrobial agent and may restore cognitive function by inhibiting neurotoxic Aβ trimers and phosphorylated tau. Aug 28 2024
E1952 BLU-222 BLU-222 is an oral, potent, and selective inhibitor of cyclin-dependent kinase (CDK) 2 and exhibits significant antitumor activity in the OVCAR-3 CDX model. Aug 28 2024
E4620 L-778123 hydrochloride L-778123 hydrochloride is a potent dual inhibitor of farnesyl protein transferase (FPTase) with an IC50 of 2 nM and geranylgeranyl protein transferase I (GGPTase-I) with an IC50 of 98 nM. It also displays promising anti-leukemia activity. Aug 28 2024
E1965 NST-628 NST-628 is a potent and well-tolerated single-agent inhibitor of both RAF and MEK. It acts as a pan-RAF–MEK molecular glue that blocks the phosphorylation and activation of MEK by RAF. Aug 28 2024
E1989 ART0380 ART0380 (IACS-030380) is a potent and selective, orally bioavailable inhibitor of ATR kinase, with an IC50 of 51.7 nM effectively inhibiting the enzyme activity of the ATR-ATRIP complex. It functions as an ATP-competitive inhibitor, binding to the ATP pocket of ATR, where ATP would typically bind. It interacts with the hinge through its morpholine oxygen and occupies the ribose pocket with a sulfoximine group. It also exhibits antitumor activity. Aug 28 2024
E4609 Amredobresib Amredobresib (BI894999) is an oral inhibitor of BET, which acts as an acetyl-lysine mimic. It prevents the bromodomains BRD4-BD1 and BRD4-BD2 from binding to acetylated histones, with an IC50 of 5 nM for BRD4-BD1 and 41 nM for BRD4-BD2. Aug 28 2024
E4847 Tosufloxacin Tosufloxacin (A-61827) is an orally active fluoroquinolone antibiotic. Tosufloxacin effectively targets a broad spectrum of antibacterial activity, including both gram-positive and gram-negative strains. Aug 28 2024
E4839 Ziprasidone Ziprasidone (CP-88059;Geodon;Zeldox) is an orally active agonist of 5-HT(1A) receptor. It is a benzisothiazolyl piperazine-type atypical antipsychotic agent that is used for the acute management of schizophrenia. Aug 28 2024
E4892 Formoterol Formoterol is a highly selective and potent long-acting beta2-adrenergic agonist that functions by binding to and activating beta2-adrenergic receptors on the smooth muscle cells of the airways. It is used in the treatment of patients with chronic obstructive pulmonary disease (COPD). Aug 28 2024
E4898 Escitalopram Escitalopram ((S)-Citalopram), (S)-+ Citalopram); Seroplex) is a selective serotonin reuptake inhibitor (SSRI) with a Ki value of 0.89 nM. Escitalopram has approximately 30-fold higher binding affinity than its R(-)-enantiomer and exhibits selectivity over both norepinephrine transporter (NET) and dopamine transporter (DAT). Escitalopram is used clinically to treat anxiety and depression. Aug 28 2024
E4889 Glafenine Glafenine (Glafenin) is a non-steroidal anti-inflammatory drug (NSAID) and is a non-narcotic analgesic agent that not only acts as a proteostasis modulator but is also one of the most potent NSAID correctors of F508del-CFTR. It exhibits COX-2 inhibition in the arachidonic acid pathway and rescues class 2 CFTR mutants. Aug 28 2024
E4619 Basimglurant Basimglurant (RG7090; CTEP Derivative) is a potent and selective negative allosteric modulator of mGlu5, with a Kd of 1.1 nM. It exhibits antidepressant-like properties, showing potential for treating depression, fragile X syndrome, anxiety, OCD, and levodopa-induced dyskinesia in Parkinson's disease. Aug 26 2024
E4879 Laninamivir Laninamivir(R-125489) is a potent inhibitor of influenza neuraminidase(NA)with IC50s of 0.90 nM, 1.83 nM and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively. It exhibits long-acting anti-influenza virus activity. Aug 26 2024
E2987 GCN2-IN-1 GCN2-IN-1 (A-92) is a specific and potent active site inhibitor of general control nonderepressible 2 kinase (GCN2) with an IC50 of <0.3 μM. It can be investigated in research related to diseases involving retroviral integration. Aug 26 2024
E4906 Cefadroxil Cefadroxil(BL-S 578) is a first-generation, cephalosporin antibiotic with broad spectrum of anti-bacterial activity. It can be used in the management of infections in the respiratory tract, urinary tract, skin and soft tissues, and bones and joints. Aug 26 2024
E4869 Niraparib hydrochloride Niraparib hydrochloride (MK-4827 hydrochloride) is a potent poly(ADP-ribose)polymerase (PARP) inhibitor with IC50s of 3.8 and 2.1 nM against both the PARP-1 and PARP-2 enzymes, respectively.It inhibits the repair of radiation-induced DNA double-strand breaks, activates apoptosis, and exhibits anti-tumor activity. Aug 26 2024
E4878 Lansoprazole sodium Lansoprazole Sodium, a sodium salt form of Lansoprazole, is an orally active inhibitor of proton pump, preventing the stomach from producing acid. Lansoprazole enhances the expression and transcriptional effectiveness of runt-related transcription factor 2 (Runx2), stimulating osteoprogenitor cell's commitment and differentiation toward their lineage. Aug 22 2024
E1859 FHD-609 FHD-609 acts as a selective inhibitor and degrader of BRD9 protein (bromodomain-containing protein 9). FHD-609 targets ncBAF and can be used in research of various cancers involving mutations in a BAF complex subunit. Aug 22 2024
P1230 Retatrutide Retatrutide (LY3437943) acts as a triple agonist peptide of the glucagon receptor (GCGR), glucagon-like peptide-1 receptor (GLP-1R) and glucosedependent insulinotropic polypeptide receptor (GIPR). Retatrutide binds to human GCGR, GLP-1R, and GIPR with EC50 values of 5.79, 0.775 nM, and 0.0643, respectively. Retatrutide has the potential for use in research on obesity. Aug 22 2024
E1771 Cycloleucine Cycloleucine is a specific antagonist of NMDA receptor(N-methyl-D-aspartate receptor coupled glycine receptor), with a Ki of 600 μM. Cycloleucine also acts as a specific inhibitor of S-adenosyl-methionine-mediated methylation. Cycloleucine exhibits anxiolytic and cytostatic effects. Aug 22 2024
E4887 Dapoxetine Dapoxetine ((S)-(+)-Dapoxetine; LY-210448) is a selective serotonin reuptake inhibitor (SSRI) with oral activity. Dapoxetine is a short-acting SSRI developed specifically for the treatment of premature ejaculation (PE). Aug 22 2024
E4853 Rolapitant hydrochloride hydrate Rolapitant hydrochloride hydrate(SCH619734 hydrochloride hydrate) is a long-acting, extremely selective antagonist of the Nk-1 receptor antagonist (NK-1RA) with antiemetic activity. It significantly penetrates the central nervous system (CNS) and used clinically to prevent chemotherapy-induced nausea and vomiting (CINV) in cancer patients undergoing high and moderate emetogenic chemotherapy. Aug 21 2024
E4867 Omadacycline Omadacycline(Amadacycline) is an oral aminomethylcycline antibacterial antibiotic used to treat moderate-to-severe infections, such as community-acquired pneumonia and acute bacterial skin and skin structure infections caused by susceptible organisms. It inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline has broad-spectrum antibacterial activity and is effective against Gram-positive and Gram-negative aerobic, anaerobic, and atypical bacteria. Aug 21 2024
E4685 Iclepertin Iclepertin (BI-425809) is a potent and selective inhibitor of glycine transporter 1 (GlyT1) that increases glycine levels in the cerebrospinal fluid (CSF). It has the potential to treat cognitive impairment associated with schizophrenia. Aug 21 2024
S8687 MPP dihydrochloride Methyl-piperidino-pyrazole (MPP) dihydrochloride is a highly selective antagonist for estrogen receptor alpha (ERα), with an affinity 200 times greater than for estrogen receptor beta (ERβ). It inhibits 17β-estradiol binding to ERα by inducing conformational changes that alter the receptor’s binding site and also increases the energy required for genistein's interaction with ERα. Aug 21 2024
E4610 SMIP34 SMIP34 is a small molecule inhibitor of proline, glutamic acid, and leucine-rich protein 1 (PELP1). It is effective in reducing cell viability, reducing invasion, and inducing apoptosis in Triple-negative breast cancer (TNBC) models. Aug 20 2024
E4655 VT104 VT104 is an inhibitor of TEAD auto-palmitoylation that effectively blocks the palmitoylation of TEAD1 and TEAD3 proteins. It selectively inhibits YAP/TAZ-TEAD-promoted gene transcription and exhibits strong antitumor and anti-proliferative effects. Aug 20 2024
E1964 BMS-986365 BMS-986365 (CC-94676) is a potent and selective, heterobifunctional ligand-directed degrader (LDD) and antagonist of androgen receptor (AR), that effectively targets both wildtype and mutant forms of the androgen receptor (AR) in the cytoplasm and nucleus. It rapidly degrades AR, suppresses AR signaling, and shows promising clinical activity in inhibiting tumor growth in patients with metastatic castration-resistant prostate cancer (mCRPC). Aug 18 2024
E1899 INCB059872 dihydrochloride INCB059872 dihydrochloride is a potent, selective, and irreversible inhibitor of Lysine-Specific Demethylase 1(LSD1). It exhibits potential antineoplastic activity and can be used in acute myeloid leukemia (AML) research. Aug 18 2024
E4877 Lefamulin Lefamulin (BC-3781), is a pleuromutilin antibiotic, inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome. It is effective against a range of gram-positive pathogens involved in community-acquired bacterial pneumonia (CABP), including Streptococcus pneumoniae, Haemophilus influenzae, Mycoplasma pneumoniae, Legionella pneumophila, Chlamydophila pneumoniae, Staphylococcus aureus (including methicillin-resistant and vancomycin-intermediate strains), and vancomycin-resistant Enterococcus faecium. Aug 18 2024
S8143 Mavoglurant Mavoglurant (AFQ056) is a structurally selective, non-competitive antagonist of mGlu5 receptor with an IC50 of 30 nM. It exhibits efficacy in treatment of L-dopa induced dyskinesia in Parkinson's disease and Fragile X syndrome. Aug 18 2024
E1847 GBD-9 GBD-9 is a double-mechanism efficient degrader of BTK and GSPT1 by recruiting the E3 ligase cereblon (CRBN). GBD-9 acts both as a PROTAC molecule to induce the degradation of BTK and as a molecular glue to degrade GSPT1.It exhibits anti-proliferative effects, inhibiting cancer cell survival. Aug 15 2024
E1683 DN02 DN02 is a selective probe of BRD8 bromodomain family. It exhibits potency against BRD8(1) with a Kd of 32 nM, and interestingly, demonstrated this activity to be selective over BRD8's second bromodomain (BRD8(2) with a Kd of >1000 nM) Aug 15 2024
E4843 Vardenafil dihydrochloride Vardenafil dihydrochloride is a potent, and selective inhibitor of phosphodiesterase-5 (PDE5), with an IC50 of 0.7 nM. It also exhibits inhibition of PDE1 and PDE6 with IC50 of 180 nM and 11 nM respectively. It can be used for the research of erectile dysfunction, hepatitis, diabetes. Aug 15 2024
E1612 Suzetrigine VX-548 (Suzetrigine), is an oral, highly selective inhibitor of voltage-gated sodium channel 1.8 (NaV1.8) with an IC50 of 0.7 nM. It can be used in research of transmitting nociceptive signals and treatment of acute pain after abdominoplasty or bunionectomy. Aug 15 2024
E1951 X5050 X5050 is a benzoimidazole-5-carboxamide derivative and a potent inhibitor of repressor element-1 silencing transcription factor (REST) with an EC50 of 2.1 μM. It can be used in research of Huntington's disease and other neurodegenerative disorders characterized by altered BDNF levels. Aug 15 2024
E4858 Rimonabant hydrochloride Rimonabant hydrochloride (SR 141716A hydrochloride) is a highly potent and selective antagonist of the central cannabinoid receptor (CB1) , with a Ki of 1.8 nM. It is an anorectic anti-obesity drug with potential to treat obesity and cardiovascular risk factors. Aug 15 2024
E4842 Vilanterol Vilanterol (GW642444) is a potent and selective agonist of β2-adrenoceptor (β2-AR) with pEC50 of β2-AR, β1-AR, and β3-AR is 10.37, 6.98 and 7.36 respectively in cAMP detection assays. Aug 15 2024
E4846 Treprostinil Treprostinil is a potent agonist of DP1 and EP2  with EC50 of 0.6 nM and 6.2 nM for DP1 and EP2 receptors, respectively. It is a vasodilator used to treat pulmonary arterial hypertension and improves mitochondrial impairment in vitro. Aug 15 2024
E1997 GLPG3970 GLPG3970 (compound 32) is a dual inhibitor of SIK2 and SIK3, with IC50 of 282.8 nM, 7.8 nM and 3.8 nM for SIK1, SIK2 and SIK3, respectively. It has the potential to treat autoimmune and inflammatory diseases. Aug 15 2024
E4870 Naratriptan Naratriptan is an agonist of 5-hydroxytryptamine1B/D (5-HT1B/D) receptors, which reduces the frequency of cluster headache. Aug 15 2024
E4866 Paroxetine Paroxetine is a potent and selective serotonin reuptake inhibitor (SSRI) used to treat depression and anxiety disorders. It inhibits pyroptosis and reduces osteoclast formation by blocking the NF-κB signalling pathway. Aug 15 2024
E1560 Raptinal Raptinal is a pro-apoptotic compound that induces apoptosis by promoting the release of cytochrome c from the mitochondria, thereby activating the intrinsic apoptotic pathway. It also inhibits the activity of caspase-activated Pannexin 1 (PANX1), a ubiquitously expressed transmembrane channel involved in regulating various cell death-associated processes. Aug 15 2024
E4868 Olsalazine Olsalazine is a salicylic acid-derived anti-inflammatory agent used to treat ulcerative colitis. Aug 15 2024
E4852 Tafamidis meglumine Tafamidis meglumine (Vyndaqel, Fx-1006A) stabilizes the tetrameric structure of transthyretin (TTR) by binding to thyroxine-binding sites. Tafamidis meglumine treats transthyretin familial amyloid polyneuropathies (TTR-FAP), a condition characterized by neurological damage from TTR amyloidosis, by preventing the misfolding and aggregation of transthyretin (TTR) into amyloid fibrils. Aug 12 2024
E1902 Nedometinib Nedometinib (NFX-179) is a highly specific and potent inhibitor of MEK1 with an IC50 of 135 nM. It also results in suppression of p-ERK levels and can be used in research and treatment of cutaneous neurofibromas (cNFs) associated with neurofibromatosis type 1 (NF1). Aug 12 2024
E1355 JNJ-64264681 JNJ-64264681 is an orally active, irreversible covalent inhibitor of Bruton's tyrosine kinase (BTK) with potent whole blood activity and exceptional kinome selectivity. It exhibits potential efficacy in treatment for B-cell malignancies and autoimmune disorders. Aug 12 2024
S5788 Tacrolimus monohydrate Tacrolimus monohydrate (Tacrolimus, FK506) is a macrolide antibiotic that primarily acts as an inhibitor of calcineurin phosphatase by binding to FK506 binding protein (FKBP). This inhibition blocks calcium-dependent processes, including interleukin-2 gene transcription, nitric oxide synthase activation, cell degranulation, and apoptosis, and also has immunosuppressive, neuroregenerative and neuroprotective properties. Aug 12 2024
E4854 Sodium picosulfate monohydrate Sodium picosulfate monohydrate, is a polyphenolic stimulant laxative and prodrug form of desacetyl bisacodyl (DAB). It is used for treating idiopathic constipation and preparing the bowel before colonoscopy. Aug 07 2024
E1978 Zelasudil Zelasudil (RXC007) is a selective inhibitor of Rho-associated coiled-coil-containing kinase 2 (ROCK2). It has been found to have the antifibrotic effect. Aug 07 2024
E4865 Noradrenaline bitartrate Noradrenaline bitartrate (Norepinephrine Bitartrate) is a central nervous system (CNS) neurotransmitter and stimulator of β1 adrenergic receptors and α-adrenergic receptors, causing increased contractility and heart rate, as well as vasoconstriction. Aug 07 2024
E4851 Tandospirone citrate Tandospirone citrate, is a potent, selective and a partial agonist of the 5-HT1A receptor. It exhibited good permeability in the intestine, with passive diffusion being the main mode of drug absorption, it also has anxiolytic effects and can be used in generalized anxiety disorder treatments. Aug 07 2024
E4840 Ziprasidone hydrochloride monohydrate Ziprasidone hydrochloride monohydrate is an antipsychotic drug, a combined antagonist of 5-HT (serotonin) and dopamine receptor. It exhibits binding affinities for D2, 5-HT2A, 5-HT1A with Ki values 4.8 nM, 0.42 nM, 3.4 nM respectively. Aug 07 2024
E1777 RIG012 RIG012 is a potent antagonist of Retinoic Acid Inducible Gene 1 (RIG-I), an innate immune receptor, with an IC50 of 0.71 μM in the NADH-coupled ATPase assay. It effectively blocks RIG-I-initiated signaling and inflammatory responses induced by SARS-CoV-2 RNA. Aug 07 2024
E4663 INF195 INF 195 is an NLRP3 inhibitor which inhibits NLRP3-driven macrophage pyrodeath and IL-1β release. At low dose, INF 195 can reduce the infarct size of isolated mouse hearts and effectively prevent myocardial ischemia/reperfusion injury. Aug 07 2024
E4855 Sertaconazole Sertaconazole(FI-7045) is an imidazole-type antifungal agent that inhibits ergosterol biosynthesis by inhibiting the cytochrome P450-dependent 14α-lanosterol demethylase or Erg11p. This inhibition disrupts fungal cell membrane integrity, ultimately leading to fungal cell death. Sertaconazole is used in the topical treatment of superficial mycoses. Aug 07 2024
E4616 Buloxibutid Buloxibutid (AT2 Agonist C21) is a selective agonist of angiotensin II type 2 receptor (AT2R) with a Ki value of 0.4 nM for the AT2 receptor and a Ki >10 µM for the AT1 receptor. Its treatment significantly reduces vascular remodelling, improves hemodynamics, and decreases pulmonary collagen deposition in the Sugen-Hypoxia model of pulmonary hypertension. Aug 07 2024
S8625 GNE-049 GNE-049 is a highly potent and selective inhibitor of CBP. It exhibits an IC50 of 1.1 nM in TR-FRET assay. GNE-049 also effectively inhibits BRET and BRD4 with IC50 values of 12 nM and 4200 nM, respectively. Aug 06 2024
E4856 Rotigotine Hydrochloride Rotigotine Hydrochloride (N-0923 Hydrochloride) is a potent Agonist of dopamine receptor, with Ki values of 0.71 nM for dopamine D3 receptor, 4-15 nM for D2, D5, D4 receptors, and 83 nM for dopamine D1 receptor. It also acts as a partial agonist of the 5-HT1A receptor, and as an antagonist of the α2B-adrenergic receptor. Aug 06 2024
E1041 SY-5609 SY-5609 (CDK7-IN-3) is an orally active and highly selective inhibitor of CDK7 with a KD value of 0.065 nM. SY-5609 exhibits poor inhibition on CDK2, CDK9, CDK12. SY-5609 displays antitumor activity and can induce apoptosis in tumor cells. Aug 06 2024
E1823 Ninerafaxstat trihydrochloride Ninerafaxstat trihydrochloride (MB-1018972 trihydrochloride; IMB-101 trihydrochloride) acts as a competitive inhibitor of 3-ketoacyl-CoA thiolase (3-KAT) to partially suppress fatty acid oxidation. It is an orally active cardiac mitochondrial drug that restores myocardial energy homeostasis. Ninerafaxstat trihydrochloride regulates myocardial substrate utilization and improves cardiac efficiency. Ninerafaxstat trihydrochloride is also used in research of cardiovascular diseases. Aug 06 2024
E4850 Tazemetostat hydrobromide Tazemetostat hydrobromide (EPZ-6438 hydrobromide) is a potent, selective, and orally available inhibitor of EZH2. It inhibits EZH2 with IC50 values of 11 and 16 nM in peptide assay and nucleosome assay, respectively. Tazemetostat hydrobromide also inhibits EZH1 with an IC50 of 392 nM. Aug 06 2024
