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CA-074

Name: CA-074
Brand: Selleck Chemicals
SKU: S9834
Availability: InStock
Rating: 5 (2 reviews)

Cat.No.S9834

CA-074 inhibits cathepsin B with a Ki value of 2-5 nM.

Chemical Structure

Molecular Weight: 383.44

Jump to Mechanism of Action Chemical Information, Storage & Stability

Quality Control

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Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Chemical Information, Storage & Stability

Molecular Weight	383.44	Formula	C18H29N3O6	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	134448-10-5	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Mechanism of Action

In vivo	Intraperitoneally injection of compound CA-074 into rats potently and selectively inhibits cathepsin B activity. Intravenously administration of CA-074 immediately after the ischaemic insult saves 67% of CA1 neurons from delayed neuronal death on day 5 in eight monkeys undergoing 20 min brain ischaemia: the extent of inhibition is excellent in three of eight and good in five of eight monkeys.
References	[1] https://www.ncbi.nlm.nih.gov/2013329 [2] https://www.ncbi.nlm.nih.gov/12437121 [3] https://www.ncbi.nlm.nih.gov/9751144

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