Home Immunology & Inflammation Histone Demethylase inhibitor TC-E5002(KDM2/7-IN-1)

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TC-E5002(KDM2/7-IN-1) Histone Demethylase inhibitor

Cat.No.E1793

TC-E5002(KDM2/7-IN-1) is a selective inhibitor of histone demethylase KDM2/7 subfamily with IC50s of 6.8, 0.2, and 1.2 µM for KDM2A, KDM7A, and KDM7B, respectively. It is selective for the KDM2/7 subfamily over KDM4A, KDM4C, KDM5A, and KDM6A/UTX with IC50s of >120, 83, 55, and 100 µM, respectively. It exhibits antiproliferative activity, indicating its potential as an anticancer agent.
TC-E5002(KDM2/7-IN-1) Histone Demethylase inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 285.38

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Chemical Information, Storage & Stability

Molecular Weight 285.38 Formula

C15H27NO4

 Storage (From the date of receipt)
CAS No. 1453071-47-0 Download SDF Storage of Stock Solutions Solutions are unstable. Prepare fresh or purchase small, pre-packaged sizes. Repackage upon receipt.

Mechanism of Action

Targets/IC50/Ki
KDM7A
0.2 μM
KDM7B
1.2 μM
KDM2A
6.8 μM
KDM5A
55 μM
KDM4C
83 μM
KDM6A
>100 μM
KDM4A
>120 μM
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