E1565 Iruplinalkib Iruplinalkib (WX-0593) is a highly selective oral inhibitor of ALK and ROS1 tyrosine kinase. It exhibits potent and promising antitumor activity in advanced non-small cell lung cancer (NSCLC) with ALK or ROS1 rearrangement. Aug 01 2024
E4632 Taminadenant Taminadenant (NIR178; PBF509) is a non-xanthine and non-furan antagonist of adenosine A2A receptor (A2AR). It can antagonize A2AR agonist-mediated cAMP accumulation and impedance responses with Kb values of 72.8 nM and 8.2 nM, respectively. It exhibits potential utility for Parkinson’s disease (PD) treatment. Aug 01 2024
E4636 W-7 hydrochloride W-7 hydrochloride is a potent antagonist of calmodulin (CaM) that inhibits Dengue virus (DENV) translation and replication. It also competitively inhibits Trypsin-treated Ca2+/calmodulin-dependent phosphodiesterase (Ca2+-PDE). It exhibits anti-proliferative and anti-tumor effect. Aug 01 2024
E1426 EAPB02303 EAPB02303 is a second-generation imiqualine that acts as a microtubule -disruptingagent and demonstrates anti-tumor effects and reduces tumor size in human melanoma xenografts. Aug 01 2024
E4841 Vorapaxar sulfate Vorapaxar sulfate (SCH 530348 sulfate) is a selective and orally active antagonist of protease-activated receptor (PAR-1), with a Ki value of 8.1 nM. Vorapaxar sulfate reduces thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner. Aug 01 2024
E4838 Cefuroxime Cefuroxime (Kefurox) is an orally active, second-generation, broad-spectrum cephalosporin antibiotic with increased stability to β-lactamase. Cefuroxime exhibits broad-spectrum activity against Gram-positive bacteria including penicillinase-producing staphylococci and non-β-lactamase-producing gram-negative bacteria. Aug 01 2024
E1403 Fumarate hydratase-IN-1 Fumarate hydratase-IN-1 is a small molecule cell-permeable inhibitor of fumarate hydratase. It induce alteration of TCA cycle metabolites, modulation of cytosolic processes, and substantial redox stress responses. Jul 29 2024
P1242 Proteinase K Proteinase K is a serine endoprotease, is used for isolating amyloid cores and is effective over a wide pH range (4–12), including in the presence of SDS or urea. It is commonly used as a preparative reagent for destruction of proteins, including DNAses and RNAses, in DNA and RNA preparations. Jul 29 2024
E1611 Atuzabrutinib Atuzabrutinib (SAR 444727; PRN473) is a reversible, selective inhibitor of Bruton's tyrosine kinase (Btk). It can effectively prevent neutrophil recruitment via inhibition of macrophage antigen‐1 signalling. Jul 25 2024
E1791 Zongertinib Zongertinib (BI 1810631; BI 764532) is a selective and potent inhibitor of human HER2 and EGFR tyrosine kinase that covalently binds to both wild-type and mutated HER2 receptors, including exon 20 insertion mutations, while sparing EGFR signaling. It exhibits effective and tolerable oral treatment for patients with HER2 aberration-positive solid tumors. Jul 25 2024
E1931 AD-5584 AD-5584 is a specific inhibitor of human acyl-CoA synthetase short chain family member 2 (ACSS2). It significantly reduces lipid storage, decreases colony formation, and increases cell death in vitro, while also confirming blood-brain barrier (BBB) permeability. Jul 25 2024
E1533 Lipofermata Lipofermata is an inhibitor of fatty acid transport protein 2 (FATP2) that demonstrates fatty acid transport inhibition with an IC50 of 4.84 μM in Caco-2 cells. It may offer therapeutic potential for diseases where lipotoxicity is a key factor. Jul 25 2024
E1877 BLU 451(LNG-451) BLU 451 (LNG-451) is a central nervous system (CNS)-penetrant, wild-type EGFR-sparing, covalent inhibitor of epidermal growth factor receptor (EGFR) exon 20 insertion (Ex20ins) with an IC50 of 7-78 nM. It also exhibits a potent anti-tumor efficacy. Jul 24 2024
E4827 Diphenhydramine Diphenhydramine is a first-generation antihistamine and sedative that acts as an antagonist of the H1 receptor and is used for treating acute allergic reactions. It is FDA-approved as an adjunct to epinephrine and corticosteroids and exhibits anticholinergic and antiemetic effects. Jul 23 2024
E1889 PCO371 PCO371 is a nonpeptidyl, orally active agonist of Parathyroid hormone type 1 receptor (PTHR1). It stimulates cAMP production in COS-7 cells with an EC50 of 2.4 μmol/L. It also acts as an osteoporosis drug and significantly enhances bone mineral density (BMD) and bone strength in the lumbar vertebrae of osteopenic ovariectomized (OVX) rats. It also restores normal serum calcium levels without increasing urinary calcium in hypocalcemic thyroparathyroidectomized (TPTX) rats. Jul 23 2024
E1985 YD23 YD23 is a PROTAC which induces the degradation of SMARCA2. It reduces chromatin accessibility in SMARCA4-deficient cells, affecting gene enhancers related to cell cycle and growth regulation, which leads to the downregulation of several cell cycle genes. It also selectively inhibits the growth of SMARCA4 mutant lung cancer cells in vitro. Jul 23 2024
E4835 Sumatriptan Sumatriptan (GR43175) is a selective agonist of 5-HT1D receptor, which is effectively used in the acute treatment of migraine. It causes a vasopressor response in the systemic and pulmonary arterial circulations and coronary artery vasoconstriction. Jul 23 2024
E4836 Bupivacaine Bupivacaine is a potent local anesthetic and sodium channel blocker used for local infiltration, nerve block, epidural, and intrathecal anesthesia. It significantly reduces cell viability and induces apoptosis. It also stimulates the production of ROS and activates MAPK pathways, which increases the expression of WDR35 in mouse neuroblastoma Neuro2a cells. It also activates NF-κB and c-Jun/AP-1 signalling pathways in Neuro2a cells. Jul 23 2024
E1961 NVL-655 NVL-655 is a selective inhibitor of anaplastic lymphoma kinase (ALK), with potential antineoplastic activity in the Ba/F3 xenograft model. It also exhibits significant inhibitory activity against ROS1, LTK, PYK2, TRKB, and FAK, with an IC50 ≤10-fold ALK and demonstrates high potency against specific ALK mutations, with an IC50 of <0.73 nM, 7 nM, 3 nM, 3 nM for G1202R, G1202R/L1196M, G1202R/G1269A and G1202R/L1198F respectively. Jul 23 2024
E1015 Angiotensin II human Angiotensin II human is a potent vasoconstrictor that induces angiogenesis by activating angiotensin II type 1 (AT1) receptor, which increases the production of vascular endothelial growth factor (VEGF) in a redox-sensitive manner and promotes the formation of capillaries from endothelial cells through the LOX-1-dependent redox-sensitive pathway. Jul 23 2024
E4837 Trimethoprim (lactate) Trimethoprim (lactate) is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), an essential enzyme responsible for the production of tetrahydrofolic acid (THF). By blocking this enzyme, trimethoprim prevents the synthesis of bacterial DNA, hindering bacterial survival. It is a standard antibiotic for treating urinary tract infections (UTIs). Jul 23 2024
E4647 Aticaprant Aticaprant (CERC-501; LY-2456302) is a potent, orally bioavailable, centrally-penetrant antagonist of the kappa opioid receptor with a Ki of 0.807 nM. It exhibits an antidepressant effect with the potential to treat major depressive disorder (MDD). Jul 23 2024
E1957 NX-1607 NX-1607 (Cbl-b-IN-3) is an oral inhibitor of Casitas B-lineage lymphoma proto-oncogene B (CBL-B), which is an E3 ubiquitin ligase and a key regulator of T, NK, and dendritic cell activation and suppresses their anti-tumor functions. NX-1607 enhances antigen recall, reduces T cell exhaustion, and increases cytokine production in response to T cell receptor stimulation, thereby counteracting suppressive signals from the tumor microenvironment. Jul 23 2024
E4826 L-Ornithine L-aspartate L-ornithine-L-aspartate (LOLA) is a stable salt composed of two natural nonessential L-amino acids: ornithine and aspartic acid. It effectively lowers blood ammonia concentration by enhancing ammonia detoxification in the muscles, and alleviating hepatic encephalopathy symptoms in liver cirrhosis. Jul 19 2024
E4822 Tacrine Tacrine is a potent acetylcholinesterase (AChE) inhibitor. It inhibits acetylcholinesterase(AChE) and butyrylcholinesterase(BChE) with an IC50 of 77 nM and 69 nM, respectively. It is used in the treatment of Alzheimer's disease (AD), also poisoning topoisomerases and inhibiting in vivo (mitochondrial)mtDNA synthesis. Jul 19 2024
E4832 DL-Alanine DL-alanine (DL-2-Aminopropionic acid) is a racemic mixture of L- and D-alanine that forms complexes with transition metals like Cu(II), Zn(II), and Cd(II). It also plays a key role in the glucose-alanine cycle between tissues and the liver. Jul 19 2024
E4831 L-Arginine (L-glutamate) L-Arginine (L-glutamate) (Arginine glutamate) is a mixture of amino acids that induces apoptosis via hypertonic stress. It also promotes gastric relaxation by providing L-arginine for nitric oxide production, thereby benefiting gastrointestinal motility and conditions associated with vagus nerve dysfunction. Jul 19 2024
E4830 Guanidine thiocyanate Guanidine thiocyanate is a potent inhibitor of nucleases and a powerful denaturant of proteins. It is used for RNA isolation due to its strong chaotropic properties, which effectively denature RNase enzymes in samples, ensuring RNA stability and purity during extraction processes. Nucleic acid extraction buffers containing guanidine thiocyanate effectively deactivate high-titer polioviruses found in potentially infectious materials. Jul 19 2024
E4825 Naphazoline (nitrate) Naphazoline (nitrate) is a agonist of peripheral α2-adrenergic receptor and used as a topical decongestant. It also acts as a vasoconstrictor that effectively reduces intraoperative bleeding and enhances postoperative analgesia. When used in conjunction with intranasal lidocaine, it significantly reduces both intra- and postoperative pain, thereby decreasing the need for rescue analgesics in the postoperative period following septorhinoplasty. Jul 19 2024
E4828 Cloperastine fendizoate Cloperastine fendizoate (Hustazol) is a sedative used to relieve cough and also has a peripheral action that desensitizes the afferent nerves in the tracheobronchial region. It inhibits the hERG K+ currents in a concentration-dependent manner, with an IC50 value of 0.027 μM. Jul 19 2024
E4824 Hydroxychloroquine Hydroxychloroquine (HCQ) is an antimalarial drug that inhibits autophagy and is used to treat systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). It exhibits immunomodulatory, antithrombotic, and antiplatelet properties. It inhibits the release endothelin-1, a potent vasoconstrictor, and restores impaired angiogenesis in TNF-α-treated endothelial cells in vitro. It also reduces the production of inflammatory cytokines such as TNF-α, IFN-γ, and IL-6 from peripheral blood mononuclear cells, upregulates IL-10 and decreases platelet aggregation. Jul 19 2024
E4806 Quinine dihydrochloride Quinine dihydrochloride is an antiparasitic used to treat malaria and is particularly important for managing malaria during the first trimester of pregnancy. It inhibits Slo3 (KCa 5.1) channel, which are a significant part of the mammalian KSper (sperm potassium conductance), by binding to hydrophobic side chains located at the intracellular region of the channel pore. Jul 19 2024
E1885 LY3522348 LY3522348 is a highly selective oral dual inhibitor of the human ketohexokinase isoforms C and A, with IC50 values of 20nM for hKHK-C and 24nM for hKHK-A. It shows a significant pharmacodynamic effect in a mouse model of fructose metabolism. Jul 19 2024
E1686 SW-100 SW-100 is a selective inhibitor of histone deacetylase 6 (HDAC6) with an IC50 of 2.3 nM. It displays 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. Jul 18 2024
E4630 Ilginatinib hydrochloride Ilginatinib hydrochloride (NS-018 hydrochloride) is a potent small-molecule inhibitor of JAK2 that is competitive with adenosine triphosphate (ATP) which exhibits 30–50-fold greater selectivity for JAK2 over other Jak-family kinases such as JAK1, JAK3, and TYK2.It inhibits JAK2, JAK1, JAK3, and TYK2 with IC50 of 0.72 nM, 33 nM, 39 nM, and 22 nM, respectively. It also showed potent inhibition of Src-family kinases, SRC and FYN. It can be used in research of myeloproliferative neoplasms. Jul 18 2024
E4823 Pargyline Pargyline is an irreversible selective inhibitor of monoamine oxidase (MAO) with Kis of 13 μM and 0.5 μM for MAO-A and MAO-B respectively. It has pharmaceutical potential as an anticancer drug for human prostate cancer. Jul 18 2024
E4829 Bismuth subnitrate Bismuth subnitrate is an antigastric ulcer and antidiarrheic agent that induces metallothionein (MT). It can be used as an adjunct in cancer chemotherapy to induce MT in target organs. Jul 18 2024
P1241 Bromelain Bromelain is an aqueous extract of pineapple that is composed of 95%-mixture of proteases, acting as an inhibitor of Prostaglandin E2 (PGE2) and Cox-2. It exhibits potent anti-inflammatory, anti-thrombotic, fibrinolytic and anti-cancer functions. Jul 18 2024
E4592 UGT8-IN-1 UGT8-IN-1 is a brain-penetrable and orally active inhibitor of ceramide galactosyltransferase enzyme (UGT8). UGT8-IN-1 targets sulfatide metabolism resulting in ceramide-induced lethal mitophagy and subsequent cancer cell death in vitro, and reduces tumour growth in mutant Kras; Gnas allografts. Jul 16 2024
E1966 VVD-214 VVD-214 (RO7589831, VVD-133214) is a synthetic allosteric inhibitor of WRN helicase. VVD-214 binds irreversibly to cysteine 727 on WRN, suppressing ATP hydrolysis and helicase activity. VVD-214 exhibits potent efficacy in inducing double-stranded DNA breaks, nuclear enlargement, and cellular apoptosis in cancers with high microsatellite instability (MSI). Jul 15 2024
E1970 BAL-0028 BAL-0028 (Compound 3), which belongs to the indazole class is an inhibitor of NLRP3 activation with an IC50 value of 25 nM. BAL-0028 binds tightly to the NACHT domain of NLRP3, with KD values ranging from 104 to 123 nM. BAL-0028 also exhibits anti-inflammatory activity. Jul 15 2024
E1186 Tenapanor Tenapanor (AZD1722, RDX5791) is a potent and orally active inhibitor of sodium/hydrogen exchanger isoform 3 (NHE3). It exhibits an IC50 of 2 and 6 nM in human and mouse ileum monolayers, respectively. Tenapanor reduces intestinal phosphate absorption predominantly by reducing passive paracellular phosphate flux. Jul 15 2024
E4821 Simvastatin acid (ammonium) Simvastatin acid (Tenivastatin) ammonium is a potent inhibitor of HMG-CoA reductase (HMGCR). Simvastatin acid ammonium also decreases Indoxyl sulfate-induced reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium regulates the expression of OATP3A1 in cardiomyocytes. Jul 15 2024
E4820 Sulbactam pivoxil Sulbactam pivoxil (CP 47904), a proagent of sulbactam, is an inhibitor of β-lactamase. Sulbactam pivoxil provides higher absorption than its parent compound and achieves high serum levels following oral administration. Jul 15 2024
E4818 Pemetrexed (disodium heptahydrate) Pemetrexed (disodium heptahydrate) is a folate antimetabolite that inhibits thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide formyltransferase. It also induces apoptosis and cell-cycle arrest in non-small-cell lung cancer carrying an EGFR exon 19 deletion. Jul 14 2024
E1290 Ziftomenib Ziftomenib (KO-539) is an oral inhibitor of menin targeting the menin–KMT2A protein-protein interaction. It exhibits antileukemic activity and induces apoptosis of acute myeloid leukemia(AML) cells. Jul 11 2024
E4819 Afatinib free base Afatinib free base (Gilotrif, BIBW2992, Boehringer Ingelheim) is a second-generation tyrosine kinase inhibitor (TKI) that irreversibly inhibits EGFR and HER2, with IC50 of 0.5 nM, 0.4 nM, 14 nM and 1 nM for wild-type EGFR, EGFR-L858R, HER2, ErbB4, respectively. Jul 11 2024
E1867 NPD4928 NPD4928 is an inhibitor of Ferroptosis Suppressor Protein 1 (FSP1) that enhances ferroptosis. It enhances the cytotoxic effects on various cell types when combined with GPX4 antagonists. Jul 11 2024
E4816 Choline hydroxide, 42.5 wt.% in water Choline hydroxide, 42.5 wt.% in water (Sincaline), is a strong organic base used as a metal-free, nontoxic, and water-soluble catalyst. It facilitates the synthesis of 1,8-naphthyridine derivatives while avoiding the use of hazardous or carcinogenic organic solvents. Jul 10 2024
E1975 HC-7366 HC-7366, is a First-in-Human modulator of General controlled nonderepressible 2 (GCN2) that activates GCN2. It demonstrates anti-metastatic efficacy, reducing lung metastases and exhibits anti-tumor activity. Jul 09 2024
A2163 Anti-mouse IL-12 p40-InVivo Anti-mouse IL-12 p40-InVivo reacts with mouse p40 also known as IL-12β. p40 is a 40 kDa subunit of IL-12 and IL-23. IL-12 is a heterodimeric cytokine composed of subunits IL-12α p35 and IL-12β p40. Jul 09 2024
A2164 Anti-mouse B220-InVivo Anti-mouse B220-InVivo reacts with mouse B220 also known as CD45R. B220 is a 220 kDa transmembrane protein tyrosine phosphatase expressed on B cells and some subsets of T and NK cells. Jul 09 2024
E4805 Methylene Blue trihydrate Methylene blue trihydrate (C.I. Basic Blue 9 trihydrate) acts as an inhibitor of soluble guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS). Methylene blue trihydrate exhibits antimalarial, antidepressant, and anxiolytic activity effects. Methylene Blue trihydrate has potential applications in treating methemoglobinemia, neurodegenerative disorders, and ifosfamide-induced encephalopathy. Jul 08 2024
E4807 Dexketoprofen trometamol Dexketoprofen trometamol (Dexketoprofen tromethamine salt) is an orally active non-selective inhibitor of COX. Dexketoprofen trometamol exhibits analgesic efficacy and can be used in treating acute pain. Jul 08 2024
E4811 Levofloxacin hydrochloride Levofloxacin hydrochloride ((-)-Ofloxacin hydrochloride), a synthetic fluoroquinolone antibiotic, is an inhibitor of DNA gyrase and Topoisomerase IV. It exhibits bactericidal effects by preventing bacterial DNA replication. Jul 08 2024
E4812 Fluoxetine Fluoxetine (LY-110140 free base) is a selective 5-hydroxytryptamine (5-HT) reuptake inhibitor. Fluoxetine is used widely in the treatment of depression, anxiety-related symptoms and also displays anticonvulsant activity. Jul 08 2024
E1987 APX2009 APX2009 is a second-generation redox-specific inhibitor of APE1/Ref-1, an essential enzyme in the base excision repair (BER) pathway. APX2009 effectively reduces breast cancer cell proliferation and colony formation. Jul 08 2024
E1944 INS018-055(ISM001-055) INS018-055 (ISM001-055, TNIK&MAP4K4-IN-2, compound 112) is an inhibitor of TNIK and MAP4K4. It exhibits an IC50 values of 12-120 nM on TNIK. Jul 08 2024
E1854 INX-315 INX-315 is an orally active and selective inhibitor of CDK2 that induces cell cycle arrest in the G1 phase. It exhibits an IC50 value of 2.3 nM in intracellular NanoBRET assay, respectively. It displays a 50-fold increased CDK2 selectivity compared to CDK1. INX-315 decreases the phosphorylation of CDK2 substrates and suppresses tumor growth in xenograft mouse models in a dose-dependent manner. Jul 05 2024
