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Laduviglusib trihydrochloride

Name: Laduviglusib trihydrochloride
Brand: Selleck Chemicals
SKU: E5780
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.E5780

Laduviglusib (CHIR-99021) trihydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. This compound shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. It is also a potent Wnt/β-catenin signaling pathway activator. This chemical enhances mouse and human embryonic stem cells self-renewal. It induces autophagy.

Chemical Structure

Molecular Weight: 574.72

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Quality Control

Batch: E578001 DMSO]100 mg/mL]false]Water]25 mg/mL]false]Ethanol]3 mg/mL]false Purity: 97.74%

Cited in Nature Medicine for its top-tier quality
COA
NMR
HPLC
SDS
Datasheet

97.74

Related Targets	PI3K Akt mTOR GSK-3 ATM/ATR DNA-PK AMPK PDPK1 PTEN PP2A
Other Others Inhibitors	BAY 2927088（Sevabertinib） Guanidinoacetic acid BAPTA-AM Blebbistatin Methyl-β-cyclodextrin (MβCD) Carbazochrome sodium sulfonate (AC-17) Ursolic Acid Osthole 4-Methylumbelliferone (4-MU) Dioscin

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (173.99 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 25 mg/mL

Ethanol : 3 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	574.72	Formula	C₂₂H₁₈Cl₂N₈.3ClH	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	1782235-14-6	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Mechanism of Action

References	[1] https://pubmed.ncbi.nlm.nih.gov/12606497/ [2] https://pubmed.ncbi.nlm.nih.gov/21389981/

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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