E1900 Simnotrelvir Simnotrelvir(SIM0417; SARS-CoV-2-IN-41) is an inhibitor of coronavirus main proteinase (3CLpro) (SARS-CoV-2 3CLpro) with an IC50 of 24 nM. It has a potential anti-SARS-CoV-2 activity. Jul 04 2024
E4809 Piperaquine tetraphosphate tetrahydrate Piperaquine tetraphosphate tetrahydrate is an inhibitor of autophagy . It is a bisquinoline antimalarial agent effective against Plasmodium falciparum. Piperaquine tetraphosphate tetrahydrate is useful in antimalarial research. Jul 04 2024
E4808 Propionyl-L-carnitine hydrochloride Propionyl-L-carnitine hydrochloride(Levocarnitine propionate hydrochloride) supports mitochondrial metabolism, offers cardiovascular benefits, acts as a free radical scavenger, and is used in treating colonic inflammatory bowel disease. Jul 04 2024
E4810 Piperacillin Piperacillin is a broad-spectrum β-lactam antibiotic with potent bactericidal activity against Gram-negative bacteria and selects Gram-positive strains via penicillin-binding proteins. Jul 04 2024
E4634 MIRA-1 MIRA-1(NSC 19630), a maleimide compound, is a selective inhibitor of Werner syndrome WRN helicase activity with an IC50 of 20 µM while sparing ATPase and exonuclease activities. It reactivates mutant p53, inducing apoptosis in various human solid tumor cell lines with tetracycline-regulated mutant p53. Jul 03 2024
E4803 Vardenafil Vardenafil is an orally active and selective inhibitor of phosphodiesterase-5 (PDE5), with an IC50 value of 0.7 nM, respectively. Vardenafil acts as a competitive inhibitor of cyclic guanosine monophosphate (cGMP) hydrolysis, thereby increasing cGMP levels. Vardenafil can be used for the research of erectile dysfunction, hepatitis, diabetes. Jul 02 2024
E1848 BGB-8035 BGB-8035 is an orally active, highly selective inhibitor of Bruton's tyrosine kinase (BTK) with IC50 values of 1.1 nM for BTK, respectively. BGB-8035 exhibits antitumor and anti-arthritis activity and displays potential for its use in research of B-cell malignancies and autoimmune diseases. Jul 02 2024
E1558 GSK-3008348 HCl GSK-3008348 HCl is a small molecule antagonist of integrin αvβ6 with an affinity (pIC50) value of 8.1 for αvβ6 in cell Adhesion assays. Jul 02 2024
E1582 Edralbrutinib Edralbrutinib (TG-1701) is an irreversible, highly specific, and potent inhibitor of Bruton's tyrosine kinase (BTK). TG-1701 shows similar efficacy but greater selectivity compared to the first-in-class BTK inhibitor ibrutinib, with a Kd value of 3 nmol/L, in both in vitro and in vivo models of B-cell non-Hodgkin lymphoma (B-NHL). Jul 02 2024
E4804 Sitagliptin phosphate Sitagliptin phosphate (MK-0431 phosphate) is a potent inhibitor of dipeptidyl peptidase IV (DPP-4) with an IC50 value of 19 nM in Caco-2 cell extracts. Jul 02 2024
E4801 Cu(II)-Elesclomol Cu(II)-Elesclomol, a Cu2+ complex of Elesclomol, is a weak inhibitor of DNA topoisomerase I. It is also highly capable of inducing cuproptosis and apoptosis. It induces DNA double-strand breaks in K562 cells and causes a G1 cell cycle block. Cu(II)-Elesclomol displays anticancer activity. Jun 27 2024
E4802 Ticarcillin disodium Ticarcillin disodium is a semisynthetic β-lactam antibiotic, which is active against Pseudomonas aeruginosa, Escherichia coli, Pseudomonas mirabilis, Pseudomonas rettgeri, and Klebsiella aerogenes. Jun 27 2024
E1858 RMC-7977 RMC-7977 is a potent, reversible, tri-complex oral inhibitor that selectively targets active (GTP-bound) forms of KRAS, HRAS, and NRAS, which exhibits broad-spectrum activity against both mutant and wild-type variants (a RASMULTI (ON) inhibitor). It also exhibits significant anti-tumor efficacy in pancreatic ductal adenocarcinoma (PDAC). Jun 27 2024
E1857 TH-Z816 TH-Z816 is an inhibitor of ,KRAS(G12D) with an IC50 of 14 μM in an SOS-catalyzed nucleotide exchange assay with GDP as the incoming nucleotide. Jun 27 2024
E1865 Envonalkib Envonalkib(TQ-B3139; CT-71; Formula 1) is a potent and orally active inhibitor of ALK, that exhibits IC50 values of 1.96 nM, 35.1 nM, and 61.3 nM for wild-type and mutated L1196M and G1269S-ALK. Envonalkib is also used in the research of non-small cell lung cancer. Jun 27 2024
E1995 AZD-5462 AZD-5462(Example 1) is a modulator of RXFP1, the cognate receptor for human relaxin, that belongs to the GPCR family 1c number. AZD-5462 exhibits anti-fibrotic and anti-inflammatory properties. Jun 27 2024
E1824 Vazegepant hydrochloride Vazegepant hydrochloride (BHV-3500, Zavegepant), is a highly potent, selective, and structurally unique small molecule antagonist of CGRP receptor. It can also be used for the acute treatment of migraine. Jun 27 2024
E1703 SF2312 SF2312 is a highly potent inhibitor of Enolase with IC50s of 37.9 nM and 42.5 nM for human recombinant ENO1 and ENO2, respectively, and also is a natural phosphonate antibiotic. SF2312 displays activity against bacteria under anaerobic conditions. Jun 27 2024
E1932 DW71177 DW71177 is a potent BD1-Selective inhibitor of BET. DW71177 selectively interacts with BD1 and exhibits strong antileukemic activity. DW71177 can also be used in the study of acute myeloid leukemia. Jun 27 2024
E1846 TL13-112 TL13-112 is a degrader of anaplastic lymphoma kinase (ALK) with an IC50 of 0.60 nM. It demonstrates anti-proliferative activity in non-small-cell lung cancer (NSCLC) and anaplastic large cell lymphoma (ALCL) cell lines. Jun 25 2024
E1580 TNG260 TNG260 is an inhibitor of CoREST-selective deacetylase (CoreDAC) that inhibits HDAC1 with 10-fold selectivity over HDAC3. It decreases intratumoral neutrophil infiltration and exhibits immune-mediated cell killing. Jun 24 2024
E1188 Brensocatib Brensocatib (AZD7986, INS1007) is an oral, selective, reversible inhibitor of dipeptidyl peptidase-1 (DPP-1). It reduces the activity of all major neutrophil serine proteases (NSPs) including, neutrophil elastase (NE), proteinase 3 (PR3), and cathepsin G (CatG) in patients with bronchiectasis. Jun 24 2024
P1238 SN 52 SN52, a cell-permeable peptide containing the p50 NLS, is a selective inhibitor of NF-κB pathway. It selectively and completely blocks the ionizing radiation (IR)-induced nuclear import of p52 and RelB. It also enhances the radiosensitivity of prostate cancer cells. Jun 24 2024
E1660 NX-5948 NX-5948(BTK-IN-24) is a novel oral small molecule that induces BTK degradation via cereblon E3 ubiquitin ligase recruitment. It mediates potent anti-inflammatory activity and can cross the blood-brain barrier in animal models. Jun 23 2024
E1986 TR-107 TR-107 is a chemical activator of the human mitochondrial protease ClpP with an EC50 of 140 nM. It exhibits excellent potency and specificity in the research of triple-negative breast cancer (TNBC) cell models. Jun 23 2024
E1947 DiR (Cy7 DiC18) DiR (Cy7 DiC18) is a near-infrared fluorescent long-chain carbocyanine dye used for labeling cell membranes, organelles, liposomes, viruses, and lipoproteins in vivo and in vitro. Jun 23 2024
E1437 PHI-101 PHI-101 is an orally active, potent third-generation inhibitor of FLT3 that overcomes resistance to multiple drug-resistant mutations. It has potential for research in relapsed or refractory acute myeloid leukemia (AML). Jun 23 2024
E1751 MSC-4381 MSC-4381 (MCT4-IN-1) is an orally active, selective inhibitor of monocarboxylate transporter 4 (MCT4) with an IC50 of 77 nM and a Ki of 11 nM. It has the potential to inhibit lactate efflux and promote intracellular lactate accumulation in MCT4-expressing cell lines. Jun 23 2024
E4607 Oseltamivir acid Oseltamivir acid(GS 4071;Ro 64-0802;Oseltamivir carboxylate), a metabolite of the antiviral compound oseltamivir, acts as a competitive inhibitor of influenza neuraminidases A and influenza neuraminidases B with IC50 of 0.1 to 4.9 nM respectively, thereby preventing virus budding and release. Jun 23 2024
E4594 Lithium iodide hydrate Lithium iodide hydrate is a reagent and the water-crystallized form of lithium iodide. It is commonly used as an electrolyte additive in dye-sensitized solar cells and Li-S batteries, enhancing their cycle life. Jun 23 2024
E4606 Dihexa Dihexa(PNB-0408), an oligopeptide drug, is an orally active and blood-brain barrier-permeable analog of angiotensin IV. It binds to hepatocyte growth factor (HGF) with high affinity and potentiates its activity at its receptor, c-Met. Dihexa can also be used as a therapeutic potential in the treatment of Alzheimer’s disease. Jun 19 2024
E1917 SLF1081851 hydrochloride SLF1081851 hydrochloride is a potential inhibitor of Spns2 that blocks S1P release with an IC50 of 1.93 μM. It can be developed as a probe for studying Spns2 biology and immune modulation. Jun 18 2024
E1528 RP-6685 RP-6685 is a potent, selective, and orally active inhibitor of DNA polymerase theta (Polθ). RP-6685 exhibits antitumor efficacy in animal models. Jun 18 2024
E1912 B102(PARP/HDAC-IN-1) B102(PARP/HDAC-IN-1) is a dual inhibitor of PARP and HDAC, with IC50 of 19.01 nM, 2.13 nM, 1.69 μM, > 10 μM for PARP1, PARP2, HDAC1, HDAC6, respectively, in an enzymatic assay. It exhibits anti-proliferative and anti-tumor effects. It also induces DNA damage and apoptosis in vitro. Jun 17 2024
E1980 Atogepant Atogepant(MK-8031, AGN-241689) is a potent, selective, orally available antagonist of the calcitonin gene-related peptide (CGRP) receptor, with ki of 0.026 nM for human CGRP receptor. It is used for the preventive treatment episodic migraine. Jun 17 2024
E1788 CQ211 CQ211 is a cell penetrant, potent and selective inhibitor of RIOK2(Right open reading frame kinase 2) with a Kd of 6.1 nM. It effectively inhibits cancer cell proliferation and shows promising in vivo efficacy in mouse xenograft models. Jun 13 2024
E1894 PROTAC tubulin-Degrader-1(compound W13) PROTAC tubulin-Degrader-1(compound W13) is an inhibitor of PROTAC tubulin exhibiting antitumor activity against human lung cancer. Jun 11 2024
P1239 ADH-1 ADH-1, an antagonist of N-cadherin, blocks N-cadherin-mediated cell adhesion. It exhibits significant antitumor activity against N-cadherin-expressing cells in vitro assays. Jun 10 2024
E1949 DuP-697 DuP-697 is a potent, irreversible, selective, and orally active inhibitor of COX-2 with an IC50 value of 10 nM for human COX-2, respectively. DuP-697 exerts antiproliferative, antiangiogenic, and apoptotic effects in colorectal cancer cells. Jun 10 2024
E1662 Elenestinib phosphate Elenestinib phosphate(BLU-263 phosphate) is a potent and orally active inhibitor of tyrosine kinase that exhibits potent inhibition of c-KIT (D816V) mutation. BLU-263 phosphate has the potential for its use in the research of systemic mastocytosis (SM). Jun 10 2024
E1908 HRO761 HRO761 is a potent, selective, allosteric inhibitor of Werner syndrome RecQ helicase (WRN). It binds at the interface of the D1 and D2 helicase domains, locking WRN in an inactive conformation, and demonstrates anti-proliferative effects specifically in microsatellite instability (MSI) cancer cells. Jun 10 2024
E4596 GSK-2879552 GSK-2879552 is a selective and potent inhibitor of Lysine-specific demethylase 1 (LSD1, KDM1A), with the potential to treat Small cell lung cancer (SCLC). It induces the expression of putative KDM1A target genes and demonstrates potent, predominantly cytostatic, antiproliferative activity in SCLC cell lines and tumor xenograft models. Jun 07 2024
E4595 SB-743921 SB-743921 (SB-921) is an inhibitor of Kinesin Spindle Protein (KSP), a mitotic protein essential for cell cycle control and motility. It functions by selectively targeting rapidly dividing cells and disrupting spindle formation during cell division, leading to G2/M phase arrest and ultimately causing cell death. It also inhibits proliferation and induces apoptosis in diffuse large B-cell lymphoma (DLBCL) cell lines. Jun 07 2024
S7512 GSK269962A GSK269962A is a potent and selective inhibitor of ROCK with IC50 values of 1.6 nM for ROCK1 and 4 nM for ROCK2. It shows potential as an alternative treatment for overactive bladder (OAB), and also exhibits anti-inflammatory and vasodilatory activities. Jun 06 2024
S9894 Vafidemstat Vafidemstat(ORY-2001) is a potent, selective, brain-penetrant dual inhibitor of lysine-specific histone demethylase (LSD1, KDM1A) and MAO-B, with IC50 values of 105 nM and 58 nM, respectively. It shows potential for treating memory deficits and behavioral alterations in neurodegenerative and psychiatric diseases. Jun 06 2024
E4593 Benzo-15-crown-5 ether Benzo-15-crown-5-ether (B15C5) is employed as a ligand in metal-catalyzed reactions to improve reactivity and selectivity by coordinating with metal cations. Additionally, it serves as a chelating agent for sodium and potassium ions. Jun 06 2024
E1872 Selnoflast Selnoflast(RO-7486967) is a selective and reversible small molecule inhibitor of NLRP3 inflammasome, with the potential to treat moderate to severe active ulcerative colitis. Jun 03 2024
E1625 Elsubrutinib Elsubrutinib(ABBV-105) is a covalent, irreversible, potent, and highly selective inhibitor of Bruton’s Tyrosine Kinase (BTK), with an IC50 of 0.18 μM for BTK catalytic domain. It specifically inhibits BTK dependent cellular functions, including both BCR and FcγR mediated signaling. It also exhibits significant efficacy in pre-clinical mechanistic models of antibody production, as well as in models of rheumatoid arthritis and lupus. Jun 03 2024
E1878 Bromoenol lactone Bromoenol lactone((6E)-Bromoenol lactone) is a selective, irreversible, potent inhibitor of calcium-independent phospholipase A2 (iPLA2β) with an IC50 value of ≈7 μM. It prevents antigen-stimulated exocytosis in mast cells without hindering Ca2+ influx. Jun 02 2024
E1761 AMG PERK 44 AMG PERK 44 is a highly selective and orally active inhibitor of PERK with an IC50 of 6 nM. AMG PERK 44 exhibits 1000-fold and 160-fold selectivity over GCN2 and B-Raf, respectively. Jun 02 2024
E1922 OX04528 OX04528 (compound 68) is a potent and G-protein-biased agonist of G protein-coupled receptor 84 (GPR84). OX04528 inhibits cAMP production with an EC50 value of 0.00598 nM (5.98 pM), respectively. Jun 02 2024
E1907 HADA hydrochloride HADA hydrochloride (HCC-Amino-D-alanine hydrochloride) is a blue fluorescent D-amino acid (FDAA) that labels peptidoglycans in live bacteria without affecting growth and also displays mitochondrial outer membrane permeability. May 28 2024
E1884 HC-258 HC-258 is a covalent acrylamide inhibitor of TEAD that reduces the CTGF, CYR61, AXL, and NF2 transcript levels and inhibits the migration of MDA-MB-231 breast cancer cells. May 27 2024
E1536 (R)-HTS-3 (GLXC-25878) (R)-HTS-3 (GLXC-25878) is a potent, selective, and cell-active inhibitor of lysophosphatidylcholine acyltransferase 3 (LPCAT3) with an IC50 of 0.09 µM, an enzyme critical for synthesizing C20:4-containing phospholipids. It reduces arachidonic acid-d8 incorporation into phospholipids and mitigates RSL3-induced ferroptosis in HT-1080 and 786-O cancer cells. May 27 2024
E1264 VIT-2763 VIT-2763 is an oral small-molecule inhibitor of ferroportin. It displaces TMR-hepcidin from ferroportin with an IC50 of 24 nM. It also ameliorates anemia, enhances erythropoiesis, and reduces organ iron loading in the Hbbth3/+ β-thalassemia intermedia disease model. May 23 2024
E1800 Oxythiamine chloride hydrochloride Oxythiamine chloride hydrochloride(Hydroxythiamine chloride hydrochloride) is a salt form of Oxythiamine. It is an inhibitor of transketolase, the enzyme that controls the nonoxidative branch of the pentose phosphate pathway. It also suppresses tumor cell proliferation and promotes apoptosis. May 23 2024
E1385 Bexotegrast Bexotegrast(PLN-74809) is potent dual selective inhibitor of αvβ6 and αvβ1 integrins with Kd of 5.7 nM and 3.4 nM, respectively. It has antifibrogenic effects, blocks multiple TGF-β activation pathways in the fibrotic lung, and is useful for researching fibrosis, including idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP). May 21 2024
E1607 RK-701 RK-701 is a highly selective, potent, and low-toxicity inhibitor of histone methyltransferases G9a and GLP1 with IC50 values of 23-27 nM and 53 nM. RK-701 treatment induces fetal globin expression in human erythroid cells and in mice and plays an essential role in γ-globin induction. RK-701 is used in the research of sickle cell disease. May 19 2024
E1632 VU0463271 VU0463271 is a selective and potent antagonist of neuronal-specific potassium-chloride cotransporter 2 KCC2, with an IC50 of 61 nM. VU0463271 demonstrates over 100-fold selectivity compared to the closely related Na-K-2Cl cotransporter 1 (NKCC1). May 16 2024
E1340 Glesatinib Glesatinib(MGCD265) is an orally bioavailable potent dual inhibitor of c-MET and SMO. Glesatinib counteracts P-glycoprotein (P-gp) mediated multidrug resistance (MDR) in non-small cell lung cancer (NSCLC). May 16 2024
E1962 RMC-9805 RMC-9805(KRAS G12D ON inhibitor) is an orally active inhibitor of KRAS G12D. RMC-9805 inhibits RAS signaling, leading to apoptosis in cancer cells with the KRAS G12D mutation. May 15 2024
E1613 UNC8153 UNC8153 is a selective degrader of nuclear receptor-binding SET domain-containing 2 (NSD2) with a binding Kd of 24 nM, effectively reducing NSD2 protein levels and the dimethylate lysine 36 of histone 3 (H3K36me2) chromatin mark. Its simple warhead promotes proteasome-dependent degradation of NSD2 via a novel mechanism. May 14 2024
E1818 PF-07265807 PF-07265807(TAM&Met-IN-1) is a dual inhibitor of AXL and MER, which exhibits anti-tumor effects. It also enhances the function of dendritic cells to cross-prime CD8+ T cells. May 14 2024
E1830 Baxdrostat Baxdrostat(CIN-107) is a selective and potent inhibitor of aldosterone synthase(CYP11B2), a rate-limiting enzyme in the pathway of aldosterone synthesis, with the potential to treat resistant hypertension. It also inhibits the function of multidrug and toxin extrusion 1 (MATE1) and MATE2-K with IC50 values of 1.34 µM and 2.67 µM, respectively. May 14 2024
E1745 Ulonivirine Ulonivirine(MK-8507) is a selective and potent inhibitor of HIV-1 nonnucleoside reverse transcriptase (NNRTI) that binds to the classic NNRTI hydrophobic binding pocket near the polymerase active site. It demonstrates a potential to treat HIV-1 infections and induce the expression of CYP3A4, an enzyme often involved in drug metabolism. May 14 2024
E1724 CRT-0105446 CRT 0105446 (compound 22d) is a potent inhibitor of LIMK1 with an IC50 of 8 nM. It can inhibit the growth of MCF-7 breast cancer cells and the invasion of MDA-MB-231 cells by reducing the expression of phosphorylated cofilin. May 09 2024
E1875 BI-3231 BI-3231 is the potent and selective chemical probe, which inhibits hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13) with an IC50 of 1 nM and Ki of 0.7 nM in the enzymatic assay. It has the potential to treat NASH and other liver diseases.  May 09 2024
E1937 PT-179 PT-179, an orthogonal Thalidomide derivative targets cereblon without causing off-target degradation effects. PT-179 specifically binds CRBN, forms a ternary complex with a target protein fused to a zinc finger (ZF) degron, and mediates the degradation of the tagged protein. May 09 2024
E1795 Triparanol(MER-29) Triparanol (MER-29) is an inhibitor of 24-dehydrocholesterol reductase (DHCR24), an enzyme involved in cholesterol biosynthesis. It exhibits antitumor properties, such as decreasing proliferation and inducing apoptosis in various cancer cell lines, while also reducing Hedgehog pathway signaling in these cells. May 09 2024
E0448 RO8191 RO8191 (CDM-3008, RO4948191), an imidazonaphthyridine compound, is an orally active and potent agonist of interferon (IFN) receptor. RO8191 binds directly to the IFNα/β receptor 2 (IFNAR2), activating IFN-stimulated genes (ISGs) expression and the phosphorylation of JAK/STAT signaling. May 09 2024
S7994 GSK864 GSK864 is a cell-penetrant, potent, and selective inhibitor of isocitrate dehydrogenase 1 (IDH1) mutants, specifically targeting the R132C, R132H, and R132G variants with IC50 values of 8.8 nM, 15.2 nM, and 16.6 nM, respectively. May 06 2024
E1929 LTGO-33 LTGO-33 is a potent and selective inhibitor of voltage-gated sodium channel NaV1.8. LTGO-33, with its potency in the nanomolar range, selectively inhibits NaV1.8 over 600 times more than human NaV1.1-NaV1.7 and NaV1.9. Its inhibition is not dependent on the state of the channels and displays consistent potency against both closed and inactivated conformations. LTGO-33 holds promise for research in pain disorders. Apr 28 2024
E1925 Butylhydroxyanisole Butylhydroxyanisole (Butylated hydroxyanisole; BHA; E320) is an inhibitor of ferroptosis, a food preservative and antioxidant that prevents the formation of harmful compounds, extending shelf life. However, it's associated with liver toxicity, reproductive organ development issues, learning delays, and sleep problems. Apr 25 2024
E1740 Mepazine hydrochloride Mepazine hydrochloride (Pecazine hydrochloride) is a potent and selective inhibitor of MALT1 protease, with IC50 values of 0.83 μM for GSTMALT1 full length and 0.42 μM for GSTMALT1 aa 325-760. It effectively suppresses the activation of the NF-kB pathway specifically in activated B cell subtype of diffuse large B cell lymphoma (ABC-DLBCL) cells and makes it a promising candidate for the treatment of ABC-DLBCL. Apr 25 2024
E1806 AGI-24512 AGI-24512 is an inhibitor of MAT2A with an IC50 of 8 nM. It increases R-Loop formation and DNA damage in MTAP-deleted and WT cell models. It also exhibits anti-proliferative activity in vitro. Apr 25 2024
E1798 HOIPIN-8 HOIPIN-8, is a potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) and NF-κB signaling with an IC50 value of 11 nM. It serves as a powerful tool for investigating the physiological and cellular functions of LUBAC. Apr 23 2024
E1699 SR10221 SR10221 is a inverse-agonist of PPARγ with IC50 of 1.6 nM in RT112/84 FABP4-NLucP reporter assay. It exhibits an antiproliferative activity in vitro. Apr 22 2024
S8546 Alrizomadlin Alrizomadlin(APG-115, AA-115) is a highly potent and efficacious inhibitor of MDM2 and binds to MDM2 with IC50 of 3.8 nM. It exhibits potent antiproliferative and apoptogenic activities and also significantly reduces tumor burden and prolonged survival in AML xenograft models. Apr 21 2024
A2162 Anti-mouse/human VLA-4 (CD49d)-InVivo Anti-mouse/human VLA-4 (CD49d)-InVivo reacts with human and mouse VLA-4 α chain also known as CD49d and integrin alpha 4. VLA-4 is a 150 kDa glycoprotein belonging to the integrin family that is expressed by many cell types including T and B lymphocytes, monocytes, eosinophils, basophils, mast cells, thymocytes, NK cells, and dendritic cells. Apr 19 2024
E4585 N-Arachidonyldopamine N-Arachidonyldopamine is a potent agonist of cannabinoid receptor 1 (CB1), with a Ki of 250 nM in rat brain membranes, showing 40-fold selectivity for CB1 over CB2 receptors. It also triggers intracellular calcium mobilization in N18TG2 neuroblastoma cells. Apr 17 2024
E1728 STC-15 STC-15 is an oral, small-molecule inhibitor of RNA methyltransferase METTL3. It inhibits tumor growth through the activation of anti-cancer immune responses associated with increased interferon signaling and synergizes with T-cell checkpoint blockade. Apr 16 2024
E1904 SKF-34288 hydrochloride SKF-34288 hydrochloride(3-Mercaptopicolinic acid hydrochloride; 3-MPA hydrochloride) is an orally active, specific inhibitor of phosphoenolpyruvate carboxykinase (PEPCK) with Ki values of 2-9 μM. SKF-34288 hydrochloride is a potent hypoglycemic agent by inhibiting glucose synthesis. SKF-34288 hydrochloride also inhibits cell proliferation, induces myogenic differentiation in vitro. Apr 14 2024
E1036 BMS-986278 BMS-986278 is a potent and orally active antagonist of lysophosphatidic acid receptor 1 (LPA1). BMS-986278 exhibits Kbs of 6.9 nM and 4.0 nM for human and mouse LPA1, respectively, and is widely used in the research of pulmonary fibrotic diseases. Apr 14 2024
S9716 H3B-8800 H3B-8800 is a potent and orally active modulator of SF3B splicing. H3B-8800 interacts directly with the SF3b complex, demonstrating anti-cancer properties. H3B-8800 holds promise for studying acute myeloid leukemia (AML) with SF3B1 mutations. Apr 10 2024
E1597 RMC-6236 RMC-6236 (RAS-IN-2) is a RAS(ON) multi-selective noncovalent inhibitor of the active, GTP-bound state of both mutant and wild-type variants of canonical RAS isoforms with broad therapeutic potential. RMC-6236 exhibits strong anticancer efficacy in RAS-addicted cell lines, especially those with mutations at codon 12 of KRAS. Apr 10 2024
E1880 OTUB2-IN-1 OTUB2-IN-1 is a specific inhibitor of OTUB2, decreases PD-L1 protein expression in tumor cells, leading to suppressed tumor growth through enhanced infiltration of cytotoxic T lymphocytes (CTLs) within the tumor microenvironment. Apr 10 2024
E1903 SLU-PP-332 SLU-PP-332 is an agonist of pan-Estrogen Receptor/ERR with EC50 values of 98nM, 230nM, and 430 nM for ERRα, ERRβ, and ERRγ, respectively with the highest potency for ERRα. SLUPP-332 amplifies mitochondrial function and cellular respiration in skeletal muscle cell lines and also offers opportunities for researching metabolic ailments and enhancing muscle functionality. Apr 10 2024
E1876 GTS-21 dihydrochloride GTS-21 dihydrochloride(DMXB-A; DMBX-anabaseine) is a selective agonist of alpha7 nicotinic acetylcholine receptor (α7-nAChR) and exhibits anti‑inflammatory and cognition‑enhancing activities. GTS-21 dihydrochloride is also an antagonist of α4β2 with a Ki value of 20 nM for humanα4β2 and 5-HT3A receptor with an IC50 value of 3.1 μM. Apr 10 2024
E1924 TI17 TI17 is an inhibitor of thyroid hormone receptor-interacting protein Trip13. TI17 efficiently suppresses the proliferation of multiple myeloma (MM) cells and triggers cell cycle arrest and apoptosis. Trip13, an AAA-ATPase involved in double-strand break (DSB) repair, is targeted by TI17, leading to impaired function and heightened DNA damage. Apr 10 2024
E1710 LY2780301 LY2780301 is a highly selective adenosine triphosphate (ATP)-competitive dual inhibitor of p70S6K and Akt. LY2780301 binds to Akt, inhibiting its activity, which consequently blocks the PI3K/Akt signaling pathway which leads to reduced cell proliferation and the initiation of apoptosis in tumor cells. Apr 08 2024
E1849 TL12-186 TL12-186 is a cereblon-dependent multi-kinase PROTAC degrader. TL12-186 also inhibits CDK2/cyclin A and CDK9/cyclin T1 with IC50 values of 73 nM and 55 nM, respectively. Apr 08 2024
S8267 RapaLink-1 RapaLink-1, a third-generation bivalent inhibitor of mTOR, combines Rapamycin with MLN0128 using an inert chemical linker. It demonstrates efficacy against resistant mutants of malignant brain tumors and inhibits cancer cell progression by binding to mesenchymal markers. Apr 06 2024
E1653 CCT241533 hydrochloride CCT241533 hydrochloride is an ATP competitive, potent, and selective inhibitor of CHK2 with an IC50 of 3 nM and a Ki of 1.16 nM and shows minimal cross-reactivity against a panel of kinases. CCT241533 inhibits CHK2 activity in human tumor cell lines when subjected to DNA damage. Apr 06 2024
E1905 Nalidixic acid sodium salt Nalidixic acid sodium salt is an inhibitor of bacterial DNA gyrase and topoisomerase IV, essential enzymes for DNA supercoiling during replication, making it an effective quinolone antibiotic against both gram-positive and gram-negative bacteria. Apr 06 2024
A2160 Anti-rat Kappa Immunoglobulin Light Chain-InVivo Anti-rat Kappa Immunoglobulin Light Chain-InVivo reacts with the kappa chain of the rat immunoglobulin light chain. The κ chain is one of two types of polypeptide subunits which make up the immunoglobulin light chain. Apr 03 2024
A2161 Anti-mouse ICOSL (CD275)-InVivo Anti-mouse ICOSL (CD275)-InVivo reacts with mouse ICOSL (inducible T cell co-stimulator ligand) also known as CD275, B7RP-1, and B7-H2. ICOSL is a 40 kDa immune checkpoint protein belonging to the Ig receptor superfamily. Apr 03 2024
E1781 Biricodar Biricodar(VX-710) is a modulator of P-glycoprotein and MRP-1 with minimal in vivo toxicity. It enhances the effectiveness of various antibiotics against numerous gram-positive pathogens and exhibits potent chemosensitizing properties in cells resistant to multiple drugs. Mar 31 2024
E1554 Tefinostat(CHR-2845) Tefinostat(CHR-2845) is a monocyte/macrophage-targeted inhibitor of pan-histone deacetylase (HDAC). Tefinostat undergoes cleavage mediated by the intracellular esterase human carboxylesterase-1 (hCE-1) to yield the active acid CHR-2847. In vitro studies reveal a specific heightened sensitivity of monocytoid leukemias to tefinostat. Mar 27 2024
E1783 Conteltinib(CT-707) Conteltinib(CT-707) is a potent multikinase inhibitor of ALK, FAK,Pyk2, showing promising anti-tumor activities. Conteltinib exhibits significant inhibitory effects on FAK with an IC50 value of 1.6 nM in vitro kinase assay. Mar 26 2024
E1114 Ifebemtinib Ifebemtinib(IN10018, BI853520) is a highly selective, potent inhibitor of focal adhesion kinase (FAK), with an IC50 of 1 nM for inhibiting FAK autophosphorylation. It also inhibits FER Kinase and FES Kinase with IC50s of 900 nM and 1040 nM, respectively, inhibiting spheroid formation and orthotopic tumor growth in malignant pleural mesothelioma. IN10018 exhibits anti-tumor activity in vitro and in vivo. Mar 25 2024
S9861 PY-60 PY-60 is a small-molecule activator of the transcriptional coactivator Yes-associated protein (YAP) with EC50 of 1.6 µM, which acts by inhibiting a central scaffolding protein in the Hippo pathway, Annexin A2. It promotes the regenerative repair of cutaneous wounds in pig and human models. Mar 24 2024
E1356 BI-0474 BI-0474 is a potent inhibitor of KRASG12C with an IC50 value of 7.0 nM. It inhibits GDP-KRAS::SOS1 protein-protein interactions. It exhibits anti-proliferative and anti-tumour activity and can be used in cancer research. Mar 24 2024
E1165 JAB-3068 JAB-3068 (SHP2-IN-6) is a potent allosteric inhibitor of SHP2. JAB-3068 enhances the anti-tumor activity of CD8+ T cells and can be used in combination to address non-responsive tumors alongside PD-1/PD-L1 antibodies. Mar 20 2024
E1768 MEDICA16 MEDICA16 is an inhibitor of ATP-citrate lyase and also acts as an agonist of G protein-coupled receptor 40 (GPR40). It functions to blunt the development of insulin resistance in the JCR:LA-cp rat as well as it is a potent triacylglycerol-lowering agent. Mar 14 2024
S9734 Bomedemstat Bomedemstat(IMG-7289) is an orally active and irreversible inhibitor of LSD1(lysine-specific demethylase 1). Bomedemstat exhibits the ability to enhance methylation levels of H3K4 and H3K9, subsequently leading to modifications in gene expression. Bomedemstat demonstrates anti-cancer properties by restraining cancer cell proliferation and prompting apoptosis. Mar 12 2024
E1341 Cerivastatin sodium Cerivastatin sodium, a sodium salt of cerivastatin, is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase with Ki of 1.3 nM. It is also a synthetic, enantiomerically pure, pyridine derivative that effectively reduces serum cholesterol levels at microgram doses. Mar 12 2024
E1694 Sardomozide dihydrochloride Sardomozide dihydrochloride (CGP 48664A) is a potent inhibitor of S-adenosylmethionine decarboxylase (SAMDC) with an IC50 of 5 nM. It is also a potent inhibitor of polyamine oxidase and exhibits with broad spectrum antiproliferative and antitumor activity. Mar 07 2024
S7972 Litronesib Litronesib (LY2523355) is a selective allosteric inhibitor of the human mitosis-specific kinesin Eg5. LY2523355 also exhibits highly schedule-dependent, broad-spectrum anticancer activity against tumor models and causes mitotic arrest and apoptosis in cancer cells. Mar 07 2024
E1754 BRD7389 BRD7389 is an inhibitor of RSK family kinases with IC50 of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively. BRD7389 also increases β-cell–specific gene expression in primary human islet cells.  Mar 06 2024
A2159 Anti-mouse CSF1R (CD115)-InVivo Anti-mouse CSF1R (CD115)-InVivo reacts with mouse colony stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CSFR), and CD115. CSF1R is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. Mar 03 2024
E1722 Acetalax(Oxyphenisatin acetate) Oxyphenisatin acetate is the pro-drug of oxyphenisatin. It has antiproliferative activity and also used to be a laxative. Mar 03 2024
E1352 Butyzamide Butyzamide is a non-peptidyl thrombopoietin receptor, activator of Mpl . It also augments the phosphorylation level of JAK2, STAT3, STAT5 and MAPK. It has potential for treatment of thrombocytopenia. Mar 03 2024
A2158 Anti-mouse Ly6G-InVivo Anti-mouse Ly6G-InVivo reacts with mouse Ly6G. Ly6G is a 21-25 kDa member of the Ly-6 superfamily of GPI-anchored cell surface proteins with roles in cell signaling and cell adhesion. Mar 01 2024
E2504 Toyocamycin Toyocamycin(Vengicide), an adenosine analog, acts as an inhibitor of XBP1. Toyocamycin is also a specific inhibitor of CDK9 with an IC50 value of 79 nM. Feb 26 2024
E1787 SN-001 SN-001 is a potent inhibitor of STING that specifically inhibits STING activation and STING-dependent signaling. SN-011 significantly decreases inflammatory cytokine production and osteoclast formation in vivo. Feb 26 2024
E1796 Dimethindene maleate Dimethindene maleate is a selective antagonist of histamine H1 and exhibits antihistamine effects. It suppresses the cromakalim-induced/glibenclamide-sensitive K+ currents in a concentration-dependent and reversible manner. Feb 26 2024
E1698 EN460 EN460 is a small-molecule inhibitor of endoplasmic reticulum oxidation 1(ERO1), which is specific for the reduced active form of ERO1α and prevents re-oxidation. It also protects cells from erastin-induced ferroptosis. Feb 26 2024
E1670 MKI-1 MKI-1(MASTL Kinase Inhibitor-1) is an small-molecule inhibitor of MASTL (microtubule-associated serine/threonine kinase-like) with an IC50 9.9 μM in kinase assay. It also exerts antitumor and radiosensitizer activities through PP2A-mediated c-Myc inhibition in breast cancer models. Feb 26 2024
E1614 OUL232 OUL232 (Compound 27) is an potent inhibitor of mono-ADP-ribosylation (mono-ARTs) PARP10 with IC50 of 7.8 nM. It also inhibits PARP7, PARP11, PARP12, PARP14, and PARP15 at nM potencies. Feb 26 2024
A2150 Armenian hamster IgG isotype control-InVivo Armenian hamster IgG isotype control-InVivo is ideal for use as an isotype control for Armenian hamster IgG antibodies in most in vivo and in vitro applications. Feb 21 2024
A2151 Anti-mouse IL-10R (CD210)-InVivo Anti-mouse IL-10R (CD210)-InVivo reacts with mouse IL-10R (IL-10 receptor) also known as CD210. The IL-10R is a class II cytokine receptor and is expressed by a variety of cell types including thymocytes, T lymphocytes, B lymphocytes, NK cells, monocytes, and macrophages. Feb 21 2024
A2152 Anti-mouse IFNγ (XMG1.2)-InVivo Anti-mouse IFNγ (XMG1.2)-InVivo reacts with mouse IFNγ (interferon gamma) a 20 kDa soluble pleiotropic cytokine and the sole member of the type II class of interferons. Feb 21 2024
A2153 Anti-mouse IL-2 (S4B6-1)-InVivo Anti-mouse IL-2 (S4B6-1)-InVivo reacts with mouse IL-2, a 17 kDa cytokine that is mainly produced by T cells in response to antigenic or mitogenic stimulation. Feb 21 2024
A2154 Anti-mouse CD86 (B7-2)-InVivo Anti-mouse CD86 (B7-2)-InVivo reacts with mouse CD86 also known as B7-2. CD86 is an 80 kDa Ig superfamily member. Feb 21 2024
A2156 Anti-human PD-L1 (B7-H1)-InVivo Anti-human PD-L1 (B7-H1)-InVivo reacts with human PD-L1 (programmed death ligand 1) also known as B7-H1 or CD274. PD-L1 is a 40 kDa type I transmembrane protein that belongs to the B7 family of the Ig superfamily. Feb 21 2024
A2157 Anti-mouse IL-6R-InVivo Anti-mouse IL-6R-InVivo reacts with the mouse IL-6 receptor α chain also known as CD126. CD126 is an 80 kDa type I cytokine receptor and a member of the immunoglobulin superfamily. Feb 21 2024
E1163 MS177 MS177 is an EZH2-targeting PRTOAC degrader and a potent inhibitor of enzymatic EZH2, that effectively depletes both canonical EZH2–PRC2 and noncanonical EZH2–cMyc complexes. MS177 induces leukemia cell growth inhibition, apoptosis, and cell cycle progression arrest. Feb 21 2024
E4578 Trilaciclib dihydrochloride Trilaciclib dihydrochloride(G1T28 dihydrochloride) is a potent inhibitor of CDK4/cyclin D1 and CDK6/cyclin D3 with IC50s of 1 nM and 4 nM for CDK4 and CDK6, respectively. Trilaciclib hydrochloride regulates cell proliferation and protects against chemotherapy toxicity in murine and canine bone marrow cells. Feb 06 2024
A2141 Anti-mouse Ter-119-InVivo Anti-mouse Ter-119-InVivo reacts with mouse Ter-119, a 52 kDa glycophorin A-associated protein that is expressed by erythroid cells from the early proerythroblast stage to mature erythrocytes. Anti-mouse Ter-119-InVivo is commonly used for identifying erythrocytes and cells in the erythroid lineage. Feb 05 2024
A2142 Anti-mouse/rat IL-1β-InVivo Anti-mouse/rat IL-1β-InVivo reacts with precursor and mature secreted forms of mouse and rat IL-1β a 17 kDa pro-inflammatory cytokine produced primarily by monocytes. Feb 05 2024
A2143 Anti-mouse 4-1BB (CD137)-InVivo Anti-mouse 4-1BB (CD137)-InVivo reacts with mouse 4-1BB, a TNF receptor superfamily member also known as CD137. Feb 05 2024
A2144 Anti-mouse TIGIT-InVivo Anti-mouse TIGIT-InVivo reacts with mouse TIGIT (T cell immunoreceptor with Ig and ITIM domains). TIGIT is a 26 kDa, type I transmembrane protein and a member of the poliovirus receptor (PVR) family. Feb 05 2024
A2145 Mouse IgG2b isotype control-InVivo Mouse IgG2b isotype control-InVivo is ideal for use as a non-reactive isotype-matched control for mouse IgG2b antibodies in most in vivo and in vitro applications. Feb 05 2024
A2146 Anti-LCMV nucleoprotein-InVivo Anti-LCMV nucleoprotein-InVivo reacts with lymphocytic choriomeningitis virus (LCMV) nucleoprotein (NP), a 63 kDa structural protein. Feb 05 2024
A2147 Anti-mouse CXCR3 (CD183)-InVivo Anti-mouse CXCR3 (CD183)-InVivo reacts with mouse CXCR3 also known as CD183, a 38 kDa chemokine receptor for CXCL9 (MIG), CXCL10 (IP-10), and CXCL11 (ITAC). Feb 05 2024
A2148 Anti-mouse GM-CSF-InVivo Anti-mouse GM-CSF-InVivo reacts with mouse granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony stimulating factor 2 (CSF2). Feb 05 2024
A2149 Anti-mouse CD19-InVivo Anti-mouse CD19-InVivo reacts with mouse CD19, a B cell-specific 95 kDa transmembrane glycoprotein of the immunoglobulin superfamily. Feb 05 2024
E1287 SB 204990 SB-204990, a γ-lactone prodrug of SB-201076, is a potent and specific inhibitor of ATP citrate lyase (ACLY). SB 204990 potently limits SARS-CoV-2 replication in vivo. Feb 04 2024
E1721 TJ-M2010-5 TJ-M2010-5 is a small molecule inhibitor of MyD88 that selectively binds to the Toll/Interleukin-1 receptor (TIR) domain of MyD88, disrupting its homodimerization and subsequently inhibiting the Toll-like receptor (TLR)/MyD88 signaling pathway. TJ-M2010-5 exhibits an anti-hepatic fibrosis effect with the potential to treat liver fibrosis. Feb 04 2024
E1713 FL118 FL118(10,11-(Methylenedioxy)-20(S)-camptothecin), a Camptothecin analog, is a potent and orally active inhibitor of Survivin. FL118 also selectively and independently inhibits three additional cancer-associated survival genes Mcl-1, XIAP, and cIAP2 in a p53 status-independent manner. FL118 displays potent antitumor activity and can be used in cancer research. Feb 04 2024
E1655 KT 474 KT-474 (SAR444656) is a selective small-molecule degrader of IRAK4 in development for the treatment of TLR/IL-1R–driven autoimmune diseases. KT-474 potently downregulates R848 (TLR7/8) and lipopolysaccharide (LPS)-induced IL-6 and IL-8 production in peripheral blood mononuclear cells (PBMCs). Feb 01 2024
E1627 BMS493 BMS493 is an inverse agonist of pan retinoic acid receptor (RAR). It increases nuclear corepressor interaction with RARs and can be used as an inhibitor for the dietary and pharmacologic manipulation of retinoic acid (RA) activity in vivo and in vitro. Feb 01 2024
E1685 D609 D609 is a selective, competitive inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC) with a Ki of 6.4 μM. It is an antioxidative protector and has antiviral and anti-inflammatory activity and also inhibits angiogenesis by preventing the synthesis of basement membrane (BM). Feb 01 2024
E1748 HG6-64-1 HG6-64-1 (HMSL 10017-101-1) is a highly potent and selective inhibitor of B-Raf with an IC50 of 0.09 μM on B-raf V600E transformed Ba/F3 cells. Feb 01 2024
E1874 Erastin2 Erastin2 is an inducer of ferroptosis. It also selectively inhibits xc(-) cystine/glutamate transporter. It induces ferroptosis in HT-1080, T98G, and A549 cells with the potential to treat neurodegenerative diseases. Feb 01 2024
E1520 NSC 663284 NSC 663284(DA-3003-10) is a potent, cell-permeable, and irreversible dual specificity phosphatase inhibitor of Cdc25, and exhibits an IC50 of 0.21 μM for Cdc25B2 and is 20 and 450-fold highly selective against Cdc25B2. NSC 663284 also inhibits NSD2 with an IC50 of 170 nM via a direct interaction with the catalytic SET domain. Jan 30 2024
E1750 XST-14 XST-14 is a potent, competitive, and highly selective inhibitor of ULK1 and exhibits an IC50 of 26.6 nM in an in vitro ULK1 kinase activity assay, respectively. XST-14 reduces the phosphorylation of the ULK1 downstream substrate and induces autophagy inhibition. It exhibits antitumor effects. Jan 30 2024
E1832 ZK53 ZK53 is a selective activator of mitochondrial caseinolytic protease P (HsClpP). It exhibits an EC50 of 1.37 μM for α-casein hydrolysis by HsClpP. ZK53 treatment allosterically activates HsClpP to uncontrollably degrade the essential mitochondrial proteins and is inactive toward bacterial ClpP proteins. Jan 30 2024
S9852 Orforglipron Orforglipron(LY3502970) is a non-peptidal agonist of glucagon-like peptide 1(GLP-1) receptor. It can be used efficiently in glycemic control and weight reduction in type 2 diabetes mellitus (T2DM), obesity or both. Jan 24 2024
E1749 limertinib limertinib (ASK120067) is an irreversible third-generation inhibitor of EGFRT790M with IC50 of 0.3 nM, with selectivity over EGFRWT having IC50 of 6.0 nM. It exhibits potent anti-proliferation activity in non-small cell lung cancer (NSCLC) tumor cells. Jan 23 2024
E4449 AG 825 AG-825 (Tyrphostin AG-825) is a potent and selective inhibitor of ErbB2 with IC50 values of 0.15 µM. It also inhibits PDGFR autophosphorylation with IC50 value of 40 µM. It exhibits anti-cancer activity and significantly induces apoptosis in cancer cells. Jan 22 2024
E1810 dCeMM1 dCeMM1 is a degrader of RBM39. dCeMM1 functions by altering the activity of the CRL4DCAF15 ligase, and also decreases RBM39 expression levels in wild-type KBM7 cells. Jan 22 2024
E1752 JNJ-42226314 JNJ-42226314 is a potent, selective, and reversible noncovalent inhibitor of monoacylglycerol lipase (MAGL). It enhances the expression of endocannabinoid 2-arachidonoylglycerol (2-AG) and exhibits antinociceptive efficacy in models of neuropathic and inflammatory pain. Jan 22 2024
E4453 Cathepsin G Inhibitor I Cathepsin G Inhibitor I exhibits reversible, competitive cathepsin G inhibition with IC50 and Ki values of 53 nM and 63 nM respectively. It can be used in antigen-processing studies and for modulation of T cell response in situ and in vivo. Jan 22 2024
E1711 FHT-1015 FHT-1015 is a potent, small-molecule, allosteric inhibitor of SMARCA4/SMARCA2 ATPase with IC50 values ≤10 nM. FHT-1205 decreases PD1+TIM3+ cells and cytokine expression in vivo. Jan 21 2024
E1634 CH6953755 CH6953755 is a potent, orally active, and selective inhibitor of YES1 kinase with an IC50 of 1.8 nM. CH6953755 demonstrates antitumor activity against YES1 gene-amplified cancers. Jan 21 2024
S6392 SHIN1(RZ-2994) SHIN1 (RZ-2994) is an inhibitor of SHMT1/2 (human serine hydroxymethyltransferase 1 and 2) with IC50 values of 5 and 13 nM, respectively, in in vitro assay. SHIN1 hinders cell growth by gradually reducing purine levels. Jan 21 2024
E4580 Sovleplenib Sovleplenib(HMPL-523) is a highly potent and selective SYK inhibitor with IC50 of 0.025 μM, that exhibits anti-tumor activities in vitro and in vivo. Sovleplenib exhibits synergistic activities in combination with BTK, PI3Kδ, and Bcl2 family inhibitors in killing human-diffused large B cell lymphoma (DLBCL). Jan 17 2024
E1769 Merbarone Merbarone(NSC 336628) is a catalytic inhibitor of topoisomerase II with IC50 of 120 μM, with anti-proliferative activity against human cancer cells. Merbarone acts primarily by blocking topoisomerase II-mediated DNA cleavage. Jan 17 2024
E1604 Vevorisertib trihydrochloride Vevorisertib trihydrochloride(ARQ 751 trihydrochloride) is a selective, allosteric inhibitor of pan-AKT and AKT1-E17K mutant with Kd values of 1.2 nM and 8.6 nM, respectively. It also has IC50 values of 0.55, 0.81, and 1.3 nM for AKT1, AKT2, and AKT3, respectively and can be used for the research of cancer. Jan 16 2024
A3176 Human IgG2sa isotype control Human IgG2sa isotype control is suitable for use as a non-targeting isotype control in various in vitro and in vivo studies, is the isotype control of human IgG2sa antibody. Jan 15 2024
E1667 LY2880070 LY2880070 is an orally active inhibitor of CHK1. LY2880070 can be used as an anticancer agent and shows promise in preclinical models of pancreatic ductal adenocarcinoma (PDAC) when used in combination with DNA-damaging agents. Jan 10 2024
E1812 N6F11 N6F11 is an inducer of ferroptosis. N6F11 is bound to the RING domain of the E3 ubiquitin ligase tripartite motif containing 25 (TRIM25) in cancer cells to trigger TRIM25-mediated K48-linked ubiquitination of glutathione peroxidase 4 (GPX4), resulting in proteasomal degradation. Jan 10 2024
E1739 MST-312 MST-312(Telomerase Inhibitor IX) is an inhibitor of telomerase. MST-312 is a chemically modified derivative of green tea epigallocatechin gallate (EGCG). MST-312 exhibits high chemical stability, lowers the effective dose in the induction of telomere shortening, and lowers drug resistance. MST-312 can be used for the research of cancer. MST-312 can also be used as a promising strategy in the treatment of multiple myeloma (MM). Jan 10 2024
E1658 PRT543 PRT543 is a potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5) with broad antitumor activity in vitro and in vivo. It also inhibits the methyltransferase activity of the PRMT5/MEP50 complex with an IC50 of 10.8 nM. Jan 09 2024
E1744 UNC5293 UNC5293 is a potent, highly selective, orally available inhibitor of MER receptor tyrosine kinase (MERTK) with IC50 of 0.9 nM and Ki 0.19 nM. Jan 09 2024
E1742 Reversan Reversan (CBLC4H10) is a selective and nontoxic inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp), with the potential to treat neuroblastoma and other MRP1-overexpressing drug-refractory tumors. Jan 09 2024
E1723 NSC16168 NSC16168 is a specific inhibitor of ERCC1-XPF, and exhibits an IC50 value of 0.42 μM in a high throughput screen (HTS) assay, respectively. NSC16168 inhibits DNA repair and potentiates cisplatin efficacy in cancer. Jan 09 2024
E1746 Protokylol hydrochloride Protokylol hydrochloride(Caytine hydrochloride, JB-251 hydrochloride) is a salt form of protokylol and is an agonist of β-adrenergic receptor. Protokylol hydrochloride is also used as a bronchodilator. Jan 07 2024
E1727 Pimicotinib Pimicotinib (ABSK021) is an orally bioavailable inhibitor of colony stimulating factor 1 receptor (CSF1R). It enhances antitumor T-cell immune responses and inhibits the proliferation of tumor cells having potential immunomodulatory and antineoplastic activities. Jan 07 2024
E1564 BI-2493 BI-2493, a structural analogue of BI-2865, is a highly selective inhibitor of pan-KRAS. BI-2493 attenuates tumor growth and can be used for cancer research. Jan 07 2024
E1620 Fluorofurimazine Fluorofurimazine is a novel furimazine analogue, with increased aqueous solubility enabling higher signal emission than furimazine for bioluminescence imaging. Fluorofurimazine enables higher substrate loading and improved optical imaging sensitivity in in-vivo. Jan 04 2024
E1435 Tinengotinib Tinengotinib (TT-00420) is a novel multiple kinase inhibitor that strongly inhibits Aurora A/B with IC50 values of 1.2/3.3 nM respectively. It also exhibits potent inhibitory activity on FGFR1/2/3, VEGFR1, JAK1/2, and CSF1R and can be used to treat several prominent signaling pathways in triple-negative breast cancer(TNBC). Jan 01 2024
E1649 Exarafenib Exarafenib(KIN-002787, KIN-2787, RAF/KIN_2787) is an orally-available, selective inhibitor of pan-RAF. Exarafenib is effective in RAF-dependent cancers, including all classes of BRAF alterations. Exarafenib suppresses MAPK signaling in RAF-dependent melanoma cell lines. KIN-2787 exhibits low nanomolar to picomolar potency against RAF1, BRAF, and ARAF with an IC50 of 0.06-3.46 nM with minimal activity towards non-RAF kinases. Dec 28 2023
E1708 Solutol HS-15 Solutol HS-15(Polyethylene glycol 12-hydroxystearate) is a Macrogol 15 hydroxy stearate, which improves permeability by disrupting the membrane structure/fluidity change. Note: Due to its chemical properties, this product will be semi-solid and solid at room temperature and low temperature. Dec 27 2023
S9463 Demecarium Bromide Demecarium Bromide, an anticholinesterase, is an inhibitor of monoamine oxidase (MAO). It induces long-term miosis and decreases intraocular pressure (IOP) in normotensive eyes of Beagles and of eyes of Beagles with inherited glaucoma. Dec 26 2023
E1538 PRGL493 PRGL493 is a potent and selective inhibitor of long-chain acyl-CoA synthetase 4 (ACSL4). PRGL493 blocks cell proliferation and tumor growth in both breast and prostate cellular and animal models. PRGL493 is used for cancer research. Dec 26 2023
E1775 2,4-Thiazolidinedione 2,4-Thiazolidinedione (Thiazolidinedione), an insulin sensitizer, is a specific agonist of peroxisome proliferator-activated receptor (PPAR)γ. Thiazolidinedione treatment corrects impaired muscle insulin action in vivo. Dec 26 2023
E1773 Fasoracetam (NS 105) Fasoracetam (NS 105) is a metabotropic glutamate receptor activator with a potential to treat vascular dementia. Dec 26 2023
E1714 B022 B022 is a potent and selective NF-κB-inducing kinase (NIK) inhibitor with a Ki of 4.2 nM. B022 protects liver from toxin-induced inflammation, oxidative stress, and injury. Dec 26 2023
E1734 OD36 OD36 is an inhibitor of RIPK2 with an IC50 value of 5.3 nM. OD36 is a macrocyclic inhibitor with potent binding to the ALK2 kinase ATP pocket. Dec 24 2023
E2983 PF-04957325 PF-04957325 is a highly potent and selective inhibitor of PDE8, with IC50 values of 0.7 nM and 0.3 nM for PDE8A and PDE8B, respectively. PF-04957325 greatly potentiates steroidogenesis in wild type adrenal cells. Dec 20 2023
E1618 TC-S 7009 TC-S 7009 is a potent and selective inhibitor of HIF-2α with a Kd value of 81 nM. TC-S 7009 is more selective for HIF-2α than HIF-1α. It disrupts HIF-2α heterodimerization, decreases DNA-binding activity, and reduces HIF-2α target gene expression. Dec 20 2023
S2520 CD437(AHPN) CD437(AHPN), a synthetic retinoid, is a selective Retinoic acid Receptor γ ( RARγ) agonist. It exhibits an antiproliferative effect and induces apoptosis via activation of AP-1 in vitro. Dec 18 2023
E1780 Alexidine dihydrochloride Alexidine dihydrochloride, a dibiguanide compound, is an effective and selective inhibitor of protein tyrosine phosphatases localized to mitochondrion 1 (PTPMT1) with an IC50 of 1.08 μM in vitro. It has the potential to treat type II diabetes. Dec 18 2023
E1605 Avotaciclib trihydrochloride Avotaciclib trihydrochloride(BEY1107 trihydrochloride) is a potent and orally active inhibitor of cyclin dependent kinase 1 (CDK1). It can be used for the research of locally advanced or metastatic pancreatic cancer. Dec 17 2023
E1678 SPOP-i-6lc SPOP-i-6lc is a selective speckle-type POZ protein (SPOP) E3 ubiquitin ligase inhibitor with IC50 of 2.1 μM and 3.5 μM, in A498 and OS-RC-2 cell lines, respectively. In vitro, It suppresses viability and proliferation of A498 and OS-RC-2 kidney cancer cell lines. Dec 17 2023
E1743 VX-561(CTP-656) VX-561 (CTP-656) is a potent CFTR modulator and exhibits an EC50 value of 255 nM for CFTR potentiation in G551D/F508del HBE cells. Dec 17 2023
A3174 Mosunetuzumab (Anti-CD20 & CD3e) Mosunetuzumab (Anti-CD20 & CD3e) is expressed from CHO. The heavy chain type is IgG1, and the light chain type is hukappa. MW: 146.72 kDa. Dec 14 2023
E1028 POMHEX POMHEX, is a potent ENO2 -specific inhibitor of enolase and a racemic mixture, a cell-permeable pivaloyloxymethyl (POM) prodrug of HEX. It is also glycolysis inhibitor and can be used for the research of cancer. Dec 13 2023
E1203 Sirpiglenastat Sirpiglenastat (DRP-104) is a broad acting glutamine antagonist. It has anticancer effects by directly targeting tumor metabolism and simultaneously inducing a potent antitumor immune response with immunomodulatory and antineoplastic activities. Dec 13 2023
S8091 25-Hydroxycholesterol 25-Hydroxycholesterol is a side-chain oxysterol and a selective suppressor of IgA production by B cells with an EC50≈65 nM. It affects the immune system and has a key role in the pathogenesis of atherosclerosis. Dec 12 2023
E1409 Zidesamtinib Zidesamtinib (NVL-520) is a potent brain-penetrating inhibitor of ROS1 tyrosine kinase with IC50 of 0.7 nM for wild-type ROS1 . It acts as a potential antineoplastic agent and can be used for the research of cancer. Dec 11 2023
S8395 INDY INDY, a benzothiazole derivative is a potent and ATP-competitive inhibitor of Dyrk1A and Dyrk1B with an IC50 value of 0.24 μM and Ki value of 0.18 μM, respectively. INDY diminishes the self-renewal capacity of normal and tumorigenic cells in primary Glioblastoma (GBM) cell lines and neural progenitor cells. Dec 11 2023
E1636 MV1035 MV1035, an inhibitor of ALKBH5 significantly reduces GBM U87-MG cell migration and invasiveness through inhibition of the RNA demethylase ALKBH5. Dec 11 2023
E1598 VT103 VT103 is an orally active and selective inhibitor of TEAD1 protein palmitoylation with anti-proliferative and anti-tumor activity. It also inhibits YAP/TAZ-TEAD promoted gene transcription, blocks TEAD auto-palmitoylation and disrupts interaction between YAP/TAZ and TEAD. Dec 07 2023
E1735 PK11007 PK11007 is a thiol-reactive anticancer agent that stabilizes p53 via selective alkylation of two surface cysteines without compromising its DNA binding. It induces mutant p53 cancer cell death by increasing reactive oxygen species (ROS) levels. Dec 07 2023
E1684 C1632 C1632 (Lin28-let-7 antagonist 1) is a RNA-binding protein and a potent antagonist of Lin28/pre-let-7 interaction. It inhibits Lin28A binding to pre-let-7a-2, with an IC50 of 8 μM as well as inhibits proliferation in human cancer cells. Dec 07 2023
E1512 M3541 M3541 is a potent and selective inhibitor of ATM kinase activity with an IC50 value of 0.25 nM in cell-free assays. M3541 suppresses double-strand breaks (DSB) repair, clonogenic cancer cell growth and potentiates antitumor activity of ionizing radiation in cancer cell lines. Dec 06 2023
E1638 ALKBH5 inhibitor 2 (Cpd 20m) ALKBH5 inhibitor (Cpd 20m) is a potent and selective inhibitor of RNA m6A demethylase AlkB homolog 5 ALKBH5 with IC50 of 21 nM. Dec 05 2023
A3173 Minretumomab (CC-49) Minretumomab (CC-49) is a monoclonal antibody against TAG-72 (tumor-associated glycoprotein 72). Minretumomab can be used in cancer and immunity research. Dec 04 2023
A2136 Anti-mouse CD40-InVivo Anti-mouse CD40-InVivo reacts with mouse CD40 also known as Bp50. CD40 is a type I transmembrane glycoprotein that belongs to the tumor necrosis factor receptor (TNFR) superfamily. Dec 04 2023
A2137 Anti-mouse CD8β (Lyt 3.2)-InVivo Anti-mouse CD8β (Lyt 3.2)-InVivo reacts with mouse CD8β also known as Lyt 3.2. The CD8 antigen is a transmembrane glycoprotein that acts as a co-receptor for the T cell receptor (TCR). Dec 04 2023
A2138 Anti-mouse IL-2-InVivo Anti-mouse IL-2-InVivo reacts with mouse IL-2, a cytokine that is mainly produced by T cells in response to antigenic or mitogenic stimulation Dec 04 2023
A2140 Anti-mouse/human/rat CD47 (IAP)-InVivo Anti-mouse/human/rat CD47 (IAP)-InVivo reacts with mouse CD47 otherwise known as integrin-associated protein (IAP). CD47 is an approximately 50 kDa glycosylated five transmembrane protein that is ubiquitously expressed by both hematopoietic cells such as T and B lymphocytes, monocytes, platelets and erythrocytes and non-hematopoietic cells. Dec 04 2023
E1603 ACT001(DMAMCL) ACT001(DMAMCL, dimethylaminomicheliolide) is a PAI-1 inhibitor and exerts antitumor effects on neuroblastoma (NB) both in vitro and in vivo. It also exerts synergistic effects in combination with cisplatin through the inhibition of the PAI-1/PI3K/AKT pathway. Nov 29 2023
E1497 Tulmimetostat Tulmimetostat (CPI-0209) is an orally bioavailable and selective inhibitor of EZH2 that has therapeutic potential for androgen receptor-dependent prostate cancer. Nov 26 2023
E4037 L-Canavanine sulfate L-Canavanine sulfate is a selective inhibitor of inducible NO synthase. L-Canavanine sulfate exhibits IC50 values ranging from 5 to 10 mM in arginine-rich media and causes a limited degree of cytotoxicity in HeLa, Hep G2, and SK-HEP-1 cells. Nov 26 2023
E1731 JW74 JW74 is a specific inhibitor of the canonical Wnt signaling with IC50 790 nM in the ST-Luc assay. It inhibit the growth of tumor cells in both mouse xenograft model of colorectal cancer and in ApcMin mice. Nov 26 2023
E4031 8-Cyclopentyl-1,3-dimethylxanthine 8-Cyclopentyl-1,3-dimethylxanthine is a selective adenosine A1 receptor antagonist with Ki's of 10.9 nM and 1440 nM for A1 receptor and A2 receptor, respectively. Nov 26 2023
E1733 PBIT PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1 (JARID1) enzymes. It inhibits JARID1B (KDM5B/PLU1), JARID1Aand JARID1C with an IC50 of 3 μM, 6 μM and 4.9 μM respectively. It is capable of inhibiting the multiplication of breast cancer cell lines expressing high levels of JARIDB1. Nov 26 2023
E1574 FSEN1 FSEN1 is a potent and non-competitive FSP1 inhibitor with an IC50 value of 313 nM. It triggers iron death in cancer cells by inhibiting FSP1 and can be used in research of cancer. Nov 26 2023
E1579 UCL-TRO-1938 UCL-TRO-1938 is a potent allosteric activator of PI3Kα . UCL-TRO-1938 can induce cell proliferation and has cardioprotective and neural regeneration effects. Nov 22 2023
E4466 Saquinavir Mesylate Saquinavir mesylate (Ro 31-8959/003) is a potent inhibitor of HIV Protease used in antiretroviral therapy. It blocks proteolysis of polyproteins containing either wild-type or single-chain dimer retroviral proteinase (PR). Nov 22 2023
S9460 Ethotoin Ethotoin (Peganone) is a hydantoin derivative and an orally active anticonvulsant agent. It also exerts an antiepileptic effect and can be used in epilepsy research. Nov 21 2023
S8545 TEN-010 ((S)-JQ-35) TEN-010 (RG6146, Ro-6870810,(S)-JQ-35) is an inhibitor of the Bromodomain and Extra-Terminal(BET) family bromodomain-containing proteins with potential antineoplastic activity. Nov 21 2023
E4454 DL-Thiorphan Thiorphan (DL-3-Mercapto-2-benzylpropanoylglycine) is a selective NEP (neprilysin) inhibitor with an IC50 of 6.9 nM. It is also a potent inhibitor of enkephalinase, with antinociceptive activity. Nov 19 2023
E1490 IAG933 IAG933 (YAP-TEAD-IN-3) is a small molecule and acts as a YAP/TAZ-TEAD inhibitor. It also inhibits NCI-H2052 and can be used in research of tumor invasion and metastatic spread of solid tumors. Nov 19 2023
E1651 CD532 CD532 is a potent  Aurora A kinase inhibitor with an IC50 of 45 nM. It breaks the native conformation of Aurora-A, drives the degradation of N-Myc in N-Myc-driven cancers, and also exhibits anti-proliferative effects. Nov 19 2023
E1732 Itacnosertib (TP-0184) Itacnosertib (TP-0184) is a small-molecule inhibitor of the BMP type 1 receptor ALK2 (also known as ACVR1). Itacnosertib reduces hepcidin induction and elevated serum iron levels in turpentine and lung cancer mouse models of ACD. Nov 19 2023
E2986 ONO-AE3-208 ONO-AE3-208(AE 3-208) is a selective and orally active EP4 receptor antagonist with a Ki of 1.3 nM, less potent to EP3, FP, and TP receptors with Ki of 30 nM, 790 nM, and 2400 nM, respectively. Nov 19 2023
S8617 Acriflavine Acriflavine is a HIF-1 dimerization inhibitor and have potent inhibitory effects on tumor growth and vascularization. It is used as fluorescent dye for labeling high molecular weight RNA. Nov 14 2023
E1709 Fialuridine Fialuridine(FIAU, DRG-0098, NSC 678514) is a nucleoside analog with antiviral activity. It blocks DNAsynthesis in human cytomegalovirus and hepatitis B, as well as herpes simplex. Nov 10 2023
E1716 SR9011 SR9011 is a REV-ERBα/β agonist with IC50s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively. It is specifically lethal to cancer cells and oncogene-induced senescent cells, including melanocytic naevi. Nov 10 2023
E1507 Zilurgisertib fumarate Zilurgisertib fumarate(INCB-000928 fumarate, NBU-928 fumarate) is a selective ALK 2 inhibitor.It is under development for the treatment of heterotopic ossification and fibrodysplasia ossificans progressiva. Nov 08 2023
E1712 FM19G11 FM19G11 is a hypoxia-inducible factor-1-alpha (HIF-1α) inhibitor, and it inhibits hypoxia-induced luciferase activity with an IC50 of 80 nM in HeLa cells. Nov 08 2023
E4447 Coenzyme Q1 Coenzyme Q1 (CoQ1) is localized to the hydrophobic domain of the phospholipid bilayer of mitochondria, plasma lipoproteins, and other biological membranes. CoQ1 reduction has a strong rotenone-insensitive component and can be used to measure the mitochondrial respiratory chain complex 1 activity. Nov 08 2023
E1529 ART812 ART812 is an orally active DNA polymerase Polθ inhibitor with an IC50 value of 7.6 nM. Nov 06 2023
E1509 Bezuclastinib Bezuclastinib(CGT9486; PLX 9486) is a potent inhibitor of c-kit and c-kit D816V with an IC50 value of <1 μM. Bezuclastinib is also an inhibitor of tyrosine kinase. Nov 05 2023
E1573 ARV-766 ARV-766 (Luxdegalutamide) is an orally active and potent degrader of proteolysis targeting chimera (PROTAC) protein. ARV-766 degrades wild-type androgen receptor (AR) but also relevant AR LBD mutants, including the most prevalent AR L702H, H875Y, and T878A mutations. Nov 05 2023
E1661 Adaptaquin Adaptaquin is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PHD2), with an IC50 of 2 μM. Adaptaquin also inhibits lipid peroxidation and maintains mitochondrial function. Nov 05 2023
E4448 EGTA tetrasodium EGTA tetrasodium(Ethylene glycol-bis(β-aminoethyl ether)-N,N,N',N'-tetraacetic acid tetrasodium salt) is a calcium chelator, used for the determination of calcium in the presence of magnesium. EGTA tetrasodium significantly inhibits the substrate adherence capacity of inflammatory macrophages. Nov 01 2023
E1478 BDTX-1535 BDTX-1535 (EGFR-IN-76) is an orally available, highly potent, selective, and irreversible EGFR inhibitor that can penetrate the blood-brain barrier, with the potential to treat Glioblastoma or Non-Small Cell Lung Cancer. Nov 01 2023
E1599 VT107 VT107 is an enantiomer analogous to VT10 and is a potent inhibitor of pan-TEAD auto-palmitoylation with IC50 of 4.93 nM that blocks TEAD-mediated gene transcription by preventing its association with YAP/TAZ. Oct 31 2023
E1537 MMRi62 MMRi62 is a ferroptosis inducer, targeting MDM2-MDM4 with Kd value of 1.39 μM. It exhibits a P53-independent pro-apoptotic activity against pancreatic ductal adenocarcinoma (PDAC) cells and induce autophagy. Oct 31 2023
E1689 NADPH tetrasodium salt NADPH tetrasodium salt is a ubiquitous coenzyme that acts as an electron donor in many reactions utilizing dehydrogenase and reductase enzymes. It plays a crucial role as a cofactor in the biosynthesis of nucleotides, proteins, and fatty acids. It is essential for neutralizing elevated levels of reactive oxygen species (ROS) generated by increased metabolic activity. Oct 31 2023
S9459 Mecamylamine Hydrochloride Mecamylamine hydrochloride is an orally active, nonselective, noncompetitive nAChR(nicotinic acetylcholine receptors) antagonist.It is also a ganglionic blocker and can across the blood-brain barrier. It can be used in the research of neuropsychiatric disorders, hypertension, antidepressant area. Oct 30 2023
E4477 Lumateperone Lumateperone (ITI-007) is an antagonist of 5-HT2A receptor with Ki of 0.54 nM. It has anticancer activity and can also be used in studies of psychiatric disorders such as schizophrenia. Oct 29 2023
E4587 Sodium alginate Sodium alginate is a sodium salt of alginic acid, can be extracted and purified from the cell walls brown seaweed Laminaria japonica. It has chelating activity and can be used to adsorb heavy metal ions, also has mucosal-protective and hemostatic effects and used in food additives and pharmaceuticals. Oct 29 2023
E1280 Ubrogepant Ubrogepant (MK-1602) is an antagonist of human calcitonin gene-related peptide receptor (CGRP). It potently blocks human α–CGRP–stimulated cAMP responses with an IC50 of 0.081 nM in human CGRP receptor-expressing HEK293 cells. Oct 27 2023
E1495 PF-07220060 (CDK4/6-IN-6) PF-07220060 (CDK4/6-IN-6) is a potent CDK4/CDK6 inhibitor with a Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively. Oct 27 2023
S8418 Zeocin (Phleomycin D1, zeomycin) Zeocin (Phleomycin D1, Zeomycin, PLM D1), a glycopeptide antibiotic, is a member of the Bleomycin/Phleomycin family. It causes cell death by binding and cleaving DNA. It shows antiproliferative activities and strong cytotoxicity against HT-29 cells. Oct 27 2023
E4026 Poly(2-hydroxyethyl methacrylate) Poly(2-hydroxyethyl methacrylate) is one of the most important hydrogels in the world of biomaterials. It is the basic component of contact lenses and is also used in the implantation of soft tissues, synthetic transplant for gristle and bone, regeneration of neurotic tissue, transmission of agents, etc. Oct 27 2023
E2981 PI4KIIIbeta-IN-10 PI4KIIIbeta-IN-10 is a potent inhibitor of PI4KIIIβ with an IC50 of 3.6 nM. It also exhibits weak inhibition of PI3KC2γ, PI3Kα, and PI4KIIIα, and <20% inhibition at concentrations up to 20 µM for PI4K2α, PI4K2β, and PI3Kβ. Oct 27 2023
E1517 ZEN-3694 ZEN-3694 is an orally bioavailable bromodomain extraterminal inhibitor (BETi) that leads to down-regulation of expression of AR-signaling in metastatic castrationresistant prostate cancer (mCRPC) models. Oct 24 2023
E4474 Infigratinib Phosphate Infigratinib Phosphate (NVP-BGJ398 phosphate) is the phosphate salt form of infigratinib, an orally bioavailable pan-inhibitor of human fibroblast growth factor receptors (FGFRs) with IC50 of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4 respectively. It also has potential antiangiogenic, antineoplastic and antitumor activities. Oct 24 2023
E1691 Muvalaplin(LY3473329) Muvalaplin(LY3473329) is an orally administered small molecule that inhibits lipoprotein (a) (Lp (a)) formation by blocking the apo(a)-apo B100 interaction. It can be used in research of atherosclerotic disease and aortic stenosis. Oct 23 2023
E4468 Cabotegravir Sodium Cabotegravir (GSK-1265744) sodium is a orally active and long-acting HIV integrase strand transfer inhibitor. It also inhibits organic anion transporter 1/3 (OAT1/OAT3) with IC50 of 0.41 μM and 0.81 μM for OAT3 and OAT1, respectively. Oct 19 2023
E4505 Deoxyribonucleic acid, single stranded from salmon testes Deoxyribonucleic acid, single-stranded from salmon testes, is a ready-to-use solution of a high-quality, sonicated, single-stranded template nonspecific DNA blocking agent that reduces background in nucleic acid hybridization. Oct 19 2023
E4472 Clavulanic acid Clavulanic acid is a naturally occurring, powerful bacterial β-lactamase inhibitor. The beta-lactam ring found in clavulanic acid binds to the active site of beta-lactamase, resulting in enzyme inactivation and enhancing the antibacterial activity of beta-lactam antibiotics like amoxicillin. Oct 19 2023
E1692 BAY 2965501 BAY 2965501 is a potent selective inhibitor of diacylglycerol kinases zeta (DGKζ), restores T-cell cellular DAG level, and induces pERK activation in anergic T-cells via DGK inhibition to assist T-cell mediate tumor cell kill. Oct 19 2023
A2126 Anti-mouse VEGFR-2-InVivo Anti-mouse VEGFR-2-InVivo (Clone: DC101) monoclonal antibody reacts with mouse VEGFR-2 (vascular endothelial growth factor receptor 2) also known as CD309, KDR, and Flk-1 and inhibit VEGFR-2 signaling in vivo. VEGFR-2 plays a key role in vascular development and permeability. Oct 17 2023
A2127 Anti-human CD28-InVivo Anti-human CD28-InVivo (Clone: 9.3) monoclonal antibody reacts with human CD28, a 45 kDa costimulatory receptor and a member of the Ig superfamily. It stimulate the proliferation of human T cells in vitro. Oct 17 2023
A2129 Anti-mouse Thy1.2 (CD90.2)-InVivo Anti-mouse Thy1.2 (CD90.2)-InVivo(clone 30H12) is a monoclonal antibody reacts with mouse Thy1.2 also known as CD90.2. It induces Ca2+ flux in thymocytes and is particularly useful for depleting T lymphocytes. Oct 17 2023
A2130 Anti-mouse LFA-1α (CD11a)-InVivo Anti-mouse LFA-1α (CD11a)-InVivo(clone M17/4) is a monoclonal antibody reacts with mouse LFA-1α (lymphocyte function-associated antigen 1 alpha) also known as integrin alpha L chain and CD11a. It plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAM-1 (CD54), ICAM-2 (CD102), and ICAM-3 (CD50), and also functions in lymphocyte costimulatory signaling. Oct 17 2023
A2131 Anti-mouse TIM-3 (CD366)-InVivo Anti-mouse TIM-3 (CD366)-InVivo monoclonal antibody reacts with mouse TIM-3 (T cell immunoglobulin and mucin domain-3) also known as CD366. TIM-3 is specifically expressed at high levels on the surface of Th1 lymphocytes. This B8.2C12 antibody binds to the BALB/c allele of TIM-3 while reactivity to the C57Bl/6 allele. Inhibition of TIM-3 signaling in mice exacerbates experimental autoimmune encephalomyelitis and promotes IFNγ production and Th1 cell proliferation. Oct 17 2023
A2132 Anti-mouse/human/rat CCL2 (MCP-1)-InVivo Anti-mouse/human/rat CCL2 (MCP-1)-InVivo (Clone: 2H5) antibody reacts with mouse, human, and rat CCL2, also known as monocyte chemoattractant protein 1 (MCP-1). MCP-1 is a 13 kDa chemokine produced mainly by monocytes/macrophages and is a potent monocyte-attracting chemokine. The 2H5 antibody has been shown to neutralize the biological effects of CCL2 in vivo. Oct 17 2023
A2133 Anti-mouse LAG-3-InVivo Anti-mouse LAG-3-InVivo (Clone: C9B7W) monoclonal antibody reacts with mouse LAG-3 also known as CD223. LAG-3 promotes immune responses by activating antigen-presenting cells. The C9B7W antibody has been reported to block the function of murine LAG-3 in vivo and in vitro. Oct 17 2023
A2134 Anti-mouse IL-18-InVivo Anti-mouse IL-18-InVivo (Clone:YIGIF74-1G7) monoclonal antibody reacts with mouse IL-18. IL-18 an 18 kDa pro-inflammatory cytokine is expressed by activated macrophages, keratinocytes, Kupffer cells, intestinal epithelial cells, and osteoblasts. Oct 17 2023
E4465 Potassium clavulanate cellulose Potassium clavulanate cellulose (Potassium clavulanate:cellulose (1:1)) is a mixture of potassium clavulanate and cellulose, is a bacterial β-lactamase inhibitor. Potassium clavulanate with the combination of amoxicillin can be used for the research of different infections caused by bacteria, such as sinusitis, pneumonia, ear infections, bronchitis, urinary tract infections, and infections of the skin. Oct 17 2023
E1469 ITF3756 ITF3756 is a selective histone deacetylase 6 (HDAC6) inhibitor bearing a pentaheterocyclic scaffold. It can be used in research of autoimmune disorders, neurodegenerative diseases, and cancer. Oct 17 2023
E1575 EN450 EN450 is a cysteine-reactive covalent molecular glue degrader targeting NF-κB. It interacts with allosteric C111 in the E2 ubiquitin ligase UBE2D that induces the ternary complex formation between UBE2D and NFKB1. It exhibits anti-proliferative effects through a Cullin E3 ligase and proteasome-dependent mechanism. Oct 17 2023
E4467 Temozolomide Acid Temozolomide acid is a carboxylic acid derivative of Temozolomide. It has an anticancer activity by causing breaks in DNA double strand, cell cycle arrest, and eventually cell death. Oct 16 2023
E4473 Lactate Lactate (Lactic acid) is the product of glycolysis, produced due to lack of oxygen in contracting skeletal muscle in vivo, and can be utilised under fully aerobic conditions. It plays a key role as a metabolic intermediate and can be used as hemodynamic marker and resuscitation endpoint in several cohorts of critically ill patients. Oct 16 2023
E4478 Acetrizoic acid Acetrizoic acid is a first monomeric, water-soluble, iodinated ionic compound used as an X-ray contrast agent having nephrotropic property that can be intravenously administered for clinical applications. Oct 16 2023
E4016 Phenylarsine oxide Phenylarsine oxide (Oxophenylarsine) is a membrane-permeable protein tyrosine phosphatase inhibitor with IC50 18 µM. It Stimulates 2-deoxyglucose transport in insulin-resistant human skeletal muscle. Oct 13 2023
E1318 Mavorixafor Mavorixafor (AMD-070) is a potent, selective CXCR4 antagonist, with an IC50 value of 13 nM against CXCR4 125I-SDF binding. Oct 13 2023
E4464 Hexythiazox Hexythiazox is a selective acaricide with ovicidal, larvicidal and nymphicidal activities. It is widely used for chemical control of mites on cotton, fruits and vegetables. Oct 13 2023
A2817 Anti-CD34 Anti-CD34 is a humanized monoclonal antibody against CD34 surface antigen on human stem cells. MW: 145.9 KD. Oct 11 2023
A3081 Anti-CAPRIN1 Anti-CAPRIN1 is a humanized antibody targeting CAPRIN-1. It is used as a novel and universal target for cancer therapies. MW :141.44 KD. Oct 11 2023
E1486 Zamaporvint (RXC004) Zamaporvint (RXC004) is an orally active and selective inhibitor of Wnt. It targets membrane-bound o-acyltransferase Porcupine and inhibits Wnt ligand palmitoylation, secretion, and pathway activation. RXC004 exhibits potent antiproliferative effects in Wnt ligand-dependent colorectal and pancreatic cell lines and possesses multiple antitumor mechanisms. Oct 11 2023
A2831 Anti-CD59 Anti-CD59 is a humanized monoclonal antibody against CD59 with the potential to treat anti-tumour activity. MW: 145.08 KD. Oct 11 2023
E4432 3,3-Dimethyl-1-butanol 3,3-Dimethyl-1-butanol (Neohexanol) is an orally active inhibitor of trimethylamine (TMA) and trimethylamine N-oxide (TMAO). 3,3-dimethyl-1-butanol negatively inhibits the signalling pathways of p65 NF-κB and  TGF-β1/Smad3. 3,3-dimethyl-1-butanol has potential applications in cardiovascular disease (CVD). Oct 11 2023
E1526 Zasocitinib Zasocitinib( NDI-034858, TAK-279) is a TYK2 inhibitor, which is currently being investigated in a phase IIb trial for moderate-to-severe plaque psoriasis. Oct 11 2023
E4443 S-Nitrosoglutathione S-nitrosoglutathione (GSNO, RVC-588, S-Nitroso-L-glutathione,Nitrosoglutathione) is an amino acid and nitric oxide donor that, under physiological conditions, spontaneously releases nitric oxide. S-nitrosoglutathione (GSNO) selectively inhibits platelet and NF-κB activation. It induces apoptosis in T cells in low concentrations (< 0.6 mM) while protecting T cells from apoptosis in higher concentrations (1-2 mM). Oct 11 2023
A3090 Anti-DCSTAMP Anti-DCSTAMP is an antibody targeting Dendritic cell-specific transmembrane protein, DC-STAMP. It is essential for cell-to-cell fusion to form multinucleated osteoclasts (OCs) during osteoclastogenesis. MW :146.2 KD. Oct 11 2023
A3091 Anti-GAD65 Anti-GAD65 is an autoantibody targeting glutamic acid decarboxylase (GAD65). It is used in treatment of Stiff person syndrome (SPS). MW :146.38 KD. Oct 11 2023
A3092 Anti-MICB Anti-MICB is an antibody that specifically target human major histocompatibility complex class I chain-related A and B (MICA/B). It can be used in treating a cancer. MW :143.66 KD. Oct 11 2023
A2837 Anti-CD83 Anti-CD83 is a humanized monoclonal antibody against CD83 with the potential to treat auto-immune diseases. MW: 144.8 KD. Oct 11 2023
A2838 Anti-CD9 Anti-CD9 is a humanized monoclonal antibody against CD9 with potential anti-tumor activity. MW: 145.98 KD. Oct 11 2023
A2839 Anti-CDH1 / E-cadherin / CD324 Anti-CDH1 / E-cadherin / CD324 is an IgG1 monoclonal antibody against E-cadherin, an epithelial adhesion molecule. MW: 146.6 KD. Oct 11 2023
E4218 L-Cysteine (hydrochloride hydrate) L-Cysteine hydrochloride hydrate is an essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione, and taurine. L-Cysteine hydrochloride hydrate suppresses ghrelin and reduces appetite in rodents and humans. Oct 11 2023
A2844 Anti-Clathrin Heavy Chain / CHC Anti-Clathrin Heavy Chain / CHC is a human monoclonal antibody against clathrin heavy chain (CHC) with potential anti-angiogenesis and anti-tumor activity. MW: 145.62 KD. Oct 11 2023
E1479 I-138 I-138 is an orally active, potent reversible inhibitor of USP1-UAF1 with IC50 0f 4.1 nM. I-138 is structurally related to ML323 and induces the monoubiquitination of FANCD2 and PCNA in MDA-MB-436 cells and increases PCNA and FANCD2 monoubiquitination in HAP-1 USP1 WT cells. Oct 11 2023
A3103 Anti-TrkB / NTRK2 Anti-TrkB / NTRK2 is an antibody targeting TrkB. It is used to improve nerve function, including treatment of peripheral neuropathies. MW :146.68 KD. Oct 11 2023
E1650 Opevesostat (ODM208) Opevesostat (ODM208) is the first-in-class, selective, nonsteroidal, oral CYP11A1 inhibitor. ODM208 exhibits a rapid, complete, durable, and reversible inhibition of the steroid hormone biosynthesis in an adrenocortical carcinoma cell model in vitro, in adult noncastrated male mice and dogs, and in patients with CRPC. Oct 11 2023
E4469 Sodium Montmorillonite Sodium Montmorillonite is a layered clay mineral (2:1 phyllosilicate) that belongs to a class of the smectite group. It can be used for preparation of new drug delivery systems, especially for slow release of protonable drugs due to its high degree of surface area and high capacity for cation exchange. Oct 11 2023
E4470 Potassium Chloride Potassium chloride is an inorganic salt commonly used in fertilizer industry. It is also extensively used as a potassium supplement. Oct 11 2023
A3106 Volociximab (Anti-Integrin a5b1 (ITGA5 & ITGB1)) Volociximab (Anti-Integrin a5b1 (ITGA5 & ITGB1)) is a monoclonal antibody targeting Integrin a5b1 (ITGA5 & ITGB1). It can be used in treatment of solid tumors, renal cell carcinoma, melanoma, pancreatic cancer, lung cancer, and ovarian cancer. MW :145.52 KD. Oct 11 2023
E4471 Nonaethylene glycol Monododecyl ether Nonaethylene glycol monododecyl ether is a non-ionic surfactant. It has been used to assess a procedure for analyzing total lipid and triacylglycerol using bovine liver tissue. Oct 11 2023
A3107 Anti-VCAM1 / CD106 Anti-VCAM1 / CD106 is a conjugated liposome targeting vascular cell adhesion molecule (VCAM)-1. It serves as a drug delivery system with dual functions: targeted delivery and solubilizing capacity. MW :143.4 KD. Oct 11 2023
A2596 Tilvestamab (Anti-AXL / UFO) Tilvestamab (Anti-AXL / UFO) is a humanized antibody targeting AXL.Tilvestamab can be used in cancer research, particularly in AXL overexpressing renal cell carcinomas. MW :146.16 KD. Oct 11 2023
A2601 Amivantamab (Anti-HGFR / c-Met) Amivantamab (Anti-HGFR / c-Met) is a human bispecific antibody targeting EGFR-MET.It has immune anticancer activity in non-small cell lung cancer (NSCLC). MW :146.1 KD. Oct 11 2023
A2857 Anti-Sphingosine-1-phosphate Anti-Sphingosine-1-phosphate is a human IgG1 monoclonal anti-Sphingosine-1-phosphate antibody that targets lysosphingolipids, thereby lowering the concentration of S1P in the extracellular fluid. MW: 145.74 KD. Oct 11 2023
A3116 Anti-GLP1R Anti-GLP1R is a humanized antibody targeting GLP-1 receptor (GLP-1R). It can be used in therapy for type 2 diabetes mellitus. MW : 144.5 KD. Oct 11 2023
A3123 Setoxaximab (Anti-Shiga toxin (E.coli)) Setoxaximab (Anti-Shiga toxin (E.coli)) is a mouse chimeric IgG1(kappa) antiboy that target shiga toxin 1 and shiga toxin 2, produced by E. coli. It can be used in the treatment of hemolytic-uremic syndrome (HUS). MW :147.08 KD. Oct 11 2023
A2615 Anti-PMEL Anti-PMEL is a monoclonal antibody targeting human PMEL protein. It is used as a target for antibody drug conjugate (ADC) therapy in melanoma. MW :145.38 KD. Oct 11 2023
A2873 Anti-ICAM3 / CD50 Anti-ICAM3 / CD50 is an IgG1 monoclonal antibody against intercellular adhesion molecules-3 (ICAM-3, also known as CD50)) with the potential to have anti-proliferative activities. MW: 145.22 KD. Oct 11 2023
A2874 Anti-MUC17 Anti-MUC17 is an IgG1 monoclonal antibody against MUC17, a membrane-bound protein highly expressed on the surface of intestinal cells. MW: 146.66 KD. Oct 11 2023
A2627 Anti-Complement C5aR1 (G2_anti-C5aR) Anti-Complement C5aR1 (G2_anti-C5aR) is a rat monoclonal antibody that detects Complement 5a receptor (C5aR). It exhibit potent proinflammatory stimulus with immunomodulatory activities. MW :146.08 KD. Oct 11 2023
A2633 Anti-OX2R / CD200R1 Anti-OX2R / CD200R1 is a monoclonal antibody targeting CD200. It exhibited potential in regulating tissue inflammation during skin wound healing. MW :146.58 KD. Oct 11 2023
E4265 Pyrimidine Pyrimidine is an endogenous metabolite. It is used to study the photoinduced ion chemistry of the halogenated pyrimidines, a class of prototype radiosensitizing molecules, and is also used to assess pyrimidine/purine asymmetry quantitatively. Oct 11 2023
D4060 Mirvetuximab-MMAE Mirvetuximab-MMAE is an ADC targeting FOLR1 (folate receptor 1). It can be used in ovarian and other FRα-positive cancer research. MW :145.96 KD. Oct 11 2023
A2639 Anti-CEACAM6 / CD66c (NEO-201) Anti-CEACAM6 / CD66c (NEO-201) is a humanized IgG1 monoclonal antibody that targets of CEACAM family. It enhances natural killer cell cytotoxicity against tumor cells. MW :145.48 KD. Oct 11 2023
D4061 Anti-GPC3 / Glypican-3 (Codrituzumab-MMAE) Anti-GPC3 / Glypican-3 (Codrituzumab-MMAE) is an ADC targeting GPC3 (glypican-3). It induces antibody-dependent cellular cytotoxicity (ADCC) and inhibits tumor growth and can be used in the research of hepatocellular carcinoma (HCC). MW :145.58 KD. Oct 11 2023
A2640 Anti-CHI3L1 Anti-CHI3L1 is a monoclonal antibody targeting Chitinase 3–like 1 (CHI3L1). It proves a promising therapy for pulmonary metastasis and progression. MW :147.04 KD. Oct 11 2023
D4062 Anti-KAAG1 (ADCT-901-MMAE) Anti-KAAG1 (ADCT-901-MMAE) is an ADC composed of a humanized monoclonal antibody (3A4) targeting human KAAG1. It is used for the treatment of advanced solid tumors including platinum resistant ovarian cancer and triple negative breast cancer. MW :145.28 KD. Oct 11 2023
A2642 Zolbetuximab (Anti-CLDN18.2) Zolbetuximab (Anti-CLDN18.2) is a monoclonal antibody targeting Claudin-18.2. It can be used for the research of gastrointestinal adenocarcinomas and pancreatic tumors. MW :150 KD. Oct 11 2023
A3154 Anti-CDH17 / Cadherin-17 (10C12) Anti-CDH17 / Cadherin-17 (10C12) is a humanized monoclonal antibody targeting Cadherin-17 (CDH17), a prominent cancer biomarker. It has growth inhibitory effect on liver and stomach tumour cells. It can be used as therapeutics for treating lung metastasis of hepatocellular carcinoma (HCC). MW :143.68 KD. Oct 11 2023
A2643 Anti-CLDN6 (IMAB027) Anti-CLDN6 (IMAB027) is a fully humanized antibody targeting CLDN6. It gets conjugated to monomethyl auristatin E( MMAE) resulting in the potential therapeutic CLDN6–23-ADC. It exhibits antitumor efficacy in ovarian epithelial carcinomas.MW :144.42 KD. Oct 11 2023
A2899 Margetuximab (Anti-ERBB2 / HER2 / CD340) Margetuximab (Anti-ERBB2 / HER2 / CD340) is a Fc-domain optimized IgG monoclonal antibody directed against the human epidermal growth factor receptor 2 (HER2) with potential immunomodulating and antineoplastic activities. MW: 146.1 KD. Oct 11 2023
A3155 Anti-CDH17 / Cadherin-17 (PTA001_A4) Anti-CDH17 / Cadherin-17 (PTA001_A4) is a humanized monoclonal antibody targeting Cadherin-17 (CDH17), a prominent cancer biomarker. It has growth inhibitory effect on tumour cells. It can be used as therapeutics for treating various cancers, including colorectal cancer. MW :149.12 KD. Oct 11 2023
E4275 β-Aminopropionitrile β-Aminopropionitrile (BAPN) is an orally active, specific, and irreversible inhibitor of lysyl oxidase (LOX). It targets the active site of LOX or LOXL isoenzymes. Oct 11 2023
A2646 Anti-CXCL9 Anti-CXCL9 is an antibody targeting CXCL9 chemokine. It has the potemtial of inhibiting inflammation. MW :150 KD. Oct 11 2023
A2648 Anti-DC-SIGN / CD209 Anti-DC-SIGN / CD209 is a humanized monoclonal antibody that specifically targets DC-SIGN. It inhibits infection caused by human cytomegalovirus (CMV) in immunocompromised patients, namely in organ-transplanted recipients or AIDS patients. ME :146.62 KD. Oct 11 2023
A3161 Gemtuzumab (Anti-Siglec-3 / CD33) Gemtuzumab (Anti-Siglec-3 / CD33) a monoclonal antibody targeting CD33 antigen, which present on leukemic myeloblasts of acute myeloid leukemia (AML). It can be used for the research of acute myeloid leukemia.MW :145.22 KD. Oct 11 2023
A2650 Anti-TNFRSF21 / DR6 / CD358 Anti-TNFRSF21 / DR6 / CD358 is a humanized monoclonal antibody that specifically targets TNFRSF21. It can be used in treatment of cancer. MW :150 KD. Oct 11 2023
A2909 Anti-FGFR1 / CD331 Anti-FGFR1 / CD331 is a monoclonal antibody againts human fibroblast growth factor receptor 1. MW: 150 KD. Oct 11 2023
A2910 Anti-TSPAN8 Anti-TSPAN8 is a monoclonal IgG1 antibody (mAb) directed against Co-029, a membrane protein of the family of tetraspanins (TSPAN8 or TM4SF3). MW: 145.94 KD. Oct 11 2023
A2656 Anti-CSF3R / G-CSFR Anti-CSF3R / G-CSFR is an antibody that targets G-CSF. I t can be used in the research of inflammatory diseases. MW :150 KD. Oct 11 2023
A2914 Ivuxolimab (Anti-TNFRSF4 / OX40 / CD134) Ivuxolimab (Anti-TNFRSF4 / OX40 / CD134) is an agonistic antibody that recognizes the co-stimulatory receptor OX40 (CD134; TNFRSF4) with potential immunostimulatory activity. MW: 144.18 KD. Oct 11 2023
A3170 Tidutamab (Anti-CD3 & SSTR2) Tidutamab (Anti-CD3 & SSTR2) is a humanized and affinity-optimized bispecific antibody (bsAb) targeting SSTR2 binding domain and T-cell binding domain (CD3). It can be used in neuroendocrine tumors (NETs) and small cell lung cancer (SCLC). MW :147.36 KD. Oct 11 2023
A2659 Anti-Haptoglobin Anti-Haptoglobin is an antibody targeting the human haptoglobin (HP). It can be used for immunoblotting after isoelectric focusing to determine Hp alpha subtypes. MW :150 KD. Oct 11 2023
A2915 Anti-ERG Anti-ERG is a monoclonal IgG1 antibody (mAb) directed against the proto-oncogene ETS-related gene (ERG). It has the potential to treat prostate cancer, Ewing's sarcoma, acute myeloid leukemia, endothelial cancer, and colon cancer. MW: 145.4. Oct 11 2023
A2661 Ficlatuzumab (Anti-HGF / SF) Ficlatuzumab (Anti-HGF / SF) is a monoclonal antibody (McAb) targeting human hepatocyte growth factor (HGF). It inhibits c-Met receptor-mediated cancer cell proliferation, migration, and invasion and can be used to treat head and neck squamous cell carcinoma (HNSCC). MW :150 KD. Oct 11 2023
A2662 Emibetuzumab (Anti-HGFR / c-Met) Emibetuzumab (Anti-HGFR / c-Met) is a humanized bivalent MET antibody targeting both HGF-dependent and HGF-independent MET pathway activation and tumor growth. It can be used in study of cancer. MW :144.56 KD. Oct 11 2023
E4294 (-)-CAMPHOR (-)-CAMPHOR is obtained from the wood of the camphor tree and is used as a remedy for treating a variety of symptoms such as inflammation, ingestion, infection, congestion, pain, and irritation. Few components of the camphor tree have suppressive and anti­mutagenic effects on a number of human cancer cells without harming the healthy cells. Oct 11 2023
A2663 Anti-IDO2 Anti-IDO2 is a monoclonal antibody targeting Indoleamine 2,3-dioxygenase 2 (IDO2). It exhibits potency that ameliorates arthritis and autoimmune disease. MW :151.06 KD. Oct 11 2023
A2665 Anrukinzumab (Anti-IL-13) Anrukinzumab (Anti-IL-13) is a humanized monoclonal antibody targeting IL-13. It reduces lung inflammation and can be used in studies of ulcerative colitis (UC) as well as asthma. MW :150 KD. Oct 11 2023
E4298 (-)-Carvone (-)-Carvone is an insect neurotoxin and is an irreversible inhibitor of acetylcholinesterase (AChE). It can be used as a bird repellent, inhibits larval growth, decreases pupation rate, and increases the mortality of larvae. Oct 11 2023
A2666 Anti-IL-13Ra2 / CD213a2 Anti-IL-13Ra2 / CD213a2 is a humanized monoclonal antibody targeting IL-13Ra2. It exhibits potentcy against malignant gliomas (MG), head and neck tumors, ovarian cancer and kidney cancer. MW :150 KD. Oct 11 2023
E4299 Chitosan Chitosan(Deacetylated chitin (MW 150000); Poly(D-glucosamine) (MW 150000)) is a polycationic linear polysaccharide derived from chitin with the molecular weight of 150000. Chitosan is an versatile biomaterial because of its non-toxicity, low allergenicity, biocompatibility and biodegradability. Chitosan also has antitumor, antibacterial, antifungal, and antioxidant activities. Oct 11 2023
A2923 Lodapolimab (Anti-B7-H1 / PD-L1 / CD274) Lodapolimab (Anti-B7-H1 / PD-L1 / CD274) is a fully human IgG1λ monoclonal antibody that binds to human PD-L1 with high affinity and inhibits interactions of PD-L1 with its two cognate receptors, PD-1 and CD80. MW: 143.86 KD. Oct 11 2023
A2668 Etokimab (Anti-IL-33) Etokimab (Anti-IL-33) is a humanized monoclonal antibody that targets IL-33. It can be used for the research of atopic dermatitis. MW :146.56 KD. Oct 11 2023
A2925 Anti-GPR64 / ADGRG2 Anti-GPR64 / ADGRG2 is a monoclonal antibody (mAb) against G protein-coupled receptor 64 isoform 4 (anti-GPR64) with potential anti-tumour activity. MW: 146.1. Oct 11 2023
A2672 Anti-MAGEA3 Anti-MAGEA3 is an antibody that targets MAGE-A. It can be used in the treatment of metastatic cancer treatment. MW :145.56 KD. Oct 11 2023
A2929 Anti-KID3 Anti-KID3 is a monoclonal antibody (MAb) directed against KID3, a carbohydrate epitope found in the colon and several forms of cancer. MW: 147.04 KD. Oct 11 2023
A2681 Brontictuzumab (Anti-NOTCH1) Brontictuzumab (Anti-NOTCH1) is a monoclonal antibody that targets Notch1 signal. It inhibits tumor cell proliferation and can be used in the research of leukemia and lymphoma. MW :150 KD. Oct 11 2023
A2684 Anti-PDGFC / VEGFE Anti-PDGFC / VEGFE is a monoclonal antibody targeting PDGF-CC. It can be used in the research of cancer, fibrosis and neuropathologies. MW :145.9 KD. Oct 11 2023
A2689 Anti-RSPO1 Anti-RSPO1 is a monoclonal antibodies against R-spondin1 gene (RSPO1) with potential anti-tumor activity . MW: 150 KD. Oct 11 2023
A2691 Anti-SIRPa / CD172a Anti-SIRPa / CD172a is an immunoglobulin G1 (IgG1) monoclonal antibody targeting human signal-regulatory protein alpha (SIRPa; CD172a), with potential immune checkpoint inhibitory, phagocytosis-inducing and antineoplastic activities. MW : 147.06 kD. Oct 11 2023
A2948 Nipocalimab (Anti-FcRn) (FCGRT & B2M) Nipocalimab (anti-FcRn) (FCGRT & B2M) is a fully human monoclonal antibody that targets the neonatal crystallizable fragment receptor (FcRn) with potential immunomodulating activity. MW: 142.12 KD. Oct 11 2023
A2695 Anti-TGFb1 (M7824) Anti-TGFb1 (M7824) is a bifunctional monoclonal antibody targeting programmed death ligand 1 (PD-L1) and transforming growth factor beta 1 (TGFb1). It exhibits anti-tumor efficacy against breast and colon carcinomas. Oct 11 2023
E4074 p-Toluic acid p-Toluic acid (4-Methylbenzoic acid) is a methylbenzoic acid and can be used as an intermediate for the synthesis of para-aminomethylbenzoic acid (PAMBA), p-tolunitrile, etc. It also exhibits hepatotoxicological potential in humanised-liver mice. Oct 11 2023
A2961 Anti-F8 / Factor VIII Anti-F8 / Factor VIII is a monoclonal IgG anti-factor VIII antibody that hydrolyzes FVIII in acquired hemophilia. MW: 145.14 KD. Oct 11 2023
A2706 Anti-CXCR3 / GPR9 / CD183 Anti-CXCR3 / GPR9 / CD183 is a monoclonal antibody binds to Chemokine (C-X-C motif) receptor 3 (CXCR3, also known as G protein-coupled receptor 9 (GPR9)) . It has the potentially to be used in the treatment of diabetes mellitus type I (T1D). MW: 146.38 KD. Oct 11 2023
A2709 Anti-GPR44 / PTGDR2 / CD294 Anti-GPR44 / PTGDR2 / CD294 is a monoclonal antibody against a transmembrane G-protein-coupled receptor (GPR44, also known as CRTH2, PTGDR2,or CD294) with the potential to treat asthma. MW: 147.66 KD. Oct 11 2023
A2710 Anti-GOLM1 Anti-GOLM1 is a monoclonal antibody against Golgi protein-73 (GP73, Golgi Membrane Protein 1, GOLM1) with the potential to be used in research on hepatocellular carcinoma (HCC). MW: 145.62 KD. Oct 11 2023
A2711 Anti-GREM1 / Gremlin Anti-GREM1 / Gremlin is a monoclonal antibody that binds to human gremlin-1 (GREM1) with potential anti-tumor activity. MW: 144.58 KD. Oct 11 2023
E4087 Sodium oleate Sodium oleate (Oleic acid sodium salt) is an abundant monounsaturated fatty acid sodium. It is a Na+/K+ ATPase activator and inhibits cancer cell growth and survival in low metastatic carcinoma cells, such as gastric carcinoma SGC7901 and breast carcinoma MCF-7 cell lines. Oct 11 2023
A2713 Anti-Nogo Receptor / NgR Anti-Nogo Receptor / NgR is a monoclonal anti-NgR antibody with the potential to promote axonal regeneration. MW: 146.18 KD. Oct 11 2023
A2714 Anti-Complement Factor P / Properdin Anti-Complement Factor P / Properdin is a monoclonal anti-Properdin antibody with the potential to treat chronic complement-mediated and complement-associated disorders. MW: 145.54 KD. Oct 11 2023
E4345 L-Norvaline L-Norvaline is a non-proteinogenic amino acid, an isomer of valine, and an inhibitor of arginase and p70 ribosomal S6 kinase 1 (p70S6K1) kinase. L-norvaline enhances NO production from activated macrophages. Oct 11 2023
A2715 Anti-TAT226 Anti-TAT226 is a monoclonal antibody that binds to TAT226 with potential anti-tumor activity. MW: 144.66 KD. Oct 11 2023
A2716 Anti-TMPRSS2 Anti-TMPRSS2 is a monoclonal antibody with possible antiviral activity that detects transmembrane serine protease 2 (TMPRSS2). MW: 146.06 KD. Oct 11 2023
A2717 Anti-HGFA Anti-HGFA is a monoclonal anti-HGFA antibody that detects endogenous levels of HGFA protein in biological samples. MW: 141.18 KD. Oct 11 2023
E4092 Ricinoleic acid Ricinoleic acid is a hydroxy fatty acid. It is an attractive feedstock for the production of high-performance lubricants, cosmetics, polymers, surfactants, and coatings. Oct 11 2023
A2718 Anti-KLK5 / Kallikrein 5 Anti-KLK5 / Kallikrein 5 is a monoclonal antibody kallikrein-related peptidase 5 (KLK5) with the potential to be used in research on immune-based therapies. MW: 144.76 KD. Oct 11 2023
A2719 Anti-Orai1 Anti-Orai1 is a human monoclonal anti-Orai1 antibody (mAb) with the potential to treat autoimmune diseases. MW: 143.86 KD. Oct 11 2023
A2720 Anti-SERPINE1 Anti-SERPINE1 is a monoclonal antibody that specifically binds to Plasminogen Activator Inhibitor Type-1 (PAI-1, SERPINE1) with the potential to be used in cardiovascular diseases. MW: 145.72 KD. Oct 11 2023
A2721 Anti-CXCL4 / PF4 Anti-CXCL4 / PF4 is a monoclonal antibody against anti-CXC chemokine ligand 4 (CXCL4, also called PF4). MW: 144.86 KD. Oct 11 2023
A2722 Anti-Albumin Anti-Albumin is a human monoclonal antibody that is specific for human serum albumin (HSA) and has the potential to be used in research on type 1 diabetes. MW: 144.24 KD. Oct 11 2023
E4353 Ampicillin Ampicillin (D-(-)-alpha-Aminobenzylpenicillin) is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative bacteria. It exhibits a good minimum inhibitory concentration for Staphylococcus aureus, Escherichia coli, Hemophilus influenzae, and Streptococcus pneumoniae with MICs of 0.6–1 mg/L, 4 mg/L, 0.25 mg/L, and 0.03-0.06 mg/L, respectively. Oct 11 2023
A2723 Anti-STOP1 Anti-STOP1 is a human monoclonal antibody against stable tubule-only polypeptides (STOP), a protein responsible for microtubule cold stabilization. MW: 145.78 KD. Oct 11 2023
A2724 Anti-TMEFF2 Anti-TMEFF2 is a human monoclonal anti-TMEFF2 antibody with potential anti-tumor activity. MW: 144.08 KD. Oct 11 2023
A2725 Anti-TIE2 / CD202b Anti-TIE2 / CD202b is a fully human monoclonal antibody that binds to human Tie2 and blocks the interaction between Tie2 or Tie2 ligands (angiopoietin). It has the potential to treat angiogenesis disorders. MW: 146.6 KD. Oct 11 2023
E4356 Pseudotropine Pseudotropine(3β-Tropanol, ψ-Tropine) is an alkaloid and a plant metabolite of the tropane tropinone that has been found in A. belladonna. It is used in the preparation of novel nicotinic receptor agonists. Oct 11 2023
A2726 Anti-ANO1 / TMEM16A Anti-ANO1 / TMEM16A is a humanized monoclonal antibody that binds to human TMEM16A and modulates its activity, with potential anti-tumor activity. MW: 146.8 KD. Oct 11 2023
A2982 Anti-IL-6Ra / CD126 (APX007) Anti-IL-6Ra / CD126 (APX007) is a monoclonal antibody targeting IL-6R/CD126. It can be used in the pathogenesis of multiple myeloma. MW :144.6 KD. Oct 11 2023
A2727 Anti-Polyubiquitin Anti-Polyubiquitin is a monoclonal anti-Polyubiquitin antibody used for isolating polyubiquitin chain-tagged proteins. MW: 144.98 KD. Oct 11 2023
A2728 Anti-SCN9a / Nav1.7 Anti-SCN9a / Nav1.7 is a fully human antibody that binds to human Nav1.7 (hNav1.7, SCN9a) with the potential to treat acute or chronic pain conditions or inflammatory conditions. MW: 145.72 KD. Oct 11 2023
E4105 Quinizarin Quinizarin (1,4-Dihydroxyanthraquinone) is a part of the anticancer agents such as Doxorubicin and Adriamycin, interacts with DNA by intercalating mode. It is used as a fungicide and pesticide chemical and has shown the ability to inhibit tumor cell growth. Oct 11 2023
A2730 Anti-Histone H3 Anti-Histone H3 is a monoclonal anti-Histone H3 antibody antibody used for detection of Histone H3 (histone 3-H3). MW: 150 KD. Oct 11 2023
A2732 Anti-ANGPTL8 Anti-ANGPTL8 is a monoclonal antibody againts Angiopoietin-like protein (ANGPTL8) with potential to treat hypertriglyceridemia. MW: 145.16 KD. Oct 11 2023
A2988 Vatelizumab (Anti-Integrin a2b1 (ITGA2 & ITGB1)) Vatelizumab (Anti-Integrin a2b1 (ITGA2 & ITGB1)) is a monoclonal antibody targeting the α2 subunit (CD49b) of very late antigen-2 (VLA-2). It can be used for the research of multiple sclerosis. MW: 144.56 KD. Oct 11 2023
E4363 L-Cystine (dihydrochloride) L-Cystine dihydrochloride is used as a cell culture media component for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies and as a sulfur-containing precursor of glutathione (GSH) synthesis. L-Cystine dihydrochloride homeostasis is also important for GSH functions. Oct 11 2023
A2733 Anti-CXC-ELR Anti-CXC-ELR is a monoclonal antibody that binds to an ELR+ CXC chemokine and inhibits its biological activity. MW: 146.56 KD. Oct 11 2023
A2991 Etaracizumab (Anti-Integrin aVb3 (ITGAV & ITGB3)) Etaracizumab (Anti-Integrin aVb3 (ITGAV & ITGB3)) is an IgG1 monoclonal antibody targeting αvβ3 integrin. It inhibits angiogenesis and melanoma tumor growth and can be used to research anticancer. MW :144.18 KD. Oct 11 2023
E4112 Menthol Menthol is a natural analgesic compound that causes a feeling of coolness due to stimulation of ‘cold’ receptors by inhibiting Ca++ currents of neuronal membranes. Oct 11 2023
A2737 Anti-Matriptase Anti-Matriptase is a monoclonal matriptase-specific antibody. MW: 144.28 KD. Oct 11 2023
E4114 Arabinose Arabinose((±)​-​Arabinose; DL-​Arabinose; dl-​Arabinose) is an endogenous metabolite. It is a natural sugar molecule that exhibits sweetness profiles similar to sucrose, making it a valuable alternative in low-calorie foods and excipients or cocrystallization agents in pharmaceutical formulations. Oct 11 2023
A2739 Anti-158P1D7 Anti-158P1D7 is a monoclonal anti-158P1D7 antibody used in the production of antibody drug conjugates (adc) that bind to 158P1D7 proteins. MW: 146.0 KD. Oct 11 2023
A2740 Anti-Dysadherin Anti-Dysadherin is a monoclonal antibody against dysadherin with anti-metastasis activity. MW: 147.56 KD. Oct 11 2023
A2741 Anti-TMEFF1 / Tomoregulin-1 Anti-TMEFF1 / Tomoregulin-1 is a monoclonal antibody against TMEFF1 (a transmembrane protein with EGF-like and two Follistatin-like domains, Tomoregulin 1), a type I transmembrane glycoprotein. MW: 146.08 KD. Oct 11 2023
A2742 Anti-c-RET Anti-c-RET is a monoclonal antibody against the receptor tyrosine kinase Ret (c-Ret) expressed in cells of neuroblastoma and substantia nigra, a responsive locus of Parkinson's disease. MW: 146.74 KD. Oct 11 2023
E4118 (-)-Menthone (-)-Menthone is a monoterpene component of the essential oil of maturing peppermint. (+)-Neomenthyl-β-d-glucoside is a metabolite of (-)-Menthone. Mortality of two biological forms of Anopheles stephensi (larvae) exposed to about 45 ppm (-)-Menthone is 27.67% and 94.92%. Oct 11 2023
A3000 Orilanolimab (Anti-FcRn (FCGRT & B2M)) Orilanolimab (Anti-FcRn (FCGRT & B2M)) is a humanized monoclonal antibody targeting FcRn. It disrupts the interaction of FcRn and IgG for the treatment autoimmune diseases. MW :144.28 KD. Oct 11 2023
A2745 Anti-Integrin a11 / ITAG11 Anti-Integrin a11 / ITAG11 is a monoclonal antibody against Integrin alpha 11 (ITGA11), a transmembrane glycoprotein expressed in adult cardiac and uterine smooth muscle and developing myocytes. MW: 145.7 KD. Oct 11 2023
A3001 Anti-AXL / UFO (ORY012) Anti-AXL / UFO (ORY012) is a polyclonal antibody that targets receptor tyrosine kinase AXL (UFO). It can be used in research of glioblastoma multiforme (GBM) and pancreatic cancers. MW :146.28 KD. Oct 11 2023
A3002 Anti-Mesothelin (BMS-986148) Anti-Mesothelin (BMS-986148) is a fully human IgG1 monoclonal antibody targeting mesothelin. It is used to synthesize antibody-drug conjugate (ADC). It has potential multimodal therapeutic strategies in patients with advanced solid tumors. MW :150 KD. Oct 11 2023
A2749 Anti-DSG3 Anti-DSG3 is an anti-desmoglein 3 (Dsg3) monoclonal antibody that depletes desmosomes of Dsg3 and has the potential to be used in research on Pemphigus vulgaris (PV). MW: 146.54 KD. Oct 11 2023
A3006 Anti-INHBB / Activin B Anti-INHBB / Activin B is a monoclonal antibody targeting the betaB subunit of Activin B. It has potent uses in treatment of fatigue syndrome/myalgic encephalomyelitis (CFS/ME). MW:146.02 KD. Oct 11 2023
A2752 Anti-MUSK Anti-MUSK is a monoclonal IgG antibody against muscle-specific kinase (MuSK) with the potential to treat Myasthenia gravis. MW: 145.24 KD. Oct 11 2023
A2756 Anti-SCN11a / Nav1.9 Anti-SCN11a / Nav1.9 is a monoclonal anti-Nav1.9 (SCN11A) antibody used in antigen-specific immunodetection in biological samples. MW: 143.94 KD. Oct 11 2023
A2757 Anti-TLR7 Anti-TLR7 is a monoclonal antibody against Toll-like receptor 7 (TLR7) with the potential to treat autoimmune disease. MW: 145.04 KD. Oct 11 2023
A2761 Abrilumab (Anti-Integrin a4b7 ITGA4 & ITGB7) Abrilumab (Anti-Integrin a4b7 ITGA4 & ITGB7) is a fully human monoclonal immunoglobulin G2 antibody that targets the alpha4beta7 integrin and prevents interaction with MADCAM-1. It has the potential to be used in research on inflammatory bowel disease (IBD). MW: 143.8 kD. Oct 11 2023
A3017 Anti-PCLA Anti-PCLA is a fully human IgG4 monoclonal antibody targeting prostate cancer lipid-like antigen (PCLA) It can be used in treatment of prostate cancer. MW :145.52 KD. Oct 11 2023
A3019 Anti-MRC2 / CD280 Anti-MRC2 / CD280 is a monoclonal antibody targeting ENDO180. It can be used as therapeutic strategy of sarcoma subtypes, primary tumor and in metastatic disease. MW :142.92 KD. Oct 11 2023
E4141 Octadecanedioic acid Octadecanedioic acid(1,18-Octadecanedioic acid), an endogenous metabolite, is a long-chain dicarboxylic acid. Octadecanedioic acid when mono-conjugated via an ester linkage to paclitaxel exhibits higher maximum tolerated doses and increased efficacy in vivo in multiple subcutaneous murine xenograft models of human cancer. Oct 11 2023
A3024 Anti-PCSK9 (RG7652) Anti-PCSK9 (RG7652) is a fully human immunoglobulin G1 (IgG1) monoclonal antibody targeting proprotein convertase subtilisin/kexin type 9 (PCSK9). It exhibits potential efficacy in coronary heart disease (CHD). MW :144.84 KD. Oct 11 2023
A3026 Anti-ASIC1 Anti-ASIC1 is a mouse monoclonal antibody targeting acid-sensing ion channel-1 (ASIC1). It exhibits potential application in pain,neurodegenerative diseases, and psychiatric diseases. MW :144.04 KD. Oct 11 2023
E4147 Indole-3-carboxaldehyde Indole-3-carboxaldehyde (3-Formylindole), a banlangen extract, is the product of the oxidative degradation of indole-3-acetic acid (IAA) by crude enzyme preparations from etiolated pea seedlings. It is identified as an active principle component in Marinomonas sp., and it efficiently inhibits biofilm formation by Vibrio cholerae O1 (VCO1) without selection pressure. Oct 11 2023
A2773 Anti-MSPR / RON / CD136 Anti-MSPR / RON / CD136 is a monoclonal antibody that blocks RON binding to its ligand, macrophage-stimulating protein (MSP), and can be used in cancer research. MW: 139.86 KD. Oct 11 2023
A2776 Batoclimab (Anti-FcRn (FCGRT & B2M)) Batoclimab (anti-FcRn (FCGRT & B2M)) is a human monoclonal antibody directed against the neonatal crystallizable fragment receptor (FcRn) with potential immunomodulating activity. It has the potential to be used in research on autoimmune diseases mediated by pathogenic IgG antibodies. MW: 143.76 kD. Oct 11 2023
E4407 Thiobarbituric acid Thiobarbituric acid (2-Thiobarbituric acid) is a colorimetric reagent commonly used in the detection of malondialdehyde (MDA), a marker of lipid peroxidation. Oct 11 2023
A2782 Sudubrilimab (Anti-B7-H1 / PD-L1 / CD274) Sudubrilimab (Anti-B7-H1 / PD-L1 / CD274) is an immunoglobulin G1-kappa, anti-(homo sapiens CD274 (programmed death ligand 1, PDL1, pd-l1, B7 homolog 1, B7H1)), monoclonal antibody. MW: 144.6 kD. Oct 11 2023
A3039 Tislelizumab (Anti-PDCD1 / PD-1 / CD279) Tislelizumab (Anti-PDCD1 / PD-1 / CD279) is a monoclonal antibody targeting programmed cell death protein 1 (anti-PD-1). It can be used for the research of advanced squamous non-small-cell lung cancer. MW :144.46 KD Oct 11 2023
E4416 Stearamide Stearamide is a a primary fatty acid amide that displays cytotoxic and ichthytoxic activity. Stearamide is also used as a lubricating agent in the polymer industry. Oct 11 2023
E4420 NADP sodium salt NADP sodium salt, a nicotinamide adenine dinucleotide, is a coenzyme that plays a vital role in various metabolic reactions within living cells. NADP sodium salt is a key cofactor for electron transfer in the metabolism, being alternately oxidized (NADP+) and reduced (NADPH). Oct 11 2023
A3046 Anti-CYR61 / CCN1 Anti-CYR61 / CCN1 is a monoclonal antibody targeting cysteine-rich protein 61(CCN1/Cyr61) . It can be used in breast cancer treatment. MW :144.42 KD. Oct 11 2023
A2792 Anti-ABCB5 Anti-ABCB5 is a monoclonal antibody (mAb) against ABCB5 (ATP-binding cassette transporter, sub-family B (MDR/TAP), member 5) with the potential to be used in research on melanoma. MW: 147.74 KD. Oct 11 2023
A2793 Anti-CD151 Anti-CD151 is an anti-CD151 monoclonal antibody (mAb) with potential anti-metastatic and anti-tumor activity activity. MW: 146.76 KD. Oct 11 2023
A3049 Anti-RAMP3 Anti-RAMP3 is a polyclonal antibody targeting RAMP2. It is useful in the treatment of cancer. MW :147.04 KD. Oct 11 2023
A2794 Anti-EMMPRIN / CD147 Anti-EMMPRIN / CD147 is a monoclonal antibody against extracellular matrix metalloproteinase inducer (EMMPRIN; CD147) with potential anti-proliferative activity. MW: 145.42 KD. Oct 11 2023
A2797 Anti-IL-25 Anti-IL-25 is a humanised monoclonal antibody against Interleukin-25 (IL-25) with the potential to treat airway hyperresponsiveness (AHR). MW: 146.02 KD. Oct 11 2023
A3053 Anti-BST2 / CD317 Anti-BST2 / CD317 monoclonal antibody that targets Bone marrow stromal antigen 2. It can be used in cancer research. MW :145.52. KD. Oct 11 2023
E4175 (±)-Naringenin (±)-Naringenin is a naturally occurring flavonoid. (±)-Naringenin displays a vasorelaxant effect on endothelium-denuded vessels via activating BKCa channels in myocytes. Oct 11 2023
D4058 IMGN779 IMGN779 is an antibody-drug conjugate (ADC) targeting CD33. It exhibits promising therapeutic approaches in acute myeloid leukemia (AML). MW :146.48 KD. Oct 11 2023
A3065 Tadocizumab (Anti-Integrin a2b3 (ITGA2 & ITGB3)) Tadocizumab (Anti-Integrin a2b3 (ITGA2 & ITGB3)) is a humanized monoclonal antibody tageting integrin αIIbβ3. It has antiplatelet and antithrombotic effects, and can be used for cardiovascular disease research. MW :145.3 KD. Oct 11 2023
D4001 Trastuzumab deruxtecan (DS-8201a, T-DXd) Trastuzumab deruxtecan (DS-8201a, T-DXd) is an antibody-drug conjugate (ADC) composed of an anti-HER2 (human epidermal growth factor receptor 2) antibody and a cytotoxic topoisomerase I inhibitor. Trastuzumab deruxtecan shows durable antitumor activity. Trastuzumab deruxtecan has a molecular weight of 153KDa. This product is supplied as 10mg/ml PBS solution. Oct 09 2023
D4002 Sacituzumab govitecan Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate (ADC) targeting Trop-2 for delivery of SN-38, showing anticancer activity. Sacituzumab govitecan has a molecular weight of 160KDa. This product is supplied as 10mg/ml PBS solution. Oct 09 2023
D4003 Trastuzumab Emtansine（T-DM1） Trastuzumab Emtansine(T-DM1,Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1.Trastuzumab emtansine has a molecular weight of 145kDa.This product is supplied as 10mg/ml PBS solution. Oct 09 2023
E4312 CSRM617 hydrochloride CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. It induces apoptosis by appearance of cleaved Caspase-3 and PARP and is well tolerated in the prostate cancer mouse model. Oct 08 2023
E1657 Gamcemetinib (CC-99677) Gamcemetinib (CC-99677,BMS-986371) is a potent, covalent, and irreversible inhibitor of the mitogen-activated protein (MAP) kinase-activated protein kinase-2 (MK2) (MAPKAPK2 (MK2)) pathway in both biochemical (IC50=156.3 nM) and cell based assays (EC50=89 nM). Oct 08 2023
E1656 AS601245 AS601245 is an orally active, selective, ATP-competitive JNK (c-Jun NH2-terminal protein kinase) inhibitor with IC50 of 150, 220, and 70 nM for three JNK human isoforms hJNK1, hJNK2, and hJNK3, respectively. Oct 08 2023
E4445 3-Benzoylpropionic acid 3-Benzoylpropionic acid is a carboxylate compound which can be used as a fungicide and an oligonucleotide synthesis reagent. Sep 27 2023
E4451 Pyronin Y Pyronin Y is a fluorescent probe which stains double stranded RNA in living or fixed cells as well as in tissues. Sep 25 2023
E4444 Soy Phospholipids Soy Phospholipids is a mixture of phospholipids. Sep 25 2023
E1474 BI-2865 BI-2865 is a none-covalent pan-KRAS Inhibitor. It binds to WT, G12C, G12D, G12V and G13D mutant KRAS with KDs of 6.9, 4.5, 32, 26, 4.3 nM respectively and inhibits the proliferation of G12C, G12D or G12V mutant KRAS expressing BaF3 ce Sep 24 2023
E4446 S-(5'-Adenosyl)-L-methionine p-toluenesulfonate salt S-(5′-Adenosyl)-L-methionine p-toluenesulfonate salt (AdoMet) is a methyl donor and cofactor for enzyme-catalyzed methylations including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). It has an anti-apoptotic activity and can be used for the treatment of depression, liver cirrhosis, cholestasis and degenerative joint disease. Sep 24 2023
E4452 Trypsin Trypsin(Cocoonase) is a serine protease enzyme, and hydrolyzes proteins at the carboxyl side of the Lysine or Arginine. It activates PAR2 and PAR4 and induces cell-to-cell membrane fusion in PDCoV infection by the interaction of S glycoprotein of PDCoV and pAPN. It also promotes cell proliferation and differentiation and can be used in the research of wound healing and neurogenic inflammation. Sep 24 2023
E4450 N6-Cyclopentyladenosine N6-Cyclopentyladenosine is an adenosine derivative and a potent adenosine receptor agonist with Ki values of 2.3 nM, 790 nM and 43 nM for human A1, A2A and A3 receptors, respectively. It acts as an anticonvulsant and might exhibit protective actions against (AMPH)-induced seizures. Sep 24 2023
E1445 Palovarotene Palovarotene (R 667; Ro 3300074) is a nuclear retinoic acid receptor γ (RAR-γ) agonist. It reduces heterotopic ossification (HO) in cultures and in murine and rat fibrodysplasia ossificans progressiva (FOP) models. Sep 24 2023
E1483 IK-930 IK-930 is a selective, small-molecule inhibitor of TEAD that prevents palmitate binding and thereby disrupts aberrant TEAD-dependent transcription. IK-930 demonstrates antitumor activity in mouse xenograft models with Hippo pathway genetic alterations. Sep 24 2023
E1480 DJ4 DJ4 (EX-A7863) is a potent, selective ATP-competitive inhibitor of ROCK1/2 and MRCKα/β with IC50 of 5/50 nM and 10/100 nM respectively. It blocks stress fiber formation and inhibits migration and invasion of multiple cancer cell line Sep 21 2023
E1477 EP4-IN-1 EP4-IN-1 is a potent prostanoid EP4 receptor inhibitor. It exhibits prospects in tumor immunity and anti-inflammatory analgesia research. Sep 21 2023
E1549 AZD0095 AZD0095 is a selective and orally active Monocarboxylate transporter 4 (MCT4) inhibitor with IC50 of 1.3 nM and effectively inhibits the tumor growth in NCI-H358 xenografts in combination with Cediranib. Sep 21 2023
E2985 Capadenoson Capadenoson (BAY 68-4986) is an orally bioavailable, non-nucleoside partial adenosine A1 receptor agonist that exhibits an anti-ischemic effect. Sep 21 2023
E1433 LY3537982 (KRAS G12C inhibitor 19) LY3537982 (KRAS G12C inhibitor 19) is a highly selective and potent inhibitor of the  KRAS-G12C protein. LY3537982 selectively inhibits the growth of KRAS G12C mutant cells H23 G12C, H358 G12C, and H2122 G12C with IC50s of 1.04 nM, 1.16 nM, and 11.38 nM, respectively. Sep 21 2023
E1578 garsorasib (D-1553 ) Garsorasib (D-1553 ) is a potent and selective oral KRASG12C inhibitor with antitumor activity. It has the potential to treat KRAS G12C-mutated non-small cell lung cancer (NSCLC). Sep 21 2023
E1606 RMC-6291 RMC-6291 is an orally active and covalent inhibitor of KRASG12C(ON). RMC-6291 forms a tri-complex within tumor cells between KRASG12C(ON) and cyclophilin A (CypA). Sep 21 2023
E1535 icFSP1 icFSP1 is a potent, selective human ferroptosis suppressor protein-1 (hFSP1) inhibitor, promotes ferroptosis and indirectly inhibits FSP1 by inducing condensate formation. Sep 21 2023
E1596 AOH1996 AOH1996 is an orally active small-molecule PCNA inhibitor with potential anti-tumor activity. It enhances the interaction between PCNA and RPB1, the largest subunit of RNA polymerase II. Sep 21 2023